Cardioprotection of dapagliflozin and vildagliptin in rats with cardiac ischemia-reperfusion injury

Journal of Endocrinology

Volumn 236, Issue 2, 2018, Pages 69-84

  Tanajak, Pongpan ^a,b   Sa nguanmoo, Piangkwan ^a,b   Sivasinprasasn, Sivaporn ^a   Thummasorn, Savitree ^a,b   Siri Angkul, Natthaphat ^a,b   Chattipakorn, Siriporn C ^a,b   Chattipakorn, Nipon ^a,b  

^a Faculty of Medicine Chiang Mai University   (Thailand)

^b CHIANG MAI UNIVERSITY   (Thailand)

Author keywords

Cardiac I R injury; Cardioprotection; Dapagliflozin; DPP4 inhibitors; Pre diabetes; SGLT2 inhibitors; Vildagliptin

Indexed keywords

CASPASE 3; DAPAGLIFLOZIN; FIBROBLAST GROWTH FACTOR 21; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN; REACTIVE OXYGEN METABOLITE; VILDAGLIPTIN; 2-(3-(4-ETHOXYBENZYL)-4-CHLOROPHENYL)-6-HYDROXYMETHYLTETRAHYDRO-2H-PYRAN-3,4,5-TRIOL; BENZHYDRYL DERIVATIVE; CARDIOTONIC AGENT; GLUCOSIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR PARAMETERS; CELL FUNCTION; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY OCCLUSION; DRUG EFFICACY; HEART ARRHYTHMIA; HEART EJECTION FRACTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART STROKE VOLUME; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HOMEOSTASIS MODEL ASSESSMENT; INSULIN RESISTANCE; LIPID DIET; LIPID PEROXIDATION; M MODE ECHOCARDIOGRAPHY; METABOLIC PARAMETERS; METABOLIC REGULATION; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL DYNAMICS; MITOCHONDRION; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROPHYLAXIS; RAT; REPERFUSION INJURY; SURGICAL TECHNIQUE; SYSTOLIC BLOOD PRESSURE; URINALYSIS; ANIMAL; CELL PROTECTION; DRUG EFFECT; HEART; HEART INFARCTION; MALE; MYOCARDIAL ISCHEMIA REPERFUSION INJURY; PATHOLOGY; PREVENTION AND CONTROL; WISTAR RAT;

ANIMALS; BENZHYDRYL COMPOUNDS; CARDIOTONIC AGENTS; CYTOPROTECTION; DIET, HIGH-FAT; GLUCOSIDES; HEART; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; RATS; RATS, WISTAR; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT; VILDAGLIPTIN;

EID: 85042119123     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-17-0457     Document Type: Article

References (39)

