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Volumn 259, Issue , 2018, Pages 198-204

Circulating Interleukin-6 is a biomarker for coronary atherosclerosis in nonalcoholic fatty liver disease: Results from the Multi-Ethnic Study of Atherosclerosis

Author keywords

Atherosclerosis; Biomarker; Cardiovascular disease; Fatty liver; Inflammation; Nonalcoholic fatty liver disease

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; C REACTIVE PROTEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GAMMA GLUTAMYLTRANSFERASE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; PLASMINOGEN ACTIVATOR INHIBITOR 1; SOLUBLE INTERCELLULAR ADHESION MOLECULE 1; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; IL6 PROTEIN, HUMAN;

EID: 85044109366     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2018.01.046     Document Type: Article
Times cited : (56)

References (44)
  • 1
    • 84880245463 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988–1994
    • Lazo, M., Hernaez, R., Eberhardt, M.S., et al. Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988–1994. Am. J. Epidemiol. 178 (2013), 38–45.
    • (2013) Am. J. Epidemiol. , vol.178 , pp. 38-45
    • Lazo, M.1    Hernaez, R.2    Eberhardt, M.S.3
  • 2
    • 84876130551 scopus 로고    scopus 로고
    • Association between noninvasive fibrosis markers and mortality among adults with nonalcoholic fatty liver disease in the United States
    • Kim, D., Kim, W.R., Kim, H.J., et al. Association between noninvasive fibrosis markers and mortality among adults with nonalcoholic fatty liver disease in the United States. Hepatology 57 (2013), 1357–1365.
    • (2013) Hepatology , vol.57 , pp. 1357-1365
    • Kim, D.1    Kim, W.R.2    Kim, H.J.3
  • 3
    • 84939143953 scopus 로고    scopus 로고
    • Association of Nonalcoholic Fatty Liver Disease with Subclinical Cardiovascular Changes: a systematic review and meta-analysis
    • Bonci, E., Chiesa, C., Versacci, P., et al. Association of Nonalcoholic Fatty Liver Disease with Subclinical Cardiovascular Changes: a systematic review and meta-analysis. Biomed. Res. Int., 2015, 2015, 213737.
    • (2015) Biomed. Res. Int. , vol.2015
    • Bonci, E.1    Chiesa, C.2    Versacci, P.3
  • 4
    • 84862314680 scopus 로고    scopus 로고
    • Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease
    • Coulon, S., Francque, S., Colle, I., et al. Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease. Cytokine 59 (2012), 442–449.
    • (2012) Cytokine , vol.59 , pp. 442-449
    • Coulon, S.1    Francque, S.2    Colle, I.3
  • 5
    • 24744435772 scopus 로고    scopus 로고
    • Directing transition from innate to acquired immunity: defining a role for IL-6
    • Jones, S.A., Directing transition from innate to acquired immunity: defining a role for IL-6. J. Immunol. 175 (2005), 3463–3468.
    • (2005) J. Immunol. , vol.175 , pp. 3463-3468
    • Jones, S.A.1
  • 6
    • 34147092226 scopus 로고    scopus 로고
    • Serum interleukin-6 correlates with endothelial dysfunction in healthy men independently of insulin sensitivity
    • Esteve, E., Castro, A., Lopez-Bermejo, A., et al. Serum interleukin-6 correlates with endothelial dysfunction in healthy men independently of insulin sensitivity. Diabetes Care 30 (2007), 939–945.
    • (2007) Diabetes Care , vol.30 , pp. 939-945
    • Esteve, E.1    Castro, A.2    Lopez-Bermejo, A.3
  • 7
    • 33845717106 scopus 로고    scopus 로고
    • Association of interleukin-6 and C-reactive protein with subclinical carotid atherosclerosis (the Rancho Bernardo Study)
    • Lee, W.Y., Allison, M.A., Kim, D.J., et al. Association of interleukin-6 and C-reactive protein with subclinical carotid atherosclerosis (the Rancho Bernardo Study). Am. J. Cardiol. 99 (2007), 99–102.
    • (2007) Am. J. Cardiol. , vol.99 , pp. 99-102
    • Lee, W.Y.1    Allison, M.A.2    Kim, D.J.3
  • 8
    • 84859215358 scopus 로고    scopus 로고
    • The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
    • Interleukin-6 Receptor Mendelian Randomisation Analysis C, Swerdlow, D.I., Holmes, M.V., et al. The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet 379 (2012), 1214–1224.
