Nonalcoholic Steatohepatitis is the Most Rapidly Increasing Indication for Liver Transplantation in Young Adults in the United States

Journal of Clinical Gastroenterology

Volumn 52, Issue 4, 2018, Pages 339-346

  Doycheva, Iliana ^a   Issa, Danny ^b   Watt, Kymberly D ^c   Lopez, Rocio ^d   Rifai, Ghassoub ^d   Alkhouri, Naim ^e  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c MAYO CLINIC   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

^e Texas Liver Institute   (United States)

Author keywords

cirrhosis; Fatty liver; outcomes; survival; UNOS

Indexed keywords

ADULT; ARTICLE; CLINICAL OUTCOME; COHORT ANALYSIS; FEMALE; GRAFT SURVIVAL; HUMAN; LIVER CIRRHOSIS; LIVER METABOLISM; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; NONALCOHOLIC FATTY LIVER; PRIORITY JOURNAL; RETRANSPLANTATION; RETROSPECTIVE STUDY; TREATMENT INDICATION; TREND STUDY; UNITED STATES; YOUNG ADULT; ADOLESCENT; FACTUAL DATABASE; KAPLAN MEIER METHOD; MORTALITY; RISK FACTOR;

ADOLESCENT; ADULT; DATABASES, FACTUAL; FEMALE; GRAFT SURVIVAL; HUMANS; KAPLAN-MEIER ESTIMATE; LIVER TRANSPLANTATION; MALE; NON-ALCOHOLIC FATTY LIVER DISEASE; RISK FACTORS; UNITED STATES; YOUNG ADULT;

EID: 85044340628     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/MCG.0000000000000925     Document Type: Article

References (28)

1. Wong RJ, Aguilar M, Cheung R, et al. Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States. Gastroenterology. 2015;148:547-555.
2. Singal AK, Hasanin M, Kaif M, et al. Nonalcoholic steatohepatitis is the most rapidly growing indication for simultaneous liver kidney transplantation in the United States. Transplantation. 2016;100:607-612.
3. Schwimmer JB, Deutsch R, Kahen T, et al. Prevalence of fatty liver in children and adolescents. Pediatrics. 2006;118:1388-1393.
4. Alkhouri N, Hanouneh IA, Zein NN, et al. Liver transplantation for nonalcoholic steatohepatitis in young patients. Transpl Int. 2016;29:418-424.
5. United States Census Bureau. Millennials outnumber baby boomers and are far more diverse, Census Bureau Reports. 2015. Available at: Www.census.gov/newsroom/press-releases/2015/cb15-113.html. Accessed January 12, 2017.
6. Williams CD, Stengel J, Asike MI, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study. Gastroenterology. 2011; 140:124-131.
7. Kwan MY, Cairney J, Faulkner GE, et al. Physical activity and other health-risk behaviors during the transition into early adulthood: A longitudinal cohort study. Am J Prev Med. 2012; 42:14-20.
8. Niemeier HM, Raynor HA, Lloyd-Richardson EE, et al. Fast food consumption and breakfast skipping: Predictors of weight gain from adolescence to adulthood in a nationally representative sample. J Adolesc Health. 2006;39:842-849.
9. Flegal KM, Kruszon-Moran D, Carroll MD, et al. Trends in obesity among adults in the United States, 2005 to 2014. JAMA. 2016;315:2284-2291.
10. Aguilar M, Bhuket T, Torres S, et al. Prevalence of the metabolic syndrome in the United States, 2003-2012. JAMA. 2015;313:1973-1974.
11. Mrad RA, Merjaneh N, Mubarak G, et al. The increasing burden of nonalcoholic fatty liver disease among young adults in the United States: A growing epidemic (letter to the editor). Hepatology. 2016;64:1386-1387.
12. Welsh JA, Karpen S, Vos MB. Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988-1994 to 2007-2010. J Pediatr. 2013;162:496.e491-500.e491.
13. Charlton MR, Burns JM, Pedersen RA, et al. Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology. 2011;141: 1249-1253.
14. Wong RJ, Cheung R, Ahmed A. Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the US. Hepatology. 2014;59:2188-2195.
15. Caldwell SH, Crespo DM. The spectrum expanded: Cryptogenic cirrhosis and the natural history of non-alcoholic fatty liver disease. J Hepatol. 2004;40:578-584.
16. Afzali A, Berry K, Ioannou GN. Excellent posttransplant survival for patients with nonalcoholic steatohepatitis in the United States. Liver Transpl. 2012;18:29-37.
17. Kim WR, Lake JR, Smith JM, et al. OPTN/SRTR 2015 annual data report: Liver. Am J Transplant. 2017;17 (suppl 1):174-251.
18. Ogden CL, Carroll MD, Lawman HG, et al. Trends in obesity prevalence among children and adolescents in the United States, 1988-1994 through 2013-2014. JAMA. 2016;315: 2292-2299.
19. Holterman AX, Guzman G, Fantuzzi G, et al. Nonalcoholic fatty liver disease in severely obese adolescent and adult patients. Obesity (Silver Spring). 2013;21:591-597.
20. Rotman Y, Koh C, Zmuda JM, et al. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology. 2010;52:894-903.
21. Del Chierico F, Nobili V, Vernocchi P, et al. Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta-omics-based approach. Hepatology. 2017;65:451-464.
22. Agopian VG, Kaldas FM, Hong JC, et al. Liver transplantation for nonalcoholic steatohepatitis: The new epidemic. Ann Surg. 2012;256:624-633.
23. Kennedy C, Redden D, Gray S, et al. Equivalent survival following liver transplantation in patients with non-alcoholic steatohepatitis compared with patients with other liver diseases. HPB (Oxford). 2012;14:625-634.
24. Malik SM, deVera ME, Fontes P, et al. Outcome after liver transplantation for NASH cirrhosis. Am J Transplant. 2009;9: 782-793.
25. Yalamanchili K, Saadeh S, Klintmalm GB, et al. Nonalcoholic fatty liver disease after liver transplantation for cryptogenic cirrhosis or nonalcoholic fatty liver disease. Liver Transpl. 2010;16:431-439.
26. Wang X, Li J, Riaz DR, et al. Outcomes of liver transplantation for nonalcoholic steatohepatitis: A systematic review and metaanalysis. Clin Gastroenterol Hepatol. 2014;12:394-402 e391.
27. Hagstrom H, Stal P, Hultcrantz R, et al. Overweight in late adolescence predicts development of severe liver disease later in life: A 39years follow-up study. J Hepatol. 2016;65:363-368.
28. Doycheva I, Watt KD, Rifai G, et al. Increasing burden of chronic liver disease among adolescents and young adults in the USA: A silent epidemic. Dig Dis Sci. 2017;62:1373-1380.