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Volumn 20, Issue , 2018, Pages 47-58

What have we learnt from “real world” data, observational studies and meta-analyses

Author keywords

antidiabetic drug; clinical trial; cohort study; DPP IV inhibitor; GLP 1 analogue; incretin therapy

Indexed keywords

ALBIGLUTIDE; ALOGLIPTIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DULAGLUTIDE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; INSULIN; LINAGLIPTIN; LIRAGLUTIDE; LIXISENATIDE; METFORMIN; SAXAGLIPTIN; SEMAGLUTIDE; SITAGLIPTIN; VILDAGLIPTIN; ANTIDIABETIC AGENT; GLUCAGON LIKE PEPTIDE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR;

EID: 85041055357     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.13178     Document Type: Review
Times cited : (35)

References (67)
  • 1
    • 84919999219 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015;38(1):140-149.
    • (2015) Diabetes Care , vol.38 , Issue.1 , pp. 140-149
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 2
    • 85002412626 scopus 로고    scopus 로고
    • Real-world evidence - what is it and what can it tell us?
    • Sherman RE, Anderson SA, Dal Pan GJ, et al. Real-world evidence - what is it and what can it tell us? N Engl J Med. 2016;375(23):2293-2297.
    • (2016) N Engl J Med , vol.375 , Issue.23 , pp. 2293-2297
    • Sherman, R.E.1    Anderson, S.A.2    Dal Pan, G.J.3
  • 3
    • 0141684982 scopus 로고    scopus 로고
    • Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy
    • Tunis SR, Stryer DB, Clancy CM. Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy. JAMA. 2003;290(12):1624-1632.
    • (2003) JAMA , vol.290 , Issue.12 , pp. 1624-1632
    • Tunis, S.R.1    Stryer, D.B.2    Clancy, C.M.3
  • 4
    • 84895918167 scopus 로고    scopus 로고
    • Randomized controlled trials and real life studies. Approaches and methodologies: a clinical point of view
    • Saturni S, Bellini F, Braido F, et al. Randomized controlled trials and real life studies. Approaches and methodologies: a clinical point of view. Pulm Pharmacol Ther. 2014;27(2):129-138.
    • (2014) Pulm Pharmacol Ther , vol.27 , Issue.2 , pp. 129-138
    • Saturni, S.1    Bellini, F.2    Braido, F.3
  • 5
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse JB, Rosenstock J, Sesti G, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet. 2009;374(9683):39-47.
    • (2009) Lancet , vol.374 , Issue.9683 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 6
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber A, Henry R, Ratner R, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet. 2009;373(9662):473-481.
    • (2009) Lancet , vol.373 , Issue.9662 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 7
    • 84873085581 scopus 로고    scopus 로고
    • Long-term efficacy and safety comparison of liraglutide, glimepiride and placebo, all in combination with metformin in type 2 diabetes: 2-year results from the LEAD-2 study
    • Nauck M, Frid A, Hermansen K, et al. Long-term efficacy and safety comparison of liraglutide, glimepiride and placebo, all in combination with metformin in type 2 diabetes: 2-year results from the LEAD-2 study. Diabetes Obes Metab. 2013;15(3):204-212.
    • (2013) Diabetes Obes Metab , vol.15 , Issue.3 , pp. 204-212
    • Nauck, M.1    Frid, A.2    Hermansen, K.3
  • 8
    • 84905012167 scopus 로고    scopus 로고
    • Efficacy and safety of dulaglutide added onto pioglitazone and metformin versus exenatide in type 2 diabetes in a randomized controlled trial (AWARD-1)
    • Wysham C, Blevins T, Arakaki R, et al. Efficacy and safety of dulaglutide added onto pioglitazone and metformin versus exenatide in type 2 diabetes in a randomized controlled trial (AWARD-1). Diabetes Care. 2014;37(8):2159-2167.
    • (2014) Diabetes Care , vol.37 , Issue.8 , pp. 2159-2167
    • Wysham, C.1    Blevins, T.2    Arakaki, R.3
  • 9
    • 84908177336 scopus 로고    scopus 로고
    • Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial
    • Dungan KM, Povedano ST, Forst T, et al. Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial. Lancet. 2014;384(9951):1349-1357.
