메뉴 건너뛰기




Volumn 20, Issue , 2018, Pages 68-76

Efficacy of glucagon-like peptide-1 receptor agonists compared to dipeptidyl peptidase-4 inhibitors for the management of type 2 diabetes: A meta-analysis of randomized clinical trials

Author keywords

DPP 4; GLP 1; meta analysis; type 2 diabetes

Indexed keywords

ALBIGLUTIDE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DULAGLUTIDE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; HEMOGLOBIN A1C; LIRAGLUTIDE; LIXISENATIDE; SAXAGLIPTIN; SITAGLIPTIN; TASPOGLUTIDE; VILDAGLIPTIN; ANTIDIABETIC AGENT; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

EID: 85041072418     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.13137     Document Type: Review
Times cited : (31)

References (50)
  • 1
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes
    • Kahn SE. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia. 2003;46:3–19.
    • (2003) Diabetologia , vol.46 , pp. 3-19
    • Kahn, S.E.1
  • 2
    • 85009168575 scopus 로고    scopus 로고
    • Pharmacologic approaches to glycemic treatment
    • American Diabetes Association. Pharmacologic approaches to glycemic treatment. Diabetes Care. 2017;40(suppl 1):S64–S74.
    • (2017) Diabetes Care , vol.40 , pp. S64-S74
  • 3
    • 84919999219 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015;38:140–149.
    • (2015) Diabetes Care , vol.38 , pp. 140-149
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 4
    • 85002833256 scopus 로고    scopus 로고
    • Pharmacologic management of type 2 diabetes: 2016 interim update
    • Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. Pharmacologic management of type 2 diabetes: 2016 interim update. Can J Diabetes. 2016;40:484–486.
    • (2016) Can J Diabetes , vol.40 , pp. 484-486
  • 5
    • 85041027061 scopus 로고    scopus 로고
    • Type 2 diabetes in adults management., Accessed February 16, 2017.
    • National Institute for Health and Clinical Excellence. Type 2 diabetes in adults: management. 2016. https://www.nice.org.uk/guidance/ng28/resources/type-2-diabetes-in-adults-management-1837338615493. Accessed February 16, 2017.
    • (2016)
  • 6
    • 84957878858 scopus 로고    scopus 로고
    • Incretin therapies: highlighting common features and differences in the modes of action of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors
    • Nauck M. Incretin therapies: highlighting common features and differences in the modes of action of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. Diab Obes Metab. 2016;18:203–216.
    • (2016) Diab Obes Metab , vol.18 , pp. 203-216
    • Nauck, M.1
  • 7
    • 84898964381 scopus 로고    scopus 로고
    • GLP-1 receptor agonists vs. DPP-4 inhibitors for type 2 diabetes: is one approach more successful or preferable than the other?
    • Brunton S. GLP-1 receptor agonists vs. DPP-4 inhibitors for type 2 diabetes: is one approach more successful or preferable than the other? Int J Clin Pract. 2014;68:557–567.
    • (2014) Int J Clin Pract , vol.68 , pp. 557-567
    • Brunton, S.1
  • 8
    • 67651173077 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus
    • Lovshin JA, Drucker DJ. Incretin-based therapies for type 2 diabetes mellitus. Nat Rev Endocrinol. 2009;5:262–269.
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 262-269
    • Lovshin, J.A.1    Drucker, D.J.2
  • 9
    • 84904963065 scopus 로고    scopus 로고
    • HARMONY 3: 104-week randomized, double-blind, placebo- and active-controlled trial assessing the efficacy and safety of albiglutide compared with placebo, sitagliptin, and glimepiride in patients with type 2 diabetes taking metformin
    • Ahrén B, Johnson SL, Stewart M, et al. HARMONY 3: 104-week randomized, double-blind, placebo- and active-controlled trial assessing the efficacy and safety of albiglutide compared with placebo, sitagliptin, and glimepiride in patients with type 2 diabetes taking metformin. Diabetes Care. 2014;37:2141–2148.
    • (2014) Diabetes Care , vol.37 , pp. 2141-2148
    • Ahrén, B.1    Johnson, S.L.2    Stewart, M.3
  • 10
    • 77955573674 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomized trial
    • Bergenstal RM, Wysham C, MacConnell L, et al. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomized trial. Lancet. 2010;376:431–439.
