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Volumn 39, Issue 9, 2017, Pages 1780-1789.e33

Gastrointestinal Adverse Events of Dipeptidyl Peptidase 4 Inhibitors in Type 2 Diabetes: A Systematic Review and Network Meta-analysis

Author keywords

dipeptidyl peptidase 4 inhibitors; gastrointestinal adverse events; network meta analysis; type 2 diabetes

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALOGLIPTIN; ALPHA GLUCOSIDASE INHIBITOR; ANAGLIPTIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GEMIGLIPTIN; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; HEMOGLOBIN A1C; INSULIN; KOMBIGLYZEXR; LINAGLIPTIN; LINAGLIPTIN PLUS METFORMIN; LIOVEL; LIRAGLUTIDE; METFORMIN; METFORMIN PLUS SITAGLIPTIN; METFORMIN PLUS VILDAGLIPTIN; PLACEBO; SAXAGLIPTIN; SIMVASTATIN PLUS SITAGLIPTIN; SITAGLIPTIN; SODIUM GLUCOSE COTRANSPORTER 2; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; SULFONYLUREA; TENELIGLIPTIN; VILDAGLIPTIN;

EID: 85027680161     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2017.07.036     Document Type: Article
Times cited : (36)

References (40)
  • 1
    • 77953956398 scopus 로고    scopus 로고
    • Prevalence of diabetes among men and women in China
    • Shi, Z., Prevalence of diabetes among men and women in China. N Engl J Med, 362(25), 2010, 2425.
    • (2010) N Engl J Med , vol.362 , Issue.25 , pp. 2425
    • Shi, Z.1
  • 2
    • 77949285419 scopus 로고    scopus 로고
    • Sitagliptin: a review of its use in patients with type 2 diabetes mellitus
    • Dhillon, S., Sitagliptin: a review of its use in patients with type 2 diabetes mellitus. Drugs 70:4 (2010), 489–512.
    • (2010) Drugs , vol.70 , Issue.4 , pp. 489-512
    • Dhillon, S.1
  • 3
    • 84870175927 scopus 로고    scopus 로고
    • Use of the dipeptidyl peptidase-4 inhibitor linagliptin in combination therapy for type 2 diabetes
    • Lajara, R., Use of the dipeptidyl peptidase-4 inhibitor linagliptin in combination therapy for type 2 diabetes. Expert Opin Pharmacother 13:18 (2012), 2663–2671.
    • (2012) Expert Opin Pharmacother , vol.13 , Issue.18 , pp. 2663-2671
    • Lajara, R.1
  • 4
    • 84922093847 scopus 로고    scopus 로고
    • Linagliptin: an update of its use in patients with type 2 diabetes mellitus
    • McKeage, K., Linagliptin: an update of its use in patients with type 2 diabetes mellitus. Drugs 74:16 (2014), 1927–1946.
    • (2014) Drugs , vol.74 , Issue.16 , pp. 1927-1946
    • McKeage, K.1
  • 5
    • 84900386303 scopus 로고    scopus 로고
    • Vildagliptin: a review of its use in type 2 diabetes mellitus
    • Keating, G.M., Vildagliptin: a review of its use in type 2 diabetes mellitus. Drugs 74:5 (2014), 587–610.
    • (2014) Drugs , vol.74 , Issue.5 , pp. 587-610
    • Keating, G.M.1
  • 6
    • 84889043453 scopus 로고    scopus 로고
    • Alogliptin: a new dipeptidyl peptidase-4 inhibitor for type 2 diabetes mellitus
    • Jarvis, C.I., Cabrera, A., Charron, D., Alogliptin: a new dipeptidyl peptidase-4 inhibitor for type 2 diabetes mellitus. Ann Pharmacother 47:11 (2013), 1532–v1539.