    • (2012) Lancet , vol.379 , pp. 1214-1224
    • Interleukin-6 Receptor Mendelian Randomisation Analysis C1    Swerdlow, D.I.2    Holmes, M.V.3
  • 9
    • 84859210770 scopus 로고    scopus 로고
    • Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
    • Collaboration IRGCERF, Sarwar, N., Butterworth, A.S., et al. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet 379 (2012), 1205–1213.
    • (2012) Lancet , vol.379 , pp. 1205-1213
    • Sarwar, N.1    Butterworth, A.S.2
  • 10
    • 84895860734 scopus 로고    scopus 로고
    • Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis
    • Kaptoge, S., Seshasai, S.R., Gao, P., et al. Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis. Eur. Heart J. 35 (2014), 578–589.
    • (2014) Eur. Heart J. , vol.35 , pp. 578-589
    • Kaptoge, S.1    Seshasai, S.R.2    Gao, P.3
  • 11
    • 84995493598 scopus 로고    scopus 로고
    • Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease
    • Ajmera, V., Perito, E.R., Bass, N.M., et al. Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease. Hepatology 65 (2017), 65–77.
    • (2017) Hepatology , vol.65 , pp. 65-77
    • Ajmera, V.1    Perito, E.R.2    Bass, N.M.3
  • 12
    • 0036840537 scopus 로고    scopus 로고
    • Multi-Ethnic Study of Atherosclerosis: objectives and design
    • Bild, D.E., Bluemke, D.A., Burke, G.L., et al. Multi-Ethnic Study of Atherosclerosis: objectives and design. Am. J. Epidemiol. 156 (2002), 871–881.
    • (2002) Am. J. Epidemiol. , vol.156 , pp. 871-881
    • Bild, D.E.1    Bluemke, D.A.2    Burke, G.L.3
  • 13
    • 84925507275 scopus 로고    scopus 로고
    • The association of nonalcoholic fatty liver disease, obesity, and metabolic syndrome, with systemic inflammation and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA)
    • Al Rifai, M., Silverman, M.G., Nasir, K., et al. The association of nonalcoholic fatty liver disease, obesity, and metabolic syndrome, with systemic inflammation and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 239 (2015), 629–633.
    • (2015) Atherosclerosis , vol.239 , pp. 629-633
    • Al Rifai, M.1    Silverman, M.G.2    Nasir, K.3
  • 14
    • 84992083453 scopus 로고    scopus 로고
    • Biomarkers of key biological pathways in CVD
    • (e3)
    • Jenny, N.S., Olson, N.C., Allison, M.A., et al. Biomarkers of key biological pathways in CVD. Glob. Heart 11 (2016), 327–336 (e3).
    • (2016) Glob. Heart , vol.11 , pp. 327-336
    • Jenny, N.S.1    Olson, N.C.2    Allison, M.A.3
  • 15
    • 84884552573 scopus 로고    scopus 로고
    • Associations between total serum GGT activity and metabolic risk: MESA
    • Bradley, R., Fitzpatrick, A.L., Jenny, N.S., et al. Associations between total serum GGT activity and metabolic risk: MESA. Biomark. Med 7 (2013), 709–721.
    • (2013) Biomark. Med , vol.7 , pp. 709-721
    • Bradley, R.1    Fitzpatrick, A.L.2    Jenny, N.S.3
  • 16
    • 84865378821 scopus 로고    scopus 로고
    • Intraindividual variability of C-reactive protein: the Multi-Ethnic Study of Atherosclerosis
    • EM, DeGoma, French, B., Dunbar, R.L., et al. Intraindividual variability of C-reactive protein: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 224 (2012), 274–279.
    • (2012) Atherosclerosis , vol.224 , pp. 274-279
    • EM, D.1    French, B.2    Dunbar, R.L.3
  • 17
    • 84898543772 scopus 로고    scopus 로고
    • Baseline elevated Lp-PLA2 is associated with increased risk for re-stenosis after stent placement
    • Zheng, D., Zeng, F., Cai, A., et al. Baseline elevated Lp-PLA2 is associated with increased risk for re-stenosis after stent placement. Lipids Health Dis., 13, 2014, 41.