    • (2010) Lancet , vol.376 , pp. 431-439
    • Bergenstal, R.M.1    Wysham, C.2    MacConnell, L.3
  • 11
    • 77952309372 scopus 로고    scopus 로고
    • Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomized, parallel-group, open-label trial
    • Pratley RE, Nauck M, Bailey T, et al. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomized, parallel-group, open-label trial. Lancet. 2010;375:1447–1456.
    • (2010) Lancet , vol.375 , pp. 1447-1456
    • Pratley, R.E.1    Nauck, M.2    Bailey, T.3
  • 12
    • 69149107165 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
    • W64.
    • Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151:264–269. W64.
    • (2009) Ann Intern Med , vol.151 , pp. 264-269
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 13
    • 84866650686 scopus 로고    scopus 로고
    • Efficacy and safety of switching from the DPP-4 inhibitor sitagliptin to the human GLP-1 analog liraglutide after 52 weeks in metformin-treated patients with type 2 diabetes
    • Pratley RE, Nauck MA, Bailey T, et al. Efficacy and safety of switching from the DPP-4 inhibitor sitagliptin to the human GLP-1 analog liraglutide after 52 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care. 2012;35:1986–1993.
    • (2012) Diabetes Care , vol.35 , pp. 1986-1993
    • Pratley, R.E.1    Nauck, M.A.2    Bailey, T.3
  • 14
    • 79955960213 scopus 로고    scopus 로고
    • DURATION-2: efficacy and safety of switching from maximum daily sitagliptin or pioglitazone to once-weekly exenatide
    • Wysham C, Bergenstal R, Malloy J, et al. DURATION-2: efficacy and safety of switching from maximum daily sitagliptin or pioglitazone to once-weekly exenatide. Diabet Med. 2011;28:705–714.
    • (2011) Diabet Med , vol.28 , pp. 705-714
    • Wysham, C.1    Bergenstal, R.2    Malloy, J.3
  • 15
    • 84987668834 scopus 로고    scopus 로고
    • Efficacy and safety of switching from sitagliptin to liraglutide in subjects with type 2 diabetes (LIRA-SWITCH): a randomized, double-blind, double-dummy, active-controlled 26-week trial
    • Bailey TS, Takács R, Tinahones FJ, et al. Efficacy and safety of switching from sitagliptin to liraglutide in subjects with type 2 diabetes (LIRA-SWITCH): a randomized, double-blind, double-dummy, active-controlled 26-week trial. Diabetes Obes Metab. 2016;18:1191–1198.
    • (2016) Diabetes Obes Metab , vol.18 , pp. 1191-1198
    • Bailey, T.S.1    Takács, R.2    Tinahones, F.J.3
  • 16
    • 84923566574 scopus 로고    scopus 로고
    • Vildagliptin vs liraglutide as a second-line therapy switched from sitagliptin-based regimens in patients with type 2 diabetes: a randomized, parallel-group study
    • Takeshita Y, Takamura T, Kita Y, et al. Vildagliptin vs liraglutide as a second-line therapy switched from sitagliptin-based regimens in patients with type 2 diabetes: a randomized, parallel-group study. J Diabetes Invest. 2015;6:192–200.
    • (2015) J Diabetes Invest , vol.6 , pp. 192-200
    • Takeshita, Y.1    Takamura, T.2    Kita, Y.3
  • 17
    • 84867191797 scopus 로고    scopus 로고
    • A randomized non-inferiority study comparing the addition of exenatide twice daily to sitagliptin or switching from sitagliptin to exenatide twice daily in patients with type 2 diabetes experiencing inadequate glycaemic control on metformin and sitagliptin
    • Violante R, Oliveira HA, Yoon KH, et al. A randomized non-inferiority study comparing the addition of exenatide twice daily to sitagliptin or switching from sitagliptin to exenatide twice daily in patients with type 2 diabetes experiencing inadequate glycaemic control on metformin and sitagliptin. Diabet Med. 2012;29:e417–e424.
    • (2012) Diabet Med , vol.29 , pp. e417-e424
    • Violante, R.1    Oliveira, H.A.2    Yoon, K.H.3
  • 18
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–1558.