    • (2013) Ann Pharmacother , vol.47 , Issue.11 , pp. 1532-v1539
    • Jarvis, C.I.1    Cabrera, A.2    Charron, D.3
  • 7
    • 77957696165 scopus 로고    scopus 로고
    • Alogliptin: a review of its use in the management of type 2 diabetes mellitus
    • Scott, L.J., Alogliptin: a review of its use in the management of type 2 diabetes mellitus. Drugs 70:15 (2010), 2051–2072.
    • (2010) Drugs , vol.70 , Issue.15 , pp. 2051-2072
    • Scott, L.J.1
  • 8
    • 84871496792 scopus 로고    scopus 로고
    • Saxagliptin overview: special focus on safety and adverse effects
    • Ali, S., Fonseca, V., Saxagliptin overview: special focus on safety and adverse effects. Expert Opin Drug Saf 12:1 (2013), 103–109.
    • (2013) Expert Opin Drug Saf , vol.12 , Issue.1 , pp. 103-109
    • Ali, S.1    Fonseca, V.2
  • 9
    • 84890346982 scopus 로고    scopus 로고
    • Teneligliptin for the treatment of type 2 diabetes
    • Goda, M., Kadowaki, T., Teneligliptin for the treatment of type 2 diabetes. Drugs Today (Barc) 49:10 (2013), 615–629.
    • (2013) Drugs Today (Barc) , vol.49 , Issue.10 , pp. 615-629
    • Goda, M.1    Kadowaki, T.2
  • 10
    • 79956326006 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and HbA1c target of <7% in type 2 diabetes: meta-analysis of randomized controlled trials
    • Esposito, K., Cozzolino, D., Bellastella, G., et al. Dipeptidyl peptidase-4 inhibitors and HbA1c target of <7% in type 2 diabetes: meta-analysis of randomized controlled trials. Diabetes Obes Metab 13:7 (2011), 594–603.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.7 , pp. 594-603
    • Esposito, K.1    Cozzolino, D.2    Bellastella, G.3
  • 12
    • 85100415918 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. accessed by December 20
    • Higgins JPT. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. http://www.cochrane-handbook.org. accessed by December 20, 2016.
    • (2016)
    • Higgins, J.P.T.1
  • 13
    • 0022992740 scopus 로고
    • Meta-analysis in clinical trials
    • DerSimonian, R., Laird, N., Meta-analysis in clinical trials. Control Clin Trials 7:3 (1986), 177–188.
    • (1986) Control Clin Trials , vol.7 , Issue.3 , pp. 177-188
    • DerSimonian, R.1    Laird, N.2
  • 14
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • Higgins, J.P., Thompson, S.G., Quantifying heterogeneity in a meta-analysis. Stat Med 21:11 (2002), 1539–1558.
    • (2002) Stat Med , vol.21 , Issue.11 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 15
    • 84859721063 scopus 로고    scopus 로고
    • DPP-4 inhibitors in the management of type 2 diabetes: a critical review of head-to-head trials
    • Scheen, A.J., DPP-4 inhibitors in the management of type 2 diabetes: a critical review of head-to-head trials. Diabetes Metab 38:2 (2012), 89–101.
    • (2012) Diabetes Metab , vol.38 , Issue.2 , pp. 89-101
    • Scheen, A.J.1
  • 16
    • 33749871472 scopus 로고    scopus 로고
    • Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes
    • Herman, G.A., Bergman, A., Stevens, C., et al. Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes. J Clin Endocrinol Metab 91:11 (2006), 4612–4619.
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.11 , pp. 4612-4619
    • Herman, G.A.1    Bergman, A.2    Stevens, C.3
  • 17
    • 45449105789 scopus 로고    scopus 로고
    • Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insufficiency
    • Chan, J.C., Scott, R., Ferreira, J.C., et al. Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insufficiency. Diabetes Obes Metab 10:7 (2008), 545–555.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.7 , pp. 545-555
    • Chan, J.C.1    Scott, R.2    Ferreira, J.C.3
  • 18
    • 34347393269 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus
    • He, Y., Serra, D., Wang, Y., et al. Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus. Clin Pharmacokinet 46:7 (2007), 577–588.
