Cerebral hemodynamic assessment and neuroimaging across the lifespan in sickle cell disease

Journal of Cerebral Blood Flow and Metabolism

Volumn 38, Issue 9, 2018, Pages 1438-1448

  Jordan, Lori C ^a   DeBaun, Michael R ^b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b MEHARRY MEDICAL COLLEGE   (United States)

Author keywords

Arterial spin labelling; brain imaging; cerebral hemodynamics; cognitive impairment; hematology; lacunar infarcts; stroke

Indexed keywords

HEMOGLOBIN; HEMOGLOBIN S;

ARTERIAL SPIN LABELING; BLOOD OXYGEN TENSION; BLOOD TRANSFUSION; BOLD SIGNAL; BRAIN BLOOD FLOW; BRAIN HEMORRHAGE; BRAIN INFARCTION; CAROTID ARTERY OBSTRUCTION; CEREBRAL METABOLIC RATE OF OXYGEN; CEREBROVASCULAR DISEASE; COGNITION; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; DIFFUSION WEIGHTED IMAGING; HEALTH CARE COST; HEMODYNAMIC PARAMETERS; HIGH RISK PATIENT; HUMAN; INTELLIGENCE QUOTIENT; NEUROIMAGING; NEUROLOGICAL COMPLICATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN EXTRACTION FRACTION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECURRENCE RISK; REVASCULARIZATION; REVIEW; SENSITIVITY AND SPECIFICITY; SICKLE CELL ANEMIA; TRANSCRANIAL DOPPLER ULTRASONOGRAPHY; X-RAY COMPUTED TOMOGRAPHY; ADULT; BRAIN CIRCULATION; CEREBROVASCULAR ACCIDENT; CHILD; COMPLICATION; DIAGNOSTIC IMAGING; FEMALE; HEMODYNAMICS; MALE; PHYSIOLOGY; PROCEDURES;

ADULT; ANEMIA, SICKLE CELL; CEREBROVASCULAR CIRCULATION; CHILD; FEMALE; HEMODYNAMICS; HUMANS; MALE; NEUROIMAGING; STROKE;

EID: 85041398865     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1177/0271678X17701763     Document Type: Review

References (55)