    • (2002) Stat Med , vol.21 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 19
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–1101.
    • (1994) Biometrics , vol.50 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 20
    • 85041068639 scopus 로고    scopus 로고
    • Efficacy and tolerability of ITCA 650 versus sitagliptin in uncontrolled type 2 diabetes patients on metformin monotherapy results of the FREEDOM-2 study. September 15,, Accessed January 28, 2017.
    • Baron MA, Denham D, Prabhakar P, Azeem R, Kjems L, Rosenstock J. Efficacy and tolerability of ITCA 650 versus sitagliptin in uncontrolled type 2 diabetes patients on metformin monotherapy: results of the FREEDOM-2 study. September 15, 2016. http://www.easdvirtualmeeting.org/resources/efficacy-and-tolerability-of-itca-650-versus-sitagliptin-in-uncontrolled-type-2-diabetes-patients-on-metformin-monotherapy-results-of-the-freedom-2-study. Accessed January 28, 2017.
    • (2016)
    • Baron, M.A.1    Denham, D.2    Prabhakar, P.3    Azeem, R.4    Kjems, L.5    Rosenstock, J.6
  • 21
    • 84871126011 scopus 로고    scopus 로고
    • Efficacy and safety of taspoglutide versus sitagliptin for type 2 diabetes mellitus (T-Emerge 4 Trial)
    • Bergenstal RM, Forti A, Chiasson JL, Woloschak M, Boldrin M, Balena R. Efficacy and safety of taspoglutide versus sitagliptin for type 2 diabetes mellitus (T-Emerge 4 Trial). Diabetes Ther. 2012;3:1–19.
    • (2012) Diabetes Ther , vol.3 , pp. 1-19
    • Bergenstal, R.M.1    Forti, A.2    Chiasson, J.L.3    Woloschak, M.4    Boldrin, M.5    Balena, R.6
  • 22
    • 84906707189 scopus 로고    scopus 로고
    • Effect of exenatide, sitagliptin, or glimepiride on β-cell secretory capacity in early type 2 diabetes
    • Gudipaty L, Rosenfeld NK, Fuller CS, Gallop R, Schutta MH, Rickels MR. Effect of exenatide, sitagliptin, or glimepiride on β-cell secretory capacity in early type 2 diabetes. Diabetes Care. 2014;37:2451–2458.
    • (2014) Diabetes Care , vol.37 , pp. 2451-2458
    • Gudipaty, L.1    Rosenfeld, N.K.2    Fuller, C.S.3    Gallop, R.4    Schutta, M.H.5    Rickels, M.R.6
  • 23
    • 84930278561 scopus 로고    scopus 로고
    • Efficacy and safety comparison of add-on therapy with liraglutide, saxagliptin and vildagliptin, all in combination with current conventional oral hypoglycemic agents therapy in poorly controlled Chinese type 2 diabetes
    • Li CJ, Yu Q, Yu P, et al. Efficacy and safety comparison of add-on therapy with liraglutide, saxagliptin and vildagliptin, all in combination with current conventional oral hypoglycemic agents therapy in poorly controlled Chinese type 2 diabetes. Exp Clin Endocrinol Diabetes. 2014;122:469–476.
    • (2014) Exp Clin Endocrinol Diabetes , vol.122 , pp. 469-476
    • Li, C.J.1    Yu, Q.2    Yu, P.3
  • 24
    • 84938699899 scopus 로고    scopus 로고
    • Patient preference and tolerability of a DPP-4 inhibitor versus a GLP-1 analog in patients with type 2 diabetes mellitus inadequately controlled with metformin: a 24-week, randomized, multicenter, crossover study
    • Lüdemann J, Dütting ED, Dworak M. Patient preference and tolerability of a DPP-4 inhibitor versus a GLP-1 analog in patients with type 2 diabetes mellitus inadequately controlled with metformin: a 24-week, randomized, multicenter, crossover study. Ther Adv Endocrinol Metab. 2015;6:141–148.
