Insurance status and cancer treatment mediate the association between race/ethnicity and cervical cancer survival

PLoS ONE

Volumn 13, Issue 2, 2018, Pages

  Markt, Sarah C ^a   Tang, Tianyu ^a   Cronin, Angel M ^b,c   Katz, Ingrid T ^c,d,e   Howitt, Brooke E ^c,d   Horowitz, Neil S ^b,d   Lee, Larissa J ^b,c,d   Wright, Alexi A ^b,c,d  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AFRICAN AMERICAN; ALL CAUSE MORTALITY; ARTICLE; BRACHYTHERAPY; CANCER MORTALITY; CANCER PROGNOSIS; CANCER THERAPY; ETHNIC DIFFERENCE; EXTERNAL BEAM RADIOTHERAPY; FEMALE; HEALTH INSURANCE; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; MEDICAID; MIDDLE AGED; PELVIS EXENTERATION; RACE DIFFERENCE; RADICAL HYSTERECTOMY; SOCIOECONOMICS; UNITED STATES; UTERINE CERVIX CANCER; ANCESTRY GROUP; CANCER REGISTRY; CAUCASIAN; ECONOMICS; EPIDEMIOLOGY; ETHNIC GROUP; HEALTH CARE DISPARITY; INSURANCE; MORTALITY; PROPORTIONAL HAZARDS MODEL; UTERINE CERVIX TUMOR; YOUNG ADULT;

ADULT; AFRICAN AMERICANS; CONTINENTAL POPULATION GROUPS; ETHNIC GROUPS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HEALTHCARE DISPARITIES; HISPANIC AMERICANS; HUMANS; INSURANCE COVERAGE; INSURANCE, HEALTH; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; SEER PROGRAM; UNITED STATES; UTERINE CERVICAL NEOPLASMS; YOUNG ADULT;

EID: 85042183254     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0193047     Document Type: Article

References (40)

