메뉴 건너뛰기




Volumn 3, Issue 1, 2016, Pages

Management of hepatitis C genotype 4 in the directly acting antivirals era

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; ASUNAPREVIR PLUS BECLABUVIR PLUS DACLATASVIR; DACLATASVIR; ELBASVIR PLUS GRAZOPREVIR; GLECAPREVIR; LEDIPASVIR PLUS SOFOSBUVIR; PARITAPREVIR; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; PIBRENTASVIR; RIBAVIRIN; SIMEPREVIR; SOFOSBUVIR; SOFOSBUVIR PLUS VELPATASVIR; VELPATASVIR;

EID: 85038904857     PISSN: None     EISSN: 20544774     Source Type: Journal    
DOI: 10.1136/bmjgast-2016-000112     Document Type: Article
Times cited : (15)

References (80)
  • 1
    • 84898990930 scopus 로고    scopus 로고
    • New hepatitis C therapies: the toolbox, strategies, and challenges
    • Pawlotsky JM. New hepatitis C therapies: the toolbox, strategies, and challenges. Gastroenterology 2014;146:1176-92.
    • (2014) Gastroenterology , vol.146 , pp. 1176-1192
    • Pawlotsky, J.M.1
  • 2
    • 84925601848 scopus 로고    scopus 로고
    • Shorter treatments for hepatitis C: another step forward?
    • Foster GR. Shorter treatments for hepatitis C: another step forward? Lancet 2015;385:1054-5.
    • (2015) Lancet , vol.385 , pp. 1054-1055
    • Foster, G.R.1
  • 3
    • 84896132104 scopus 로고    scopus 로고
    • The beginning of the end: what is the future of interferon therapy for chronic hepatitis C?
    • Feld JJ. The beginning of the end: what is the future of interferon therapy for chronic hepatitis C? Antiviral Res 2014;105:32-8.
    • (2014) Antiviral Res , vol.105 , pp. 32-38
    • Feld, J.J.1
  • 4
    • 84925607745 scopus 로고    scopus 로고
    • Virological response after 6 week triple-drug regimens for hepatitis C: a proof-of-concept phase 2A cohort study
    • Kohli A, Osinusi A, Sims Z, et al. Virological response after 6 week triple-drug regimens for hepatitis C: a proof-of-concept phase 2A cohort study. Lancet 2015;385:1107-13.
    • (2015) Lancet , vol.385 , pp. 1107-1113
    • Kohli, A.1    Osinusi, A.2    Sims, Z.3
  • 5
    • 84919653420 scopus 로고    scopus 로고
    • Optimal therapy in genotype 4 chronic hepatitis C: finally cured?
    • Abdel-Razek W, Waked I. Optimal therapy in genotype 4 chronic hepatitis C: finally cured? Liver Int 2015;35(Suppl 1):27-34
    • (2015) Liver Int , vol.35 , pp. 27-34
    • Abdel-Razek, W.1    Waked, I.2
  • 6
    • 84914150658 scopus 로고    scopus 로고
    • Global epidemiology and genotype distribution of the hepatitis C virus infection
    • Gower E, Estes C, Blach S, et al. Global epidemiology and genotype distribution of the hepatitis C virus infection. J Hepatol 2014; 61 (1 Suppl): S45-57.
    • (2014) J Hepatol , vol.61 , Issue.1 , pp. S45-S57
    • Gower, E.1    Estes, C.2    Blach, S.3
  • 7
    • 84904720839 scopus 로고    scopus 로고
    • Historical epidemiology of hepatitis C virus (HCV) in selected countries
    • Bruggmann P, Berg T, Ovrehus AL, et al. Historical epidemiology of hepatitis C virus (HCV) in selected countries. J Viral Hepat 2014;21 (Suppl 1):5-33.
    • (2014) J Viral Hepat , vol.21 , pp. 5-33
    • Bruggmann, P.1    Berg, T.2    Ovrehus, A.L.3
  • 8
    • 84902129061 scopus 로고    scopus 로고
    • Strategies to manage hepatitis C virus (HCV) disease burden
    • Wedemeyer H, Duberg AS, Buti M, et al. Strategies to manage hepatitis C virus (HCV) disease burden. J Viral Hepat 2014;21 (Suppl 1):60-89.
    • (2014) J Viral Hepat , vol.21 , pp. 60-89
    • Wedemeyer, H.1    Duberg, A.S.2    Buti, M.3
  • 9
    • 79958698124 scopus 로고    scopus 로고
    • A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt
    • Sievert W, Altraif I, Razavi HA, et al. A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt. Liver Int 2011;31 (Suppl 2):61-80.
    • (2011) Liver Int , vol.31 , pp. 61-80
    • Sievert, W.1    Altraif, I.2    Razavi, H.A.3
  • 10
    • 84920202277 scopus 로고    scopus 로고
    • Prior to the oral therapy, what do we know about HCV-4 in Egypt: a randomized survey of prevalence and risks using data mining computed analysis
    • Abd Elrazek AE, Bilasy SE, Elbanna AE, et al. Prior to the oral therapy, what do we know about HCV-4 in Egypt: a randomized survey of prevalence and risks using data mining computed analysis. Medicine (Baltimore) 2014;93:e204.
