Hyperoxia and hypocapnia during pediatric extracorporeal membrane oxygenation: Associations with complications, mortality, and functional status among survivors

Pediatric Critical Care Medicine

Volumn 19, Issue 3, 2018, Pages 245-253

  Cashen, Katherine ^a   Reeder, Ron ^b   Dalton, Heidi J ^c   Berg, Robert A ^d   Shanley, Thomas P ^e   Newth, Christopher J L ^f   Pollack, Murray M ^g   Wessel, David ^g   Carcillo, Joseph ^h   Harrison, Rick ⁱ   Michael Dean, J ^b   Tamburro, Robert ^j   Meert, Kathleen L ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c INOVA FAIRFAX HOSPITAL   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

^f CHILDREN S HOSPITAL LOS ANGELES   (United States)

^g CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^h CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

ⁱ MATTEL CHILDREN S HOSPITAL   (United States)

^j EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

more..

Author keywords

Child; Extracorporeal membrane oxygenation; Hyperoxia; Hypocapnia; Neonate

Indexed keywords

LACTIC ACID;

ADOLESCENT; ARTERIAL GAS; ARTICLE; CHILD; CONGENITAL DIAPHRAGM HERNIA; CONTROLLED STUDY; EXTRACORPOREAL OXYGENATION; FEMALE; FUNCTIONAL STATUS; HOSPITAL DISCHARGE; HOSPITAL MORTALITY; HOSPITALIZATION; HUMAN; HYPEROXIA; HYPOCAPNIA; INFANT; INTENSIVE CARE UNIT; KIDNEY FAILURE; LACTATE BLOOD LEVEL; LENGTH OF STAY; LIVER DYSFUNCTION; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; MECONIUM ASPIRATION; MORTALITY; NEUROLOGIC DISEASE; PREMATURITY; PRIORITY JOURNAL; RESUSCITATION; SURVIVOR; THROMBOSIS; BLOOD GAS ANALYSIS; NEWBORN; PRESCHOOL CHILD; PROSPECTIVE STUDY; RISK FACTOR;

ADOLESCENT; BLOOD GAS ANALYSIS; CHILD; CHILD, PRESCHOOL; EXTRACORPOREAL MEMBRANE OXYGENATION; FEMALE; HOSPITAL MORTALITY; HUMANS; HYPEROXIA; HYPOCAPNIA; INFANT; INFANT, NEWBORN; MALE; PROSPECTIVE STUDIES; RISK FACTORS; SURVIVORS;

EID: 85044261876     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0000000000001439     Document Type: Article

References (37)