    • (2014) Lipids Health Dis. , vol.13 , pp. 41
    • Zheng, D.1    Zeng, F.2    Cai, A.3
  • 18
    • 83655181215 scopus 로고    scopus 로고
    • Biomarkers of inflammation and hemostasis associated with left ventricular mass: the Multiethnic Study of Atherosclerosis (MESA)
    • Arnett, D.K., RL, McClelland, Bank A, et al. Biomarkers of inflammation and hemostasis associated with left ventricular mass: the Multiethnic Study of Atherosclerosis (MESA). Int J Mol Epidemiol Genet 2 (2011), 391–400.
    • (2011) Int J Mol Epidemiol Genet , vol.2 , pp. 391-400
    • Arnett, D.K.1    RL, M.2    Bank, A.3
  • 19
    • 10644277990 scopus 로고    scopus 로고
    • Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) study
    • Carr, J.J., Nelson, J.C., Wong, N.D., et al. Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) study. Radiology 234 (2005), 35–43.
    • (2005) Radiology , vol.234 , pp. 35-43
    • Carr, J.J.1    Nelson, J.C.2    Wong, N.D.3
  • 20
    • 0025342374 scopus 로고
    • Quantification of coronary artery calcium using ultrafast computed tomography
    • Agatston, A.S., Janowitz, W.R., Hildner, F.J., et al. Quantification of coronary artery calcium using ultrafast computed tomography. J. Am. Coll. Cardiol. 15 (1990), 827–832.
    • (1990) J. Am. Coll. Cardiol. , vol.15 , pp. 827-832
    • Agatston, A.S.1    Janowitz, W.R.2    Hildner, F.J.3
  • 21
    • 84898919275 scopus 로고    scopus 로고
    • Ethnic and sex differences in fatty liver on cardiac computed tomography: the multi-ethnic study of atherosclerosis
    • Tota-Maharaj, R., Blaha, M.J., Zeb, I., et al. Ethnic and sex differences in fatty liver on cardiac computed tomography: the multi-ethnic study of atherosclerosis. Mayo Clin. Proc. 89 (2014), 493–503.
    • (2014) Mayo Clin. Proc. , vol.89 , pp. 493-503
    • Tota-Maharaj, R.1    Blaha, M.J.2    Zeb, I.3
  • 22
    • 27644463193 scopus 로고    scopus 로고
    • Diagnosis and management of the metabolic syndrome. an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Executive summary
    • American Heart A, National Heart L, Blood I, et al. Diagnosis and management of the metabolic syndrome. an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Executive summary. Cardiol. Rev. 13 (2005), 322–327.
    • (2005) Cardiol. Rev. , vol.13 , pp. 322-327
    • American Heart A1    National Heart L2    Blood, I.3
  • 23
    • 84963541541 scopus 로고    scopus 로고
    • IL-6 pathway in the liver: from physiopathology to therapy
    • Schmidt-Arras, D., Rose-John, S., IL-6 pathway in the liver: from physiopathology to therapy. J. Hepatol. 64 (2016), 1403–1415.
    • (2016) J. Hepatol. , vol.64 , pp. 1403-1415
    • Schmidt-Arras, D.1    Rose-John, S.2
  • 24
    • 0033678516 scopus 로고    scopus 로고
    • Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss
    • Bastard, J.P., Jardel, C., Bruckert, E., et al. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J. Clin. Endocrinol. Metab. 85 (2000), 3338–3342.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 3338-3342
    • Bastard, J.P.1    Jardel, C.2    Bruckert, E.3
  • 25
    • 20844449693 scopus 로고    scopus 로고
    • Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis
    • Schieffer, B., Selle, T., Hilfiker, A., et al. Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis. Circulation 110 (2004), 3493–3500.
    • (2004) Circulation , vol.110 , pp. 3493-3500
    • Schieffer, B.1    Selle, T.2    Hilfiker, A.3
  • 26
    • 84899930283 scopus 로고    scopus 로고
    • Association between local interleukin-6 levels and slow flow/microvascular dysfunction
    • Guo, F., Dong, M., Ren, F., et al. Association between local interleukin-6 levels and slow flow/microvascular dysfunction. J. Thromb. Thrombolysis 37 (2014), 475–482.
    • (2014) J. Thromb. Thrombolysis , vol.37 , pp. 475-482
    • Guo, F.1    Dong, M.2    Ren, F.3
  • 27
    • 84904752202 scopus 로고    scopus 로고
    • The relationship between adiposity-associated inflammation and coronary artery and abdominal aortic calcium differs by strata of central adiposity: the Multi-Ethnic Study of Atherosclerosis (MESA)
    • Hughes-Austin, J.M., Wassel, C.L., Jimenez, J., et al. The relationship between adiposity-associated inflammation and coronary artery and abdominal aortic calcium differs by strata of central adiposity: the Multi-Ethnic Study of Atherosclerosis (MESA). Vasc. Med. 19 (2014), 264–271.