    • (2014) Medicine (Baltimore) , vol.93 , pp. e204
    • Abd Elrazek, A.E.1    Bilasy, S.E.2    Elbanna, A.E.3
  • 11
    • 84905232893 scopus 로고    scopus 로고
    • The current and future disease burden of chronic hepatitis C virus infection in Egypt
    • Waked I, Doss W, El-Sayed MH, et al. The current and future disease burden of chronic hepatitis C virus infection in Egypt. Arab J Gastroenterol 2014;15:45-52.
    • (2014) Arab J Gastroenterol , vol.15 , pp. 45-52
    • Waked, I.1    Doss, W.2    El-Sayed, M.H.3
  • 12
    • 84874401795 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV) infection in Africa: a review
    • Karoney MJ, Siika AM. Hepatitis C virus (HCV) infection in Africa: a review. Pan Afr Medical J 2013;14:44.
    • (2013) Pan Afr Medical J , vol.14 , pp. 44
    • Karoney, M.J.1    Siika, A.M.2
  • 13
    • 84890528431 scopus 로고    scopus 로고
    • Review article: the epidemiology and therapy of chronic hepatitis C genotypes 4, 5 and 6
    • Wantuck JM, Ahmed A, Nguyen MH. Review article: the epidemiology and therapy of chronic hepatitis C genotypes 4, 5 and 6. Aliment Pharmacol Ther 2014;39:137-47.
    • (2014) Aliment Pharmacol Ther , vol.39 , pp. 137-147
    • Wantuck, J.M.1    Ahmed, A.2    Nguyen, M.H.3
  • 14
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial
    • Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001;358:958-65.
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3
  • 15
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002;347:975-82.
    • (2002) N Engl J Med , vol.347 , pp. 975-982
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3
  • 16
    • 84870533049 scopus 로고    scopus 로고
    • High sustained virologic response rates in rapid virologic response patients in the large real-world PROPHESYS cohort confirm results from randomized clinical trials
    • Marcellin P, Cheinquer H, Curescu M, et al. High sustained virologic response rates in rapid virologic response patients in the large real-world PROPHESYS cohort confirm results from randomized clinical trials. Hepatology 2012;56:2039-50.
    • (2012) Hepatology , vol.56 , pp. 2039-2050
    • Marcellin, P.1    Cheinquer, H.2    Curescu, M.3
  • 17
    • 84881218751 scopus 로고    scopus 로고
    • The Effect of Peginterferon Alpha-2a vs. Peginterferon Alpha-2b in Treatment of Naive Chronic HCV Genotype-4 Patients: A Single Centre Egyptian Study
    • El Raziky M, Fathalah WF, El-Akel WA, et al. The Effect of Peginterferon Alpha-2a vs. Peginterferon Alpha-2b in Treatment of Naive Chronic HCV Genotype-4 Patients: A Single Centre Egyptian Study. Hepatitis Monthly 2013;13:e10069.
    • (2013) Hepatitis Monthly , vol.13
    • El Raziky, M.1    Fathalah, W.F.2    El-Akel, W.A.3
  • 18
    • 84872043136 scopus 로고    scopus 로고
    • How to optimize HCV therapy in genotype 4 patients
    • Esmat G, El Kassas M, Hassany M, et al. How to optimize HCV therapy in genotype 4 patients. Liver Int 2013;33(Suppl 1):41-5.
    • (2013) Liver Int , vol.33 , pp. 41-45
    • Esmat, G.1    El Kassas, M.2    Hassany, M.3
  • 19
    • 37749046123 scopus 로고    scopus 로고
    • Pegylated interferon alpha-2b plus ribavirin in patients with genotype 4 chronic hepatitis C: the role of rapid and early virologic response
    • Kamal SM, El Kamary SS, Shardell MD, et al. Pegylated interferon alpha-2b plus ribavirin in patients with genotype 4 chronic hepatitis C: the role of rapid and early virologic response. Hepatology 2007;46:1732-40.
    • (2007) Hepatology , vol.46 , pp. 1732-1740
    • Kamal, S.M.1    El Kamary, S.S.2    Shardell, M.D.3
  • 20
    • 34250625319 scopus 로고    scopus 로고
    • Observational VHCSG. Epidemiological characteristics and response to peginterferon plus ribavirin treatment of hepatitis C virus genotype 4 infection
    • Roulot D, Bourcier V, Grando V, et al. Observational VHCSG. Epidemiological characteristics and response to peginterferon plus ribavirin treatment of hepatitis C virus genotype 4 infection. J Viral Hepat 2007;14:460-7.
    • (2007) J Viral Hepat , vol.14 , pp. 460-467
    • Roulot, D.1    Bourcier, V.2    Grando, V.3
  • 21
    • 84901036125 scopus 로고    scopus 로고
    • ABT-450/r-ombitasvir and dasabuvir with ribavirin for hepatitis C with cirrhosis
    • Poordad F, Hezode C, Trinh R, et al. ABT-450/r-ombitasvir and dasabuvir with ribavirin for hepatitis C with cirrhosis. N Engl J Med 2014;370:1973-82.
    • (2014) N Engl J Med , vol.370 , pp. 1973-1982
    • Poordad, F.1    Hezode, C.2    Trinh, R.3
  • 22
    • 67349172961 scopus 로고    scopus 로고
    • Peginterferon alfa-2b and ribavirin: effective in patients with hepatitis C who failed interferon alfa/ribavirin therapy
    • Poynard T, Colombo M, Bruix J, et al. Peginterferon alfa-2b and ribavirin: effective in patients with hepatitis C who failed interferon alfa/ribavirin therapy. Gastroenterology 2009;136:1618-1628.e2.
