메뉴 건너뛰기




Volumn 37, Issue 24, 2018, Pages 3216-3228

Gene activation of CEBPA using saRNA: Preclinical studies of the first in human saRNA drug candidate for liver cancer

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA SMALL ACTIVATING RNA; LIPOSOME; RNA; UNCLASSIFIED DRUG; CCAAT ENHANCER BINDING PROTEIN; CEBPA PROTEIN, HUMAN; DIETHYLNITROSAMINE; SMALL UNTRANSLATED RNA;

EID: 85042877246     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/s41388-018-0126-2     Document Type: Article
Times cited : (66)

References (22)
  • 1
    • 84984677163 scopus 로고    scopus 로고
    • Treatment of patients with cirrhosis
    • 27557303
    • Ge PS, Runyon BA. Treatment of patients with cirrhosis. N Engl J Med. 2016;375:767-77.
    • (2016) N Engl J Med , vol.375 , pp. 767-777
    • Ge, P.S.1    Runyon, B.A.2
  • 2
    • 84995772564 scopus 로고    scopus 로고
    • Time trends in the health care burden and mortality of acute on chronic liver failure in the United States
    • 27696493
    • Allen AM, Kim WR, Moriarty JP, Shah ND, Larson JJ, Kamath PS. Time trends in the health care burden and mortality of acute on chronic liver failure in the United States. Hepatology. 2016;64:2165-72.
    • (2016) Hepatology , vol.64 , pp. 2165-2172
    • Allen, A.M.1    Kim, W.R.2    Moriarty, J.P.3    Shah, N.D.4    Larson, J.J.5    Kamath, P.S.6
  • 3
    • 77951456114 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection
    • 20432259
    • Starley BQ, Calcagno CJ, Harrison SA. Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepatology. 2010;51:1820-32.
    • (2010) Hepatology , vol.51 , pp. 1820-1832
    • Starley, B.Q.1    Calcagno, C.J.2    Harrison, S.A.3
  • 4
    • 84928209634 scopus 로고    scopus 로고
    • Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up
    • 25125077
    • Ekstedt M, Hagström H, Nasr P, Fredrikson M, Stål P, Kechagias S. et al. Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up. Hepatology. 2015;61:1547-54.
    • (2015) Hepatology , vol.61 , pp. 1547-1554
    • Ekstedt, M.1    Hagström, H.2    Nasr, P.3    Fredrikson, M.4    Stål, P.5    Kechagias, S.6
  • 5
    • 84862833567 scopus 로고    scopus 로고
    • Small RNA and transcriptional upregulation
    • 21823233 3154074
    • Portnoy V, Huang V, Place RF, Li LC. Small RNA and transcriptional upregulation. WIREs RNA. 2011;2:748-60.
    • (2011) WIREs RNA , vol.2 , pp. 748-760
    • Portnoy, V.1    Huang, V.2    Place, R.F.3    Li, L.C.4
  • 6
    • 84960111950 scopus 로고    scopus 로고
    • SaRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription
    • 26902284 4783471
    • Portnoy V, Lin SHS, Li KH, Burlingame A, Hu Z-H, Li H, et al. saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription. Cell Res. 2016;26:320-35.
    • (2016) Cell Res , vol.26 , pp. 320-335
    • Portnoy, V.1    Lin, S.H.S.2    Li, K.H.3    Burlingame, A.4    Hu, Z.H.5    Li, H.6
  • 7
    • 34249892151 scopus 로고    scopus 로고
    • In vivo transfection of C/EBP-alpha gene could ameliorate CCL(4)-induced hepatic fibrosis in mice
    • 17539996
    • Mei S, Wang X, Zhang J, Qian J, Ji J. In vivo transfection of C/EBP-alpha gene could ameliorate CCL(4)-induced hepatic fibrosis in mice. Hepatol Res. 2007;37:531-9.
    • (2007) Hepatol Res , vol.37 , pp. 531-539
    • Mei, S.1    Wang, X.2    Zhang, J.3    Qian, J.4    Ji, J.5
  • 8