    • (2014) Lancet , vol.384 , Issue.9951 , pp. 1349-1357
    • Dungan, K.M.1    Povedano, S.T.2    Forst, T.3
  • 10
    • 84939565260 scopus 로고    scopus 로고
    • Safety and efficacy of once-weekly dulaglutide versus sitagliptin after 2 years in metformin-treated patients with type 2 diabetes (AWARD-5): a randomized, phase III study
    • Weinstock RS, Guerci B, Umpierrez G, Nauck MA, Skrivanek Z, Milicevic Z. Safety and efficacy of once-weekly dulaglutide versus sitagliptin after 2 years in metformin-treated patients with type 2 diabetes (AWARD-5): a randomized, phase III study. Diabetes Obes Metab. 2015;17(9):849-858.
    • (2015) Diabetes Obes Metab , vol.17 , Issue.9 , pp. 849-858
    • Weinstock, R.S.1    Guerci, B.2    Umpierrez, G.3    Nauck, M.A.4    Skrivanek, Z.5    Milicevic, Z.6
  • 11
    • 84885384645 scopus 로고    scopus 로고
    • Safety and tolerability of Sitagliptin in type 2 diabetes: pooled analysis of 25 clinical studies
    • Engel SS, Round E, Golm GT, Kaufman KD, Goldstein BJ. Safety and tolerability of Sitagliptin in type 2 diabetes: pooled analysis of 25 clinical studies. Diabetes Ther. 2013;4(1):119-145.
    • (2013) Diabetes Ther , vol.4 , Issue.1 , pp. 119-145
    • Engel, S.S.1    Round, E.2    Golm, G.T.3    Kaufman, K.D.4    Goldstein, B.J.5
  • 12
    • 77953777057 scopus 로고    scopus 로고
    • EBM, HTA, and CER: clearing the confusion
    • Luce BR, Drummond M, Jonsson B, et al. EBM, HTA, and CER: clearing the confusion. Milbank Q. 2010;88(2):256-276.
    • (2010) Milbank Q , vol.88 , Issue.2 , pp. 256-276
    • Luce, B.R.1    Drummond, M.2    Jonsson, B.3
  • 13
    • 34447267513 scopus 로고    scopus 로고
    • Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis
    • Amori RE, Lau J, Pittas AG. Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. JAMA. 2007;298(2):194-206.
    • (2007) JAMA , vol.298 , Issue.2 , pp. 194-206
    • Amori, R.E.1    Lau, J.2    Pittas, A.G.3
  • 14
    • 84862152967 scopus 로고    scopus 로고
    • Efficacy of GLP-1 receptor agonists and DPP-4 inhibitors: meta-analysis and systematic review
    • Aroda VR, Henry RR, Han J, et al. Efficacy of GLP-1 receptor agonists and DPP-4 inhibitors: meta-analysis and systematic review. Clin Ther. 2012;34(6):1247-58.e22.
    • (2012) Clin Ther , vol.34 , Issue.6 , pp. 1247-58.e22
    • Aroda, V.R.1    Henry, R.R.2    Han, J.3
  • 15
    • 84863309250 scopus 로고    scopus 로고
    • Glycaemic efficacy of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors as add-on therapy to metformin in subjects with type 2 diabetes-a review and meta analysis
    • Deacon CF, Mannucci E, Ahren B. Glycaemic efficacy of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors as add-on therapy to metformin in subjects with type 2 diabetes-a review and meta analysis. Diabetes Obes Metab. 2012;14(8):762-767.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.8 , pp. 762-767
    • Deacon, C.F.1    Mannucci, E.2    Ahren, B.3
  • 16
  • 17
    • 0037199837 scopus 로고    scopus 로고
    • Network meta-analysis for indirect treatment comparisons
    • Lumley T. Network meta-analysis for indirect treatment comparisons. Stat Med. 2002;21(16):2313-2324.
    • (2002) Stat Med , vol.21 , Issue.16 , pp. 2313-2324
    • Lumley, T.1
  • 18
    • 84873089881 scopus 로고    scopus 로고
    • A network meta-analysis to compare glycaemic control in patients with type 2 diabetes treated with exenatide once weekly or liraglutide once daily in comparison with insulin glargine, exenatide twice daily or placebo
    • Scott DA, Boye KS, Timlin L, Clark JF, Best JH. A network meta-analysis to compare glycaemic control in patients with type 2 diabetes treated with exenatide once weekly or liraglutide once daily in comparison with insulin glargine, exenatide twice daily or placebo. Diabetes Obes Metab. 2013;15(3):213-223.