1. Apaijai N, Pintana H, Chattipakorn SC & Chattipakorn N 2013 Effects of vildagliptin versus sitagliptin, on cardiac function, heart rate variability and mitochondrial function in obese insulin-resistant rats. British Journal of Pharmacology 169 1048-1057. (https://doi. org/10.1111/bph.12176)
2. Apaijai N, Chinda K, Palee S, Chattipakorn S & Chattipakorn N 2014 Combined vildagliptin and metformin exert better cardioprotection than monotherapy against ischemia-reperfusion injury in obeseinsulin resistant rats. PLoS ONE 9 e102374. (https://doi.org/10.1371/ journal.pone.0102374)
3. Apaijai N, Inthachai T, Lekawanvijit S, Chattipakorn SC & Chattipakorn N 2016 Effects of dipeptidyl peptidase-4 inhibitor in insulin-resistant rats with myocardial infarction. Journal of Endocrinology 229 245-258. (https://doi.org/10.1530/JOE-16-0096)
4. Bigger JT Jr, Fleiss JL, Steinman RC, Rolnitzky LM, Kleiger RE & Rottman JN 1992 Frequency domain measures of heart period variability and mortality after myocardial infarction. Circulation 85 164-171. (https://doi.org/10.1161/01.CIR.85.1.164)
5. Burman JL, Pickles S, Wang C, Sekine S, Vargas JNS, Zhang Z, Youle AM, Nezich CL, Wu X, Hammer JA, et al. 2017 Mitochondrial fission facilitates the selective mitophagy of protein aggregates. Journal of Cell Biology 216 3231-3247. (https://doi.org/10.1083/jcb.201612106)
6. Chinda K, Sanit J, Chattipakorn S & Chattipakorn N 2014 Dipeptidyl peptidase-4 inhibitor reduces infarct size and preserves cardiac function via mitochondrial protection in ischaemia-reperfusion rat heart. Diabetes and Vascular Disease Research 11 75-83. (https://doi. org/10.1177/1479164113516134)
7. Curtis MJ, Hancox JC, Farkas A, Wainwright CL, Stables CL, Saint DA, Clements-Jewery H, Lambiase PD, Billman GE, Janse MJ, et al. 2013 The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias. Pharmacology and Therapeutics 139 213-248. (https://doi.org/10.1016/j. pharmthera.2013.04.008)
8. Duncan JG 2011 Peroxisome proliferator activated receptor-alpha (PPARalpha) and PPAR gamma coactivator-1alpha (PGC-1alpha) regulation of cardiac metabolism in diabetes. Pediatric Cardiology 32 323-328. (https://doi.org/10.1007/s00246-011-9889-8)
9. Feng Y, Madungwe NB, da Cruz Junho CV & Bopassa JC 2017 Activation of G protein-coupled estrogen receptor 1 at the onset of reperfusion protects the myocardium against ischemia/reperfusion injury by reducing mitochondrial dysfunction and mitophagy. British Journal of Pharmacology 174 4329-4344. (https://doi.org/10.1111/bph.14033)
10. Han S, Hagan DL, Taylor JR, Xin L, Meng W, Biller SA, Wetterau JR, Washburn WN & Whaley JM 2008 Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats. Diabetes 57 1723-1729. (https://doi.org/10.2337/db07-1472)
11. He YL, Zhang Y, Serra D, Wang Y, Ligueros-Saylan M & Dole WP 2011 Thorough QT study of the effects of vildagliptin, a dipeptidyl peptidase IV inhibitor, on cardiac repolarization and conduction in healthy volunteers. Current Medical Research and Opinion 27 1453-1463. (https://doi.org/10.1185/03007995.2011.585395)
12. Hillebrand S, Gast KB, de Mutsert R, Swenne CA, Jukema JW, Middeldorp S, Rosendaal FR & Dekkers OM 2013 Heart rate variability and first cardiovascular event in populations without known cardiovascular disease: meta-analysis and dose-response metaregression. Europace 15 742-749. (https://doi.org/10.1093/europace/ eus341)
13. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG & Group NCRRGW 2010 Animal research: reporting in vivo experiments: the ARRIVE guidelines. British Journal of Pharmacology 160 1577-1579. (https://doi.org/10.1111/j.1476-5381.2010.00872.x)
14. Kleiger RE, Miller JP, Bigger JT Jr & Moss AJ 1987 Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. American Journal of Cardiology 59 256-262. (https://doi.org/10.1016/0002-9149(87)90795-8)
15. La Rovere MT, Bigger JT Jr, Marcus FI, Mortara A & Schwartz PJ 1998 Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Lancet 351 478-484. (https://doi.org/10.1016/S0140-6736(97)11144-8)
16. Lambers Heerspink HJ, de Zeeuw D, Wie L, Leslie B & List J 2013 Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. Diabetes, Obesity and Metabolism 15 853-862. (https://doi.org/10.1111/dom.12127)
17. Lee TM, Chang NC & Lin SZ 2017a Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts. Free Radical Biology and Medicine 104 298-310. (https://doi.org/10.1016/j. freeradbiomed.2017.01.035)
18. Lee Y, Kwon I, Jang Y, Song W, Cosio-Lima LM & Roltsch MH 2017b Potential signaling pathways of acute endurance exerciseinduced cardiac autophagy and mitophagy and its possible role in cardioprotection. Journal of Physiological Sciences 67 639-654. (https:// doi.org/10.1007/s12576-017-0555-7)
19. Li Q, Dong QT, Yang YJ, Tian XQ, Jin C, Huang PS, Jiang LP & Chen GH 2016 AMPK-mediated cardioprotection of atorvastatin relates to the reduction of apoptosis and activation of autophagy in infarcted rat hearts. American Journal of Translational Research 8 4160-4171.
20. Liao D, Carnethon M, Evans GW, Cascio WE & Heiss G 2002 Lower heart rate variability is associated with the development of coronary heart disease in individuals with diabetes: the atherosclerosis risk in communities (ARIC) study. Diabetes 51 3524-3531. (https://doi. org/10.2337/diabetes.51.12.3524)
21. Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS & Stanley WC 2010 Myocardial fatty acid metabolism in health and disease. Physiological Reviews 90 207-258. (https://doi.org/10.1152/physrev.00015.2009)
22. Lucas E, Vila-Bedmar R, Arcones AC, Cruces-Sande M, Cachofeiro V, Mayor F Jr & Murga C 2016 Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels. Cardiovascular Diabetology 15 155. (https:// doi.org/10.1186/s12933-016-0474-6)
23. Lundkvist P, Sjostrom CD, Amini S, Pereira MJ, Johnsson E & Eriksson JW 2017 Dapagliflozin once-daily and exenatide once-weekly dual therapy: a 24-week randomized, placebo-controlled, phase II study examining effects on body weight and prediabetes in obese adults without diabetes. Diabetes, Obesity and Metabolism 19 49-60. (https:// doi.org/10.1111/dom.12779)
24. Meyer JN, Leuthner TC & Luz AL 2017 Mitochondrial fusion, fission, and mitochondrial toxicity. Toxicology 391 42-53. (https://doi. org/10.1016/j.tox.2017.07.019)
25. Neves FA, Cortez E, Bernardo AF, Mattos AB, Vieira AK, Malafaia Tde O, Thole AA, Rodrigues-Cunha AC, Garcia-Souza EP, Sichieri R, et al. 2014 Heart energy metabolism impairment in Western-diet induced obese mice. Journal of Nutritional Biochemistry 25 50-57. (https://doi. org/10.1016/j.jnutbio.2013.08.014)
26. Ong SB, Subrayan S, Lim SY, Yellon DM, Davidson SM & Hausenloy DJ 2010 Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury. Circulation 121 2012-2022. (https://doi. org/10.1161/CIRCULATIONAHA.109.906610)
27. Pipatpiboon N, Pintana H, Pratchayasakul W, Chattipakorn N & Chattipakorn SC 2013 DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption. European Journal of Neuroscience 37 839-849. (https:// doi.org/10.1111/ejn.12088)
28. Pongkan W, Chattipakorn SC & Chattipakorn N 2015 Chronic testosterone replacement exerts cardioprotection against cardiac ischemia-reperfusion injury by attenuating mitochondrial dysfunction in testosterone-deprived rats. PLoS ONE 10 e0122503. (https://doi.org/10.1371/journal.pone.0122503)
29. Pongkan W, Pintana H, Jaiwongkam T, Kredphoo S, Sivasinprasasn S, Chattipakorn SC & Chattipakorn N 2016 Vildagliptin reduces cardiac ischemic-reperfusion injury in obese orchiectomized rats. Journal of Endocrinology 231 81-95. (https://doi.org/10.1530/JOE-16-0232)
30. Riess ML, Rhodes SS, Stowe DF, Aldakkak M & Camara AK 2009 Comparison of cumulative planimetry versus manual dissection to assess experimental infarct size in isolated hearts. Journal of Pharmacological and Toxicological Methods 60 275-280. (https://doi. org/10.1016/j.vascn.2009.05.012)
31. Sa-Nguanmoo P, Tanajak P, Kerdphoo S, Jaiwongkam T, Pratchayasakul W, Chattipakorn N & Chattipakorn SC 2017 SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFDinduced obese rats. Toxicology and Applied Pharmacology 333 43-50. (https://doi.org/10.1016/j.taap.2017.08.005)
32. Sharp WW, Beiser DG, Fang YH, Han M, Piao L, Varughese J & Archer SL 2015 Inhibition of the mitochondrial fission protein dynaminrelated protein 1 improves survival in a murine cardiac arrest model. Critical Care Medicine 43 e38-e47. (https://doi.org/10.1097/ CCM.0000000000000817)
33. Tanajak P, Sa-Nguanmoo P, Wang X, Liang G, Li X, Jiang C, Chattipakorn SC & Chattipakorn N 2016 Fibroblast growth factor 21 (FGF21) therapy attenuates left ventricular dysfunction and metabolic disturbance by improving FGF21 sensitivity, cardiac mitochondrial redox homoeostasis and structural changes in pre-diabetic rats. Acta Physiologica 217 287-299. (https://doi.org/10.1111/apha.12698)
34. Tanajak P, Pintana H, Siri-Angkul N, Khamseekaew J, Apaijai N, Chattipakorn SC & Chattipakorn N 2017 Vildagliptin and caloric restriction for cardioprotection in pre-diabetic rats. Journal of Endocrinology 232 189-204. (https://doi.org/10.1530/JOE-16-0406)
35. Thummasorn S, Kumfu S, Chattipakorn S & Chattipakorn N 2011 Granulocyte-colony stimulating factor attenuates mitochondrial dysfunction induced by oxidative stress in cardiac mitochondria. Mitochondrion 11 457-466. (https://doi.org/10.1016/j.mito.2011.01.008)
36. Vrhovac I, Balen Eror D, Klessen D, Burger C, Breljak D, Kraus O, Radovic N, Jadrijevic S, Aleksic I, Walles T, et al. 2015 Localizations of Na(+)-D-glucose cotransporters SGLT1 and SGLT2 in human kidney and of SGLT1 in human small intestine, liver, lung, and heart. Pflügers Archiv 467 1881-1898. (https://doi.org/10.1007/s00424-014-1619-7)
37. Weber MA, Mansfield TA, Cain VA, Iqbal N, Parikh S & Ptaszynska A 2016 Blood pressure and glycaemic effects of dapagliflozin versus placebo in patients with type 2 diabetes on combination antihypertensive therapy: a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Diabetes and Endocrinology 4 211-220. (https://doi. org/10.1016/S2213-8587(15)00417-9)
38. Young ME, Guthrie PH, Razeghi P, Leighton B, Abbasi S, Patil S, Youker KA & Taegtmeyer H 2002 Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart. Diabetes 51 2587-2595. (https://doi.org/10.2337/ diabetes.51.8.2587)
39. Zhou B, Lei S, Xue R, Leng Y, Xia Z & Xia ZY 2017 DJ-1 overexpression restores ischaemic post-conditioning-mediated cardioprotection in diabetic rats: role of autophagy. Clinical Science 131 1161-1178. (https://doi.org/10.1042/CS20170052)