    • (2015) Ther Adv Endocrinol Metab , vol.6 , pp. 141-148
    • Lüdemann, J.1    Dütting, E.D.2    Dworak, M.3
  • 25
    • 84904992244 scopus 로고    scopus 로고
    • Efficacy and safety of dulaglutide versus sitagliptin after 52 weeks in type 2 diabetes in a randomized controlled trial (AWARD-5)
    • Nauck M, Weinstock RS, Umpierrez GE, Guerci B, Skrivanek Z, Milicevic Z. Efficacy and safety of dulaglutide versus sitagliptin after 52 weeks in type 2 diabetes in a randomized controlled trial (AWARD-5). Diabetes Care. 2014;37:2149–2158.
    • (2014) Diabetes Care , vol.37 , pp. 2149-2158
    • Nauck, M.1    Weinstock, R.S.2    Umpierrez, G.E.3    Guerci, B.4    Skrivanek, Z.5    Milicevic, Z.6
  • 26
    • 84859013614 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naïve patients with type 2 diabees (DURATION-4): a 26-week double-blind study
    • Russell-Jones D, Cuddihy RM, Hanefeld M, et al. Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naïve patients with type 2 diabees (DURATION-4): a 26-week double-blind study. Diabetes Care. 2012;35:252–258.
    • (2012) Diabetes Care , vol.35 , pp. 252-258
    • Russell-Jones, D.1    Cuddihy, R.M.2    Hanefeld, M.3
  • 27
    • 84992157064 scopus 로고    scopus 로고
    • Biliary effects of liraglutide and sitagliptin, a 12-week randomized placebo-controlled trial in type 2 diabetes patients
    • Smits MM, Tonneijck L, Muskiet MHA, et al. Biliary effects of liraglutide and sitagliptin, a 12-week randomized placebo-controlled trial in type 2 diabetes patients. Diabetes Obes Metab. 2016;18:1217–1225.
    • (2016) Diabetes Obes Metab , vol.18 , pp. 1217-1225
    • Smits, M.M.1    Tonneijck, L.2    Muskiet, M.H.A.3
  • 28
    • 84903166988 scopus 로고    scopus 로고
    • Efficacy and safety of the glucagon-like peptide-1 receptor agonist lixisenatide versus the dipeptidyl peptidase-4 inhibitor sitagliptin in young (<50 years) obese patients with type 2 diabetes mellitus
    • Van Gaal L, Souhami E, Zhou T, Aronson R. Efficacy and safety of the glucagon-like peptide-1 receptor agonist lixisenatide versus the dipeptidyl peptidase-4 inhibitor sitagliptin in young (<50 years) obese patients with type 2 diabetes mellitus. J Clin Transl Endocrinol. 2014;1:31–37.
    • (2014) J Clin Transl Endocrinol , vol.1 , pp. 31-37
    • Van Gaal, L.1    Souhami, E.2    Zhou, T.3    Aronson, R.4
  • 29
    • 84970990680 scopus 로고    scopus 로고
    • Efficacy and safety of liraglutide versus sitagliptin, both in combination with metformin, in Chinese patients with type 2 diabetes: a 26-week, open-label, randomized, active comparator clinical trial
    • Zang L, Liu Y, Geng J, et al. Efficacy and safety of liraglutide versus sitagliptin, both in combination with metformin, in Chinese patients with type 2 diabetes: a 26-week, open-label, randomized, active comparator clinical trial. Diabetes Obes Metab. 2016;18:803–811.
    • (2016) Diabetes Obes Metab , vol.18 , pp. 803-811
    • Zang, L.1    Liu, Y.2    Geng, J.3
  • 30
    • 84905472510 scopus 로고    scopus 로고
    • Comparison of GLP-1 analogues versus sitagliptin in the management of type 2 diabetes: systematic review and meta-analysis of head-to-head studies
    • Wang T, Gou Z, Wang F, Ma M, Zhai SD. Comparison of GLP-1 analogues versus sitagliptin in the management of type 2 diabetes: systematic review and meta-analysis of head-to-head studies. PLoS One. 2014;9:e103798.
    • (2014) PLoS One , vol.9
    • Wang, T.1    Gou, Z.2    Wang, F.3    Ma, M.4    Zhai, S.D.5
  • 31
    • 85020513481 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists: a systematic review of comparative effectiveness research
    • Levin PA, Nguyen H, Wittbrodt ET, Kim SC. Glucagon-like peptide-1 receptor agonists: a systematic review of comparative effectiveness research. Diabetes Metab Syndr Obes. 2017;10:123–139.