    • (2013) Diabetes Obes Metab , vol.15 , Issue.3 , pp. 213-223
    • Scott, D.A.1    Boye, K.S.2    Timlin, L.3    Clark, J.F.4    Best, J.H.5
  • 19
    • 85013382101 scopus 로고    scopus 로고
    • Efficacy and safety of glucagon-like peptide-1 receptor agonists in type 2 diabetes: a systematic review and mixed-treatment comparison analysis
    • Htike ZZ, Zaccardi F, Papamargaritis D, Webb DR, Khunti K, Davies MJ. Efficacy and safety of glucagon-like peptide-1 receptor agonists in type 2 diabetes: a systematic review and mixed-treatment comparison analysis. Diabetes Obes Metab. 2017;19(4):524-536.
    • (2017) Diabetes Obes Metab , vol.19 , Issue.4 , pp. 524-536
    • Htike, Z.Z.1    Zaccardi, F.2    Papamargaritis, D.3    Webb, D.R.4    Khunti, K.5    Davies, M.J.6
  • 20
    • 84888607940 scopus 로고    scopus 로고
    • Combining incretin-based therapies with insulin: realizing the potential in type 2 diabetes
    • Vora J. Combining incretin-based therapies with insulin: realizing the potential in type 2 diabetes. Diabetes Care. 2013;36(suppl 2):S226-S232.
    • (2013) Diabetes Care , vol.36 , pp. S226-S232
    • Vora, J.1
  • 21
    • 84871158996 scopus 로고    scopus 로고
    • Longer term safety of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes mellitus: systematic review and meta-analysis
    • Goossen K, Graber S. Longer term safety of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes mellitus: systematic review and meta-analysis. Diabetes Obes Metab. 2012;14(12):1061-1072.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.12 , pp. 1061-1072
    • Goossen, K.1    Graber, S.2
  • 22
    • 85027680161 scopus 로고    scopus 로고
    • Gastrointestinal adverse events of dipeptidyl peptidase 4 inhibitors in type 2 diabetes: a systematic review and network meta-analysis
    • Wu S, Chai S, Yang J, et al. Gastrointestinal adverse events of dipeptidyl peptidase 4 inhibitors in type 2 diabetes: a systematic review and network meta-analysis. Clin Ther. 2017;39(9):1780-9.e33.
    • (2017) Clin Ther , vol.39 , Issue.9 , pp. 1780-9.e33
    • Wu, S.1    Chai, S.2    Yang, J.3
  • 23
    • 84878185729 scopus 로고    scopus 로고
    • A critical analysis of the clinical use of incretin-based therapies: are the GLP-1 therapies safe?
    • Butler PC, Elashoff M, Elashoff R, Gale EAM. A critical analysis of the clinical use of incretin-based therapies: are the GLP-1 therapies safe? Diabetes Care. 2013;36(7):2118-2125.
    • (2013) Diabetes Care , vol.36 , Issue.7 , pp. 2118-2125
    • Butler, P.C.1    Elashoff, M.2    Elashoff, R.3    Gale, E.A.M.4
  • 24
    • 84879231610 scopus 로고    scopus 로고
    • A critical analysis of the clinical use of incretin-based therapies: the benefits by far outweigh the potential risks
    • Nauck MA. A critical analysis of the clinical use of incretin-based therapies: the benefits by far outweigh the potential risks. Diabetes Care. 2013;36(7):2126-2132.
    • (2013) Diabetes Care , vol.36 , Issue.7 , pp. 2126-2132
    • Nauck, M.A.1
  • 25
    • 84899029163 scopus 로고    scopus 로고
    • Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies
    • Li L, Shen J, Bala MM, et al. Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies. BMJ. 2014;348:g2366.
    • (2014) BMJ , vol.348 , pp. g2366
    • Li, L.1    Shen, J.2    Bala, M.M.3
  • 26
    • 84995466951 scopus 로고    scopus 로고
    • Cardiovascular safety of incretin-based therapies in type 2 diabetes: systematic review of integrated analyses and randomized controlled trials
    • Mannucci E, Monami M. Cardiovascular safety of incretin-based therapies in type 2 diabetes: systematic review of integrated analyses and randomized controlled trials. Adv Ther. 2017;34(1):1-40.
    • (2017) Adv Ther , vol.34 , Issue.1 , pp. 1-40
    • Mannucci, E.1    Monami, M.2
  • 27
    • 85021438535 scopus 로고    scopus 로고
    • Association between sitagliptin use and heart failure hospitalization and related outcomes in type 2 diabetes mellitus: secondary analysis of a randomized clinical trial
    • McGuire DK, Van de Werf F, Armstrong PW, et al. Association between sitagliptin use and heart failure hospitalization and related outcomes in type 2 diabetes mellitus: secondary analysis of a randomized clinical trial. JAMA Cardiol. 2016;1(2):126-135.
