Live-Attenuated Influenza Vaccine Effectiveness in Children From 2009 to 2015-2016: A Systematic Review and Meta-Analysis

Open Forum Infectious Diseases

Volumn 4, Issue 3, 2017, Pages

  Caspard, Herve ^a   Mallory, Raburn M ^a   Yu, Jing ^a   Ambrose, Christopher S ^a  

^a MEDIMMUNE   (United States)

Author keywords

children; influenza; live attenuated influenza vaccine (LAIV); meta analysis; vaccine effectiveness

Indexed keywords

EID: 85034981851     PISSN: None     EISSN: 23288957     Source Type: Journal    
DOI: 10.1093/OFID/OFX111     Document Type: Review

References (52)

1. Belshe RB, Mendelman PM, Treanor J, et al. The efficacy of live attenuated, coldadapted, trivalent, intranasal influenza virus vaccine in children. N Engl J Med 1998; 338:1405-12.
2. Bracco Neto H, Farhat CK, Tregnaghi MW, et al. Efficacy and safety of 1 and 2 doses of live attenuated influenza vaccine in vaccine-naive children. Pediatr Infect Dis J 2009; 28:365-71.
3. Forrest BD, Pride MW, Dunning AJ, et al. Correlation of cellular immune responses with protection against culture-confirmed influenza virus in young children. Clin Vaccine Immunol 2008; 15:1042-53.
4. Lum LC, Borja-Tabora CF, Breiman RF, et al. Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children. Vaccine 2010; 28:1566-74.
5. Tam JS, Capeding MR, Lum LC, et al. Efficacy and safety of a live attenuated, coldadapted influenza vaccine, trivalent against culture-confirmed influenza in young children in Asia. Pediatr Infect Dis J 2007; 26:619-28.
6. Vesikari T, Fleming DM, Aristegui JF, et al. Safety, efficacy, and effectiveness of cold-adapted influenza vaccine-trivalent against community-acquired, culture-confirmed influenza in young children attending day care. Pediatrics 2006; 118:2298-312.
7. Ashkenazi S, Vertruyen A, Arístegui J, et al. Superior relative efficacy of live attenuated influenza vaccine compared with inactivated influenza vaccine in young children with recurrent respiratory tract infections. Pediatr Infect Dis J 2006; 25:870-9.
8. Belshe RB, Edwards KM, Vesikari T, et al. Live attenuated versus inactivated influenza vaccine in infants and young children. N Engl J Med 2007; 356:685-96.
9. Fleming DM, Crovari P, Wahn U, et al. Comparison of the efficacy and safety of live attenuated cold-adapted influenza vaccine, trivalent, with trivalent inactivated influenza virus vaccine in children and adolescents with asthma. Pediatr Infect Dis J 2006; 25:860-9.
10. Belongia EA, Kieke BA, Donahue JG, et al. Effectiveness of inactivated influenza vaccines varied substantially with antigenic match from the 2004-2005 season to the 2006-2007 season. J Infect Dis 2009; 199:159-67.
11. Eisenberg KW, Szilagyi PG, Fairbrother G, et al. Vaccine effectiveness against laboratory-confirmed influenza in children 6 to 59 months of age during the 2003-2004 and 2004-2005 influenza seasons. Pediatrics 2008; 122:911-9.
12. Griffin MR, Monto AS, Belongia EA, et al. Effectiveness of non-adjuvanted pandemic influenza A vaccines for preventing pandemic influenza acute respiratory illness visits in 4 U.S. communities. PLoS One 2011; 6:e23085.
13. Hadler JL, Baker TN, Papadouka V, et al. Effectiveness of 1 dose of 2009 influenza A (H1N1) vaccine at preventing hospitalization with pandemic H1N1 influenza in children aged 7 months-9 years. J Infect Dis 2012; 206:49-55.
14. Uzicanin A, Thompson M, Smith P, et al. Effectiveness of 1 dose of influenza A (H1N1) 2009 monovalent vaccines in preventing reverse-transcription polymerase chain reaction-confirmed H1N1 infection among school-aged children in Maine. J Infect Dis 2012; 206:1059-68.
15. Grohskopf LA, Olsen SJ, Sokolow LZ, et al. Prevention and control of seasonal influenza with vaccines: Recommendations of the Advisory Committee on Immunization Practices (ACIP)-United States, 2014-15 influenza season. Am J Transplant 2014; 14:2906-13.
16. Grohskopf LA, Sokolow LZ, Olsen SJ, et al. Prevention and control of influenza with vaccines: recommendations of the advisory committee on immunization practices, United States, 2015-16 influenza season. MMWR Morb Mortal Wkly Rep 2015; 64:818-25.
