Effects of triple combination therapy with azilsartan/amlodipine/hydrochlorothiazide on office/home blood pressure: A randomized-controlled trial in Japanese essential hypertensive patients

Blood Pressure Monitoring

Volumn 23, Issue 2, 2018, Pages 91-102

  Rakugi, Hiromi ^a   Shimizu, Kohei ^b   Sano, Yuhei ^b   Nishiyama, Yuya ^b   Kinugawa, Yoshinobu ^b   Terashio, Souhei ^b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

amlodipine; azilsartan; blood pressure; hydrochlorothiazide; randomized controlled trial; triple combination therapy

Indexed keywords

AMLODIPINE BESYLATE PLUS AZILSARTAN; AMLODIPINE BESYLATE PLUS AZILSARTAN PLUS HYDROCHLOROTHIAZIDE; ANTIHYPERTENSIVE AGENT; HYDROCHLOROTHIAZIDE; PLACEBO; POTASSIUM; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA; URIC ACID; AMLODIPINE; AZILSARTAN; BENZIMIDAZOLE DERIVATIVE; OXADIAZOLE DERIVATIVE;

ADULT; ANTIHYPERTENSIVE THERAPY; ARTICLE; BACKACHE; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE MONITORING; BLOOD PRESSURE REGULATION; CHRONOPHARMACOLOGY; CLINICAL EVALUATION; COMBINATION DRUG THERAPY; COMPARATIVE EFFECTIVENESS; CONNECTIVE TISSUE DISEASE; CONTROLLED STUDY; CONTUSION; DIASTOLIC BLOOD PRESSURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; ECZEMA; ESSENTIAL HYPERTENSION; EXPLORATORY RESEARCH; FALLING; FEMALE; GASTROINTESTINAL SYMPTOM; HEADACHE; HEMATURIA; HOME; HOME BLOOD PRESSURE; HUMAN; HYPERURICEMIA; INCIDENCE; INFECTION; INFESTATION; INJURY; INTOXICATION; JAPAN; JAPANESE (PEOPLE); LACERATION; MAJOR CLINICAL STUDY; MALE; MEDIASTINUM DISEASE; MIDDLE AGED; MONOTHERAPY; MORNING DOSAGE; MULTICENTER STUDY; MUSCULOSKELETAL DISEASE; NEUROLOGIC DISEASE; OBSERVATIONAL STUDY; OFFICE BLOOD PRESSURE; PARALLEL DESIGN; PHARYNGITIS; POSITIONAL DIZZINESS; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; PROTEINURIA; RANDOMIZED CONTROLLED TRIAL; RASH; RESPIRATORY TRACT DISEASE; RHINOPHARYNGITIS; SIDE EFFECT; SINGLE BLIND PROCEDURE; SKIN MANIFESTATION; SOFT TISSUE DISEASE; SYSTOLIC BLOOD PRESSURE; TELEMETRY; THERAPY EFFECT; THORAX DISEASE; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; UPPER RESPIRATORY TRACT INFECTION; UREA BLOOD LEVEL; URIC ACID BLOOD LEVEL; AGED; CLINICAL TRIAL; DRUG EFFECT; PATHOPHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME;

AGED; AMLODIPINE; ANTIHYPERTENSIVE AGENTS; BENZIMIDAZOLES; BLOOD PRESSURE; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ESSENTIAL HYPERTENSION; FEMALE; HUMANS; HYDROCHLOROTHIAZIDE; JAPAN; MALE; MIDDLE AGED; OXADIAZOLES; TREATMENT OUTCOME;

EID: 85044638156     PISSN: 13595237     EISSN: 14735725     Source Type: Journal    
DOI: 10.1097/MBP.0000000000000308     Document Type: Article

References (11)

1. Shimamoto K, Ando K, Fujita T, Hasebe N, Higaki J, Horiuchi M, et al. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014). Hypertens Res 2014; 37:253-390.
2. Rakugi H, Enya K, Sugiura K, Ikeda Y. Comparison of the efficacy and safety of azilsartan with that of candesartan cilexetil in Japanese patients with grade I-II essential hypertension: a randomized, double-blind clinical study. Hypertens Res 2012; 35:552-558.
3. Haria M, Wagstaff AJ. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease. Drugs 1995; 50:560-586.
4. Derosa G, Maffioli P. Drug safety evaluation of amlodipine. Expert Opin Drug Saf 2011; 10:795-804.
5. Padilla MC, Armas-Hernández MJ, Hernández RH, Israili ZH, Valasco M. Update of diuretics in the treatment of hypertension. Am J Ther 2007; 14:154-160.
6. Oshikawa J, Toya Y, Morita S, Taguri M, Hanaoka K, Hasegawa T, et al. Angiotensin receptor blocker (ARB)-diuretic versus ARB-calcium channel blocker combination therapy for hypertension uncontrolled by ARB monotherapy. Clin Exp Hypertens 2014; 36:244-250.
7. Rakugi H, Nakata E, Sasaki E, Kagawa T. Evaluation of the efficacy and tolerability of fixed-dose combination therapy of azilsartan and amlodipine besylate in Japanese patients with grade I to II essential hypertension. Clin Ther 2014; 36:711-721.
8. Calhoun DA, Crikelair NA, Yen J, Glazer RD. Amlodipine/valsartan/hydrochlorothiazide triple combination therapy in moderate/severe hypertension: secondary analyses evaluating efficacy and safety. Adv Ther 2009; 26:1012-1023.
9. Chrysant SG, Izzo JL Jr, Kereiakes DJ, Littlejohn T 3rd, Oparil S, Melino M, et al. Efficacy and safety of triple-combination therapy with olmesartan, amlodipine, and hydrochlorothiazide in study participants with hypertension and diabetes: a subpopulation analysis of the TRINITY study. J Am Soc Hypertens 2012; 6:132-141.
10. El Assaad MA, Topouchian JA, Darné BM, Asmar RG. Validation of the Omron HEM-907 device for blood pressure measurement. Blood Press Monit 2002; 7:237-241.
11. Takahashi H, Yoshika M, Yokoi T. Validation of two automatic devices: Omron HEM-7252G-HP and Omron HEM-7251G for self-measurement of blood pressure according to the European Society of Hypertension International Protocol revision 2010. Blood Press Monit 2015; 20:286-290.