Raising concerns about the Sepsis-3 definitions

World Journal of Emergency Surgery

Volumn 13, Issue 1, 2018, Pages

  Sartelli, Massimo ^a   Kluger, Yoram ^b   Ansaloni, Luca ^c   Hardcastle, Timothy C ^d,bu   Rello, Jordi ^e   Watkins, Richard R ^f,g   Bassetti, Matteo ^h   Giamarellou, Eleni ⁱ   Coccolini, Federico ^c   Abu Zidan, Fikri M ^j   Adesunkanmi, Abdulrashid K ^k   Augustin, Goran ^l   Baiocchi, Gian L ^m   Bala, Miklosh ⁿ   Baraket, Oussema ^o   Beltran, Marcelo A ^p   Jusoh, Asri Che ^q   Demetrashvili, Zaza ^r   De Simone, Belinda ^s   de Souza, Hamilton P ^t   Cui, Yunfeng ^u   Davies, R Justin ^v   Dhingra, Sameer ^w   Diaz, Jose J ^x   Di Saverio, Salomone ^v   Dogjani, Agron ^y   Elmangory, Mutasim M ^z   Enani, Mushira A ^aa   Ferrada, Paula ^ab   Fraga, Gustavo P ^ac   Frattima, Sabrina ^ad   Ghnnam, Wagih ^ae   Gomes, Carlos A ^af   Kanj, Souha S ^ag   Karamarkovic, Aleksandar ^ah   Kenig, Jakub ^ai   Khamis, Faryal ^aj   Khokha, Vladimir ^ak   Koike, Kaoru ^al   Kok, Kenneth Y Y ^am   Isik, Arda ^an   Labricciosa, Francesco M ^ao   Latifi, Rifat ^ap   Lee, Jae G ^aq   Litvin, Andrey ^ar   Machain, Gustavo M ^as   Manzano Nunez, Ramiro ^at   Major, Piotr ^ai   Marwah, Sanjay ^au   McFarlane, Michael ^av   Memish, Ziad A ^aw,bv   Mesina, Cristian ^ax   Moore, Ernest E ^ay   Moore, Frederick A ^az   Naidoo, Noel ^ba   Negoi, Ionut ^bb   Ofori Asenso, Richard ^bc   Olaoye, Iyiade ^bd   Ordoñez, Carlos A ^be   Ouadii, Mouaqit ^bf   Paolillo, Ciro ^h   Picetti, Edoardo ^bg   Pintar, Tadeja ^bh   Ponce de Leon, Alfredo ^bi   Pupelis, Guntars ^bj   Reis, Tarcisio ^bk,bw   Sakakushev, Boris ^bl   Kafil, Hossein Samadi ^bm   Sato, Norio ^bn   Shah, Jay N ^bo   Siribumrungwong, Boonying ^bp   Talving, Peep ^bq   Tranà, Cristian ^a   Ulrych, Jan ^br,bx   Yuan, Kuo Ching ^bs   Catena, Fausto ^bt   more..

^a Macerata Hospital   (Italy)

^b Departments of Pediatric Surgery   (Israel)

^c BUFALINI HOSPITAL   (Italy)

^d INKOSI ALBERT LUTHULI CENTRAL HOSPITAL   (South Africa)

^e HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^f Infectious Disease Section   (United States)

^g Northeast Ohio Medical University   (United States)

^h S Maria Hospital   (Italy)

ⁱ IASO GENERAL HOSPITAL   (Greece)

^j UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^k OBAFEMI AWOLOWO UNIVERSITY   (Nigeria)

^l KBC Zagreb   (Croatia)

^m UNIVERSITY OF BRESCIA   (Italy)

ⁿ HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^o Regional Hospital of Bizerte   (Tunisia)

^p Hospital de La Serena   (Chile)

^q Kuala Krai Hospital   (Malaysia)

^r Institute Ltd Academician N Kipshidze Central University Clinic   (Georgia)

^s Cannes Hospital   (France)

^t PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^u TIANJIN MEDICAL UNIVERSITY   (China)

^v ADDENBROOKE S HOSPITAL   (United Kingdom)

^w UNIVERSITY OF THE WEST INDIES   (Trinidad and Tobago)

^x UNIVERSITY OF MARYLAND   (United States)

^y UNIVERSITY HOSPITAL CENTER MOTHER TERESA   (Albania)

^z FEDERAL MINISTRY OF HEALTH   (Sudan)

^aa KING FAHAD MEDICAL CITY   (Saudi Arabia)

^ab VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ac UNIVERSITY OF CAMPINAS   (Brazil)

^ad Clinica San Rocco di Franciacorta   (Italy)

^ae MANSOURA UNIVERSITY   (Egypt)

^af Hospital e Maternidade Therezinha de Jesus   (Brazil)

^ag AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^ah UNIVERSITY OF BELGRADE   (Serbia)

^ai JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^aj ROYAL HOSPITAL   (Oman)

^ak Department of Emergency Surgery   (Belarus)

^al KYOTO UNIVERSITY   (Japan)