17. Grohskopf LA, Sokolow LZ, Broder KR, et al. Prevention and control of seasonal influenza with vaccines. MMWR Recomm Rep 2016; 65:1-54.
18. Foppa IM, Ferdinands JM, Chaves SS, et al. The case test-negative design for studies of the effectiveness of influenza vaccine in inpatient settings. Int J Epidemiol 2016; 45:2052-9.
19. Katz J. Prevention and control of influenza: information for the vaccine and related biological products advisory committee. 2015; Available at: http://www.fda.gov/downloads/ AdvisoryCommittees/CommitteesMeetingMaterials/BloodVaccinesandOtherBiologics/ VaccinesandRelatedBiologicalProductsAdvisoryCommittee/UCM437587.pdf. Accessed 15 February 2017.
20. Osterholm MT, Kelley NS, Sommer A, Belongia EA. Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis. Lancet Infect Dis 2012; 12:36-44.
21. Ambrose CS, Wu X, Knuf M, Wutzler P. The efficacy of intranasal live attenuated influenza vaccine in children 2 through 17 years of age: a meta-analysis of 8 randomized controlled studies. Vaccine 2012; 30:886-92.
22. Pebody R, Sile B, Warburton F, et al. Live attenuated influenza vaccine effectiveness against hospitalisation due to laboratory-confirmed influenza in children two to six years of age in England in the 2015/16 season. Euro Surveill 2017; 22:pii30450.
23. National Services Scotland. Flu vaccine effectiveness in Scottish primary school age children from the 2015/16 season. Available at: http://www.hps.scot.nhs.uk/ resourcedocument.aspx?id=5529. Accessed 21 February 2017.
24. Kwong JC, Pereira JA, Quach S, et al. Randomized evaluation of live attenuated vs. inactivated influenza vaccines in schools (RELATIVES) cluster randomized trial: pilot results from a household surveillance study to assess direct and indirect protection from influenza vaccination. Vaccine 2015; 33:4910-5.
25. Loeb M, Russell ML, Manning V, et al. Live attenuated versus inactivated influenza vaccine in Hutterite children: a cluster randomized blinded trial. Ann Intern Med 2016; 165:617-24.
26. Brooks WA, Zaman K, Lewis KD, et al. Efficacy of a Russian-backbone live attenuated influenza vaccine among young children in Bangladesh: a randomised, double-blind, placebo-controlled trial. Lancet Glob Health 2016; 4:e946-54.
27. Victor JC, Lewis KD, Diallo A, et al. Efficacy of a Russian-backbone live attenuated influenza vaccine among children in Senegal: a randomised, double-blind, placebo-controlled trial. Lancet Glob Health 2016; 4:e955-65.
28. Caspard H, Coelingh KL, Mallory RM, Ambrose CS. Association of vaccine handling conditions with effectiveness of live attenuated influenza vaccine against H1N1pdm09 viruses in the United States. Vaccine 2016; 34:5066-72.
29. Isakova-Sivak I. Use of live attenuated influenza vaccines in young children in resource-poor settings. Lancet Glob Health 2016; 4:e879-80.
30. Cotter CR, Jin H, Chen Z. A single amino acid in the stalk region of the H1N1pdm influenza virus HA protein affects viral fusion, stability and infectivity. PLoS Pathog 2014; 10:e1003831.
31. Klick B, Durrani S, Chan KH, et al. Live attenuated seasonal and pandemic influenza vaccine in school-age children: a randomized controlled trial. Vaccine 2013; 31:1937-43.
32. Treanor JJ, Talbot HK, Ohmit SE, et al. Effectiveness of seasonal influenza vaccines in the United States during a season with circulation of all three vaccine strains. Clin Infect Dis 2012; 55:951-9.
33. Ohmit SE, Thompson MG, Petrie JG, et al. Influenza vaccine effectiveness in the 2011-2012 season: protection against each circulating virus and the effect of prior vaccination on estimates. Clin Infect Dis 2014; 58:319-27.
34. McLean HQ, Thompson MG, Sundaram ME, et al. Influenza vaccine effectiveness in the United States during 2012-2013: variable protection by age and virus type. J Infect Dis 2015; 211:1529-40.
35. Gaglani M, Pruszynski J, Murthy K, et al. Influenza vaccine effectiveness against 2009 pandemic influenza A(H1N1) virus differed by vaccine type during 2013-2014 in the United States. J Infect Dis 2016; 213:1546-56.