    • (2009) Gastroenterology , vol.136 , pp. 1618.e2-1628.e2
    • Poynard, T.1    Colombo, M.2    Bruix, J.3
  • 23
    • 84874105854 scopus 로고    scopus 로고
    • Virologic response and characterisation of HCV genotype 2-6 in patients receiving TMC435 monotherapy (study TMC435-C202)
    • Lenz O, Vijgen L, Berke JM, et al. Virologic response and characterisation of HCV genotype 2-6 in patients receiving TMC435 monotherapy (study TMC435-C202). J Hepatology 2013;58:445-51.
    • (2013) J Hepatology , vol.58 , pp. 445-451
    • Lenz, O.1    Vijgen, L.2    Berke, J.M.3
  • 24
    • 84877730954 scopus 로고    scopus 로고
    • Sofosbuvir for previously untreated chronic hepatitis C infection
    • Lawitz E, Mangia A, Wyles D, et al. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med 2013;368:1878-87.
    • (2013) N Engl J Med , vol.368 , pp. 1878-1887
    • Lawitz, E.1    Mangia, A.2    Wyles, D.3
  • 25
    • 84878976866 scopus 로고    scopus 로고
    • Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial
    • Kowdley KV, Lawitz E, Crespo I, et al. Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial. Lancet 2013;381:2100-7.
    • (2013) Lancet , vol.381 , pp. 2100-2107
    • Kowdley, K.V.1    Lawitz, E.2    Crespo, I.3
  • 26
    • 84925619517 scopus 로고    scopus 로고
    • Efficacy and safety of simeprevir with PegIFN/ribavirin in naive or experienced patients infected with chronic HCV genotype 4
    • Moreno C, Hezode C, Marcellin P, et al. Efficacy and safety of simeprevir with PegIFN/ribavirin in naive or experienced patients infected with chronic HCV genotype 4. J Hepatol 2015;62:1047-55..
    • (2015) J Hepatol , vol.62 , pp. 1047-1055
    • Moreno, C.1    Hezode, C.2    Marcellin, P.3
  • 27
    • 84906053496 scopus 로고    scopus 로고
    • Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial
    • Jacobson IM, Dore GJ, Foster GR, et al. Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet 2014;384:403-13.
    • (2014) Lancet , vol.384 , pp. 403-413
    • Jacobson, I.M.1    Dore, G.J.2    Foster, G.R.3
  • 28
    • 84901217985 scopus 로고    scopus 로고
    • Simeprevir with peginterferon and ribavirin leads to high rates of SVR in patients with HCV genotype 1 who relapsed after previous therapy: a phase 3 trial
    • Forns X, Lawitz E, Zeuzem S, et al. Simeprevir with peginterferon and ribavirin leads to high rates of SVR in patients with HCV genotype 1 who relapsed after previous therapy: a phase 3 trial. Gastroenterology 2014;146:1669-1679.e3.
    • (2014) Gastroenterology , vol.146 , pp. 1669.e3-1679.e3
    • Forns, X.1    Lawitz, E.2    Zeuzem, S.3
  • 29
    • 85051096926 scopus 로고    scopus 로고
    • High efficacy of a 12-week simeprevir plus pegylated interferon alfa 2a/ribavirin regimen in treatment naïve patients with chronic HCV genotype 4 infection and mild-to-moderate fibrosis
    • Asseleh T, Moreno C, Sarrazin C, et al. High efficacy of a 12-week simeprevir plus pegylated interferon alfa 2a/ribavirin regimen in treatment naïve patients with chronic HCV genotype 4 infection and mild-to-moderate fibrosis. Hepatology 2015;62:792A.
    • (2015) Hepatology , vol.62 , pp. 792A
    • Asseleh, T.1    Moreno, C.2    Sarrazin, C.3
  • 30
    • 84932619401 scopus 로고    scopus 로고
    • Daclatasvir plus peginterferon alfa and ribavirin for treatment-naive chronic hepatitis C genotype 1 or 4 infection: a randomised study
    • Hézode C, Hirschfield GM, Ghesquiere W, et al. Daclatasvir plus peginterferon alfa and ribavirin for treatment-naive chronic hepatitis C genotype 1 or 4 infection: a randomised study. Gut 2014;64: 948-56.
    • (2014) Gut , vol.64 , pp. 948-956
    • Hézode, C.1    Hirschfield, G.M.2    Ghesquiere, W.3
  • 31
    • 84931576743 scopus 로고    scopus 로고
    • Daclatasvir and asunaprevir plus peginterferon alfa and ribavirin in HCV genotype 1 or 4 non-responders
    • Jensen D, Sherman KE, Hezode C, et al. Daclatasvir and asunaprevir plus peginterferon alfa and ribavirin in HCV genotype 1 or 4 non-responders. J Hepatol 2015;63:30-7.
    • (2015) J Hepatol , vol.63 , pp. 30-37
    • Jensen, D.1    Sherman, K.E.2    Hezode, C.3
  • 33
    • 84903975871 scopus 로고    scopus 로고
    • Antiviral treatment of hepatitis C
    • Feeney ER, Chung RT. Antiviral treatment of hepatitis C. BMJ 2014;348:g3308.