    • (2014) Vasc. Med. , vol.19 , pp. 264-271
    • Hughes-Austin, J.M.1    Wassel, C.L.2    Jimenez, J.3
  • 28
    • 0035824178 scopus 로고    scopus 로고
    • Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: effects of an early invasive or noninvasive strategy
    • Lindmark, E., Diderholm, E., Wallentin, L., et al. Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: effects of an early invasive or noninvasive strategy. JAMA 286 (2001), 2107–2113.
    • (2001) JAMA , vol.286 , pp. 2107-2113
    • Lindmark, E.1    Diderholm, E.2    Wallentin, L.3
  • 29
    • 0034681920 scopus 로고    scopus 로고
    • Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
    • Ridker, P.M., Rifai, N., Stampfer, M.J., et al. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 101 (2000), 1767–1772.
    • (2000) Circulation , vol.101 , pp. 1767-1772
    • Ridker, P.M.1    Rifai, N.2    Stampfer, M.J.3
  • 30
    • 55249087635 scopus 로고    scopus 로고
    • Genetically elevated C-reactive protein and ischemic vascular disease
    • Zacho, J., Tybjaerg-Hansen, A., Jensen, J.S., et al. Genetically elevated C-reactive protein and ischemic vascular disease. N. Engl. J. Med. 359 (2008), 1897–1908.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 1897-1908
    • Zacho, J.1    Tybjaerg-Hansen, A.2    Jensen, J.S.3
  • 31
    • 67649961412 scopus 로고    scopus 로고
    • Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease
    • Elliott, P., Chambers, J.C., Zhang, W., et al. Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA 302 (2009), 37–48.
    • (2009) JAMA , vol.302 , pp. 37-48
    • Elliott, P.1    Chambers, J.C.2    Zhang, W.3
  • 32
    • 44949233003 scopus 로고    scopus 로고
    • Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis
    • Wieckowska, A., Papouchado, B.G., Li, Z., et al. Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis. Am. J. Gastroenterol. 103 (2008), 1372–1379.
    • (2008) Am. J. Gastroenterol. , vol.103 , pp. 1372-1379
    • Wieckowska, A.1    Papouchado, B.G.2    Li, Z.3
  • 33
    • 84951999389 scopus 로고    scopus 로고
    • The balance between IL-17 and IL-22 produced by liver-infiltrating T-helper cells critically controls NASH development in mice
    • Rolla, S., Alchera, E., Imarisio, C., et al. The balance between IL-17 and IL-22 produced by liver-infiltrating T-helper cells critically controls NASH development in mice. Clin. Sci. (Lond.) 130 (2016), 193–203.
    • (2016) Clin. Sci. (Lond.) , vol.130 , pp. 193-203
    • Rolla, S.1    Alchera, E.2    Imarisio, C.3
  • 34
    • 84928137790 scopus 로고    scopus 로고
    • Severity of non-alcoholic fatty liver disease is associated with high systemic levels of tumor necrosis factor alpha and low serum interleukin 10 in morbidly obese patients
    • Paredes-Turrubiarte, G., Gonzalez-Chavez, A., Perez-Tamayo, R., et al. Severity of non-alcoholic fatty liver disease is associated with high systemic levels of tumor necrosis factor alpha and low serum interleukin 10 in morbidly obese patients. Clin. Exp. Med. 16 (2016), 193–202.
    • (2016) Clin. Exp. Med. , vol.16 , pp. 193-202
    • Paredes-Turrubiarte, G.1    Gonzalez-Chavez, A.2    Perez-Tamayo, R.3
  • 35
    • 53849098905 scopus 로고    scopus 로고
    • Markers of inflammation and coronary artery calcification: a systematic review
    • Hamirani, Y.S., Pandey, S., Rivera, J.J., et al. Markers of inflammation and coronary artery calcification: a systematic review. Atherosclerosis 201 (2008), 1–7.
    • (2008) Atherosclerosis , vol.201 , pp. 1-7
    • Hamirani, Y.S.1    Pandey, S.2    Rivera, J.J.3
  • 36
    • 62649128874 scopus 로고    scopus 로고
    • Association between IL-6 and the extent of coronary atherosclerosis in the veterans affairs diabetes trial (VADT)
    • Saremi, A., Anderson, R.J., Luo, P., et al. Association between IL-6 and the extent of coronary atherosclerosis in the veterans affairs diabetes trial (VADT). Atherosclerosis 203 (2009), 610–614.