1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015; 136(5): E359–86. https://doi.org/10.1002/ijc.29210 PMID: 25220842.
2. Bray F, Ren JS, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 2013; 132(5):1133–45. https://doi.org/10.1002/ijc.27711 PMID: 22752881.
3. (CDC) CfDCaP. Vital signs: cervical cancer incidence, morality and screening—United States, 2007–2012. 2014.
4. Cervical Cancer Rates by Race and Ethnicity. In: Control CfD, editor. 2015.
5. Ward E, Jemal A, Cokkinides V, Singh GK, Cardinez C, Ghafoor A, et al. Cancer disparities by race/ethnicity and socioeconomic status. CA Cancer J Clin. 2004; 54(2):78–93. PMID: 15061598.
6. Cowburn SC, M.J.; Lapidus J.A.; DeVoe J.E. The Association Between Insurance Status and Cervical Cancer Screening in Community Health Centers: Exploring the Potential of Electronic Health Records for Population-Level Surveillance, 2008–2010. Prev Chronic Dis. 2013;10.
7. Churilla T, Egleston B, Dong Y, Shaikh T, Murphy C, Mantia-Smaldone G, et al. Disparities in the management and outcome of cervical cancer in the United States according to health insurance status. (1095–6859 (Electronic)). doi: D—NLM: NIHMS772744 [Available on 06/01/17] D—NLM: PMC4877265 [Available on 06/01/17] EDAT- 2016/03/26 06:00 MHDA- 2016/03/26 06:00 CRDT-2016/03/26 06:00 PMCR- 2017/06/01 PHST- 2015/12/08 [received] PHST- 2016/03/12 [revised] PHST- 2016/03/18 [accepted] AID - S0090-8258(16)30081-6 [pii] AID—10.1016/j.ygyno.2016.03.025 [doi] PST—ppublish.
8. Simard EP, Fedewa S, Ma J, Siegel R, Jemal A. Widening socioeconomic disparities in cervical cancer mortality among women in 26 states, 1993–2007. Cancer. 2012; 118(20):5110–6. https://doi.org/10.1002/cncr.27606 PMID: 22707306
9. Eggleston KS, Coker AL, Williams M, Tortolero-Luna G, Martin JB, Tortolero SR. Cervical cancer survival by socioeconomic status, race/ethnicity, and place of residence in Texas, 1995–2001. J Womens Health (Larchmt). 2006; 15(8):941–51. https://doi.org/10.1089/jwh.2006.15.941 PMID: 17087618.
10. Coker AL, Desimone CP, Eggleston KS, White AL, Williams M. Ethnic disparities in cervical cancer survival among Texas women. J Womens Health (Larchmt). 2009; 18(10):1577–83. https://doi.org/10.1089/jwh.2008.1342 PMID: 19788363; PubMed Central PMCID: PMCPMC2825716.
11. Howell EA, Chen YT, Concato J. Differences in cervical cancer mortality among black and white women. Obstet Gynecol. 1999; 94(4):509–15. PMID: 10511350.
12. Rauh-Hain JA, Clemmer JT, Bradford LS, Clark RM, Growdon WB, Goodman A, et al. Racial disparities in cervical cancer survival over time. Cancer. 2013; 119(20):3644–52. https://doi.org/10.1002/cncr. 28261 PMID: 23913530.
13. Patel DA, Barnholtz-Sloan JS, Patel MK, Malone JM Jr., Chuba PJ, Schwartz K. A population-based study of racial and ethnic differences in survival among women with invasive cervical cancer: analysis of Surveillance, Epidemiology, and End Results data. Gynecol Oncol. 2005; 97(2):550–8. https://doi.org/10.1016/j.ygyno.2005.01.045 PMID: 15863159.
14. Sheppard CS, El-Zein M, Ramanakumar AV, Ferenczy A, Franco EL. Assessment of mediators of racial disparities in cervical cancer survival in the United States. Int J Cancer. 2016; 138(11):2622–30. https://doi.org/10.1002/ijc.29996 PMID: 26756569.
15. Surveillance, Epidemiology, and End Results (SEER) Program (http://www.seer.cancer.gov/) SEER*Stat Database: Incidence—SEER 18 Regs Research Data + Hurricane Katrine Impacted Louisianna Cases, Nov 2015 Sub (1973–2013) —Linked To County Attributes—Total U.S., 1969–2012 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch, released April 2016, based on the November 2015 submission. [Internet].
16. Lin DY, Fleming TR, De Gruttola V. Estimating the proportion of treatment effect explained by a surrogate marker. Stat Med. 1997; 16(13):1515–27. PMID: 9249922.
17. Jun HJ, Austin SB, Wylie SA, Corliss HL, Jackson B, Spiegelman D, et al. The mediating effect of childhood abuse in sexual orientation disparities in tobacco and alcohol use during adolescence: results from the Nurses’ Health Study II. Cancer Causes Control. 2010; 21(11):1817–28. https://doi.org/10.1007/s10552-010-9609-3 PMID: 20640883; PubMed Central PMCID: PMCPMC2962696.
18. Valeri L, VanderWeele TJ. SAS macro for causal mediation analysis with survival data. (1531–5487 (Electronic)).
19. VanderWeele TJ. Causal mediation analysis with survival data. (1531–5487 (Electronic)). doi: D—NLM: NIHMS293732 D—NLM: PMC3109321 EDAT- 2011/06/07 06:00 MHDA- 2011/12/13 00:00 CRDT-2011/06/07 06:00 AID—10.1097/EDE.0b013e31821db37e [doi] AID—00001648-201107000-00025 [pii] PST—ppublish.
20. Coker AL, Du XL, Fang S, Eggleston KS. Socioeconomic status and cervical cancer survival among older women: findings from the SEER-Medicare linked data cohorts. Gynecol Oncol. 2006; 102(2):278–84. https://doi.org/10.1016/j.ygyno.2005.12.016 PMID: 16434087