1. Hassell KL. Population estimates of sickle cell disease in the U.S. Am J Prev Med 2010; 38: S512–S521
2. Piel FB, Hay SI, Gupta S, Global burden of sickle cell anaemia in children under five, 2010-2050: Modelling based on demographics, excess mortality, and interventions. PLoS Med 2013; 10: e1001484
3. Ohene-Frempong K, Weiner SJ, Sleeper LA, Cerebrovascular accidents in sickle cell disease: Rates and risk factors. Blood 1998; 91: 288–294
4. Kassim AA, Pruthi S, Day M, Silent cerebral infarcts and cerebral aneurysms are prevalent in adults with sickle cell anemia. Blood 2016; 127: 2038–2040
5. Strouse JJ, Jordan LC, Lanzkron S, The excess burden of stroke in hospitalized adults with sickle cell disease. Am J Hematol 2009; 84: 548–552
6. Casella JF, King AA, Barton B, Design of the silent cerebral infarct transfusion (SIT) trial. Pediatr Hematol Oncol 2010; 27: 69–89
7. DeBaun MR, Sarnaik SA, Rodeghier MJ, Associated risk factors for silent cerebral infarcts in sickle cell anemia: Low baseline hemoglobin, sex, and relative high systolic blood pressure. Blood 2012; 119: 3684–3690
8. Bernaudin F, Verlhac S, Arnaud C, Chronic and acute anemia and extracranial internal carotid stenosis are risk factors for silent cerebral infarcts in sickle cell anemia. Blood 2015; 125: 1653–1661
9. Miller ST, Macklin EA, Pegelow CH, Silent infarction as a risk factor for overt stroke in children with sickle cell anemia: A report from the Cooperative Study of Sickle Cell Disease. J Pediatr 2001; 139: 385–390
10. Pegelow CH, Macklin EA, Moser FG, Longitudinal changes in brain magnetic resonance imaging findings in children with sickle cell disease. Blood 2002; 99: 3014–3018
11. Nottage KA, Ware RE, Aygun B, Hydroxycarbamide treatment and brain MRI/MRA findings in children with sickle cell anaemia. Brit J Haematol 2016; 175: 331–338
12. King AA, Strouse JJ, Rodeghier MJ, Parent education and biologic factors influence on cognition in sickle cell anemia. Am J Hematol 2014; 89: 162–167
13. King AA, Rodeghier MJ, Panepinto JA, Silent cerebral infarction, income, and grade retention among students with sickle cell anemia. Am J Hematol 2014; 89: E188–E192
14. Wayne AS, Schoenike SE, Pegelow CH. Financial analysis of chronic transfusion for stroke prevention in sickle cell disease. Blood 2000; 96: 2369–2372
15. Platt OS, Brambilla DJ, Rosse WF, Mortality in sickle cell disease. Life expectancy and risk factors for early death. New Engl J Med 1994; 330: 1639–1644
16. Adams RJ, McKie VC, Brambilla D, Stroke prevention trial in sickle cell anemia. Control Clin Trials 1998; 19: 110–129
17. Nabavizadeh SA, Vossough A, Ichord RN, Intracranial aneurysms in sickle cell anemia: Clinical and imaging findings. J Neurointerv Surg 2015; 8: 434–440
18. Armstrong FD, Thompson RJ, Jr. Wang W, Cognitive functioning and brain magnetic resonance imaging in children with sickle Cell disease. Neuropsychology Committee of the Cooperative Study of Sickle Cell Disease. Pediatrics 1996; 97: 864–870
19. Schatz J, White DA, Moinuddin A, Lesion burden and cognitive morbidity in children with sickle cell disease. J Child Neurol 2002; 17: 891–895
20. Vichinsky EP, Neumayr LD, Gold JI, Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia. JAMA 2010; 303: 1823–1831
21. Sanger M, Jordan L, Pruthi S, Cognitive deficits are associated with unemployment in adults with sickle cell anemia. J Clin Exper Neuropsychol 2016; 38: 661–671
22. Silva GS, Vicari P, Figueiredo MS, Brain magnetic resonance imaging abnormalities in adult patients with sickle cell disease: Correlation with transcranial Doppler findings. Stroke 2009; 40: 2408–2412
23. Prohovnik I, Hurlet-Jensen A, Adams R, Hemodynamic etiology of elevated flow velocity and stroke in sickle-cell disease. J Cereb Blood Flow Metab 2009; 29: 803–810
24. Kuwabara Y, Sasaki M, Hirakata H, Cerebral blood flow and vasodilatory capacity in anemia secondary to chronic renal failure. Kidney Int 2002; 61: 564–569
25. Nur E, Kim YS, Truijen J, Cerebrovascular reserve capacity is impaired in patients with sickle cell disease. Blood 2009; 114: 3473–3478
26. Quinn CT, McKinstry RC, Dowling MM, Acute silent cerebral ischemic events in children with sickle cell anemia. JAMA Neurol 2013; 70: 58–65
27. Dowling MM, Quinn CT, Plumb P, Acute silent cerebral ischemia and infarction during acute anemia in children with and without sickle cell disease. Blood 2012; 120: 3891–3897
28. Hulbert ML, McKinstry RC, Lacey JL, Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease. Blood 2011; 117: 772–779