    • (2009) Atherosclerosis , vol.203 , pp. 610-614
    • Saremi, A.1    Anderson, R.J.2    Luo, P.3
  • 37
    • 84860390493 scopus 로고    scopus 로고
    • C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients
    • Zimmermann, E., Anty, R., Tordjman, J., et al. C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients. J. Hepatol. 55 (2011), 660–665.
    • (2011) J. Hepatol. , vol.55 , pp. 660-665
    • Zimmermann, E.1    Anty, R.2    Tordjman, J.3
  • 38
    • 35548984404 scopus 로고    scopus 로고
    • X-linked inhibitor of apoptosis protein regulates human interleukin-6 in umbilical vein endothelial cells via stimulation of the nuclear factor-kappaB and MAP kinase signaling pathways
    • Resch, U., Winsauer, G., Hofer-Warbinek, R., et al. X-linked inhibitor of apoptosis protein regulates human interleukin-6 in umbilical vein endothelial cells via stimulation of the nuclear factor-kappaB and MAP kinase signaling pathways. Pharmacol. Rep. 58:Suppl (2006), 111–117.
    • (2006) Pharmacol. Rep. , vol.58 , pp. 111-117
    • Resch, U.1    Winsauer, G.2    Hofer-Warbinek, R.3
  • 39
    • 0030789285 scopus 로고    scopus 로고
    • Expression of interleukin-6 in the ventricles and coronary arteries of patients with myocardial infarction
    • Kaneko, K., Kanda, T., Yokoyama, T., et al. Expression of interleukin-6 in the ventricles and coronary arteries of patients with myocardial infarction. Res. Commun. Mol. Pathol. Pharmacol. 97 (1997), 3–12.
    • (1997) Res. Commun. Mol. Pathol. Pharmacol. , vol.97 , pp. 3-12
    • Kaneko, K.1    Kanda, T.2    Yokoyama, T.3
  • 40
    • 84884176199 scopus 로고    scopus 로고
    • Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance
    • Asrih, M., Jornayvaz, F.R., Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance. J. Endocrinol. 218 (2013), R25–36.
    • (2013) J. Endocrinol. , vol.218 , pp. R25-36
    • Asrih, M.1    Jornayvaz, F.R.2
  • 41
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis—an inflammatory disease
    • Ross, R., Atherosclerosis—an inflammatory disease. N. Engl. J. Med. 340 (1999), 115–126.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 115-126
    • Ross, R.1
  • 42
    • 70449096095 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: quantitative assessment of liver fat content by computed tomography, magnetic resonance imaging and proton magnetic resonance spectroscopy
    • Zhong, L., Chen, J.J., Chen, J., et al. Nonalcoholic fatty liver disease: quantitative assessment of liver fat content by computed tomography, magnetic resonance imaging and proton magnetic resonance spectroscopy. J. Dig. Dis. 10 (2009), 315–320.
    • (2009) J. Dig. Dis. , vol.10 , pp. 315-320
    • Zhong, L.1    Chen, J.J.2    Chen, J.3
  • 43
    • 84896745824 scopus 로고    scopus 로고
    • Long-term assessment of systemic inflammation and the cumulative incidence of age-related hearing impairment in the epidemiology of hearing loss study
    • Nash, S.D., Cruickshanks, K.J., Zhan, W., et al. Long-term assessment of systemic inflammation and the cumulative incidence of age-related hearing impairment in the epidemiology of hearing loss study. J. Gerontol. A Biol. Sci. Med. Sci. 69 (2014), 207–214.
    • (2014) J. Gerontol. A Biol. Sci. Med. Sci. , vol.69 , pp. 207-214
    • Nash, S.D.1    Cruickshanks, K.J.2    Zhan, W.3
  • 44
    • 85029568219 scopus 로고    scopus 로고
    • Antiinflammatory therapy with Canakinumab for atherosclerotic disease
    • Ridker, P.M., Everett, B.M., Thuren, T., et al. Antiinflammatory therapy with Canakinumab for atherosclerotic disease. N. Engl. J. Med. 377 (2017), 1119–1131.
    • (2017) N. Engl. J. Med. , vol.377 , pp. 1119-1131
    • Ridker, P.M.1    Everett, B.M.2    Thuren, T.3


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