    • 84862793486 scopus 로고    scopus 로고
    • C/EBP-α ameliorates CCl(4)-induced liver fibrosis in mice through promoting apoptosis of hepatic stellate cells with little apoptotic effect on hepatocytes in vitro and in vivo
    • 22307857
    • Tao L-L, Cheng Y-Y, Ding D, Mei S, Xu J-W, Yu J, et al. C/EBP-α ameliorates CCl(4)-induced liver fibrosis in mice through promoting apoptosis of hepatic stellate cells with little apoptotic effect on hepatocytes in vitro and in vivo. Apoptosis. 2012;17:492-502.
    • (2012) Apoptosis , vol.17 , pp. 492-502
    • Tao, L.L.1    Cheng, Y.Y.2    Ding, D.3    Mei, S.4    Xu, J.W.5    Yu, J.6
  • 9
    • 84891940175 scopus 로고    scopus 로고
    • Age-associated change of C/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4 treatments
    • 24273171
    • Hong I-H, Lewis K, Iakova P, Jin J, Sullivan E, Jawanmardi N, et al. Age-associated change of C/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4 treatments. J Biol Chem. 2014;289:1106-8.
    • (2014) J Biol Chem , vol.289 , pp. 1106-1108
    • Hong, I.H.1    Lewis, K.2    Iakova, P.3    Jin, J.4    Sullivan, E.5    Jawanmardi, N.6
  • 10
    • 28544438792 scopus 로고    scopus 로고
    • CAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma
    • Ee HT, Shing CH, Mirtha L, Esther W, Sathivel P, Aileen W. et al. CAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma. Cancer Res.2005;65:10330-7.
    • (2005) Cancer Res. , vol.65 , pp. 10330-10337
    • Ee, H.T.1    Shing, C.H.2    Mirtha, L.3    Esther, W.4    Sathivel, P.5    Aileen, W.6
  • 11
    • 84883746123 scopus 로고    scopus 로고
    • C/EBPα inhibits hepatocellular carcinoma by reducing Notch3/Hes1/p27 cascades
    • 23816696
    • Shi Y-C, Zhao H, Yin C, Zeng X, Zhang Q, Xu W-P, et al. C/EBPα inhibits hepatocellular carcinoma by reducing Notch3/Hes1/p27 cascades. Dig Liver Dis. 2013;45:844-51.
    • (2013) Dig Liver Dis , vol.45 , pp. 844-851
    • Shi, Y.C.1    Zhao, H.2    Yin, C.3    Zeng, X.4    Zhang, Q.5    Xu, W.P.6
  • 12
    • 84894856234 scopus 로고    scopus 로고
    • Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo
    • 23929703
    • Reebye V, Sætrom P, Mintz PJ, Huang K-W, Swiderski P, Peng L, et al. Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo. Hepatology. 2014;59:216-27.
    • (2014) Hepatology , vol.59 , pp. 216-227
    • Reebye, V.1    Sætrom, P.2    Mintz, P.J.3    Huang, K.W.4    Swiderski, P.5    Peng, L.6
  • 13
    • 85028675354 scopus 로고    scopus 로고
    • Development and mechanism of small activating RNA targeting CEBPA, a novel therapeutic in clinical trials for liver cancer
    • Voutila J, Reebye V, Roberts TC, Protopapa P, Andrikakou P, Blakey DC et al. Development and mechanism of small activating RNA targeting CEBPA, a novel therapeutic in clinical trials for liver cancer. Mol Ther 2017;25:2705-14.
    • (2017) Mol Ther , vol.25 , pp. 2705-2714
    • Voutila, J.1    Reebye, V.2    Roberts, T.C.3    Protopapa, P.4    Andrikakou, P.5    Blakey, D.C.6    Al, E.7
  • 15
    • 84894856234 scopus 로고    scopus 로고
    • Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo
    • 23929703
    • Reebye V, Sætrom P, Mintz PJ, Huang K-W, Swiderski P, Peng L, et al. Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo. Hepatology. 2014;59:216-27.
    • (2014) Hepatology , vol.59 , pp. 216-227