    • (2014) BMJ , vol.348 , pp. g3308
    • Feeney, E.R.1    Chung, R.T.2
  • 34
    • 84916891867 scopus 로고    scopus 로고
    • Finally sofosbuvir: an oral anti-HCV drug with wide performance capability
    • Kayali Z, Schmidt WN. Finally sofosbuvir: an oral anti-HCV drug with wide performance capability. Pharmgenomics Pers Med 2014;7:387-98.
    • (2014) Pharmgenomics Pers Med , vol.7 , pp. 387-398
    • Kayali, Z.1    Schmidt, W.N.2
  • 35
    • 84919386783 scopus 로고    scopus 로고
    • Sofosbuvir as backbone of interferon free treatments
    • Bourliere M, Oules V, Ansaldi C, et al. Sofosbuvir as backbone of interferon free treatments. Dig Liver Dis 2014;46(Suppl 5): S212-220.
    • (2014) Dig Liver Dis , vol.46 , pp. S212-S220
    • Bourliere, M.1    Oules, V.2    Ansaldi, C.3
  • 36
    • 84927796279 scopus 로고    scopus 로고
    • Sofosbuvir plus ribavirin for the treatment of chronic genotype 4 hepatitis C virus infection in patients of Egyptian ancestry
    • Ruane PJ, Ain D, Stryker R, et al. Sofosbuvir plus ribavirin for the treatment of chronic genotype 4 hepatitis C virus infection in patients of Egyptian ancestry. J Hepatol 2015;62:1040-6.
    • (2015) J Hepatol , vol.62 , pp. 1040-1046
    • Ruane, P.J.1    Ain, D.2    Stryker, R.3
  • 37
    • 84922417595 scopus 로고    scopus 로고
    • Sofosbuvir Plus Ribavirin in the Treatment of Egyptian Patients with Chronic Genotype 4 HCV
    • Esmat GE, Shiha G, Omar RF, et al. Sofosbuvir Plus Ribavirin in the Treatment of Egyptian Patients with Chronic Genotype 4 HCV. Hepatology 2014;60(4 Suppl):133A.
    • (2014) Hepatology , vol.60 , Issue.4 , pp. 133A
    • Esmat, G.E.1    Shiha, G.2    Omar, R.F.3
  • 38
    • 84922477979 scopus 로고    scopus 로고
    • All Oral Treatment for Genotype 4 Chronic Hepatitis C Infection with Sofosbuvir and Ledipasvir: Interim Results from the NIAID SYNERGY Trial
    • Kapoor R, Kohli A, Sidhartan S, et al. All Oral Treatment for Genotype 4 Chronic Hepatitis C Infection with Sofosbuvir and Ledipasvir: Interim Results from the NIAID SYNERGY Trial. Hepatology 2014;60(4 Suppl):91A.
    • (2014) Hepatology , vol.60 , Issue.4 , pp. 91A
    • Kapoor, R.1    Kohli, A.2    Sidhartan, S.3
  • 39
    • 84898669547 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection
    • Afdhal N, Reddy KR, Nelson DR, et al. Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. N Engl J Med 2014;370:1483-93.
    • (2014) N Engl J Med , vol.370 , pp. 1483-1493
    • Afdhal, N.1    Reddy, K.R.2    Nelson, D.R.3
  • 40
    • 84900339263 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection
    • Afdhal N, Zeuzem S, Kwo P, et al. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med 2014;370: 1889-98.
    • (2014) N Engl J Med , vol.370 , pp. 1889-1898
    • Afdhal, N.1    Zeuzem, S.2    Kwo, P.3
  • 41
    • 84911409020 scopus 로고    scopus 로고
    • Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study
    • Lawitz E, Sulkowski MS, Ghalib R, et al. Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study. Lancet 2014;384:1756-65.
    • (2014) Lancet , vol.384 , pp. 1756-1765
    • Lawitz, E.1    Sulkowski, M.S.2    Ghalib, R.3
  • 42
    • 84939269033 scopus 로고    scopus 로고
    • A Phase 3 study of 12-weeks of simeprevir (SMV) plus sofosbuvir (SOF) in treatment-naïve or treatment experienced patients with chronic HCV genotype 1 infection and cirrhosis: (OPTIMIST 2)
    • Lawitz E, Matusow G, DeJesus E, et al. A Phase 3 study of 12-weeks of simeprevir (SMV) plus sofosbuvir (SOF) in treatment-naïve or treatment experienced patients with chronic HCV genotype 1 infection and cirrhosis: (OPTIMIST 2). J Hepatol 2015;62:S264-265.
    • (2015) J Hepatol , vol.62 , pp. S264-S265
    • Lawitz, E.1    Matusow, G.2    DeJesus, E.3
  • 43
    • 84996586973 scopus 로고    scopus 로고
    • Treatment of hepatitis C genotype 4 patients with simeprevir and sofosbuvir: Preliminary results from a phase IIa, partially randomised, open-label trial conducted in Egypt (OSIRIS)
    • El Raziky M, Gamil M, Hammad R, et al. Treatment of hepatitis C genotype 4 patients with simeprevir and sofosbuvir: Preliminary results from a phase IIa, partially randomised, open-label trial conducted in Egypt (OSIRIS). Hepatology 2015;62(1 Suppl):145A.
