Multitarget therapy for maintenance treatment of lupus nephritis

Journal of the American Society of Nephrology

Volumn 28, Issue 12, 2017, Pages 3671-3678

  Zhang, Haitao ^a   Liu, Zhengzhao ^a   Zhou, Minlin ^a   Liu, Zhangsuo ^b   Chen, Jianghua ^c   Xing, Changying ^d   Lin, Hongli ^e   Ni, Zhaohui ^f   Fu, Ping ^g   Liu, Fuyou ^h   Chen, Nan ⁱ   He, Yongcheng ^j   Liu, Jianshe ^k   Zeng, Caihong ^a   Liu, Zhihong ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b ZHENGZHOU UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY   (China)

^d THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^e DALIAN MEDICAL UNIVERSITY   (China)

^f Department of Nephrology ^*  (United States)

^g SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^h SICHUAN UNIVERSITY   (China)

ⁱ CENTRAL SOUTH UNIVERSITY   (China)

^j THE FIRST AFFILIATED HOSPITAL OF SHENZHEN UNIVERSITY   (China)

^k HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CREATININE; CYCLOPHOSPHAMIDE; HEMOGLOBIN; MYCOPHENOLATE MOFETIL; PREDNISONE; PROTEIN; RETINOL BINDING PROTEIN; SERUM ALBUMIN; TACROLIMUS; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID;

ADULT; ALBUMIN BLOOD LEVEL; ARTICLE; BONE NECROSIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; GASTROINTESTINAL SYMPTOM; HERPES SIMPLEX; HERPES ZOSTER; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TUBULE FUNCTION; LEUKOPENIA; LIVER DYSFUNCTION; LUPUS ERYTHEMATOSUS NEPHRITIS; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; MENSTRUATION DISORDER; MULTICENTER STUDY; PNEUMONIA; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RANDOMIZED CONTROLLED TRIAL; RECURRENCE RISK; RELAPSE; SLEDAI; THERAPEUTIC INDEX; TREATMENT DURATION; TREATMENT OUTCOME; UPPER RESPIRATORY TRACT INFECTION; URINARY TRACT INFECTION; ADOLESCENT; AGED; CHINA; CLINICAL TRIAL; COMBINATION DRUG THERAPY; DRUG EFFECTS; KIDNEY; MIDDLE AGED; RECURRENT DISEASE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AZATHIOPRINE; CHINA; CYCLOPHOSPHAMIDE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; LUPUS NEPHRITIS; MALE; MIDDLE AGED; MYCOPHENOLIC ACID; PREDNISONE; RECURRENCE; TACROLIMUS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 85038423330     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2017030263     Document Type: Article

References (23)