36. Flannery B, Clippard J. End-of-season influenza vaccine effectiveness estimates for the 2014-15 season: US influenza vaccine effectiveness (Flu VE) network. In: Meeting of the Advisory Committee on Immunization Practices (ACIP); June 24, 2015; Atlanta, GA.
37. Flannery B, Chung J. Influenza vaccine effectiveness, including LAIV vs IIV in children and adolescents, US Flu VE Network, 2015-16. In: Centers for Disease Control and Prevention Advisory Committee on Immunization Practices (ACIP) Meeting, June 22-23, 2016; Atlanta, GA. Available at: https://www.cdc.gov/ vaccines/acip/meetings/downloads/slides-2016-06/influenza-05-flannery.pdf. Accessed 26 April 2017.
38. Eick-Cost AA, Tastad KJ, Guerrero AC, et al. Effectiveness of seasonal influenza vaccines against influenza-associated illnesses among US military personnel in 2010-11: a case-control approach. PLoS One 2012; 7:e41435.
39. MacIntosh VH, Tastad KJ, Eick-Cost AA. Mid-season influenza vaccine effectiveness 2011-2012: a Department of Defense global, laboratory-based, influenza surveillance system case-control study estimate. Vaccine 2013; 31:1651-5.
40. Eick-Cost AA, Hu Z, Cooper MJ, et al. Mid-season influenza vaccine effectiveness for the 2012-2013 influenza season. MSMR 2013; 20:15-6.
41. Cost AA, Hiser MJ, Hu Z, et al. Brief report: mid-season influenza vaccine effectiveness estimates for the 2013-2014 influenza season. MSMR 2014; 21:15-7.
42. Helmeke C, Gräfe L, Irmscher HM, et al. Effectiveness of the 2012/13 trivalent live and inactivated influenza vaccines in children and adolescents in Saxony-Anhalt, Germany: a test-negative case-control study. PLoS One 2015; 10:e0122910.
43. Helmeke C. [Effektivität der Influenza-Impfstoffe bei Kindern in Sachsen-Anhalt und Niedersachsen 2015/16]. Available at: http://www.verbraucherschutz. sachsen-anhalt.de/fileadmin/Bibliothek/Politik-und-Verwaltung/ MS/LAV-Verbraucherschutz/hygiene/influenza/Effektivitaet-der- Influenzaimpfstoffe-2015-16.pdf. Accessed 15 February 2017.
44. Skowronski DM, Chambers C, Sabaiduc S, et al. Integrated sentinel surveillance linking genetic, antigenic, and epidemiologic monitoring of influenza vaccine-virus relatedness and effectiveness during the 2013-2014 influenza season. J Infect Dis 2015; 212:726-39.
45. Skowronski D. Live attenuated influenza vaccine (LAIV) vs. inactivated influenza vaccine (IIV): summary of effectiveness evidence since 2009. In: National Advisory Committee on Immunization (NACI) International Working Group; February 10-11, 2016; Ottawa, Ontario.
46. Ohmit SE, Petrie JG, Malosh RE, et al. Substantial influenza vaccine effectiveness in households with children during the 2013-2014 influenza season, when 2009 pandemic influenza A (H1N1) virus predominated. J Infect Dis 2016; 213:1229-36.
47. Caspard H, Gaglani M, Clipper L, et al. Effectiveness of live attenuated influenza vaccine and inactivated influenza vaccine in children 2-17 years of age in 2013-2014 in the United States. Vaccine 2016; 34:77-82.
48. Caspard H, Gaglani M, Clipper L, et al. Multicenter study of live-attenuated influenza vaccine effectiveness in children, 2014-15. Open Forum Infect Dis 2015; 2:1352.
49. Ambrose CS. 2015-16 US Influenza Vaccine Effectiveness Influenza Clinical Investigation for Children (ICICLE) Study. In: Advisory Committee on Immunization Practices; June 22-23, 2016; Atlanta, GA. Available at: https:// www.cdc.gov/vaccines/acip/meetings/downloads/slides-2016-06/influenza- 06-ambrose.pdf.
50. Pebody R, Warburton F, Andrews N, et al. Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 end of season results. Euro Surveill 2015; 20: doi: 10.2807/1560-7917.ES.2015.20.36.30013.
51. Pebody R, Warburton F, Ellis J, et al. Effectiveness of seasonal influenza vaccine for adults and children in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 end-of-season results. Euro Surveill 2016; 21: doi: 10.2807/1560-7917.ES.2016.21.38.30348.
52. Nohynek H, Baum U, Syrjänen R, et al. Effectiveness of the live attenuated and the inactivated influenza vaccine in two-year-olds-a nationwide cohort study Finland, influenza season 2015/16. Euro Surveill 2016; 21: doi: 10.2807/1560-7917.ES.2016.21.38.30346.