Stress granule-inducing eukaryotic translation initiation factor 4A inhibitors block influenza A virus replication

Viruses

Volumn 9, Issue 12, 2017, Pages

  Slaine, Patrick D ^a   Kleer, Mariel ^a   Smith, Nathan K ^a   Khaperskyy, Denys A ^a   McCormick, Craig ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

eIF4A helicase; Influenza A virus; Pateamine A; Silvestrol; Stress granule; Translation

Indexed keywords

ANTINEOPLASTIC AGENT; INITIATION FACTOR; INITIATION FACTOR 4A; MESSENGER RNA; PATEAMINE A; PATHOGEN ASSOCIATED MOLECULAR PATTERN; PROTEIN SYNTHESIS INHIBITOR; PUROMYCIN; SILVESTROL; UNCLASSIFIED DRUG; VIRAL PROTEIN; VIRUS RNA; ANTIVIRUS AGENT; ENZYME INHIBITOR; EPOXIDE; MACROLIDE; THIAZOLE DERIVATIVE; TRITERPENE;

ANIMAL CELL; ARTICLE; CELL AGGREGATION; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; INFLUENZA; INFLUENZA A VIRUS; NONHUMAN; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; RESAZURIN ASSAY; STRESS GRANULE; VIRUS REPLICATION; VIRUS STRAIN; WESTERN BLOTTING; A-549 CELL LINE; ANTAGONISTS AND INHIBITORS; DRUG EFFECT; HUMAN; METABOLISM; PHYSIOLOGY;

A549 CELLS; ANTIVIRAL AGENTS; ENZYME INHIBITORS; EPOXY COMPOUNDS; EUKARYOTIC INITIATION FACTOR-4A; HUMANS; INFLUENZA A VIRUS; MACROLIDES; PROTEIN BIOSYNTHESIS; THIAZOLES; TRITERPENES; VIRUS REPLICATION;

EID: 85038885062     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v9120388     Document Type: Article

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