1. Appel GB, Contreras G, Dooley MA, Ginzler EM, Isenberg D, Jayne D, Li LS, Mysler E, Sánchez-Guerrero J, Solomons N, Wofsy D; Aspreva Lupus Management Study Group: Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis. J Am Soc Nephrol 20: 1103-1112, 2009
2. Chan TM, Li FK, Tang CS,Wong RW, Fang GX, Ji YL, Lau CS,Wong AK, Tong MK, Chan KW, Lai KN; Hong Kong-Guangzhou Nephrology Study Group: Efficacy of mycophenolatemofetil in patients with diffuse proliferative lupus nephritis. N Engl J Med 343: 1156-1162, 2000
3. Dooley MA, Jayne D, Ginzler EM, Isenberg D, Olsen NJ, Wofsy D, Eitner F, Appel GB, Contreras G, Lisk L, Solomons N; ALMS Group: Mycophenolate versus azathioprine as maintenance therapy for lupus nephritis. N Engl J Med 365: 1886-1895, 2011
4. Liu Z, Zhang H, Liu Z, Xing C, Fu P, Ni Z, Chen J, Lin H, Liu F, He Y, He Y, Miao L, Chen N, Li Y, Gu Y, Shi W, HuW, Liu Z, Bao H, Zeng C, Zhou M: Multitarget therapy for induction treatment of lupus nephritis: A randomized trial. Ann Intern Med 162: 18-26, 2015
5. Chan TM, Tse KC, Tang CS, Mok MY, Li FK; Hong Kong Nephrology StudyGroup: Long-term study ofmycophenolatemofetil as continuous induction and maintenance treatment for diffuse proliferative lupus nephritis. J AmSoc Nephrol 16: 1076-1084, 2005
6. ACCESS Trial Group: Treatment of lupus nephritis with abatacept: The Abatacept and Cyclophosphamide Combination Efficacy and Safety Study. Arthritis Rheumatol 66: 3096-3104, 2014
7. Stone JH, Merkel PA, Spiera R, Seo P, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Turkiewicz A, Tchao NK,Webber L, Ding L, Sejismundo LP, Mieras K, Weitzenkamp D, Ikle D, Seyfert-Margolis V, Mueller M, Brunetta P, Allen NB, Fervenza FC, Geetha D, Keogh KA, Kissin EY, Monach PA, Peikert T, Stegeman C, Ytterberg SR, Specks U; RAVE-ITN Research Group: Rituximab versus cyclophosphamide for ANCA-associated vasculitis. N Engl J Med 363: 221-232, 2010
8. Specks U, Merkel PA, Seo P, Spiera R, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Fessler BJ, Ding L, Viviano L, Tchao NK, Phippard DJ, Asare AL, Lim N, Ikle D, Jepson B, Brunetta P, Allen NB, Fervenza FC, Geetha D, Keogh K, Kissin EY, Monach PA, Peikert T, Stegeman C, Ytterberg SR, Mueller M, Sejismundo LP, Mieras K, Stone JH; RAVE-ITN Research Group: Efficacy of remission-induction regimens for ANCA-associated vasculitis. N Engl J Med 369: 417-427, 2013
9. NaesensM, Kuypers DR, SarwalM:Calcineurin inhibitor nephrotoxicity. Clin J Am Soc Nephrol 4: 481-508, 2009
10. Bock ME, Cohn RA, Ali FN: Treatment of childhood nephrotic syndrome with long-term, low-dose tacrolimus. Clin Nephrol 79: 432-438, 2013
11. Yuan H, Liu N, Sun GD, Jia Y, Luo P, Miao LN: Effect of prolonged tacrolimus treatment in idiopathic membranous nephropathy with nephrotic syndrome. Pharmacology 91: 259-266, 2013
12. El Hachmi M, Jadoul M, Lefèbvre C, Depresseux G, Houssiau FA: Relapses of lupus nephritis: Incidence, risk factors, serology and impact on outcome. Lupus 12: 692-696, 2003
13. Gibson KL, Gipson DS, Massengill SA, Dooley MA, Primack WA, Ferris MA, Hogan SL: Predictors of relapse and end stage kidney disease in proliferative lupus nephritis: Focus on children, adolescents, and young adults. Clin J Am Soc Nephrol 4: 1962-1967, 2009
14. Houssiau FA, D'Cruz D, Sangle S, Remy P, Vasconcelos C, Petrovic R, Fiehn C, de Ramon Garrido E, Gilboe IM, Tektonidou M, Blockmans D, Ravelingien I, le Guern V, Depresseux G, Guillevin L, Cervera R; MAINTAIN Nephritis Trial Group: Azathioprine versus mycophenolate mofetil for long-term immunosuppression in lupus nephritis: Results from the MAINTAIN nephritis trial. Ann Rheum Dis 69: 2083-2089, 2010
15. IlleiGG, Takada K, ParkinD, Austin HA, CraneM, Yarboro CH, Vaughan EM, Kuroiwa T, Danning CL, Pando J, Steinberg AD, Gourley MF, Klippel JH, BalowJE, BoumpasDT: Renal flares are common in patients with severe proliferative lupus nephritis treated with pulse immunosuppressive therapy: Long-term followup of a cohort of 145 patients participating in randomized controlled studies. Arthritis Rheum 46: 995-1002, 2002
16. Chen YE, Korbet SM, Katz RS, Schwartz MM, Lewis EJ; Collaborative Study Group: Value of a complete or partial remission in severe lupus nephritis. Clin J Am Soc Nephrol 3: 46-53, 2008
17. Chen W, Liu Q, Chen W, Tang X, Fu P, Liu F, Liao Y, Yang Z, Zhang J, Chen J, Lou T, Fu J, Kong Y, Liu Z, Li Z, Yu X:Outcomes of maintenance therapy with tacrolimus versus azathioprine for active lupus nephritis: A multicenter randomized clinical trial. Lupus 21: 944-952, 2012
18. Ferguson RM, Rynasiewicz JJ, SutherlandDE, Simmons RL,Najarian JS: Cyclosporin A in renal transplantation: A prospective randomized trial. Surgery 92: 175-182, 1982
19. Vincenti F, Laskow DA, Neylan JF, Mendez R, Matas AJ: One-year follow-up of an open-label trial of FK506 for primary kidney transplantation. A report of the U.S. multicenter FK506 kidney transplant group. Transplantation 61: 1576-1581, 1996
20. Moroni G, Doria A, Mosca M, Alberighi OD, Ferraccioli G, Todesco S, Manno C, Altieri P, Ferrara R, Greco S, Ponticelli C: A randomized pilot trial comparing cyclosporine and azathioprine for maintenance therapy in diffuse lupus nephritis over four years. Clin J AmSocNephrol 1: 925-932, 2006
21. Ekberg H, Tedesco-Silva H, Demirbas A, Vítko S, Nashan B, Gürkan A, Margreiter R, Hugo C, Grinyó JM, Frei U, Vanrenterghem Y, Daloze P, Halloran PF; ELITE-Symphony Study: Reduced exposure to calcineurin inhibitors in renal transplantation.NEngl J Med 357: 2562-2575, 2007
22. Ekberg H, Bernasconi C, Tedesco-SilvaH, Vítko S,Hugo C,Demirbas A, Acevedo RR, Grinyó J, Frei U, Vanrenterghem Y, Daloze P, Halloran P: Calcineurin inhibitor minimization in the Symphony study: Observational results 3 years after transplantation. Am J Transplant 9: 1876-1885, 2009
23. Sinclair A, Appel G, Dooley MA, Ginzler E, Isenberg D, Jayne D, Wofsy D, Solomons N: Mycophenolate mofetil as induction and maintenance therapy for lupus nephritis: Rationale and protocol for the randomized, controlled Aspreva Lupus Management Study (ALMS). Lupus 16: 972-980, 2007