Efficacy Against Human Prostate Cancer by Prostate-specific Membrane Antigen-specific, Transforming Growth Factor-β Insensitive Genetically Targeted CD8+ T-cells Derived from Patients with Metastatic Castrate-resistant Disease

European Urology

Volumn 73, Issue 5, 2018, Pages 648-652

  Zhang, Qiang ^a   Helfand, Brian T ^b   Carneiro, Benedito A ^a   Qin, Weijun ^c   Yang, Ximing J ^a   Lee, Chung ^a   Zhang, Weipeng ^d   Giles, Francis J ^a   Cristofanilli, Massimo ^a   Kuzel, Timothy M ^e  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d Northwestern University   (United States)

^e RUSH MEDICAL COLLEGE   (United States)

Author keywords

CD8+ T cells; mCRPC; Prostate cancer; PSMA; TGF

Indexed keywords

CHIMERIC ANTIGEN RECEPTOR; GANCICLOVIR; PROSTATE SPECIFIC MEMBRANE ANTIGEN; RETROVIRUS VECTOR; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ZETA CHAIN; THYMIDINE KINASE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG; FOLH1 PROTEIN, HUMAN; GLUTAMATE CARBOXYPEPTIDASE II; MEMBRANE ANTIGEN; PROSTATE SPECIFIC ANTIGEN;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CASTRATION RESISTANT PROSTATE CANCER; CD8+ T LYMPHOCYTE; CELL INVASION; CELL SURVIVAL; CHROMIUM RELEASE ASSAY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKAPHERESIS; LYMPHOCYTIC INFILTRATION; MALE; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR MICROENVIRONMENT; ANIMAL; DISEASE MODEL; DRUG EFFECT; IMMUNOLOGY; IMMUNOTHERAPY; MOLECULARLY TARGETED THERAPY; NUDE MOUSE; PATHOLOGY; PROCEDURES; TREATMENT OUTCOME; TUMOR CELL LINE;

ANIMALS; ANTIGENS, SURFACE; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; GLUTAMATE CARBOXYPEPTIDASE II; HUMANS; IMMUNOTHERAPY; MALE; MICE; MICE, NUDE; MOLECULAR TARGETED THERAPY; NEOPLASM METASTASIS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME;

EID: 85038859482     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2017.12.008     Document Type: Article

References (10)

1. Drake, C.G., Prostate cancer as a model for tumor immunotherapy. Nat Rev Immunol 10 (2010), 580–593.
2. Kantoff, P.W., Higano, C.S., Shore, N.D., et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 363 (2008), 411–422.
3. Gulley, J.L., Arlen, P.M., Madan, R.A., et al. Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic castrate-resistant prostate cancer. Cancer Immunol Immunother 59 (2010), 663–674.
4. Schellhammer, P.F., Chodak, G., Whitmore, J.B., Sims, R., Frohlich, M.W., Kantoff, P.W., Lower baseline prostate-specific antigen is associated with a greater overall survival benefit from sipuleucel-T in the immunotherapy for prostate adenocarcinoma treatment (IMPACT) trial. Urology 81 (2013), 1297–1302.
5. Ananias, H.J.K., van den Heuvel, M.C., Helfrich, W., De Jong, I.J., Expression of the gastrin-releasing peptide receptor, the prostate stem cell antigen and the prostate-specific membrane antigen in lymph node and bone metastases of prostate cancer. Prostate 69 (2009), 1101–1108.
6. Maher, J., Brentjens, R.J., Gunset, G., Riviere, I., Sadelain, M., Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta/CD28 receptor. Nat Biotechnol 20 (2002), 70–75.
7. Zhang, Q., Yang, X.J., Kundu, S.D., et al. Blockade of transforming growth factor-{beta} signaling in tumor-reactive CD8(+) T cells activates the antitumor immune response cycle. Mol Cancer Ther 5 (2006), 1733–1743.
8. Zhang, Q., Yang, X., Pins, M., et al. Adoptive transfer of tumor-reactive transforming growth factor-beta-insensitive CD8+ T cells: eradication of autologous mouse prostate cancer. Cancer Res 65 (2005), 1761–1769.
9. Chen, W., Ten Dijke, P., Immunoregulation by members of the TGFβ superfamily. Nat Rev Immunol 16 (2016), 723–740.
10. Klebanoff, C.A., Gattinoni, L., Restifo, N.P., CD8+ T-cell memory in tumor immunology and immunotherapy. Immunol Rev 211 (2006), 214–224.