    • (2017) Diabetes Metab Syndr Obes , vol.10 , pp. 123-139
    • Levin, P.A.1    Nguyen, H.2    Wittbrodt, E.T.3    Kim, S.C.4
  • 32
    • 79960777404 scopus 로고    scopus 로고
    • Efficacy and safety of long-acting glucagon-like peptide-1 receptor agonists compared with exenatide twice daily and sitagliptin in type 2 diabetes mellitus: a systematic review and meta-analysis
    • Pinelli NR, Hurren KM. Efficacy and safety of long-acting glucagon-like peptide-1 receptor agonists compared with exenatide twice daily and sitagliptin in type 2 diabetes mellitus: a systematic review and meta-analysis. Ann Pharmacother. 2011;45:850–860.
    • (2011) Ann Pharmacother , vol.45 , pp. 850-860
    • Pinelli, N.R.1    Hurren, K.M.2
  • 33
    • 53349129304 scopus 로고    scopus 로고
    • Commentary: heterogeneity in meta-analysis should be expected and appropriately quantified
    • Higgins J. Commentary: heterogeneity in meta-analysis should be expected and appropriately quantified. Int J Epidemiol. 2008;37:1158–1160.
    • (2008) Int J Epidemiol , vol.37 , pp. 1158-1160
    • Higgins, J.1
  • 34
    • 46749099101 scopus 로고    scopus 로고
    • Reasons or excuses for avoiding meta-analysis in forest plots
    • Ioannidis JPA, Patsopoulos NA, Rothstein HR. Reasons or excuses for avoiding meta-analysis in forest plots. BMJ. 2008;366:1413–1415.
    • (2008) BMJ , vol.366 , pp. 1413-1415
    • Ioannidis, J.P.A.1    Patsopoulos, N.A.2    Rothstein, H.R.3
  • 35
    • 55549136417 scopus 로고    scopus 로고
    • Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study
    • DeFronzo RA, Okerson T, Viswanathan P, Guan X, Holcombe JH, MacConell L. Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study. Curr Med Res Opin. 2008;24:2943–2952.
    • (2008) Curr Med Res Opin , vol.24 , pp. 2943-2952
    • DeFronzo, R.A.1    Okerson, T.2    Viswanathan, P.3    Guan, X.4    Holcombe, J.H.5    MacConell, L.6
  • 36
    • 84864674632 scopus 로고    scopus 로고
    • Elevated amylase and lipase levels in patients using glucagonlike peptide-1 receptor agonists or dipeptidyl-peptidase-4 inhibitors in the outpatient setting
    • Lando HM, Alattar M, Dua AP. Elevated amylase and lipase levels in patients using glucagonlike peptide-1 receptor agonists or dipeptidyl-peptidase-4 inhibitors in the outpatient setting. Endocr Pract. 2012;8:472–477.
    • (2012) Endocr Pract , vol.8 , pp. 472-477
    • Lando, H.M.1    Alattar, M.2    Dua, A.P.3
  • 37
    • 85006240253 scopus 로고    scopus 로고
    • Effects of DPP-4 inhibitor linagliptin and GLP-1 receptor agonist liraglutide on physiological response to hypoglycaemia in Japanese subjects with type 2 diabetes: a randomized, open-label, 2-arm parallel comparative, exploratory trial
    • Yabe D, Eto T, Shiramoto M, et al. Effects of DPP-4 inhibitor linagliptin and GLP-1 receptor agonist liraglutide on physiological response to hypoglycaemia in Japanese subjects with type 2 diabetes: a randomized, open-label, 2-arm parallel comparative, exploratory trial. Diabetes Obes Metab. 2017;19:442–447.
    • (2017) Diabetes Obes Metab , vol.19 , pp. 442-447
    • Yabe, D.1    Eto, T.2    Shiramoto, M.3
  • 38
    • 77955262909 scopus 로고    scopus 로고
    • Further improvement in postprandial glucose control with addition of exenatide or sitagliptin to combination therapy with insulin glargine and metformin: a proof-of-concept study
    • Arnold S, Dellweg S, Clair J, et al. Further improvement in postprandial glucose control with addition of exenatide or sitagliptin to combination therapy with insulin glargine and metformin: a proof-of-concept study. Diabetes Care. 2010;33:1509–1515.