    • Reebye, V.1    Sætrom, P.2    Mintz, P.J.3    Huang, K.W.4    Swiderski, P.5    Peng, L.6
  • 16
    • 0035300430 scopus 로고    scopus 로고
    • Expression profiling suggested a regulatory role of liver-enriched transcription factors in human hepatocellular carcinoma
    • 11306505
    • Xu L, Hui L, Wang S, Gong J, Jin Y, Wang Y, et al. Expression profiling suggested a regulatory role of liver-enriched transcription factors in human hepatocellular carcinoma. Cancer Res. 2001;61:3176-81.
    • (2001) Cancer Res , vol.61 , pp. 3176-3181
    • Xu, L.1    Hui, L.2    Wang, S.3    Gong, J.4    Jin, Y.5    Wang, Y.6
  • 17
    • 0344837364 scopus 로고    scopus 로고
    • Down-regulated expression of the CCAAT/enhancer binding protein alpha and beta genes in human hepatocellular carcinoma: A possible prognostic marker
    • 12680236
    • Tomizawa M, Watanabe K, Saisho H, Nakagawara A, Tagawa M. Down-regulated expression of the CCAAT/enhancer binding protein alpha and beta genes in human hepatocellular carcinoma: a possible prognostic marker. Anticancer Res. 2003;23:351-4.
    • (2003) Anticancer Res , vol.23 , pp. 351-354
    • Tomizawa, M.1    Watanabe, K.2    Saisho, H.3    Nakagawara, A.4    Tagawa, M.5
  • 18
    • 77955507119 scopus 로고    scopus 로고
    • C/EBPalpha is up-regulated in a subset of hepatocellular carcinomas and plays a role in cell growth and proliferation
    • 20347819
    • Lu G-D, Leung CH-W, Yan B, Tan CM-Y, Low SY, Aung MO, et al. C/EBPalpha is up-regulated in a subset of hepatocellular carcinomas and plays a role in cell growth and proliferation. Gastroenterology. 2010;139:632-43.
    • (2010) Gastroenterology , vol.139 , pp. 632-643
    • Lu, G.D.1    Leung, C.H.W.2    Yan, B.3    Tan, C.M.Y.4    Low, S.Y.5    Aung, M.O.6
  • 19
    • 34547133494 scopus 로고    scopus 로고
    • The C/EBP family of transcription factors: A paradigm for interaction between gene expression and proliferation control
    • 17658261
    • Nerlov C. The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control. Trends Cell Biol. 2007;17:318-24.
    • (2007) Trends Cell Biol , vol.17 , pp. 318-324
    • Nerlov, C.1
  • 20
    • 7244221588 scopus 로고    scopus 로고
    • Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis
    • 15292250
    • Inoue Y, Inoue J, Lambert G, Yim SH, Gonzalez FJ. Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis. J Biol Chem. 2004;279:44740-8.
    • (2004) J Biol Chem , vol.279 , pp. 44740-44748
    • Inoue, Y.1    Inoue, J.2    Lambert, G.3    Yim, S.H.4    Gonzalez, F.J.5
  • 21
    • 0030022255 scopus 로고    scopus 로고
    • Impaired proliferation and tumorigenicity induced by CCAAT/enhancer-binding protein
    • 8640762
    • Watkins PJ, Condreay JP, Huber BE, Jacobs SJ, Adams DJ. Impaired proliferation and tumorigenicity induced by CCAAT/enhancer-binding protein. Cancer Res. 1996;56:1063-7.
    • (1996) Cancer Res , vol.56 , pp. 1063-1067
    • Watkins, P.J.1    Condreay, J.P.2    Huber, B.E.3    Jacobs, S.J.4    Adams, D.J.5
  • 22
    • 84869219338 scopus 로고    scopus 로고
    • MiR-34-a microRNA replacement therapy is headed to the clinic
    • 22783274 3387671
    • Bader AG. miR-34-a microRNA replacement therapy is headed to the clinic. Front Genet. 2012;3:120.
    • (2012) Front Genet , vol.3 , pp. 120
    • Bader, A.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.