    • (2015) Hepatology , vol.62 , Issue.1 , pp. 145A
    • El Raziky, M.1    Gamil, M.2    Hammad, R.3
  • 44
    • 84892619580 scopus 로고    scopus 로고
    • Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection
    • Sulkowski MS, Gardiner DF, Rodriguez-Torres M, et al. Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection. N Engl J Med 2014;370:211-21.
    • (2014) N Engl J Med , vol.370 , pp. 211-221
    • Sulkowski, M.S.1    Gardiner, D.F.2    Rodriguez-Torres, M.3
  • 45
    • 84950981068 scopus 로고    scopus 로고
    • SVR12 results from the Phase II, open-label IMPACT study of simeprevir (SMV) in combination with daclatasvir (DCV) and sofosbuvir (SOF) in treatment-naïve and -experienced patients with chronic HCV genotype 1/4 infection and decompensated liver disease
    • Lawitz E, Poordad F, Gutierrez J, et al. SVR12 results from the Phase II, open-label IMPACT study of simeprevir (SMV) in combination with daclatasvir (DCV) and sofosbuvir (SOF) in treatment-naïve and -experienced patients with chronic HCV genotype 1/4 infection and decompensated liver disease. Hepatology 2015;62(1 Suppl):62A.
    • (2015) Hepatology , vol.62 , Issue.1 , pp. 62A
    • Lawitz, E.1    Poordad, F.2    Gutierrez, J.3
  • 46
    • 84896460675 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A inhibitors and drug resistance mutations
    • Nakamoto S, Kanda T, Wu S, et al. Hepatitis C virus NS5A inhibitors and drug resistance mutations. World J Gastroenterol 2014;20:2902-12.
    • (2014) World J Gastroenterol , vol.20 , pp. 2902-2912
    • Nakamoto, S.1    Kanda, T.2    Wu, S.3
  • 47
    • 84952883325 scopus 로고    scopus 로고
    • Sofosbuvir and velpatasvir for HCV genotype 1,2,4,5 and 6 infection
    • Feld JJ, Jacobson IM, Hezode C, et al. Sofosbuvir and velpatasvir for HCV genotype 1,2,4,5 and 6 infection. N Engl J Med 2015;373:2599-607.
    • (2015) N Engl J Med , vol.373 , pp. 2599-2607
    • Feld, J.J.1    Jacobson, I.M.2    Hezode, C.3
  • 48
    • 84905868341 scopus 로고    scopus 로고
    • Ombitasvir: a potent pan-genotypic inhibitor of NS5A for the treatment of hepatitis C virus infection
    • Gentile I, Buonomo AR, Borgia G. Ombitasvir: a potent pan-genotypic inhibitor of NS5A for the treatment of hepatitis C virus infection. Expert Rev Anti Infect Ther 2014;12:1033-43.
    • (2014) Expert Rev Anti Infect Ther , vol.12 , pp. 1033-1043
    • Gentile, I.1    Buonomo, A.R.2    Borgia, G.3
  • 49
    • 84910050876 scopus 로고    scopus 로고
    • Ombitasvir (ABT-267), a novel NS5A inhibitor for the treatment of hepatitis C
    • Stirnimann G. Ombitasvir (ABT-267), a novel NS5A inhibitor for the treatment of hepatitis C. Expert Opin Pharmacother 2014;15:2609-22.
    • (2014) Expert Opin Pharmacother , vol.15 , pp. 2609-2622
    • Stirnimann, G.1
  • 50
    • 84925428093 scopus 로고    scopus 로고
    • Ombitasvir, Paritaprevir Co-dosed With Ritonavir, Dasabuvir, and Ribavirin for Hepatitis C in Patients Co-infected With HIV-1: A Randomized Trial
    • Sulkowski MS, Eron JJ, Wyles D, et al. Ombitasvir, Paritaprevir Co-dosed With Ritonavir, Dasabuvir, and Ribavirin for Hepatitis C in Patients Co-infected With HIV-1: A Randomized Trial. JAMA 2015;313:1223-31.
    • (2015) JAMA , vol.313 , pp. 1223-1231
    • Sulkowski, M.S.1    Eron, J.J.2    Wyles, D.3
  • 51
    • 84899068302 scopus 로고    scopus 로고
    • Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin
    • Feld JJ, Kowdley KV, Coakley E, et al. Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. N Engl J Med 2014;370:1594-603.
    • (2014) N Engl J Med , vol.370 , pp. 1594-1603
    • Feld, J.J.1    Kowdley, K.V.2    Coakley, E.3
  • 52
    • 84901044326 scopus 로고    scopus 로고
    • ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV
    • Ferenci P, Bernstein D, Lalezari J, et al. ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV. N Engl J Med 2014;370:1983-92.
    • (2014) N Engl J Med , vol.370 , pp. 1983-1992
    • Ferenci, P.1    Bernstein, D.2    Lalezari, J.3
  • 53
    • 84922875663 scopus 로고    scopus 로고
    • Dasabuvir: a new direct antiviral agent for the treatment of hepatitis C
    • Trivella JP, Gutierrez J, Martin P. Dasabuvir: a new direct antiviral agent for the treatment of hepatitis C. Expert Opin Pharmacother 2015;16:617-24.