    • (2007) Clin Pharmacokinet , vol.46 , Issue.7 , pp. 577-588
    • He, Y.1    Serra, D.2    Wang, Y.3
  • 19
    • 84885384645 scopus 로고    scopus 로고
    • Safety and tolerability of sitagliptin in type 2 diabetes: pooled analysis of 25 clinical studies
    • Engel, S.S., Round, E., Golm, G.T., et al. Safety and tolerability of sitagliptin in type 2 diabetes: pooled analysis of 25 clinical studies. Diabetes Ther 4:1 (2013), 119–145.
    • (2013) Diabetes Ther , vol.4 , Issue.1 , pp. 119-145
    • Engel, S.S.1    Round, E.2    Golm, G.T.3
  • 20
    • 84863457464 scopus 로고    scopus 로고
    • The efficacy and safety of vildagliptin in patients with type 2 diabetes: a meta-analysis of randomized clinical trials
    • Cai, L., Cai, Y., Lu, Z.J., et al. The efficacy and safety of vildagliptin in patients with type 2 diabetes: a meta-analysis of randomized clinical trials. J Clin Pharm Ther 37:4 (2012), 386–398.
    • (2012) J Clin Pharm Ther , vol.37 , Issue.4 , pp. 386-398
    • Cai, L.1    Cai, Y.2    Lu, Z.J.3
  • 21
    • 84874397294 scopus 로고    scopus 로고
    • Efficacy of alogliptin in type 2 diabetes treatment: a meta-analysis of randomized doubleblind controlled studies
    • Berhan, A., Berhan, Y., Efficacy of alogliptin in type 2 diabetes treatment: a meta-analysis of randomized doubleblind controlled studies. BMC Endocr Disord, 13, 2013, 9.
    • (2013) BMC Endocr Disord , vol.13 , pp. 9
    • Berhan, A.1    Berhan, Y.2
  • 22
    • 84906938284 scopus 로고    scopus 로고
    • Safety and tolerability of linagliptin in patients with type 2 diabetes: a comprehensive pooled analysis of 22 placebo-controlled studies
    • Lehrke, M., Marx, N., Patel, S., et al. Safety and tolerability of linagliptin in patients with type 2 diabetes: a comprehensive pooled analysis of 22 placebo-controlled studies. Clin Ther 36:8 (2014), 1130–1146.
    • (2014) Clin Ther , vol.36 , Issue.8 , pp. 1130-1146
    • Lehrke, M.1    Marx, N.2    Patel, S.3
  • 23
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • Scirica, B.M., Bhatt, D.L., Braunwald, E., et al., SAVOR-TIMI 53 Steering Committee and Investigators. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 369:14 (2013), 1317–1326.
    • (2013) N Engl J Med , vol.369 , Issue.14 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3
  • 24
    • 84905472510 scopus 로고    scopus 로고
    • Comparison of GLP-1 Analogues versus sitagliptin in the management of type 2 diabetes: systematic review and meta-analysis of head-to-head studies
    • Wang, T., Gou, Z., Wang, F., et al. Comparison of GLP-1 Analogues versus sitagliptin in the management of type 2 diabetes: systematic review and meta-analysis of head-to-head studies. PLoS ONE, 9(8), 2014, e103798.
    • (2014) PLoS ONE , vol.9 , Issue.8 , pp. e103798
    • Wang, T.1    Gou, Z.2    Wang, F.3
  • 25
    • 84888158473 scopus 로고    scopus 로고
    • Comparison of extended release GLP-1 receptor agonist therapy versus sitagliptin in the management of type 2 diabetes
    • Stolar, M.W., Grimm, M., Chen, S., Comparison of extended release GLP-1 receptor agonist therapy versus sitagliptin in the management of type 2 diabetes. Diabetes Metab Syndr Obes 22:6 (2013), 435–444.
