Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase

ACS Medicinal Chemistry Letters

Volumn 9, Issue 1, 2018, Pages 39-44

  Feng, Danqing ^a   Biftu, Tesfaye ^a   Romero, F Anthony ^a   Kekec, Ahmet ^a   Dropinski, James ^a   Kassick, Andrew ^a   Xu, Shiyao ^a   Kurtz, Marc M ^a   Gollapudi, Anantha ^a   Shao, Qing ^a   Yang, Xiaodong ^a   Lu, Ku ^a   Zhou, Gaochao ^a   Kemp, Daniel ^a   Myers, Robert W ^a   Guan, Hong Ping ^a   Trujillo, Maria E ^a   Li, Cai ^a   Weber, Ann ^a   Sebhat, Iyassu K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

ACC; activator; AMPK; liver selectivity; T2DM

Indexed keywords

6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; MK 8722; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; ENZYME ACTIVATION; EXPERIMENTAL HYPERGLYCEMIA; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; UNBOUND FRACTION;

EID: 85041594043     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.7b00417     Document Type: Article

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