    • (2015) Expert Opin Pharmacother , vol.16 , pp. 617-624
    • Trivella, J.P.1    Gutierrez, J.2    Martin, P.3
  • 54
    • 84922430521 scopus 로고    scopus 로고
    • Interferon-Free Regimen of Ombitasvir and ABT-450/r With or Without Ribavirin in Patients with HCV Genotype 4 Infection: PEARL-1 Study Results
    • Pol S, Reddy KR, Baykal T, et al. Interferon-Free Regimen of Ombitasvir and ABT-450/r With or Without Ribavirin in Patients with HCV Genotype 4 Infection: PEARL-1 Study Results. Hepatology 2014;60(4 Suppl):1129A.
    • (2014) Hepatology , vol.60 , Issue.4 , pp. 1129A
    • Pol, S.1    Reddy, K.R.2    Baykal, T.3
  • 55
    • 85051093016 scopus 로고    scopus 로고
    • Viekirax Product Summary
    • Abbvie. Viekirax Product Summary. 2014. http://www.viekiraxexviera.co.uk/prescribing-information.html
    • (2014)
  • 56
    • 84975233756 scopus 로고    scopus 로고
    • Efficacy and safety of ombitasvir/paritaprevir/ritonavir co-administered with ribavirin in adults with genotype 4 chronic hepatitis C infection and cirrhosis (AGATE-1)
    • Asselah T, Hassaneln TI, Qaqish RB, et al. Efficacy and safety of ombitasvir/paritaprevir/ritonavir co-administered with ribavirin in adults with genotype 4 chronic hepatitis C infection and cirrhosis (AGATE-1). Hepatology 2015;62(1 Suppl): 119A.
    • (2015) Hepatology , vol.62 , Issue.1 , pp. 119A
    • Asselah, T.1    Hassaneln, T.I.2    Qaqish, R.B.3
  • 57
    • 84975240022 scopus 로고    scopus 로고
    • Efficacy and safety of co-formulated ombitasvir/paritaprevir/ritonavir with ribavirin in adults with chronic HCV genotype 4 infection without cirrhosis and with compensated cirrhosis in Egypt (AGATE-II)
    • Esmat G, Doss W, Qaqish RB, et al. Efficacy and safety of co-formulated ombitasvir/paritaprevir/ritonavir with ribavirin in adults with chronic HCV genotype 4 infection without cirrhosis and with compensated cirrhosis in Egypt (AGATE-II). Hepatology 2015;62 (1 Suppl):118A.
    • (2015) Hepatology , vol.62 , Issue.1 , pp. 118A
    • Esmat, G.1    Doss, W.2    Qaqish, R.B.3
  • 58
    • 84892761609 scopus 로고    scopus 로고
    • Efficacy of an interferon- and ribavirin-free regimen of daclatasvir, asunaprevir, and BMS-791325 in treatment-naive patients with HCV genotype 1 infection
    • Everson GT, Sims KD, Rodriguez-Torres M, et al. Efficacy of an interferon- and ribavirin-free regimen of daclatasvir, asunaprevir, and BMS-791325 in treatment-naive patients with HCV genotype 1 infection. Gastroenterology 2014;146:420-9.
    • (2014) Gastroenterology , vol.146 , pp. 420-429
    • Everson, G.T.1    Sims, K.D.2    Rodriguez-Torres, M.3
  • 59
    • 84927786570 scopus 로고    scopus 로고
    • A randomized trial of daclatasvir in combination with asunaprevir and beclabuvir in patients with chronic hepatitis C virus genotype 4 infection
    • Hassanein T, Sims KD, Bennett M, et al. A randomized trial of daclatasvir in combination with asunaprevir and beclabuvir in patients with chronic hepatitis C virus genotype 4 infection. J Hepatol 2015;62:1204-6.
    • (2015) J Hepatol , vol.62 , pp. 1204-1206
    • Hassanein, T.1    Sims, K.D.2    Bennett, M.3
  • 60
    • 84907302681 scopus 로고    scopus 로고
    • Treatment of HCV infection with the novel NS3/4A protease inhibitors
    • De Luca A, Bianco C, Rossetti B. Treatment of HCV infection with the novel NS3/4A protease inhibitors. Current Opin Pharmacol 2014;18:9-17.
    • (2014) Current Opin Pharmacol , vol.18 , pp. 9-17
    • De Luca, A.1    Bianco, C.2    Rossetti, B.3
  • 61
    • 84925424553 scopus 로고    scopus 로고
    • Efficacy and safety of 12 weeks versus 18 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin for hepatitis C virus genotype 1 infection in previously untreated patients with cirrhosis and patients with previous null response with or without cirrhosis (C-WORTHY): a randomised, open-label phase 2 trial
    • Lawitz E, Gane E, Pearlman B, et al. Efficacy and safety of 12 weeks versus 18 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin for hepatitis C virus genotype 1 infection in previously untreated patients with cirrhosis and patients with previous null response with or without cirrhosis (C-WORTHY): a randomised, open-label phase 2 trial. Lancet 2014;385:1075-86.
    • (2014) Lancet , vol.385 , pp. 1075-1086
    • Lawitz, E.1    Gane, E.2    Pearlman, B.3
  • 62
    • 84919674940 scopus 로고    scopus 로고
    • C-SWIFT: Grazoprevir (MK-5172) + Elbasvir (MK-8742) + Sofosbuvir in Treatment-Naive Patients With Hepatitis C Virus Genotype 1 Infection, With and Without Cirrhosis, for Durations of 4, 6, or 8 Weeks (Interim Results)
    • Poordad F, Lawitz E, Gutierrez JA, et al. C-SWIFT: Grazoprevir (MK-5172) + Elbasvir (MK-8742) + Sofosbuvir in Treatment-Naive Patients With Hepatitis C Virus Genotype 1 Infection, With and Without Cirrhosis, for Durations of 4, 6, or 8 Weeks (Interim Results). Hepatology 2014;60(Suppl 1):S192-3.