    • (2013) Diabetes Metab Syndr Obes , vol.22 , Issue.6 , pp. 435-444
    • Stolar, M.W.1    Grimm, M.2    Chen, S.3
  • 26
    • 77950880269 scopus 로고    scopus 로고
    • Dipeptydil peptidase-4 inhibitors in type 2 diabetes: a meta-analysis of randomized clinical trials
    • Monami, M., Iacomelli, I., Marchionni, N., Mannucci, E., Dipeptydil peptidase-4 inhibitors in type 2 diabetes: a meta-analysis of randomized clinical trials. Nutr Metab Cardiovasc Dis 20:4 (2010), 224–235.
    • (2010) Nutr Metab Cardiovasc Dis , vol.20 , Issue.4 , pp. 224-235
    • Monami, M.1    Iacomelli, I.2    Marchionni, N.3    Mannucci, E.4
  • 27
    • 84859174317 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta analysis
    • Karagiannis, T., Paschos, P., Paletas, K., et al. Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta analysis. BMJ, 12(344), 2012, e1369.
    • (2012) BMJ , vol.12 , Issue.344 , pp. e1369
    • Karagiannis, T.1    Paschos, P.2    Paletas, K.3
  • 28
    • 60449089649 scopus 로고    scopus 로고
    • Zinman; AmericanDiabetes Association; European Association for Study of Diabetes, Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan, D.M., Buse, J.B., Davidson, M.B., et al. Zinman; AmericanDiabetes Association; European Association for Study of Diabetes, Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 32:1 (2009), 193–203.
    • (2009) Diabetes Care , vol.32 , Issue.1 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 29
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber, A., Henry, R., Ratner, R., et al., LEAD-3 (Mono) Study Group. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 373:9662 (2009), 473–481.
    • (2009) Lancet , vol.373 , Issue.9662 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 30
    • 51549095571 scopus 로고    scopus 로고
    • Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naïve patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study
    • Moretto, T.J., Milton, D.R., Ridge, T.D., et al. Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naïve patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 30:8 (2008), 1448–1460.
    • (2008) Clin Ther , vol.30 , Issue.8 , pp. 1448-1460
    • Moretto, T.J.1    Milton, D.R.2    Ridge, T.D.3
  • 31
    • 84859013614 scopus 로고    scopus 로고
    • DURATION-4 Study Group, Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naïve patients with type 2 diabetes (DURATION-4)
    • Russell-Jones, D., Cuddihy, R.M., Hanefeld, M., et al. DURATION-4 Study Group, Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naïve patients with type 2 diabetes (DURATION-4). Diabetes Care 35:2 (2012), 252–258.
    • (2012) Diabetes Care , vol.35 , Issue.2 , pp. 252-258
    • Russell-Jones, D.1    Cuddihy, R.M.2    Hanefeld, M.3
  • 32
    • 0033754530 scopus 로고    scopus 로고
    • Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: a 6-month randomized placebo-controlled dose-response study
    • Aronoff, S., Rosenblatt, S., Braithwaite, S., et al. Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: a 6-month randomized placebo-controlled dose-response study. Diabetes Care 23:11 (2000), 1605–1611.
    • (2000) Diabetes Care , vol.23 , Issue.11 , pp. 1605-1611
    • Aronoff, S.1    Rosenblatt, S.2    Braithwaite, S.3
  • 33
    • 15944382350 scopus 로고    scopus 로고
    • Reduced hypoglycemia risk with insulin glargine
    • Rosenstock, J., Dailey, G., Massi-Benedetti, M., et al. Reduced hypoglycemia risk with insulin glargine. Diabetes Care 28:4 (2005), 950–955.