1. Kilgannon JH, Jones AE, Shapiro NI, et al; Emergency Medicine Shock Research Network (EMShockNet) Investigators: Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 2010; 303:2165–2171
2. Kilgannon JH, Jones AE, Parrillo JE, et al; Emergency Medicine Shock Research Network (EMShockNet) Investigators: Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation 2011; 123:2717–2722
3. Ferguson LP, Durward A, Tibby SM: Relationship between arterial partial oxygen pressure after resuscitation from cardiac arrest and mortality in children. Circulation 2012; 126:335–342
4. Davis DP, Meade W, Sise MJ, et al: Both hypoxemia and extreme hyperoxemia may be detrimental in patients with severe traumatic brain injury. J Neurotrauma 2009; 26:2217–2223
5. Brenner M, Stein D, Hu P, et al: Association between early hyperoxia and worse outcomes after traumatic brain injury. Arch Surg 2012; 147:1042–1046
6. Klinger G, Beyene J, Shah P, et al: Do hyperoxaemia and hypocapnia add to the risk of brain injury after intrapartum asphyxia? Arch Dis Child Fetal Neonatal Ed 2005; 90:F49–52
7. Hayes RA, Shekar K, Fraser JF: Is hyperoxaemia helping or hurting patients during extracorporeal membrane oxygenation? Review of a complex problem. Perfusion 2013; 28:184–193
8. McDonald CI, Fraser JF, Coombes JS, et al: Oxidative stress during extracorporeal circulation. Eur J Cardiothorac Surg 2014; 46:937–943
9. Helmerhorst HJ, Roos-Blom MJ, van Westerloo DJ, et al: Associations of arterial carbon dioxide and arterial oxygen concentrations with hospital mortality after resuscitation from cardiac arrest. Crit Care 2015; 19:348
10. Roberts BW, Kilgannon JH, Chansky ME, et al: Association between postresuscitation partial pressure of arterial carbon dioxide and neurological outcome in patients with post-cardiac arrest syndrome. Circulation 2013; 127:2107–2113
11. Schneider AG, Eastwood GM, Bellomo R, et al: Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest. Resuscitation 2013; 84:927–934
12. Del Castillo J, López-Herce J, Matamoros M, et al; Iberoamerican Pediatric Cardiac Arrest Study Network RIBEPCI: Hyperoxia, hypocapnia and hypercapnia as outcome factors after cardiac arrest in children. Resuscitation 2012; 83:1456–1461
13. Ramaiah VK, Sharma D, Ma L, et al: Admission oxygenation and ventilation parameters associated with discharge survival in severe pediatric traumatic brain injury. Childs Nerv Syst 2013; 29:629–634
14. Warner KJ, Cuschieri J, Copass MK, et al: The impact of prehospital ventilation on outcome after severe traumatic brain injury. J Trauma 2007; 62:1330–1336
15. Solaiman O, Singh JM: Hypocapnia in aneurysmal subarachnoid hemorrhage: Incidence and association with poor clinical outcomes. J Neurosurg Anesthesiol 2013; 25:254–261
16. Pappas A, Shankaran S, Laptook AR, et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network: Hypocarbia and adverse outcome in neonatal hypoxic-ischemic encephalopathy. J Pediatr 2011; 158:752–758.e1
17. 2 derangements on clinical outcomes after cerebral injury: A systematic review. Resuscitation 2015; 91:32–41
18. Sznycer-Taub NR, Lowery R, Yu S, et al: Hyperoxia is associated with poor outcomes in pediatric cardiac patients supported on venoarterial extracorporeal membrane oxygenation. Pediatr Crit Care Med 2016; 17:350–358
19. Spoelstra-de Man AM, Smit B, et al: Cardiovascular effects of hyperoxia during and after cardiac surgery. Anaesthesia 2015; 70:1307–1319
20. Quarti A, Nardone S, Manfrini F, et al: Effect of the adjunct of carbon dioxide during cardiopulmonary bypass on cerebral oxygenation. Perfusion 2013; 28:152–155
21. Caputo M, Mokhtari A, Rogers CA, et al: The effects of normoxic versus hyperoxic cardiopulmonary bypass on oxidative stress and inflammatory response in cyanotic pediatric patients undergoing open cardiac surgery: A randomized controlled trial. J Thorac Cardiovasc Surg 2009; 138:206–214
22. Dalton HJ, Reeder R, Garcia-Filion P, et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network: Factors associated with bleeding and thrombosis in children receiving extracorporeal membrane oxygenation. Am J Respir Crit Care Med 2017; 196:762–771
23. Gaies MG, Gurney JG, Yen AH, et al: Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatr Crit Care Med 2010; 11:234–238
24. Gaies MG, Jeffries HE, Niebler RA, et al: Vasoactive-inotropic score is associated with outcome after infant cardiac surgery: An analysis from the Pediatric Cardiac Critical Care Consortium and Virtual PICU System Registries. Pediatr Crit Care Med 2014; 15:529–537
25. Ortiz RM, Cilley RE, Bartlett RH: Extracorporeal membrane oxygenation in pediatric respiratory failure. Pediatr Clin North Am 1987; 34:39–46
26. Bennett KS, Clark AE, Meert KL, et al; Pediatric Emergency Care Medicine Applied Research Network: Early oxygenation and ventilation measurements after pediatric cardiac arrest: Lack of association with outcome. Crit Care Med 2013; 41:1534–1542
27. Guerra-Wallace MM, Casey FL 3rd, Bell MJ, et al: Hyperoxia and hypoxia in children resuscitated from cardiac arrest. Pediatr Crit Care Med 2013; 14:e143–e148
28. Pollack MM, Holubkov R, Glass P, et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network: Functional Status Scale: New pediatric outcome measure. Pediatrics 2009; 124:e18–e28
29. Furnival GM, Wilson RW: Regressions by leaps and bounds. Technometrics 1974; 16:499–511
30. Munshi L, Kiss A, Cypel M, et al: Oxygen thresholds and mortality during extracorporeal life support in adult patients. Crit Care Med 2017; 45:1997–2005
31. Barbaro RP, Paden ML, Guner YS, et al; ELSO member centers: Pediatric extracorporeal life support organization registry international report 2016. ASAIO J 2017; 63:456–463
32. Short BL, Walker LK, Bender KS, et al: Impairment of cerebral autoregulation during extracorporeal membrane oxygenation in newborn lambs. Pediatr Res 1993; 33:289–294
33. O’Brien NF, Hall MW: Extracorporeal membrane oxygenation and cerebral blood flow velocity in children. Pediatr Crit Care Med 2013; 14:e126–e134
34. Bembea MM, Lee R, Masten D, et al: Magnitude of arterial carbon dioxide change at initiation of extracorporeal membrane oxygenation support is associated with survival. J Extra Corpor Technol 2013; 45:26–32
35. Peralta C, Jiménez-Castro MB, Gracia-Sancho J: Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu. J Hepatol 2013; 59:1094–1106
36. Aufderheide TP, Lurie KG: Death by hyperventilation: A common and life-threatening problem during cardiopulmonary resuscitation. Crit Care Med 2004; 32:S345–S351
37. Howard TS, Kalish BT, Wigmore D, et al: Association of extracorporeal membrane oxygenation support adequacy and residual lesions with outcomes in neonates supported after cardiac surgery. Pediatr Crit Care Med 2016; 17:1045–1054