    • (2014) Hepatology , vol.60 , pp. S192-S193
    • Poordad, F.1    Lawitz, E.2    Gutierrez, J.A.3
  • 63
    • 84996540251 scopus 로고    scopus 로고
    • High efficacy of elbasvir and grazoprevir with or without ribavirin in 103 treatment-naïve and experienced patients with HCV genotype 4 infection: a pooled analysis
    • Asselah T, Reesink H, Gerstoft J, et al. High efficacy of elbasvir and grazoprevir with or without ribavirin in 103 treatment-naïve and experienced patients with HCV genotype 4 infection: a pooled analysis. Hepatology 2015;62(1 Suppl):340A.
    • (2015) Hepatology , vol.62 , Issue.1 , pp. 340A
    • Asselah, T.1    Reesink, H.2    Gerstoft, J.3
  • 64
    • 84928238023 scopus 로고    scopus 로고
    • A Next Generation HCV DAA Combination: Potent Pangenotypic Inhibitors ABT-493 and ABT-530 with High Barriers to Resistance
    • Ng T, Pilot-Matias T, Lu L, et al. A Next Generation HCV DAA Combination: Potent Pangenotypic Inhibitors ABT-493 and ABT-530 with High Barriers to Resistance. Hepatology 2014;(Suppl 1):1148A.
    • (2014) Hepatology , pp. 1148A
    • Ng, T.1    Pilot-Matias, T.2    Lu, L.3
  • 65
    • 85016006736 scopus 로고    scopus 로고
    • High Efficacy of an 8-Week 3-Drug Regimen of Grazeoprevir/MK-8408/MK-3682 in HCV Genotype 1,2 and 3-infected patients: SVR24 Data from the Phase- 2 C-CREST 1 and 2 Studies
    • Gane EJ, Pianko S, Roberts SK, et al. High Efficacy of an 8-Week 3-Drug Regimen of Grazeoprevir/MK-8408/MK-3682 in HCV Genotype 1,2 and 3-infected patients: SVR24 Data from the Phase- 2 C-CREST 1 and 2 Studies. J Hepatol 2016;64:S759.
    • (2016) J Hepatol , vol.64 , pp. S759
    • Gane, E.J.1    Pianko, S.2    Roberts, S.K.3
  • 66
    • 84902953427 scopus 로고    scopus 로고
    • Effectiveness of telaprevir or boceprevir in treatment-experienced patients with HCV genotype 1 infection and cirrhosis
    • Hezode C, Fontaine H, Dorival C, et al. Effectiveness of telaprevir or boceprevir in treatment-experienced patients with HCV genotype 1 infection and cirrhosis. Gastroenterology 2014;147:132-142.e4.
    • (2014) Gastroenterology , vol.147 , pp. 132.e4-142.e4
    • Hezode, C.1    Fontaine, H.2    Dorival, C.3
  • 67
    • 84902481487 scopus 로고    scopus 로고
    • Sofosbuvir and Ribavirin for the Treatment of Chronic HCV with Cirrhosis and Portal Hypertension with and without Decompensation: Early Virological Response and Safety
    • Afdhal N, Everson G, Calleja JL, et al. Sofosbuvir and Ribavirin for the Treatment of Chronic HCV with Cirrhosis and Portal Hypertension with and without Decompensation: Early Virological Response and Safety J Hepatology 2014;60:S28.
    • (2014) J Hepatology , vol.60 , pp. S28
    • Afdhal, N.1    Everson, G.2    Calleja, J.L.3
  • 68
    • 84920990853 scopus 로고    scopus 로고
    • Ledipasvir/Sofosbuvir with Ribavirin for the Treatment of HCV in Patients with Decompensated Cirrhosis: Pre-liminary Results of a Prospective, Multicenter Study
    • Flamm S, Everson GT, Charlton M, et al. Ledipasvir/Sofosbuvir with Ribavirin for the Treatment of HCV in Patients with Decompensated Cirrhosis: Pre-liminary Results of a Prospective, Multicenter Study. Hepatology 2014;60(Suppl 1):320A.
    • (2014) Hepatology , vol.60 , pp. 320A
    • Flamm, S.1    Everson, G.T.2    Charlton, M.3
  • 69
    • 85051094417 scopus 로고    scopus 로고
    • Daclatasvir plus sofosbuvir with or without ribavirin in patients with HCV infection and decompensated cirrhosis: interim analysis of a French multicentre compassionate use programme
    • (accessed 4 Aug 2016).
    • Leroy V, Hezode C, Metivier S, et al. Daclatasvir plus sofosbuvir with or without ribavirin in patients with HCV infection and decompensated cirrhosis: interim analysis of a French multicentre compassionate use programme. http://ilc-congress.eu/wp-content/uploads/2016/abstracts/flipbook/mobile/index.html#p=708 (accessed 4 Aug 2016).
