Concerted action of dipeptidyl peptidase IV and glutaminyl cyclase results in formation of pyroglutamate-modified amyloid peptides in vitro

Neurochemistry International

Volumn 113, Issue , 2018, Pages 112-119

  Antonyan, Alvard ^a   Schlenzig, Dagmar ^b   Schilling, Stephan ^b   Naumann, Marcel ^b   Sharoyan, Svetlana ^a   Mardanyan, Sona ^a   Demuth, Hans Ulrich ^b  

^a H Buniatian Institute of Biochemistry National Academy of Sciences of Armenia   (Armenia)

^b FRAUNHOFER INSTITUTE FOR CELL THERAPY AND IMMUNOLOGY   (Germany)

Author keywords

Amyloid beta peptides; Dipeptidyl peptidase IV; Enzyme substrate interactions; Glutaminyl cyclase; MALDI TOF mass spectrometry

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; DIPEPTIDYL PEPTIDASE IV; GLUTAMIC ACID; GLUTAMINYL CYCLASE; LYASE; MONOMER; PYROGLUTAMIC ACID; UNCLASSIFIED DRUG; AMINOACYLTRANSFERASE; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); AMYLOID BETA-PROTEIN (3-42), PYROGLUTAMYL(3)-; DPP4 PROTEIN, HUMAN; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; PEPTIDE FRAGMENT; PROTEIN AGGREGATE;

ALZHEIMER DISEASE; ARTICLE; CATALYSIS; CONTROLLED STUDY; CYCLIZATION; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; INCUBATION TIME; IONIZATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PH; PRIORITY JOURNAL; PROTEIN AGGREGATION; AMINO ACID SEQUENCE; ANIMAL; BOVINE; DRUG EFFECT; GENETICS; HUMAN; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; PROCEDURES;

AMINO ACID SEQUENCE; AMINOACYLTRANSFERASES; AMYLOID BETA-PEPTIDES; ANIMALS; CATTLE; DIPEPTIDYL PEPTIDASE 4; HUMANS; PEPTIDE FRAGMENTS; PROTEIN AGGREGATES; PYRROLIDONECARBOXYLIC ACID; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 85037981685     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2017.12.001     Document Type: Article

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