    • (2016) JAMA Cardiol , vol.1 , Issue.2 , pp. 126-135
    • McGuire, D.K.1    Van de Werf, F.2    Armstrong, P.W.3
  • 28
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • Scirica BM, Bhatt DL, Braunwald E, et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med. 2013;369(14):1317-1326.
    • (2013) N Engl J Med , vol.369 , Issue.14 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3
  • 29
    • 84930085787 scopus 로고    scopus 로고
    • Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial
    • Zannad F, Cannon CP, Cushman WC, et al. Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial. Lancet. 2015;385(9982):2067-2076.
    • (2015) Lancet , vol.385 , Issue.9982 , pp. 2067-2076
    • Zannad, F.1    Cannon, C.P.2    Cushman, W.C.3
  • 30
    • 84937053742 scopus 로고    scopus 로고
    • Effect of Sitagliptin on cardiovascular outcomes in type 2 diabetes
    • Green JB, Bethel MA, Armstrong PW, et al. Effect of Sitagliptin on cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2015;373(3):232-242.
    • (2015) N Engl J Med , vol.373 , Issue.3 , pp. 232-242
    • Green, J.B.1    Bethel, M.A.2    Armstrong, P.W.3
  • 31
    • 85020624976 scopus 로고    scopus 로고
    • Incretin based treatments and mortality in patients with type 2 diabetes: systematic review and meta-analysis
    • Liu J, Li L, Deng K, et al. Incretin based treatments and mortality in patients with type 2 diabetes: systematic review and meta-analysis. BMJ. 2017;357:j2499.
    • (2017) BMJ , vol.357 , pp. j2499
    • Liu, J.1    Li, L.2    Deng, K.3
  • 32
    • 84978839381 scopus 로고    scopus 로고
    • Liraglutide and cardiovascular outcomes in type 2 diabetes
    • Marso SP, Daniels GH, Brown-Frandsen K, et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2016;375(4):311-322.
    • (2016) N Engl J Med , vol.375 , Issue.4 , pp. 311-322
    • Marso, S.P.1    Daniels, G.H.2    Brown-Frandsen, K.3
  • 33
    • 84994813253 scopus 로고    scopus 로고
    • Semaglutide and cardiovascular outcomes in patients with type 2 diabetes
    • Marso SP, Bain SC, Consoli A, et al. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2016;375(19):1834-1844.
    • (2016) N Engl J Med , vol.375 , Issue.19 , pp. 1834-1844
    • Marso, S.P.1    Bain, S.C.2    Consoli, A.3
  • 34
    • 85009104318 scopus 로고    scopus 로고
    • Treatment with GLP1 receptor agonists reduce serum CRP concentrations in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
    • Mazidi M, Karimi E, Rezaie P, Ferns GA. Treatment with GLP1 receptor agonists reduce serum CRP concentrations in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. J Diabetes Complications. 2017;31(7):1237-1242.
    • (2017) J Diabetes Complications , vol.31 , Issue.7 , pp. 1237-1242
    • Mazidi, M.1    Karimi, E.2    Rezaie, P.3    Ferns, G.A.4
  • 35
    • 85020859436 scopus 로고    scopus 로고
    • Effect of dipeptidyl peptidase-4 inhibitors on circulating tumor necrosis factor-α concentrations: a systematic review and meta-analysis of controlled trials
    • Atkin SL, Katsiki N, Banach M, Mikhailidis DP, Pirro M, Sahebkar A. Effect of dipeptidyl peptidase-4 inhibitors on circulating tumor necrosis factor-α concentrations: a systematic review and meta-analysis of controlled trials. J Diabetes Complications. 2017;31(9):1458-1464.
    • (2017) J Diabetes Complications , vol.31 , Issue.9 , pp. 1458-1464
    • Atkin, S.L.1    Katsiki, N.2    Banach, M.3    Mikhailidis, D.P.4    Pirro, M.5    Sahebkar, A.6
  • 36
    • 85020091693 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists and atrial fibrillation: a systematic review and meta-analysis of randomised controlled trials
    • Monami M, Nreu B, Scatena A, et al. Glucagon-like peptide-1 receptor agonists and atrial fibrillation: a systematic review and meta-analysis of randomised controlled trials. J Endocrinol Invest. 2017;40:1251-1258.
