Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations

Gastroenterology

Volumn 154, Issue 4, 2018, Pages 1080-1095

  Andersson, Emma R ^a   Chivukula, Indira V ^a   Hankeova, Simona ^a,b   Sjöqvist, Marika ^a   Tsoi, Yat Long ^a   Ramsköld, Daniel ^c   Masek, Jan ^a   Elmansuri, Aiman ^a   Hoogendoorn, Anita ^a   Vazquez, Elenae ^d   Storvall, Helena ^c   Netušilová, Julie ^b   Huch, Meritxell ^e,f   Fischler, Björn ^c   Ellis, Ewa ^c   Contreras, Adriana ^d   Nemeth, Antal ^c   Chien, Kenneth C ^a   Clevers, Hans ^e   Sandberg, Rickard ^a   Bryja, Vitezslav ^b   Lendahl, Urban ^a   more..

^a KAROLINSKA INSTITUTE   (Sweden)

^b MASARYK UNIVERSITY   (Czech Republic)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Alagille; Development; Heart; Jagged1; Kidney; Liver; Notch; Vertebrae

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; PROTEIN JAGGED 1; SOMATOMEDIN C; TRANSCRIPTOME; JAG1 PROTEIN, HUMAN; JAG1 PROTEIN, MOUSE; NOTCH2 PROTEIN, MOUSE;

ALAGILLE SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C2C12 CELL LINE; CELL POLARITY; CHOLANGIOCYTE; CONTROLLED STUDY; GENE EXPRESSION; HISTOPATHOLOGY; MISSENSE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; C3H MOUSE; C57BL MOUSE; CELL DIFFERENTIATION; COCULTURE; DISEASE MODEL; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HUMAN; INTRAHEPATIC BILE DUCT; MALE; METABOLISM; MORPHOGENESIS; ORGANOID; PATHOLOGY; PHENOTYPE; PROCEDURES; TRANSGENIC MOUSE;

ALAGILLE SYNDROME; ANIMALS; BILE DUCTS, INTRAHEPATIC; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC PREDISPOSITION TO DISEASE; HEK293 CELLS; HUMANS; JAGGED-1 PROTEIN; MALE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; MORPHOGENESIS; MUTATION, MISSENSE; ORGANOIDS; PHENOTYPE; RECEPTOR, NOTCH2; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 85043237736     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2017.11.002     Document Type: Article

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