Randomized evaluation of live attenuated vs. inactivated influenza vaccines in schools (RELATIVES) cluster randomized trial: Pilot results from a household surveillance study to assess direct and indirect protection from influenza vaccination

Vaccine

Volumn 33, Issue 38, 2015, Pages 4910-4915

  Kwong, Jeffrey C ^a,b,c,d,e   Pereira, Jennifer A ^a   Quach, Susan ^a   Pellizzari, Rosana ^f   Dusome, Edwina ^f   Russell, Margaret L ^g   Hamid, Jemila S ^h,i   Feinberg, Yael ^a   Winter, Anne Luise ^a   Gubbay, Jonathan B ^a,d   Sirtonski, Brittany ^a   Moher, Deanna ^a   Sider, Doug ^a   Finkelstein, Michael ^b,j   Loeb, Mark ^h  

^a PUBLIC HEALTH ONTARIO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c INSTITUTE FOR CLINICAL EVALUATIVE SCIENCES   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY HEALTH NETWORK   (Canada)

^f Peterborough County City Health Unit   (Canada)

^g UNIVERSITY OF CALGARY   (Canada)

^h MCMASTER UNIVERSITY   (Canada)

ⁱ ST MICHAEL'S HOSPITAL   (Canada)

^j TORONTO PUBLIC HEALTH   (Canada)

more..

Author keywords

Canada; Influenza; Influenza vaccines; Live vaccines; Ontario

Indexed keywords

INACTIVATED INFLUENZA VACCINE; INACTIVATED VACCINE; INFLUENZA VACCINE; UNCLASSIFIED DRUG; LIVE VACCINE;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CLINICAL ASSESSMENT; CLINICAL EVALUATION; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SURVEILLANCE; FEMALE; HOUSEHOLD; HUMAN; INCIDENCE; INFECTION PREVENTION; INFLUENZA; INFLUENZA A VIRUS (H1N1); INFLUENZA B; INFLUENZA VACCINATION; MAJOR CLINICAL STUDY; MALE; OPEN STUDY; OUTCOME ASSESSMENT; PRIMARY SCHOOL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL; SEASONAL VARIATION; VIRUS EXAMINATION; EPIDEMIOLOGICAL MONITORING; FAMILY SIZE; IMMUNOLOGY; INFANT; INFLUENZA, HUMAN; MIDDLE AGED; ONTARIO; PRESCHOOL CHILD; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; EPIDEMIOLOGICAL MONITORING; FAMILY CHARACTERISTICS; FEMALE; HUMANS; INCIDENCE; INFANT; INFLUENZA VACCINES; INFLUENZA, HUMAN; MALE; MIDDLE AGED; ONTARIO; SCHOOLS; TREATMENT OUTCOME; VACCINES, ATTENUATED; VACCINES, INACTIVATED; YOUNG ADULT;

EID: 84940726187     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2015.07.044     Document Type: Article

References (23)