29. Adams RJ, McKie VC, Hsu L, Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. New Engl J Med 1998; 339: 5–11
30. Adams RJ, Nichols FT, Figueroa R, Transcranial Doppler correlation with cerebral angiography in sickle cell disease. Stroke 1992; 23: 1073–1077
31. Adams R, McKie V, Nichols F, The use of transcranial ultrasonography to predict stroke in sickle cell disease. New Engl J Med 1992; 326: 605–610
32. Abboud MR, Cure J, Granger S, Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial Doppler ultrasonography findings enrolled in the STOP study. Blood 2004; 103: 2822–2826
33. Valadi N, Silva GS, Bowman LS, Transcranial Doppler ultrasonography in adults with sickle cell disease. Neurology 2006; 67: 572–574
34. Oguz KK, Golay X, Pizzini FB, Sickle cell disease: Continuous arterial spin-labeling perfusion MR imaging in children. Radiology 2003; 227: 567–574
35. Jordan LC, Gindville MC, Scott AO, Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia. Brain 2016; 139: 738–750
36. Prohovnik I, Pavlakis SG, Piomelli S, Cerebral hyperemia, stroke, and transfusion in sickle cell disease. Neurology 1989; 39: 344–348
37. Juttukonda MR, Jordan LC, Gindville MC, Quantification of arterial spin labeling efficiency in high cervical velocity conditions using phase contrast angiography. IEEE 2016; 1: 1350–1353
38. Herold S, Brozovic M, Gibbs J, Measurement of regional cerebral blood flow, blood volume and oxygen metabolism in patients with sickle cell disease using positron emission tomography. Stroke 1986; 17: 692–698
39. Grubb RL, Jr. Powers WJ, Derdeyn CP, The carotid occlusion surgery study. Neurosurg Foc 2003; 14: e9
40. Marshall RS, Festa JR, Cheung YK, Cerebral hemodynamics and cognitive impairment: Baseline data from the RECON trial. Neurology 2012; 78: 250–255
41. Chang FY, Xiao JX, Xie S, Determination of oxygen extraction fraction using magnetic resonance imaging in canine models with internal carotid artery occlusion. Sci Rep 2016; 6: 303–332
42. An H, Ford AL, Chen Y, Defining the ischemic penumbra using magnetic resonance oxygen metabolic index. Stroke 2015; 46: 982–988
43. Donahue MJ, Dethrage LM, Faraco CC, Routine clinical evaluation of cerebrovascular reserve capacity using carbogen in patients with intracranial stenosis. Stroke 2014; 45: 2335–2341
44. Smeeing DP, Hendrikse J, Petersen ET, Arterial spin labeling and blood oxygen level-dependent MRI cerebrovascular reactivity in cerebrovascular disease: A systematic review and meta-analysis. Cerebrovasc Dis 2016; 42: 288–307
45. Kosinski PD, Croal PL, Leung J, The severity of anaemia depletes cerebrovascular dilatory reserve in children with sickle cell disease: A quantitative magnetic resonance imaging study. BritJ Haematol 2017; 176: 280–287
46. Watchmaker JM, Juttukonda MR, Davis LT, Hemodynamic mechanisms underlying elevated oxygen extraction fraction (OEF) in moyamoya and sickle cell anemia patients. J Cereb Blood Flow Metab Epub ahead of print 28 December 2016. DOI: 10.1177/0271678X16682509
47. Han JS, Mikulis DJ, Mardimae A, Measurement of cerebrovascular reactivity in pediatric patients with cerebral vasculopathy using blood oxygen level-dependent MRI. Stroke 2011; 42: 1261–1269
48. DeBaun MR, Gordon M, McKinstry RC, Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia. New Engl J Med 2014; 371: 699–6710
49. Kassim AA, Galadanci NA, Pruthi S, How I treat and manage strokes in sickle cell disease. Blood 2015; 125: 3401–3410
50. Brittenham GM. Iron-chelating therapy for transfusional iron overload. New Engl J Med 2011; 364: 146–156
51. Vichinsky EP, Ohene-Frempong K, Thein SL, Transfusion and chelation practices in sickle cell disease: A regional perspective. Pediatr Hematol Oncol 2011; 28: 124–133
52. Obusez EC, Hui F, Hajj-Ali RA, High-resolution MRI vessel wall imaging: Spatial and temporal patterns of reversible cerebral vasoconstriction syndrome and central nervous system vasculitis. Am J Neuroradiol 2014; 35: 1527–1532
53. Rothman SM, Fulling KH, Nelson JS. Sickle cell anemia and central nervous system infarction: A neuropathological study. Ann Neurol 1986; 20: 684–690
54. Merkel KH, Ginsberg PL, Parker JC, Jr. Cerebrovascular disease in sickle cell anemia: A clinical, pathological and radiological correlation. Stroke 1978; 9: 45–52
55. Adams RJ, Brambilla D. Optimizing Primary Stroke Prevention in Sickle Cell Anemia Trial I. Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease. New Engl J Med 2005; 353: 2769–2778