    • (2017) J Endocrinol Invest , vol.40 , pp. 1251-1258
    • Monami, M.1    Nreu, B.2    Scatena, A.3
  • 37
    • 85016955978 scopus 로고    scopus 로고
    • Sodium-glucose co-transporter 2 (SGLT2) inhibitor: comparing trial data and real-world use
    • McGovern A, Feher M, Munro N, de Lusignan S. Sodium-glucose co-transporter 2 (SGLT2) inhibitor: comparing trial data and real-world use. Diabetes Ther. 2017;8(2):365-376.
    • (2017) Diabetes Ther , vol.8 , Issue.2 , pp. 365-376
    • McGovern, A.1    Feher, M.2    Munro, N.3    de Lusignan, S.4
  • 38
    • 79957995000 scopus 로고    scopus 로고
    • Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview
    • Golder S, Loke YK, Bland M. Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview. PLoS Med. 2011;8(5):e1001026.
    • (2011) PLoS Med , vol.8 , Issue.5
    • Golder, S.1    Loke, Y.K.2    Bland, M.3
  • 39
    • 79959428521 scopus 로고    scopus 로고
    • Safety, efficacy and tolerability of exenatide in combination with insulin in the Association of British Clinical Diabetologists nationwide exenatide audit
    • Thong KY, Jose B, Sukumar N, et al. Safety, efficacy and tolerability of exenatide in combination with insulin in the Association of British Clinical Diabetologists nationwide exenatide audit. Diabetes Obes Metab. 2011;13(8):703-710.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.8 , pp. 703-710
    • Thong, K.Y.1    Jose, B.2    Sukumar, N.3
  • 41
    • 84878324485 scopus 로고    scopus 로고
    • Safety and efficacy of liraglutide 1.2mg in patients with mild and moderate renal impairment: the ABCD nationwide liraglutide audit
    • Thong KY, Walton C, Ryder REJ, On behalf of the Association of British Clinical Diabetologists (ABCD) Nationwide Liraglutide Audit Contributors. Safety and efficacy of liraglutide 1.2mg in patients with mild and moderate renal impairment: the ABCD nationwide liraglutide audit. Practical Diabetes. 2013;30(2):71-76b.
    • (2013) Practical Diabetes , vol.30 , Issue.2 , pp. 71-76b
    • Thong, K.Y.1    Walton, C.2    Ryder, R.E.J.3
  • 42
    • 84944074514 scopus 로고    scopus 로고
    • Effectiveness and persistence with Liraglutide among patients with type 2 diabetes in routine clinical practice--EVIDENCE: a prospective, 2-year follow-up, observational, post-marketing study
    • Gautier JF, Martinez L, Penfornis A, et al. Effectiveness and persistence with Liraglutide among patients with type 2 diabetes in routine clinical practice--EVIDENCE: a prospective, 2-year follow-up, observational, post-marketing study. Adv Ther. 2015;32(9):838-853.
    • (2015) Adv Ther , vol.32 , Issue.9 , pp. 838-853
    • Gautier, J.F.1    Martinez, L.2    Penfornis, A.3
  • 43
    • 84924607557 scopus 로고    scopus 로고
    • Effectiveness and tolerability of second-line treatment with vildagliptin versus other oral drugs for type 2 diabetes in a real-world setting in the Middle East: results from the EDGE study
    • Saab C, Al-Saber FA, Haddad J, et al. Effectiveness and tolerability of second-line treatment with vildagliptin versus other oral drugs for type 2 diabetes in a real-world setting in the Middle East: results from the EDGE study. Vasc Health Risk Manag. 2015;11:149-155.
    • (2015) Vasc Health Risk Manag , vol.11 , pp. 149-155
    • Saab, C.1    Al-Saber, F.A.2    Haddad, J.3
  • 44
    • 85010417609 scopus 로고    scopus 로고
    • A real-world study of treatment patterns and outcomes in US managed-care patients with type 2 diabetes initiating injectable therapies
    • Wei W, Buysman E, Grabner M, et al. A real-world study of treatment patterns and outcomes in US managed-care patients with type 2 diabetes initiating injectable therapies. Diabetes Obes Metab. 2017;19(3):375-386.
    • (2017) Diabetes Obes Metab , vol.19 , Issue.3 , pp. 375-386
    • Wei, W.1    Buysman, E.2    Grabner, M.3
  • 45
    • 84896731936 scopus 로고    scopus 로고
    • Pancreatic safety of Incretin-based drugs – FDA and EMA assessment
    • Egan AG, Blind E, Dunder K, et al. Pancreatic safety of Incretin-based drugs – FDA and EMA assessment. N Engl J Med. 2014;370(9):794-797.
