Focused time-lapse analysis reveals novel aspects of human fertilization and suggests new parameters of embryo viability

Human Reproduction

Volumn 33, Issue 1, 2018, Pages 23-31

  Coticchio, G ^a   Renzini, M Mignini ^a   Novara, P V ^a   Lain, M ^a   Ponti, E De ^b   Turchi, D ^a   Fadini, R ^a   Canto, M Dal ^a  

^a Biogenesi   (Italy)

^b Desio Hospital ASST Monza   (Italy)

Author keywords

embryo quality; fertilization; ICSI; morphokinetics; pronuclei; time lapse microscopy

Indexed keywords

ADULT; ARTICLE; BLASTOMA; CELL DIVISION; CELL SURFACE; CHROMATIN; CYTOPLASM; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; FERTILIZATION; HUMAN; INFERTILITY; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; MALE; OOCYTE; OOCYTE CORTEX; PREDICTIVE VALUE; PREIMPLANTATION EMBRYO; PRONUCLEUS; RETROSPECTIVE STUDY; TIME-LAPSE MICROSCOPY; CYTOLOGY; IN VITRO FERTILIZATION; KINETICS; MIDDLE AGED; OOCYTE CLEAVAGE; PHYSIOLOGY; POLAR BODY; PREGNANCY; PROCEDURES; TIME LAPSE IMAGING; ZYGOTE;

ADULT; CLEAVAGE STAGE, OVUM; CYTOPLASM; EMBRYONIC DEVELOPMENT; FEMALE; FERTILIZATION; FERTILIZATION IN VITRO; HUMANS; INFERTILITY; KINETICS; MALE; MIDDLE AGED; POLAR BODIES; PREGNANCY; RETROSPECTIVE STUDIES; SPERM INJECTIONS, INTRACYTOPLASMIC; TIME-LAPSE IMAGING; ZYGOTE;

EID: 85040087984     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dex344     Document Type: Article

References (23)

1. Aguilar J, Motato Y, Escribá M-J, Ojeda M, Muñoz E, Meseguer M. The human first cell cycle: impact on implantation. Reprod Biomed Online 2014;28:475-484.
2. Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod 2011;26: 1270-1283.
3. Oxford University Press. Armstrong S, Vail A, Mastenbroek S, Jordan V, Farquhar C. Time-lapse in the IVF-lab: how should we assess potential benefit Hum Reprod 2014; 30:3-8.
4. Bebbere D, Masala L, Albertini DF, Ledda S. The subcortical maternal complex: multiple functions for one biological structure J Assist Reprod Genet 2016;33:1431-1438. Journal of Assisted Reproduction and Genetics.
5. Chamayou S, Romano S, Alecci C, Storaci G, Ragolia C, Palagiano A, Guglielmino A. Oocyte vitrification modifies nucleolar remodeling and zygote kinetics-a sibling study. J Assist Reprod Genet 2015;32:581-586.
6. Coticchio G, Brambillasca F. The Choreography of Fertilization. In: Coticchio G, Albertini DF, De Santis L (eds). Oogenesis. London: Springer London, 2013, 289-306.
7. Coticchio G. Polarization microscopy and rescue ICSI. Reprod Biomed Online 2013;26:222-223. discussion 224-5.
8. Dal Canto M, Brambillasca F, Mignini Renzini M, Coticchio G, Merola M, Lain M, De Ponti E, Fadini R. Cumulus cell-oocyte complexes retrieved from antral follicles in IVM cycles: relationship between COCs morphology, gonadotropin priming and clinical outcome. J Assist Reprod Genet 2012a;29:513-519.
9. Dal Canto M, Coticchio G, Mignini Renzini M, De Ponti E, Novara PV, Brambillasca F, Comi R, Fadini R. Cleavage kinetics analysis of human embryos predicts development to blastocyst and implantation. Reprod Biomed Online 2012b;25:474-480.
10. Davies TJ, Gardner RL. The plane of first cleavage is not related to the distribution of sperm components in the mouse. Hum Reprod 2002;17: 2368-2379.
11. Deng M, Suraneni P, Schultz RM, Li R. The ran GTPase mediates chromatin signaling to control cortical polarity during polar body extrusion in mouse oocytes. Dev Cell 2007;12:301-308.
12. Fadini R, Coticchio G, Brambillasca F, Mignini Renzini M, Novara PV, Brigante C, De Ponti E, Dal Canto M. Clinical outcomes from mature oocytes derived from preovulatory and antral follicles: reflections on follicle physiology and oocyte competence. J Assist Reprod Genet 2015;32: 255-261. Springer US.
13. Li L, Baibakov B, Dean J. A subcortical maternal complex essential for preimplantation mouse embryogenesis. Dev Cell 2008;15:416-425.
14. Lundin K, Bergh C, Hardarson T. Early embryo cleavage is a strong indicator of embryo quality in human IVF. Hum Reprod 2001;16:2652-2657.
15. Meseguer M, Herrero J, Tejera A, Hilligsøe KM, Ramsing NB, Remohí J. The use of morphokinetics as a predictor of embryo implantation. Hum Reprod 2011;26:2658-2671.
16. Mio Y. Human embryonic behavior observed by time-lapse cinematography. J Health Med Inf 2013;04:1-8.
17. Payne D, Flaherty SP, Barry MF, Matthews CD. Preliminary observations on polar body extrusion and pronuclear formation in human oocytes using time-lapse video cinematography. Hum Reprod 1997;12:532-541.
18. Petersen BM, Boel M, Montag M, Gardner DK. Development of a generally applicable morphokinetic algorithm capable of predicting the implantation potential of embryos transferred on Day 3. Hum Reprod 2016;31:2231-2244.
19. Ramalho-Santos J, Sutovsky P, Simerly C, Oko R, Wessel GM, Hewitson L, Schatten G. ICSI choreography: fate of sperm structures after monospermic rhesus ICSI and first cell cycle implications. Hum Reprod 2000; 15:2610-2620.
20. Scott L. Pronuclear scoring as a predictor of embryo development. Reprod Biomed Online 2003;6:201-214.
21. Tesarik J, Greco E. The probability of abnormal preimplantation development can be predicted by a single static observation on pronuclear stage morphology. Hum Reprod 1999;14:1318-1323.
22. Tilney LG, Jaffe LA. Actin, microvilli, and the fertilization cone of sea urchin eggs. J Cell Biol 1980;87:771-782. The Rockefeller University Press.
23. Van Blerkom J, Davis P, Alexander S. Occurrence of maternal and paternal spindles in unfertilized human oocytes: possible relationship to nucleation defects after silent fertilization. Reprod Biomed Online 2004; 8:454-459.