Prospects for passive immunity to prevent HIV infection

PLoS Medicine

Volumn 14, Issue 11, 2017, Pages

  Morris, Lynn ^a,b   Mkhize, Nonhlanhla N ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

10 E8; BISPECIFIC ANTIBODY; CABOTEGRAVIR; CD4 ANTIBODY; GLYCOPROTEIN GP 120; NEUTRALIZING ANTIBODY; PGDM 1400; UNCLASSIFIED DRUG; VRC 01; VRC 07 523; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY;

ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIRETROVIRAL THERAPY; ARTICLE; DRUG EFFICACY; DRUG POTENCY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION PREVENTION; LONG TERM CARE; PASSIVE IMMUNIZATION; PHAGOCYTOSIS; POST EXPOSURE PROPHYLAXIS; PRE-EXPOSURE PROPHYLAXIS; VIRUS NEUTRALIZATION; BLOOD; DRUG EFFECTS; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; PROCEDURES; TRENDS;

HIV ANTIBODIES; HIV INFECTIONS; HIV-1; HUMANS; IMMUNIZATION, PASSIVE;

EID: 85036581055     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1002436     Document Type: Article

References (24)

1. UNAIDS. Fact sheet—Latest statistics on the status of the AIDS epidemic. [cited 22 September 2017]. http://www.unaids.org/en/resources/fact-sheet
2. Corey L, Gray GE, Preventing acquisition of HIV is the only path to an AIDS-free generation. Proc Natl Acad Sci U S A. 2017;114(15):3798–800. doi: 10.1073/pnas.1703236114 28360202
3. Graham BS, Ambrosino DM, History of passive antibody administration for prevention and treatment of infectious diseases. Curr Opin HIV AIDS. 2015;10(3):129–34. doi: 10.1097/COH.0000000000000154 25760933
4. Pegu A, Hessell AJ, Mascola JR, Haigwood NL, Use of broadly neutralizing antibodies for HIV-1 prevention. Immunol Rev. 2017;275(1):296–312. doi: 10.1111/imr.12511 28133803
5. Bar KJ, Sneller MC, Harrison LJ, Justement JS, Overton ET, Petrone ME, et al. Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption. N Engl J Med. 2016;375(21):2037–50. doi: 10.1056/NEJMoa1608243 27959728
6. Caskey M, Klein F, Lorenzi JC, Seaman MS, West AP, JrBuckley N, et al. Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature. 2015;522(7557):487–91. doi: 10.1038/nature14411 25855300
7. Lynch RM, Boritz E, Coates EE, DeZure A, Madden P, Costner P, et al. Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection. Sci Transl Med. 2015;7(319):319ra206. doi: 10.1126/scitranslmed.aad5752 26702094
8. Wu X, Yang Z-Y, Li Y, Hogerkorp C-M, Schief WR, Seaman MS, et al. Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1. Science. 2010;329(5993):856–61. doi: 10.1126/science.1187659 20616233
9. Ledgerwood JE, Coates EE, Yamshchikov G, Saunders JG, Holman L, Enama ME, et al. Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults. Clin Exp Immunol. 2015;182(3):289–301. doi: 10.1111/cei.12692 26332605
10. Mayer KH, Seaton KE, Huang Y, Grunenberg N, Isaacs A, Allen M, et al. Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial. PLoS Med. 2017;14(11):e1002435. https://doi.org/10.1371/journal.pmed.1002435
11. Coleen K, Cunningham EJM, Capparelli EV, Muresan P, Perlowski C, Valentine M, et al. Safety and pharmacokinetics of the monoclonal antibody, VRC01, in HIV-exposed newborns. Conference on Retroviruses and Opportunistic Infections (CROI). 2017. Poster P1112: http://impaactnetwork.org/publications/croi2017.html
12. The AMP HIV Prevention Study. [cited 22 September 2017]. https://ampstudy.org.za/
13. Rudicell RS, Kwon YD, Ko SY, Pegu A, Louder MK, Georgiev IS, et al. Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo. J Virol. 2014;88(21):12669–82. doi: 10.1128/JVI.02213-14 25142607
14. Ko SY, Pegu A, Rudicell RS, Yang ZY, Joyce MG, Chen X, et al. Enhanced neonatal Fc receptor function improves protection against primate SHIV infection. Nature. 2014;514(7524):642–5. doi: 10.1038/nature13612 25119033
15. Julg B, Tartaglia LJ, Keele BF, Wagh K, Pegu A, Sok D, et al. Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge. Sci Transl Med. 2017;9(406):eaal1321. doi: 10.1126/scitranslmed.aal1321 28878010
16. Huang J, Kang BH, Ishida E, Zhou T, Griesman T, Sheng Z, et al. Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth. Immunity. 2016;45(5):1108–21. doi: 10.1016/j.immuni.2016.10.027 27851912
17. Bournazos S, Gazumyan A, Seaman MS, Nussenzweig MC, Ravetch JV, Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency. Cell. 2016;165(7):1609–20. doi: 10.1016/j.cell.2016.04.050 27315478
18. Huang Y, Yu J, Lanzi A, Yao X, Andrews CD, Tsai L, et al. Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity. Cell. 2016;165(7):1621–31. doi: 10.1016/j.cell.2016.05.024 27315479
19. Xu L, Pegu A, Rao E, Doria-Rose N, Beninga J, McKee K, et al. Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques. Science. 2017;358:85–90. doi: 10.1126/science.aan8630 28931639
20. Wagh K, Bhattacharya T, Williamson C, Robles A, Bayne M, Garrity J, et al. Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection. PLoS Pathog. 2016;12(3):e1005520. doi: 10.1371/journal.ppat.1005520 27028935
21. Hankins CA, Dybul MR, The promise of pre-exposure prophylaxis with antiretroviral drugs to prevent HIV transmission: a review. Current opinion in HIV and AIDS. 2013Jan;8(1):50–8. doi: 10.1097/COH.0b013e32835b809d 23201856. Epub 2012/12/04. eng.
22. Hessell AJ, Hangartner L, Hunter M, Havenith CE, Beurskens FJ, Bakker JM, et al. Fc receptor but not complement binding is important in antibody protection against HIV. Nature. 2007;449(7158):101–4. doi: 10.1038/nature06106 17805298
23. Abela IA, Berlinger L, Schanz M, Reynell L, Gunthard HF, Rusert P, et al. Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies. PLoS Pathog. 2012;8(4):e1002634. doi: 10.1371/journal.ppat.1002634 22496655
24. Brady JM, Baltimore D, Balazs AB, Antibody gene transfer with adeno-associated viral vectors as a method for HIV prevention. Immunol Rev. 2017;275(1):324–33. doi: 10.1111/imr.12478 28133808