Putting "multiforme" back into glioblastoma: Intratumoral transcriptome heterogeneity is a consequence of its complex morphology

Neuro-Oncology

Volumn 19, Issue 12, 2017, Pages 1570-1571

  Khagi, Simon ^a,b,c   Miller, C Ryan ^c,d,e  

^a Department of Medicine   (United States)

^b Department of Pediatrics   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d Department of Pathology and Laboratory Medicine ^*  (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

genomics; glioblastoma; heterogeneity; histology; transcriptome

Indexed keywords

TRANSCRIPTOME;

CANCER CLASSIFICATION; CELL PROLIFERATION; EDITORIAL; GENE EXPRESSION; GENE MUTATION; GENETIC HETEROGENEITY; GLIOBLASTOMA; HUMAN; MEDICAL TERMINOLOGY; RNA SEQUENCE; SIGNAL TRANSDUCTION; ADULT; ASSOCIATION; BRAIN TUMOR;

ADULT; BRAIN NEOPLASMS; CUES; GLIOBLASTOMA; HUMANS; TRANSCRIPTOME;

EID: 85040074521     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nox131     Document Type: Editorial

References (9)

1. Bailey P, Cushing H. A Classification of the Tumors of the Glioma Subgroup on a Histogenetic Basis with a Correlated Study of Prognosis. Philadelphia: J. B. Lippincott; 1926.
2. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, eds. WHO Classification of Tumours of the Central Nervous System. Revised 4th ed. Lyon: IARC; 2016.
3. Prabhu A, Kesarwani P, Kant S, Graham SF, Chinnaiyan P. Histologically defined intratumoral sequencing uncovers evolutionary cues into conserved molecular events driving gliomagenesis. Neuro Oncol. 2017;19(12):1599-1606.
4. Verhaak RG, Hoadley KA, Purdom E, et al.; Cancer Genome Atlas Research Network. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010;17(1):98-110.
5. Brennan CW, Verhaak RG, McKenna A, et al.; TCGA Research Network. The somatic genomic landscape of glioblastoma. Cell. 2013;155(2):462-477.
6. Sottoriva A, Spiteri I, Piccirillo SG, et al. Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc Natl Acad Sci U S A. 2013;110(10):4009-4014.
7. Johnson BE, Mazor T, Hong C, et al. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science. 2014;343(6167):189-193.
8. Patel AP, Tirosh I, Trombetta JJ, et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science. 2014;344(6190):1396-1401.
9. Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell. 2011;144(5):646-674.