    • (2014) N Engl J Med , vol.370 , Issue.9 , pp. 794-797
    • Egan, A.G.1    Blind, E.2    Dunder, K.3
  • 46
    • 84997521885 scopus 로고    scopus 로고
    • Association between incretin-based drugs and the risk of acute pancreatitis
    • Azoulay L, Filion KB, Platt RW, et al. Association between incretin-based drugs and the risk of acute pancreatitis. JAMA Intern Med. 2016;176(10):1464-1473.
    • (2016) JAMA Intern Med , vol.176 , Issue.10 , pp. 1464-1473
    • Azoulay, L.1    Filion, K.B.2    Platt, R.W.3
  • 47
    • 84919479662 scopus 로고    scopus 로고
    • Using real-world data to evaluate the association of incretin-based therapies with risk of acute pancreatitis: a meta-analysis of 1,324,515 patients from observational studies
    • Wang T, Wang F, Gou Z, et al. Using real-world data to evaluate the association of incretin-based therapies with risk of acute pancreatitis: a meta-analysis of 1,324,515 patients from observational studies. Diabetes Obes Metab. 2015;17(1):32-41.
    • (2015) Diabetes Obes Metab , vol.17 , Issue.1 , pp. 32-41
    • Wang, T.1    Wang, F.2    Gou, Z.3
  • 49
    • 84942303261 scopus 로고    scopus 로고
    • Incretin-based therapies and acute pancreatitis risk: a systematic review and meta-analysis of observational studies
    • Giorda CB, Sacerdote C, Nada E, Marafetti L, Baldi I, Gnavi R. Incretin-based therapies and acute pancreatitis risk: a systematic review and meta-analysis of observational studies. Endocrine. 2015;48(2):461-471.
    • (2015) Endocrine , vol.48 , Issue.2 , pp. 461-471
    • Giorda, C.B.1    Sacerdote, C.2    Nada, E.3    Marafetti, L.4    Baldi, I.5    Gnavi, R.6
  • 50
    • 84960154441 scopus 로고    scopus 로고
    • Incretin based drugs and the risk of pancreatic cancer: international multicentre cohort study
    • Azoulay L, Filion KB, Platt RW, et al. Incretin based drugs and the risk of pancreatic cancer: international multicentre cohort study. BMJ. 2016;352:i581.
    • (2016) BMJ , vol.352 , pp. i581
    • Azoulay, L.1    Filion, K.B.2    Platt, R.W.3
  • 51
    • 84973495982 scopus 로고    scopus 로고
    • Risk for hospitalized heart failure among new users of saxagliptin, sitagliptin, and other antihyperglycemic drugs: a retrospective cohort study
    • Toh S, Hampp C, Reichman ME, et al. Risk for hospitalized heart failure among new users of saxagliptin, sitagliptin, and other antihyperglycemic drugs: a retrospective cohort study. Ann Intern Med. 2016;164(11):705-714.
    • (2016) Ann Intern Med , vol.164 , Issue.11 , pp. 705-714
    • Toh, S.1    Hampp, C.2    Reichman, M.E.3
  • 52
    • 84962323033 scopus 로고    scopus 로고
    • A multicenter observational study of incretin-based drugs and heart failure
    • Filion KB, Azoulay L, Platt RW, et al. A multicenter observational study of incretin-based drugs and heart failure. N Engl J Med. 2016;374(12):1145-1154.
    • (2016) N Engl J Med , vol.374 , Issue.12 , pp. 1145-1154
    • Filion, K.B.1    Azoulay, L.2    Platt, R.W.3
  • 53
    • 84941228070 scopus 로고    scopus 로고
    • Risk of hospitalization for heart failure in patients with type 2 diabetes newly treated with DPP-4 inhibitors or other oral glucose-lowering medications: a retrospective registry study on 127,555 patients from the Nationwide OsMed Health-DB Database
    • Fadini GP, Avogaro A, Degli Esposti L, et al. Risk of hospitalization for heart failure in patients with type 2 diabetes newly treated with DPP-4 inhibitors or other oral glucose-lowering medications: a retrospective registry study on 127,555 patients from the Nationwide OsMed Health-DB Database. Eur Heart J. 2015;36(36):2454-2462.