    • Leroy, V.1    Hezode, C.2    Metivier, S.3
  • 70
    • 84979533481 scopus 로고    scopus 로고
    • Outcomes after successful direct-acting antiviral therapy for patients with chronic hepatitis C and decompensated cirrhosis
    • Cheung MCM, Walker AJ, Hudson BE, et al. Outcomes after successful direct-acting antiviral therapy for patients with chronic hepatitis C and decompensated cirrhosis. J Hepatol 2016;65:741-7.
    • (2016) J Hepatol , vol.65 , pp. 741-747
    • Cheung, M.C.M.1    Walker, A.J.2    Hudson, B.E.3
  • 71
    • 84966733521 scopus 로고    scopus 로고
    • Efficacy of direct acting antiviral combination for patients with hepatitis C virus genotype 1 infection and severe renal impairment ir end-stage renal disease
    • Pockros PJ, Reddy KR, Mantry PS, et al. Efficacy of direct acting antiviral combination for patients with hepatitis C virus genotype 1 infection and severe renal impairment ir end-stage renal disease. Gastroenterology 2016;150:1590-8.
    • (2016) Gastroenterology , vol.150 , pp. 1590-1598
    • Pockros, P.J.1    Reddy, K.R.2    Mantry, P.S.3
  • 72
    • 84947338288 scopus 로고    scopus 로고
    • Grazoprevir plus elbasvir in treatment-naïve and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4-5 chronic kidney disease (the C-SURFER study): a combination phase 3 study
    • Roth DR, Nelson DR, Bruchfield A, et al. Grazoprevir plus elbasvir in treatment-naïve and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4-5 chronic kidney disease (the C-SURFER study): a combination phase 3 study. Lancet 2015;386:1537-45.
    • (2015) Lancet , vol.386 , pp. 1537-1545
    • Roth, D.R.1    Nelson, D.R.2    Bruchfield, A.3
  • 73
    • 84938949283 scopus 로고    scopus 로고
    • Recommendations on treatment of hepatitis C
    • (accessed 4 Aug 2016).
    • EASL. Recommendations on treatment of hepatitis C. 2015. http://www.easl.eu/research/our-contributions/clinical-practice-guidelines/detail/recommendations-on-treatment-of-hepatitis-c-2015 (accessed 4 Aug 2016).
    • (2015)
  • 74
    • 84918817051 scopus 로고    scopus 로고
    • Life expectancy in patients with chronic HCV infection and cirrhosis compared with a general population
    • van der Meer AJ, Wedemeyer H, Feld JJ, et al. Life expectancy in patients with chronic HCV infection and cirrhosis compared with a general population. JAMA 2014;312:1927-8.
    • (2014) JAMA , vol.312 , pp. 1927-1928
    • van der Meer, A.J.1    Wedemeyer, H.2    Feld, J.J.3
  • 75
    • 84913599128 scopus 로고    scopus 로고
    • Simplification of antiviral hepatitis C virus therapy to support expanded access in resource-limited settings
    • Ford N, Swan T, Beyer P, et al. Simplification of antiviral hepatitis C virus therapy to support expanded access in resource-limited settings. J Hepatol 2014;61(1 Suppl):S132-138.
    • (2014) J Hepatol , vol.61 , Issue.1 , pp. S132-S138
    • Ford, N.1    Swan, T.2    Beyer, P.3
  • 76
    • 84926513721 scopus 로고    scopus 로고
    • Diagnostics for resource-limited settings in the era of interferon-free HCV therapy
    • Cooke GS, Hill AM. Diagnostics for resource-limited settings in the era of interferon-free HCV therapy. J Viral Hepat 2015;22:459-60.
    • (2015) J Viral Hepat , vol.22 , pp. 459-460
    • Cooke, G.S.1    Hill, A.M.2
  • 77
    • 85051097509 scopus 로고    scopus 로고
    • Hepatitis C drug in India to cost Rs 49 lakh less than in US
    • The Times of India. India.
    • Hepatitis C drug in India to cost Rs 49 lakh less than in US. The Times of India. India.
  • 78
    • 84965171281 scopus 로고    scopus 로고
    • L159F and V321A sofosbuvir-associated hepatitis c virus NS5B substitutions
    • Svarovskaia ES, Gane E, Dvory-Sobol H. L159F and V321A sofosbuvir-associated hepatitis c virus NS5B substitutions. J Infect Dis 2016;213:1240-7.
    • (2016) J Infect Dis , vol.213 , pp. 1240-1247
    • Svarovskaia, E.S.1    Gane, E.2    Dvory-Sobol, H.3
  • 79
    • 84946213210 scopus 로고    scopus 로고
    • Hepatitis C virus genotype 4 resistance and subtype demographic characterization of patients treated with ombitasvir plus paritaprevir/ritonavir
    • Schnell G, Tripathi R, Beyer J, et al. Hepatitis C virus genotype 4 resistance and subtype demographic characterization of patients treated with ombitasvir plus paritaprevir/ritonavir. Antimicrob Agents Chemother 2015;59:6807-15.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 6807-6815
    • Schnell, G.1    Tripathi, R.2    Beyer, J.3
  • 80
    • 84928898919 scopus 로고    scopus 로고
    • Recommendations for Testing, Managing, and Treating Hepatitis C
    • (accessed 4 Aug 2016).
    • AASLD. Recommendations for Testing, Managing, and Treating Hepatitis C. 2015. http://www.hcvguidelines.org/full-report-view (accessed 4 Aug 2016).
    • (2015)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.