    • (2010) Diabetes Care , vol.33 , pp. 1509-1515
    • Arnold, S.1    Dellweg, S.2    Clair, J.3
  • 39
    • 80053390364 scopus 로고    scopus 로고
    • Effects of exenatide twice daily versus sitagliptin on 24-h glucose, glucoregulatory and hormonal measures: a randomized, double-blind, crossover study
    • Berg JK, Shenouda SK, Heilmann CR, Gray AL, Holcombe JH. Effects of exenatide twice daily versus sitagliptin on 24-h glucose, glucoregulatory and hormonal measures: a randomized, double-blind, crossover study. Diabetes Obes Metab. 2011;13:982–989.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 982-989
    • Berg, J.K.1    Shenouda, S.K.2    Heilmann, C.R.3    Gray, A.L.4    Holcombe, J.H.5
  • 40
    • 84878837962 scopus 로고    scopus 로고
    • Efficacy and safety over 26 weeks of an oral treatment strategy including sitagliptin compared with an injectable treatment strategy with liraglutide in patients with type 2 diabetes mellitus inadequately controlled on metformin: a randomised clinical trial
    • Charbonnel B, Steinberg H, Eymard E, et al. Efficacy and safety over 26 weeks of an oral treatment strategy including sitagliptin compared with an injectable treatment strategy with liraglutide in patients with type 2 diabetes mellitus inadequately controlled on metformin: a randomised clinical trial. Diabetologia. 2013;56:1503–1511.
    • (2013) Diabetologia , vol.56 , pp. 1503-1511
    • Charbonnel, B.1    Steinberg, H.2    Eymard, E.3
  • 41
    • 84923566574 scopus 로고    scopus 로고
    • Vildagliptin vs. liraglutide as a second-line therapy switched from sitagliptin-based regimens in patients with type 2 diabetes: a randomized, parallel-group study
    • Takeshita Y, Takamura T, Kita Y, et al. Vildagliptin vs. liraglutide as a second-line therapy switched from sitagliptin-based regimens in patients with type 2 diabetes: a randomized, parallel-group study. J Diabetes Investig. 2015;6:192–200.
    • (2015) J Diabetes Investig , vol.6 , pp. 192-200
    • Takeshita, Y.1    Takamura, T.2    Kita, Y.3
  • 42
    • 84919761987 scopus 로고    scopus 로고
    • Greater efficacy and improved endothelial dysfunction in untreated type 2 diabetes with liraglutide versus sitagliptin
    • Suzuki K, Tanaka S, Aoki C, Kato K, Jojima T, Aso Y. Greater efficacy and improved endothelial dysfunction in untreated type 2 diabetes with liraglutide versus sitagliptin. Dokkyo J Med Sci. 2014;41:211–220.
    • (2014) Dokkyo J Med Sci , vol.41 , pp. 211-220
    • Suzuki, K.1    Tanaka, S.2    Aoki, C.3    Kato, K.4    Jojima, T.5    Aso, Y.6
  • 43
    • 85018723186 scopus 로고    scopus 로고
    • Efficacy and safety of once-weekly semaglutide vs sitagliptin as add-on to metformin and/or thiazolidinediones after 56 weeks in subjects with type 2 diabetes (SUSTAIN 2)
    • Ahren B, Masmiquel CL, Kumar H, et al. Efficacy and safety of once-weekly semaglutide vs sitagliptin as add-on to metformin and/or thiazolidinediones after 56 weeks in subjects with type 2 diabetes (SUSTAIN 2). Diabetologia. 2016;59(suppl 1):S365.
    • (2016) Diabetologia , vol.59 , pp. S365
    • Ahren, B.1    Masmiquel, C.L.2    Kumar, H.3
  • 44
    • 85073762622 scopus 로고    scopus 로고
    • Switching from sitagliptin to liraglutide in subjects with type 2 diabetes: analysis of composite endpoints from the LIRA-SWITCH randomised trial
    • Bailey T, Takacs R, Tinahones FJ, et al. Switching from sitagliptin to liraglutide in subjects with type 2 diabetes: analysis of composite endpoints from the LIRA-SWITCH randomised trial. Diabetologia. 2016;59(suppl 1):S1.