    • (2015) Eur Heart J , vol.36 , Issue.36 , pp. 2454-2462
    • Fadini, G.P.1    Avogaro, A.2    Degli Esposti, L.3
  • 54
    • 84917723836 scopus 로고    scopus 로고
    • Heart failure, saxagliptin, and diabetes mellitus: observations from the SAVOR-TIMI 53 randomized trial
    • Scirica BM, Braunwald E, Raz I, et al. Heart failure, saxagliptin, and diabetes mellitus: observations from the SAVOR-TIMI 53 randomized trial. Circulation. 2014;130(18):1579-1588.
    • (2014) Circulation , vol.130 , Issue.18 , pp. 1579-1588
    • Scirica, B.M.1    Braunwald, E.2    Raz, I.3
  • 55
    • 84988667387 scopus 로고    scopus 로고
    • PERS&O (PERsistent Sitagliptin treatment & outcomes): observational retrospective study on cardiovascular risk evolution in patients with type 2 diabetes on persistent sitagliptin treatment
    • Buonaiuto G, De Mori V, Braus A, et al. PERS&O (PERsistent Sitagliptin treatment & outcomes): observational retrospective study on cardiovascular risk evolution in patients with type 2 diabetes on persistent sitagliptin treatment. BMJ Open Diabetes Res Care. 2016;4(1):e000216.
    • (2016) BMJ Open Diabetes Res Care , vol.4 , Issue.1
    • Buonaiuto, G.1    De Mori, V.2    Braus, A.3
  • 56
    • 84955171790 scopus 로고    scopus 로고
    • Cardiovascular outcomes of dipeptidyl peptidase-4 inhibitors in elderly patients with type 2 diabetes: a Nationwide Study
    • Shih CJ, Chen HT, Kuo SC, Ou SM, Chen YT. Cardiovascular outcomes of dipeptidyl peptidase-4 inhibitors in elderly patients with type 2 diabetes: a Nationwide Study. J Am Med Dir Assoc. 2016;17(1):59-64.
    • (2016) J Am Med Dir Assoc , vol.17 , Issue.1 , pp. 59-64
    • Shih, C.J.1    Chen, H.T.2    Kuo, S.C.3    Ou, S.M.4    Chen, Y.T.5
  • 57
    • 85020735128 scopus 로고    scopus 로고
    • No increased risk of cardiovascular events in older adults initiating dipeptidyl peptidase-4 inhibitors vs therapeutic alternatives
    • Gokhale M, Buse JB, Jonsson Funk M, et al. No increased risk of cardiovascular events in older adults initiating dipeptidyl peptidase-4 inhibitors vs therapeutic alternatives. Diabetes Obes Metab. 2017;19(7):970-978.
    • (2017) Diabetes Obes Metab , vol.19 , Issue.7 , pp. 970-978
    • Gokhale, M.1    Buse, J.B.2    Jonsson Funk, M.3
  • 58
    • 85019621652 scopus 로고    scopus 로고
    • Efficacy and safety of incretin-based drugs in patients with type 1 diabetes mellitus: a systematic review and meta-analysis
    • (suppl C)
    • Wang W, Gao Y, Chen D, Wang C, Feng X, Ran X. Efficacy and safety of incretin-based drugs in patients with type 1 diabetes mellitus: a systematic review and meta-analysis. Diabetes Res Clin Pract. 2017;129(suppl C):213-223.
    • (2017) Diabetes Res Clin Pract , vol.129 , pp. 213-223
    • Wang, W.1    Gao, Y.2    Chen, D.3    Wang, C.4    Feng, X.5    Ran, X.6
  • 59
    • 84937418610 scopus 로고    scopus 로고
    • Antidiabetic and cardiovascular drug utilisation in patients diagnosed with type 2 diabetes mellitus over the age of 80 years: a population-based cohort study
    • Hamada S, Gulliford MC. Antidiabetic and cardiovascular drug utilisation in patients diagnosed with type 2 diabetes mellitus over the age of 80 years: a population-based cohort study. Age Ageing. 2015;44(4):566-573.
    • (2015) Age Ageing , vol.44 , Issue.4 , pp. 566-573
    • Hamada, S.1    Gulliford, M.C.2
  • 60
    • 85031696224 scopus 로고    scopus 로고
    • Effectiveness and safety of dipeptidyl peptidase 4 inhibitors in the management of type 2 diabetes in older adults: a systematic review and development of recommendations to reduce inappropriate prescribing
    • Schott G, Martinez YV, Ediriweera de Silva RE, et al. Effectiveness and safety of dipeptidyl peptidase 4 inhibitors in the management of type 2 diabetes in older adults: a systematic review and development of recommendations to reduce inappropriate prescribing. BMC Geriatr. 2017;17(suppl 1):226.