21. Ward E, Halpern M, Schrag N, Cokkinides V, DeSantis C, Bandi P, et al. Association of insurance with cancer care utilization and outcomes. CA: a cancer journal for clinicians. 2008; 58(1):9–31. https://doi.org/10.3322/CA.2007.0011 PMID: 18096863
22. Bradley CJ, Given CW, Roberts C. Health care disparities and cervical cancer. Am J Public Health. 2004; 94(12):2098–103. PMID: 15569960
23. Robbins AS, Han X, Ward EM, Simard EP, Zheng Z, Jemal A. Association Between the Affordable Care Act Dependent Coverage Expansion and Cervical Cancer Stage and Treatment in Young Women. JAMA. 2015; 314(20):2189–91. https://doi.org/10.1001/jama.2015.10546 PMID: 26599188
24. Grant SR, Walker GV, Koshy M, Shaitelman SF, Klopp AH, Frank SJ, et al. Impact of Insurance Status on Radiation Treatment Modality Selection Among Potential Candidates for Prostate, Breast, or Gynecologic Brachytherapy. Int J Radiat Oncol Biol Phys. 2015; 93(5):968–75. https://doi.org/10.1016/j.ijrobp.2015.08.036 PMID: 26452570.
25. Mundt AJ, Connell PP, Campbell T, Hwang JH, Rotmensch J, Waggoner S. Race and clinical outcome in patients with carcinoma of the uterine cervix treated with radiation therapy. Gynecol Oncol. 1998; 71 (2):151–8. https://doi.org/10.1006/gyno.1998.5203 PMID: 9826453.
26. Chatterjee S, Gupta D, Caputo TA, Holcomb K. Disparities in Gynecological Malignancies. Front Oncol. 2016; 6:36. https://doi.org/10.3389/fonc.2016.00036 PMID: 26942126; PubMed Central PMCID: PMCPMC4761838.
27. del Carmen MG, Montz FJ, Bristow RE, Bovicelli A, Cornelison T, Trimble E. Ethnic differences in patterns of care of stage 1A(1) and stage 1A(2) cervical cancer: a SEER database study. Gynecol Oncol. 1999; 75(1):113–7. https://doi.org/10.1006/gyno.1999.5543 PMID: 10502436.
28. Fleming S, Schluterman NH, Tracy JK, Temkin SM. Black and white women in Maryland receive different treatment for cervical cancer. PLoS ONE. 2014; 9(8):e104344. https://doi.org/10.1371/journal.pone.0104344 PMID: 25121587
29. Farley JH, Hines JF, Taylor RR, Carlson JW, Parker MF, Kost ER, et al. Equal care ensures equal survival for African-American women with cervical carcinoma. Cancer. 2001; 91(4):869–73. PMID: 11241257.
30. Grigsby PW, Hall-Daniels L, Baker S, Perez CA. Comparison of clinical outcome in black and white women treated with radiotherapy for cervical carcinoma. Gynecol Oncol. 2000; 79(3):357–61. https://doi.org/10.1006/gyno.2000.5974 PMID: 11104605.
31. Landoni F, Maneo A, Colombo A, Placa F, Milani R, Perego P, et al. Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet. 1997; 350(9077):535–40. https://doi.org/10.1016/S0140-6736(97)02250-2 PMID: 9284774.
32. Beavis AL, Gravitt PE, Rositch AF. Hysterectomy-corrected cervical cancer mortality rates reveal a larger racial disparity in the United States. Cancer. 2017. https://doi.org/10.1002/cncr.30507 PMID: 28112816.
33. Barrington DA, Dilley SE, Landers EE, Thomas ED, Boone JD, Straughn JM Jr., et al. Distance from a Comprehensive Cancer Center: A proxy for poor cervical cancer outcomes? Gynecol Oncol. 2016; 143 (3):617–21. https://doi.org/10.1016/j.ygyno.2016.10.004 PMID: 27720232; PubMed Central PMCID: PMCPMC5116397.
34. Timmins CL. The impact of language barriers on the health care of Latinos in the United States: a review of the literature and guidelines for practice. J Midwifery Womens Health. 2002; 47(2):80–96. PMID: 12019990.
35. Flores G. Language barriers to health care in the United States. N Engl J Med. 2006; 355(3):229–31. https://doi.org/10.1056/NEJMp058316 PMID: 16855260.
36. Schyve PM. Language differences as a barrier to quality and safety in health care: the Joint Commission perspective. J Gen Intern Med. 2007; 22 Suppl 2:360–1. https://doi.org/10.1007/s11606-007-0365-3 PMID: 17957426; PubMed Central PMCID: PMCPMC2078554.
37. Echeverria SE, Carrasquillo O. The roles of citizenship status, acculturation, and health insurance in breast and cervical cancer screening among immigrant women. Med Care. 2006; 44(8):788–92. https://doi.org/10.1097/01.mlr.0000215863.24214.41 PMID: 16862042.
38. Pearcey R, Miao Q, Kong W, Zhang-Salomons J, Mackillop WJ. Impact of adoption of chemoradiother-apy on the outcome of cervical cancer in Ontario: results of a population-based cohort study. J Clin Oncol. 2007; 25(17):2383–8. https://doi.org/10.1200/JCO.2006.09.1926 PMID: 17557951.
39. Barbera L, Paszat L, Thomas G, Covens A, Fyles A, Elit L, et al. The rapid uptake of concurrent chemotherapy for cervix cancer patients treated with curative radiation. Int J Radiat Oncol Biol Phys. 2006; 64 (5):1389–94. https://doi.org/10.1016/j.ijrobp.2005.09.046 PMID: 16413698.
40. SEER Cancer Statistics Factsheets: Cervix Uteri Cancer. National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/statfacts/html/cervix.html [accessed May 17, 2016].