    • (2016) Diabetologia , vol.59 , pp. S1
    • Bailey, T.1    Takacs, R.2    Tinahones, F.J.3
  • 45
    • 79851495878 scopus 로고    scopus 로고
    • Liraglutide improves treatment satisfaction in people with Type2 diabetes compared with sitagliptin, each as an add on to metformin
    • Davies M, Pratley R, Hammer M, Thomsen AB, Cuddihy R. Liraglutide improves treatment satisfaction in people with Type2 diabetes compared with sitagliptin, each as an add on to metformin. Diabet Med. 2011;28:333–337.
    • (2011) Diabet Med , vol.28 , pp. 333-337
    • Davies, M.1    Pratley, R.2    Hammer, M.3    Thomsen, A.B.4    Cuddihy, R.5
  • 46
    • 84881486681 scopus 로고    scopus 로고
    • Liraglutide achieves A1c targets more often than sitagliptin or exenatide when added to metformin in patients with type 2 diabetes and a baseline A1c <8.0%
    • King AB, Montanya E, Pratley RE, et al. Liraglutide achieves A1c targets more often than sitagliptin or exenatide when added to metformin in patients with type 2 diabetes and a baseline A1c <8.0%. Endocr Pract. 2013;19:64–72.
    • (2013) Endocr Pract , vol.19 , pp. 64-72
    • King, A.B.1    Montanya, E.2    Pratley, R.E.3
  • 47
    • 79952755181 scopus 로고    scopus 로고
    • One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial
    • Pratley R, Nauck M, Bailey T, et al. One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial. Int J Clin Pract. 2011;65:397–407.
    • (2011) Int J Clin Pract , vol.65 , pp. 397-407
    • Pratley, R.1    Nauck, M.2    Bailey, T.3
  • 48
    • 84994361897 scopus 로고    scopus 로고
    • Renal effects of DPP-4 inhibitor sitagliptin or GLP-1 receptor agonist liraglutide in overweight patients with type 2 diabetes: a 12-week, randomized, double-blind, placebo-controlled trial
    • Tonneijck L, Smits MM, Muskiet MH, et al. Renal effects of DPP-4 inhibitor sitagliptin or GLP-1 receptor agonist liraglutide in overweight patients with type 2 diabetes: a 12-week, randomized, double-blind, placebo-controlled trial. Diabetes Care. 2016;39:2042–2050.
    • (2016) Diabetes Care , vol.39 , pp. 2042-2050
    • Tonneijck, L.1    Smits, M.M.2    Muskiet, M.H.3
  • 49
    • 84987668067 scopus 로고    scopus 로고
    • Twelve week liraglutide or sitagliptin does not affect hepatic fat in type 2 diabetes: a randomised placebo-controlled trial
    • Smits MM, Tonneijck L, Muskiet HA, et al. Twelve week liraglutide or sitagliptin does not affect hepatic fat in type 2 diabetes: a randomised placebo-controlled trial. Diabetologia. 2016;59:2588–2593.
    • (2016) Diabetologia , vol.59 , pp. 2588-2593
    • Smits, M.M.1    Tonneijck, L.2    Muskiet, H.A.3
  • 50
    • 84939565260 scopus 로고    scopus 로고
    • Safety and efficacy of once-weekly dulaglutide versus sitagliptin after 2 years in metformin-treated patients with type 2 diabetes (AWARD-5): a randomized, phase III study
    • Weinstock RS, Guerci B, Umpierrez G, Nauck MA, Skrivanek Z, Milicevic Z. Safety and efficacy of once-weekly dulaglutide versus sitagliptin after 2 years in metformin-treated patients with type 2 diabetes (AWARD-5): a randomized, phase III study. Diabetes Obes Metab. 2015;17:849–858.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 849-858
    • Weinstock, R.S.1    Guerci, B.2    Umpierrez, G.3    Nauck, M.A.4    Skrivanek, Z.5    Milicevic, Z.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.