    • (2017) BMC Geriatr , vol.17 , pp. 226
    • Schott, G.1    Martinez, Y.V.2    Ediriweera de Silva, R.E.3
  • 61
    • 83455251226 scopus 로고    scopus 로고
    • Comparison of the efficacy and tolerability profile of liraglutide, a once-daily human GLP-1 analog, in patients with type 2 diabetes >/=65 and <65 years of age: a pooled analysis from phase III studies
    • Bode BW, Brett J, Falahati A, Pratley RE. Comparison of the efficacy and tolerability profile of liraglutide, a once-daily human GLP-1 analog, in patients with type 2 diabetes >/=65 and <65 years of age: a pooled analysis from phase III studies. Am J Geriatr Pharmacother. 2011;9(6):423-433.
    • (2011) Am J Geriatr Pharmacother , vol.9 , Issue.6 , pp. 423-433
    • Bode, B.W.1    Brett, J.2    Falahati, A.3    Pratley, R.E.4
  • 62
    • 84976891169 scopus 로고    scopus 로고
    • Similar efficacy and safety of once-weekly dulaglutide in patients with type 2 diabetes aged >/=65 and <65 years
    • Boustani MA, Pittman I IV, Yu M, Thieu VT, Varnado OJ, Juneja R. Similar efficacy and safety of once-weekly dulaglutide in patients with type 2 diabetes aged >/=65 and <65 years. Diabetes Obes Metab. 2016;18(8):820-828.
    • (2016) Diabetes Obes Metab , vol.18 , Issue.8 , pp. 820-828
    • Boustani, M.A.1    Pittman, I.2    Yu, M.3    Thieu, V.T.4    Varnado, O.J.5    Juneja, R.6
  • 63
    • 84994874856 scopus 로고    scopus 로고
    • Safety and efficacy of incretin-based therapies in patients with type 2 diabetes mellitus and CKD: a systematic review and meta-analysis
    • Howse PM, Chibrikova LN, Twells LK, Barrett BJ, Gamble JM. Safety and efficacy of incretin-based therapies in patients with type 2 diabetes mellitus and CKD: a systematic review and meta-analysis. Am J Kidney Dis. 2016;68(5):733-742.
    • (2016) Am J Kidney Dis , vol.68 , Issue.5 , pp. 733-742
    • Howse, P.M.1    Chibrikova, L.N.2    Twells, L.K.3    Barrett, B.J.4    Gamble, J.M.5
  • 64
    • 84956914555 scopus 로고    scopus 로고
    • Incretin-based therapies for the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis
    • Carbone LJ, Angus PW, Yeomans ND. Incretin-based therapies for the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2016;31(1):23-31.
    • (2016) J Gastroenterol Hepatol , vol.31 , Issue.1 , pp. 23-31
    • Carbone, L.J.1    Angus, P.W.2    Yeomans, N.D.3
  • 65
    • 84957840942 scopus 로고    scopus 로고
    • Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study
    • Armstrong MJ, Gaunt P, Aithal GP, et al. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet. 2016;387(10019):679-690.
    • (2016) Lancet , vol.387 , Issue.10019 , pp. 679-690
    • Armstrong, M.J.1    Gaunt, P.2    Aithal, G.P.3
  • 66
    • 84960145748 scopus 로고    scopus 로고
    • Effect of incretin therapies compared to pioglitazone and gliclazide in non-alcoholic fatty liver disease in diabetic patients not controlled on metformin alone: an observational, pilot study
    • Garcia Diaz E, Guagnozzi D, Gutierrez V, et al. Effect of incretin therapies compared to pioglitazone and gliclazide in non-alcoholic fatty liver disease in diabetic patients not controlled on metformin alone: an observational, pilot study. Endocrinol Nutr. 2016;63(5):194-201.
    • (2016) Endocrinol Nutr , vol.63 , Issue.5 , pp. 194-201
    • Garcia Diaz, E.1    Guagnozzi, D.2    Gutierrez, V.3
  • 67
    • 84931957090 scopus 로고    scopus 로고
    • Incretin-based medications for type 2 diabetes: an overview of reviews
    • Gamble JM, Clarke A, Myers KJ, et al. Incretin-based medications for type 2 diabetes: an overview of reviews. Diabetes Obes Metab. 2015;17(7):649-658.
    • (2015) Diabetes Obes Metab , vol.17 , Issue.7 , pp. 649-658
    • Gamble, J.M.1    Clarke, A.2    Myers, K.J.3


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