A preliminary study on topical ozonated oil in the therapeutic management of atopic dermatitis in murine

Journal of Dermatological Treatment

Volumn 29, Issue 7, 2018, Pages 676-681

  Lu, J ^a   Chen, M ^a   Gao, L ^a   Cheng, Q ^b   Xiang, Y ^a   Huang, J ^a   Wu, K ^a   Li, M ^b  

^a THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Atopic dermatitis; cytokines; immune regulation; ozone

Indexed keywords

ANTIINFLAMMATORY AGENT; BETA ACTIN; CALCIPOTRIOL; COMPLEMENTARY DNA; DERMATOLOGICAL AGENT; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 31; INTERLEUKIN 4; MESSENGER RNA; NERVE GROWTH FACTOR; OIL; OVALBUMIN; OZONATED OIL; OZONE; STAPHYLOCOCCUS ENTEROTOXIN B; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ALLERGEN; CALCITRIOL; CYTOKINE; ENTEROTOXIN; ENTEROTOXIN B, STAPHYLOCOCCAL; VEGETABLE OIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATOPIC DERMATITIS; COMPARATIVE STUDY; CONTROLLED STUDY; EPIDERMIS; FEMALE; IMMUNOREGULATION; MOUSE; MRNA EXPRESSION LEVEL; NONHUMAN; OINTMENT; OZONATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REFLECTANCE CONFOCAL MICROSCOPY; SKIN ALLERGY; SKIN DEFECT; SKIN SENSITIZATION; TH1 CELL; TH2 CELL; TOPICAL TREATMENT; TREATMENT DURATION; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CHEMISTRY; CYTOLOGY; DRUG EFFECT; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY; SKIN;

ALLERGENS; ANIMALS; CALCITRIOL; CYTOKINES; DERMATITIS, ATOPIC; ENTEROTOXINS; INTERLEUKIN-10; MICE; MICE, INBRED BALB C; OVALBUMIN; OZONE; PLANT OILS; SKIN; TH2 CELLS;

EID: 85042942429     PISSN: 09546634     EISSN: 14711753     Source Type: Journal    
DOI: 10.1080/09546634.2018.1443199     Document Type: Article

References (28)

1. Bieber T., Atopic dermatitis. N Engl J Med. 2008;358:1483–1494.
2. Nutten S., Atopic dermatitis: global epidemiology and risk factors. Ann Nutr Metab. 2015;66(1):8–16.
3. Peng W, Novak N., Pathogenesis of atopic dermatitis. Clin Exp Allergy. 2015;45:566–574.
4. Bitschar K, Wolz C, Krismer B, et al. Keratinocytes s sensors and central players in the immune defense against Staphylococcus aureus in the skin. J Dermatol Sci. 2017;87:215–220.
5. Wang AX, Xu LN., New insights into T cells and their signature cytokines in atopic dermatitis. IUBMB Life. 2015;67:601–610.
6. Noguchi A, Tominaga M, Takahashi N, et al. Differences in therapeutic effects of topically applied corticosteroid and tacrolimus on atopic dermatitis-like symptoms in NC/Nga mice. J Dermatol Sci. 2017;86:54–62.
7. Cury MJ, Martins C, Aoki V, et al. Topical tacrolimus for atopic dermatitis. Cochrane Database Syst Rev. 2015;7:CD009864.
8. Lee DE, Clark AK, Tran CK, et al. New and emerging targeted systemic therapies: a new era for atopic dermatitis. J Dermatolog Treat. 2017;19:1–11.
9. Kim HS, Noh SU, Han YW, et al. Therapeutic effects of topical application of ozone on acute cutaneous wound healing. J Korean Med Sci. 2009;24:368–374.
10. Gultekin FA, Bakkal BH, Sumer D, et al. Effects of ozonated olive oil on acute radiation proctitis in rats. Balkan Med J. 2013;30:369–374.
11. Song M, Zeng Q, Xiang Y, et al. The antibacterial effect of topical ozone on the treatment of MRSA skin infection. Mol Med Rep. 2018;17:2449–2455.
12. Tan L, Lu J, Chen M, et al. Epicutaneous sensitization with ovalbumin, staphylococcal enterotoxin B and vitamin D analogue induces atopic dermatitis in mice. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017;42:1023–1029.
13. Laouini D, Kawamoto S, Yalcindag A, et al. Epicutaneous sensitization with superantigen induces allergic skin inflammation. J Allergy Clin Immunol. 2003;112:981–987.
14. Spergel JM, Mizoguchi E, Brewer JP, et al. Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J Clin Invest. 1998;101:1614–1622.
15. Matsumura S, Terao M, Murota H, et al. Th2 cytokines enhance TrkA expression, upregulate proliferation, and downregulate differentiation of keratinocytes. J Dermatol Sci. 2015;78:215–223.
16. Papoiu AD, Wang H, Nattkemper L, et al. A study of serum concentrations and dermal levels of NGF in atopic dermatitis and healthy subjects. Neuropeptides. 2011;45:417–422.
17. Teresiak-Mikołajczak E, Czarnecka-Operacz M, Jenerowicz D, et al. Neurogenic markers of the inflammatory process in atopic dermatitis; relation to the severity and pruritus. PDA. 2013;30:286–292.
18. Luongo M, Brigida AL, Mascolo L, et al. Possible therapeutic effects of ozone mixture on hypoxia in tumor development. AR. 2017;37:425–435.
19. Zanardi I, Borrelli E, Valacchi G, et al. Ozone: a multifaceted molecule with unexpected therapeutic activity. Curr Med Chem. 2016;23:304–314.
20. Lee HJ, Lee SH., Epidermal permeability barrier defects and barrier repair therapy in atopic dermatitis. Allergy Asthma Immunol Res. 2014;6:276–287.
21. Travagli V, Zanardi I, Valacchi G, et al. Ozone and ozonated oils in skin diseases: a review. Mediators Inflamm. 2010; 2010:610418.
22. Na JI, Hwang JS, Park HJ, et al. A new moisturizer containing physiologic lipid granules alleviates atopic dermatitis. J Dermatolog Treat. 2010;21:23–27.
23. Huang SG, Yang XX, Mo LQ, et al. Optimization of emollient formulation for treating atopic dermatitis by skin physiological index testing. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:967–974.
24. Han SC, Kang GJ, Ko YJ, et al. Fermented fish oil suppresses T helper 1/2 cell response in a mouse model of atopic dermatitis via generation of CD4 + CD25 + Foxp3+ T cells. BMC Immunol. 2012;13:44.
25. Park SY, Gupta D, Kim CH, et al. Differential effects of peptidedoglycan recognition proteins on experimental atopic and contact dermatitis mediated by Treg and Th17 cells. PLoS One. 2011;6:e24961.
26. Kim JE, Kim JS, Cho DH, et al. Molecular mechanisms of cutaneous inflammatory disorder: atopic dermatitis. IJMS. 2016;17:E1234.
27. Hayashi M, Yanaba K, Umezawa Y, et al. IL-10-producing regulatory B cells are decreased in patients with psoriasis. J Dermatol Sci. 2016;81:93–100.
28. Bocci V, Borrelli E, Travagli V, et al. The ozone paradox: ozone is a strong oxidant as well as a medical drug. Med Res Rev. 2009;29:646–682.