^am The Brunei Cancer Centre   (Brunei Darussalam)

^an ERZINCAN UNIVERSITY   (Turkey)

^ao Global Alliance for Infections in Surgery   (Portugal)

^ap UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^aq Yonsei University College of Medicine   (South Korea)

^ar IMMANUEL KANT BALTIC FEDERAL UNIVERSITY   (Russian Federation)

^as UNIVERSIDAD NACIONAL DE ASUNCIÓN   (Paraguay)

^at FUNDACIÓN VALLE DEL LILI   (Colombia)

^au POST GRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

^av UNIVERSITY HOSPITAL OF THE WEST INDIES   (Jamaica)

^aw Ministry of Health   (Saudi Arabia)

^ax Emergency Hospital of Craiova   (Romania)

^ay DENVER HEALTH MEDICAL CENTER   (United States)

^az UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^ba UNIVERSITY OF KWAZULU NATAL   (South Africa)

^bb University Emergency Hospital Bucharest   (Romania)

^bc Research Unit   (Ghana)

^bd UNIVERSITY OF ILORIN   (Nigeria)

^be UNIVERSIDAD DEL VALLE   (Colombia)

^bf HASSAN II UNIVERSITY HOSPITAL   (Morocco)

^bg UNIVERSITY HOSPITAL OF PARMA   (Italy)

^bh UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^bi INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^bj RIGA EAST UNIVERSITY HOSPITAL   (Latvia)

^bk Hospital Otávio de Freitas HOF   (Brazil)

^bl UNIVERSITY HOSPITAL ST GEORGE   (Bulgaria)

^bm TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^bn EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^bo PATAN HOSPITAL   (Nepal)

^bp THAMMASAT UNIVERSITY   (Thailand)

^bq North Estonia Medical Centre   (Estonia)

^br CHARLES UNIVERSITY   (Czech Republic)

^bs TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^bt Maggiore Parma Hospital   (Italy)

^bu School of Health Sciences Nelson R School of Medicine   (South Africa)

^bv ALFAISAL UNIVERSITY   (Saudi Arabia)

^bw Osvaldo Cruz Hospital Recife   (Brazil)

^bx CHARLES UNIVERSITY   (Czech Republic)

more..

Author keywords

Infections; Organ dysfunction; Sepsis; Septic shock

Indexed keywords

ARTERIAL PRESSURE; CLASSIFICATION; CONSENSUS; GLASGOW COMA SCALE; HUMAN; MEASUREMENT ACCURACY; MORTALITY; ORGAN DYSFUNCTION SCORE; SENSITIVITY AND SPECIFICITY; SEPSIS; SEVERITY OF ILLNESS INDEX;

ARTERIAL PRESSURE; CONSENSUS; DATA ACCURACY; GLASGOW COMA SCALE; HUMANS; ORGAN DYSFUNCTION SCORES; SENSITIVITY AND SPECIFICITY; SEPSIS; SEVERITY OF ILLNESS INDEX;

EID: 85041557584     PISSN: None     EISSN: 17497922     Source Type: Journal    
DOI: 10.1186/s13017-018-0165-6     Document Type: Review

References (35)

1. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. American College of Chest Physicians/Society of Critical Care Medicine consensus conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20:864-74.
2. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med. 2003;31:1250-6.
3. Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315:801-10.
4. Sartelli M, Catena F, Di Saverio S, et al. Current concept of abdominal sepsis: WSES position paper. World J Emerg Surg. 2014;9:22.
5. Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013;369(9):840-51.
6. Simpson SQ. New sepsis criteria: a change we should not make. Chest. 2016;149:1117-8.
7. Carneiro AH, Póvoa P, Gomes JA. Dear Sepsis-3, we are sorry to say that we don't like you. Revista Brasileira de Terapia Intensiva. 2017;29(1):4-8.
8. Stevenson EK, Rubenstein AR, Radin GT, Wiener RS, Walkey AJ. Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis. Crit Care Med. 2014;42(3):625-31.
9. Zimmerman JE, Kramer AA, Knaus WA. Changes in hospital mortality for United States intensive care unit admissions from 1988 to 2012. Crit Care. 2013;17(2):R81.
10. Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA. 2014;311(13):1308-16.
11. Schultz MJ, Dunser MW, Dondorp AM, Adhikari NK, Iyer S, Kwizera A, Global Intensive Care Working Group of the European Society of Intensive Care Medicine, et al. Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future. Intensive Care Med. 2017;43(5):612-24.
12. Sartelli M, Catena F, Abu-Zidan FM, et al. Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference. World J Emerg Surg. 2017;12:22.
13. De Waele JJ. Early source control in sepsis. Langenbeck's Arch Surg. 2010;395:489-94.
14. Sotto A, Lefrant JY, Fabbro-Peray P, Muller L, Tafuri J, Navarro F, et al. Evaluation of antimicrobial therapy management of 120 consecutive patients with secondary peritonitis. J Antimicrob Chemother. 2002;50:569-76.
15. Sartelli M, Catena F, Ansaloni L, et al. Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW study. World J Emerg Surg. 2014;9:37.
16. Andaluz D, Ferrer R. SIRS, qSOFA, and organ failure for assessing sepsis at the emergency department. J Thorac Dis. 2017;9(6):1459-62. https://doi.org/10.21037/jtd.2017.05.36.
17. Sartelli M, Abu-Zidan FM, Catena F, Griffiths EA, Di Saverio S, Coimbra R, et al. Global validation of the WSES sepsis severity score for patients with complicated intra-abdominal infections: a prospective multicenter study (WISS study). World J Emerg Surg. 2015;10:61.
18. Vincent JL, Moreno R, Takala J, et al. The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. Intensive Care Med. 1996;22:707-10.
19. Ferreira FL, Bota DP, Bross A, et al. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA. 2001;286:1754-8.
20. Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, Rubenfeld G, Kahn JM, Shankar-Hari M, Singer M, et al. Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):762-74.
21. Freund Y, Lemachatti N, Krastinova E, Van Laer M, Claessens YE, Avondo A, Occelli C, Feral-Pierssens AL, Truchot J, Ortega M, et al. Prognostic accuracy of Sepsis-3 criteria for in-hospital mortality among patients with suspected infection presenting to the emergency department. JAMA. 2017;317(3):301-8.
22. Raith EP, Udy AA, Bailey M, et al. Prognostic accuracy of the SOFA score, SIRS criteria, and qSOFA score for in-hospital mortality among adults with suspected infection admitted to the intensive care unit. JAMA. 2017;317:290-300.
23. Askim Å, Moser F, Gustad LT, Stene H, Gundersen M, Åsvold BO, Dale J, Bjørnsen LP, Damås JK, Solligård E. Poor performance of quick-SOFA (qSOFA) score in predicting severe sepsis and mortality-a prospective study of patients admitted with infection to the emergency department. Scand J Trauma Resusc Emerg Med. 2017;25(1):56.
24. Tusgul S, Carron PN, Yersin B, Calandra T, Dami F. Low sensitivity of qSOFA, SIRS criteria and sepsis definition to identify infected patients at risk of complication in the prehospital setting and at the emergency department triage. Scand J Trauma Resusc Emerg Med. 2017;25(1):108.
25. Henning DJ, Puskarich MA, Self WH, Howell MD, Donnino MW, Yealy DM, Jones AE, Shapiro NI. An emergency department validation of the SEP-3 sepsis and septic shock definitions and comparison with 1992 consensus definitions. Ann Emerg Med. 2017;70(4):544-552.e5.
26. Williams JM, Greenslade JH, McKenzie JV, Chu K, Brown AFT, Lipman J. Systemic inflammatory response syndrome, quick sequential organ function assessment, and organ dysfunction: insights from a prospective database of ED patients with infection. Chest. 2017;151(3):586-96.
27. Giamarellos-Bourboulis EJ, Tsaganos T, Tsangaris I, et al. Validation of the new Sepsis-3 definitions: proposal for improvement in early risk identification. Clin Microbiol Infect. 2017;23:104-9.
28. Peake SL, Delaney A, Bailey M, Bellomo R. ARISE investigators. Potential impact of the 2016 consensus definitions of sepsis and septic shock on future sepsis research. Ann Emerg Med. 2017 Oct;70(4):553-561.e1.
29. Sartelli M, Chichom-Mefire A, Labricciosa FM, Hardcastle T, Abu-Zidan FM, Adesunkanmi AK, et al. The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections. World J Emerg Surg. 2017;12:29.
30. Machado FR, de Assunção MSC, Cavalcanti AB, Japiassú AM, de Azevedo LCP, Oliveira MC. Getting a consensus: advantages and disadvantages of Sepsis 3 in the context of middle-income settings. Revista Brasileira de Terapia Intensiva. 2016;28(4):361-5.
31. Bermejo-Martin JF, Martín-Fernandez M, Almansa R. Pre-sepsis: a necessary concept to complete the SEPSIS-3 picture? J Crit Care. 2017;44:148.
32. Rello J, Leblebicioglu H, members of ESGCIP. Sepsis and septic shock in low-income and middle-income countries: need for a different paradigm. Int J Infect Dis. 2016;48:120-2.
33. Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, et al. International study of the prevalence and outcomes in infection in intensive care units. JAMA. 2009;302:2323-9.
34. Kruisselbrink R, Kwizera A, Crowther M, Fox-Robichaud A, O'Shea T, Nakibuuka J, Ssinabulya I, Nalyazi J, Bonner A, Devji T, Wong J, Cook D. Modified early warning score (MEWS) identifies critical illness among ward patients in a resource restricted setting in Kampala, Uganda: a prospective observational study. PLoS One. 2016;11(3):e0151408.
35. Reinhart K, Daniels R, Kissoon N, Machado FR, Schachter RD, Finfer S. Recognizing sepsis as a global health priority-a WHO resolution. N Engl J Med. 2017;377(5):414-7.