Human umbilical cord mesenchymal stem cells alleviate interstitial fibrosis and cardiac dysfunction in a dilated cardiomyopathy rat model by inhibiting TNF-α and TGF-β1/ERK1/2 signaling pathways

Molecular Medicine Reports

Volumn 17, Issue 1, 2018, Pages 71-78

  Zhang, Changyi ^a   Zhou, Guichi ^a   Chen, Yezeng ^a   Liu, Sizheng ^a   Chen, Fen ^b,c   Xie, Lichun ^b,c   Wang, Wei ^a   Zhang, Yonggang ^a   Wang, Tianyou ^c   Lai, Xiulan ^a   Ma, Lian ^a,b,d  

^a SHANTOU UNIVERSITY   (China)

^b Maternal and Child Health Care Hospital of Pingshan District   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d SHENZHEN UNIVERSITY   (China)

Author keywords

Cardiac dysfunction; Dilated cardiomyopathy; Human umbilical cord mesenchymal stem cells; Tgf 1 signaling; TNF

Indexed keywords

CARDIAC MYOSIN; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 3; MOLECULAR MARKER; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL WALL THICKNESS; ARTICLE; CARDIOVASCULAR PARAMETERS; COMPARATIVE STUDY; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; DIASTOLE; FIBROSING ALVEOLITIS; HEART FUNCTION; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE WALL; HEART MUSCLE FIBROSIS; HUMAN; HUMAN CELL; INTERVENTRICULAR SEPTAL THICKNESS; LEFT VENTRICULAR DIMENSION IN END DIASTOLE; LEFT VENTRICULAR DIMENSION IN END SYSTOLE; LEFT VENTRICULAR FRACTIONAL SHORTENING; LEFT VENTRICULAR POSTERIOR WALL THICKNESS; MALE; MAPK SIGNALING; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PROTEIN EXPRESSION; RAT; STEM CELL CULTURE; SYSTOLE; THERAPY EFFECT; TWO DIMENSIONAL ECHOCARDIOGRAPHY; WESTERN BLOTTING; WHARTON JELLY; ADULT; ANIMAL; CARDIAC MUSCLE; CYTOLOGY; DISEASE MODEL; FEMALE; FIBROSIS; HEART FUNCTION TEST; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PREGNANCY; UMBILICAL CORD;

ADULT; ANIMALS; CARDIOMYOPATHY, DILATED; DISEASE MODELS, ANIMAL; FEMALE; FIBROSIS; HEART FUNCTION TESTS; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MYOCARDIUM; PREGNANCY; RATS; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL CORD;

EID: 85035062579     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2017.7882     Document Type: Article

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