    • (2005) Diabetes Care , vol.28 , Issue.4 , pp. 950-955
    • Rosenstock, J.1    Dailey, G.2    Massi-Benedetti, M.3
  • 34
    • 65549131199 scopus 로고    scopus 로고
    • Patient-directed titration for achieving glycaemic goals using a once-daily basal insulin analogue: an assessment of two different fasting plasma glucose targets—the TITRATE study
    • Blonde, L., Merilainen, M., Karwe, V., Raskin, P., Patient-directed titration for achieving glycaemic goals using a once-daily basal insulin analogue: an assessment of two different fasting plasma glucose targets—the TITRATE study. Diabetes Obes Metab 11:6 (2009), 623–631.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.6 , pp. 623-631
    • Blonde, L.1    Merilainen, M.2    Karwe, V.3    Raskin, P.4
  • 35
    • 39049105019 scopus 로고    scopus 로고
    • A randomised, 52-week, treat-to-target trial comparing insulin detemir with insulin glargine when administered as add-on to glucose-lowering drugs in insulin-naive people with type 2 diabetes
    • Rosenstock, J., Davies, M., Home, P.D., et al. A randomised, 52-week, treat-to-target trial comparing insulin detemir with insulin glargine when administered as add-on to glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetologia, 51(3), 2008, 408v416.
    • (2008) Diabetologia , vol.51 , Issue.3 , pp. 408v416
    • Rosenstock, J.1    Davies, M.2    Home, P.D.3
  • 36
    • 57649230070 scopus 로고    scopus 로고
    • A 52-week, multinational, open-label, parallel-group, noninferiority, treat-to-target trial comparing insulin detemir with insulin glargine in a basal-bolus regimen with mealtime insulin aspart in patients with type 2 diabetes
    • Hollander, P., Cooper, J., Bregnhøj, J., Pedersen, C.B., A 52-week, multinational, open-label, parallel-group, noninferiority, treat-to-target trial comparing insulin detemir with insulin glargine in a basal-bolus regimen with mealtime insulin aspart in patients with type 2 diabetes. Clin Ther 30:11 (2008), 1976–1987.
    • (2008) Clin Ther , vol.30 , Issue.11 , pp. 1976-1987
    • Hollander, P.1    Cooper, J.2    Bregnhøj, J.3    Pedersen, C.B.4
  • 37
    • 82855179439 scopus 로고    scopus 로고
    • Tolerability of dipeptidyl peptidase-4 inhibitors: a review
    • Richard, K.R., Shelburne, J.S., Kirk, J.K., Tolerability of dipeptidyl peptidase-4 inhibitors: a review. Clin Ther 33:11 (2011), 1609–1629.
    • (2011) Clin Ther , vol.33 , Issue.11 , pp. 1609-1629
    • Richard, K.R.1    Shelburne, J.S.2    Kirk, J.K.3
  • 38
    • 77958110167 scopus 로고    scopus 로고
    • Efficacy and safety of vildagliptin and voglibose in Japanese patients with type 2 diabetes: a 12-week, randomized, double-blind, active-controlled study
    • Iwamoto, Y., Kashiwagi, A., Yamada, N., et al. Efficacy and safety of vildagliptin and voglibose in Japanese patients with type 2 diabetes: a 12-week, randomized, double-blind, active-controlled study. Diabetes Obes Metab 12:8 (2010), 700–708.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.8 , pp. 700-708
    • Iwamoto, Y.1    Kashiwagi, A.2    Yamada, N.3
  • 39
    • 77954197187 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin monotherapy compared with voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind trial
    • Iwamoto, Y., Tajima, N., Kadowski, T., et al. Efficacy and safety of sitagliptin monotherapy compared with voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind trial. Diabetes Obes Metab 12:7 (2010), 613–622.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.7 , pp. 613-622
    • Iwamoto, Y.1    Tajima, N.2    Kadowski, T.3
  • 40
    • 77951069227 scopus 로고    scopus 로고
    • Safety and tolerability of sitagliptin in clinical studies: a pooled analysis of data from 10,426 patients with type 2 diabetes
    • Williams-Herman, D., Engel, S., Round, E., et al. Safety and tolerability of sitagliptin in clinical studies: a pooled analysis of data from 10,426 patients with type 2 diabetes. BMC Endocr Disord, 10, 2010, 7.
    • (2010) BMC Endocr Disord , vol.10 , pp. 7
    • Williams-Herman, D.1    Engel, S.2    Round, E.3


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