Evaluation of the efficacy and tolerability of fixed-dose combination therapy of azilsartan and amlodipine besylate in Japanese patients with grade i to ii essential hypertension

Clinical Therapeutics

Volumn 36, Issue 5, 2014, Pages 711-721

  Rakugi, Hiromi ^a   Nakata, Emi ^b   Sasaki, Emma ^b   Kagawa, Tomoya ^b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

amlodipine besylate; azilsartan; essential hypertension; fixed dose combination

Indexed keywords

AMLODIPINE BESYLATE; AZILSARTAN; CREATINE KINASE; PLACEBO; AMLODIPINE; ANTIHYPERTENSIVE AGENT; BENZIMIDAZOLE DERIVATIVE; OXADIAZOLE DERIVATIVE;

ADULT; ANTIHYPERTENSIVE ACTIVITY; ANTIHYPERTENSIVE THERAPY; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; ESSENTIAL HYPERTENSION; FEMALE; HUMAN; JAPANESE (PEOPLE); MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MULTICENTER STUDY; OUTCOME ASSESSMENT; PHYSICAL EXAMINATION; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; SIDE EFFECT; UPPER RESPIRATORY TRACT INFECTION; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CLINICAL TRIAL; DOSE RESPONSE; DRUG COMBINATION; HYPERTENSION; MIDDLE AGED;

AGED; AMLODIPINE; ANTIHYPERTENSIVE AGENTS; ASIAN CONTINENTAL ANCESTRY GROUP; BENZIMIDAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; OXADIAZOLES;

EID: 84901424611     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2014.03.009     Document Type: Article

References (17)

1. T. Teramoto, and T. Fujita Japan Guideline Assessment Panel 2 (J-GAP2) [in Japanese] Prog Med 30 2010 1437 1449
2. T. Ogihara, K. Kikuchi, and H. Matsuoka et al. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009) Hypertens Res 32 2009 3 107
3. H. Rakugi, K. Enya, and K. Sugiura et al. Comparison of the efficacy and safety of azilsartan with that of candesartan cilexetil in Japanese patients with grade I-II essential hypertension: a randomized, double-blind clinical study Hypertens Res 35 2012 552 558
4. World Medical Association. WMA Declaration of Helsinki - Ethical Principles for Medical Research Involving Human Subjects. http://www.wma.net/en/ 30publications/10policies/b3/. Accessed December 16, 2013.
5. P.P. Gerbino, and O. Shoheiber Adherence patterns among patients treated with fixed-dose combination versus separate antihypertensive agents Am J Health Syst Pharm 64 2007 1279 1283
6. K. Schroeder, T. Fahey, and S. Ebrahim How can we improve adherence to blood pressure-lowering medication in ambulatory care? systematic review of randomized controlled trials Arch Intern Med 164 2004 722 732
7. A.K. Gupta, S. Arshad, and N.R. Poulter Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis Hypertension 55 2010 399 407
8. A.V. Chobanian, G.L. Bakris, and H.R. Black et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report JAMA 289 2003 2560 2572
9. Task Force for the management of arterial hypertension of the European Society of Hypertension 2013 ESH/ESC guidelines for the Management of Arterial Hypertension Blood Press 22 2013 193 278
10. K. Miura, H. Nakagawa, and Y. Ohashi et al. Four blood pressure indexes and the risk of stroke and myocardial infarction in Japanese men and women: a meta-analysis of 16 cohort studies Circulation 119 2009 1892 1898
11. C.M. Lawes, D.A. Bennett, and V. Parag et al. Blood pressure indices and cardiovascular disease in the Asia Pacific region: a pooled analysis Hypertension 42 2003 69 75
12. R. Inoue, T. Ohkubo, and M. Kikuya et al. Predicting stroke using 4 ambulatory blood pressure monitoring-derived blood pressure indices: the Ohasama Study Hypertension 48 2006 877 882
13. B. Tomlinson, J. Woo, and N. Thomas et al. Randomized, controlled, parallel-group comparison of ambulatory and clinic blood pressure responses to amlodipine or enalapril during and after treatment in adult Chinese patients with hypertension Clin Ther 26 2004 1292 1304
14. K. Eguchi, K. Kario, and Y. Hoshide et al. Comparison of valsartan and amlodipine on ambulatory and morning blood pressure in hypertensive patients Am J Hypertens 17 2004 112 117
15. J.A. Staessen, L. Thijs, and R. Fagard et al. Predicting cardiovascular risk using conventional vs ambulatory blood pressure in older patients with systolic hypertension. Systolic Hypertension in Europe Trial Investigators JAMA 282 1999 539 546
16. M. Kikuya, T. Ohkubo, and K. Asayama et al. Ambulatory blood pressure and 10-year risk of cardiovascular and noncardiovascular mortality: the Ohasama study Hypertension 45 2005 240 245
17. K. Asayama, T. Ohkubo, and M. Kikuya et al. Prediction of stroke by home "morning" versus "evening" blood pressure values: the Ohasama study Hypertension 48 2006 737 743