A herpesvirus entry mediator mutein with selective agonist action for the inhibitory receptor B and T lymphocyte attenuator

Journal of Biological Chemistry

Volumn 292, Issue 51, 2017, Pages 21060-21070

  Sedy J ^a   Balmert, M Olivia ^a   Ware, Brian C ^a   Smith, Wendell ^a   Nemčovičova, Ivana ^b   Norris, Paula S ^a   Miller, Brian R ^c   Aivazian, Dikran ^c   Ware, Carl F ^a  

^a BURNHAM INSTITUTE   (United States)

^b INSTITUTE OF CHEMISTRY   (Slovakia)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CHEMICAL ACTIVATION; CYTOLOGY; LIGANDS; T-CELLS;

ANTI-INFLAMMATORIES; B AND T LYMPHOCYTE ATTENUATORS; EVASION STRATEGY; HUMAN CYTOMEGALOVIRUS; INFLAMMATORY SIGNALING; INHIBITORY ACTIVITY; NATURAL KILLER CELLS; OPENING READING FRAMES;

CELL SIGNALING;

CD160 ANTIGEN; HERPESVIRUS ENTRY MEDIATOR; IMMUNOGLOBULIN RECEPTOR; LYMPHOCYTE ANTIGEN; PROTEIN BTLA; PROTEIN HVEM; PROTEIN UL144; UNCLASSIFIED DRUG; BTLA PROTEIN, HUMAN; CD160 PROTEIN, HUMAN; FUSION PROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; LEUKOCYTE ANTIGEN; LIGAND; MEMBRANE PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; TNFRSF14 PROTEIN, HUMAN; UL144 ORF PROTEIN, HUMAN HERPESVIRUS 5; VIRAL PROTEIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; IMMUNE EVASION; LIGAND BINDING; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; WILD TYPE; AGONISTS; AMINO ACID SUBSTITUTION; B LYMPHOCYTE; BINDING SITE; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DRUG DESIGN; DRUG EFFECT; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; KINETICS; METABOLISM; MOLECULAR MODEL; MUTATION; NATURAL KILLER CELL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN ENGINEERING; T LYMPHOCYTE; TUMOR CELL LINE;

AMINO ACID SUBSTITUTION; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIGENS, CD; B-LYMPHOCYTES; BINDING SITES; CELL LINE, TUMOR; DRUG DESIGN; GPI-LINKED PROTEINS; HEK293 CELLS; HUMANS; KILLER CELLS, NATURAL; KINETICS; LIGANDS; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, TUMOR NECROSIS FACTOR, MEMBER 14; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES; VIRAL PROTEINS;

EID: 85039444490     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M117.813295     Document Type: Article

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