1. Brownstein J.S., Kleinman K.P., Mandl K.D. Identifying pediatric age groups for influenza vaccination using a real-time regional surveillance system. Am J Epidemiol 2005, 162(7):686-693.
2. Fox J.P., Cooney M.K., Hall C.E., Foy H.M. Influenzavirus infections in Seattle families, 1975-1979. II. Pattern of infection in invaded households and relation of age and prior antibody to occurrence of infection and related illness. Am J Epidemiol 1982, 116(2):228-242.
3. Glezen W.P., Couch R.B. Interpandemic influenza in the Houston area, 1974-76. N Engl J Med 1978, 298(11):587-592.
4. Monto A.S., Koopman J.S., Longini I.M. Tecumseh study of illness. XIII. Influenza infection and disease, 1976-1981. Am J Epidemiol 1985, 121(6):811-822.
5. Poehling K.A., Talbot H.K., Williams J.V., Zhu Y., Lott J., Patterson L., et al. Impact of a school-based influenza immunization program on disease burden: comparison of two Tennessee counties. Vaccine 2009, 27(20):2695-2700.
6. Loeb M., Russell M.L., Moss L., Fonseca K., Fox J., Earn D.J., et al. Effect of influenza vaccination of children on infection rates in Hutterite communities: a randomized trial. JAMA 2010, 303(10):943-950.
7. Basta N.E., Chao D.L., Halloran M.E., Matrajt L., Longini I.M. Strategies for pandemic and seasonal influenza vaccination of schoolchildren in the United States. Am J Epidemiol 2009, 170(6):679-686.
8. Longini I.M., Halloran M.E. Strategy for distribution of influenza vaccine to high-risk groups and children. Am J Epidemiol 2005, 161(4):303-306.
9. King J.C., Stoddard J.J., Gaglani M.J., Moore K.A., Magder L., McClure E., et al. Effectiveness of school-based influenza vaccination. N Engl J Med 2006, 355(24):2523-2532.
10. National Vaccine Advisory Committee The promise and challenge of adolescent immunization. Am J Prev Med 2008, 35(2):152-157.
11. Sales J.M., Painter J.E., Pazol K., Gargano L.M., Orenstein W., Hughes J.M., et al. Rural parents' vaccination-related attitudes and intention to vaccinate middle and high school children against influenza following educational influenza vaccination intervention. Hum Vaccin 2011, 7(11):1146-1152.
12. Painter J.E., Sales J.M., Pazol K., Wingood G.M., Windle M., Orenstein W.A., et al. Adolescent attitudes toward influenza vaccination and vaccine uptake in a school-based influenza vaccination intervention: a mediation analysis. J Sch Health 2011, 81(6):304-312.
13. Ambrose C.S., Luke C., Coelingh K. Current status of live attenuated influenza vaccine in the United States for seasonal and pandemic influenza. Influenza Other Respir Viruses 2008, 2(6):193-202.
14. Ashkenazi S., Vertruyen A., Aristegui J., Esposito S., McKeith D.D., Klemola T., et al. Superior relative efficacy of live attenuated influenza vaccine compared with inactivated influenza vaccine in young children with recurrent respiratory tract infections. Pediatr Infect Dis J 2006, 25(10):870-879.
15. Fleming D.M., Crovari P., Wahn U., Klemola T., Schlesinger Y., Langussis A., et al. Comparison of the efficacy and safety of live attenuated cold-adapted influenza vaccine, trivalent, with trivalent inactivated influenza virus vaccine in children and adolescents with asthma. Pediatr Infect Dis J 2006, 25(10):860-869.
16. Belshe R.B., Toback S.L., Yi T., Ambrose C.S. Efficacy of live attenuated influenza vaccine in children 6 months to 17 years of age. Influenza Other Respir Viruses 2010, 4(3):141-145.
17. Rhorer J., Ambrose C.S., Dickinson S., Hamilton H., Oleka N.A., Malinoski F.J., et al. Efficacy of live attenuated influenza vaccine in children: a meta-analysis of nine randomized clinical trials. Vaccine 2009, 27(7):1101-1110.
18. Kwong J.C., Pereira J.A., Quach S., Pellizzari R., Dusome E., Russell M.L., et al. Randomized evaluation of live attenuated vs. inactivated influenza vaccines in schools (RELATIVES) pilot study: a cluster randomized trial. Vaccine 2015, 33(4):535-541.
19. Duncan C., Guthrie J.L., Tijet N., Elgngihy N., Turenne C., Seah C., et al. Analytical and clinical validation of novel real-time reverse transcriptase-polymerase chain reaction assays for the clinical detection of swine-origin H1N1 influenza viruses. Diagn Microbiol Infect Dis 2011, 69(2):167-171.
20. Hurwitz E.S., Haber M., Chang A., Shope T., Teo S., Ginsberg M., et al. Effectiveness of influenza vaccination of day care children in reducing influenza-related morbidity among household contacts. JAMA 2000, 284(13):1677-1682.
21. Ghendon Y.Z., Kaira A.N., Elshina G.A. The effect of mass influenza immunization in children on the morbidity of the unvaccinated elderly. Epidemiol Infect 2006, 134(1):71-78.
22. Glezen W.P., Gaglani M.J., Kozinetz C.A., Piedra P.A. Direct and indirect effectiveness of influenza vaccination delivered to children at school preceding an epidemic caused by 3 new influenza virus variants. J Infect Dis 2010, 202(11):1626-1633.
23. Piedra P.A., Gaglani M.J., Kozinetz C.A., Herschler G.B., Fewlass C., Harvey D., et al. Trivalent live attenuated intranasal influenza vaccine administered during the 2003-2004 influenza type A (H3N2) outbreak provided immediate, direct, and indirect protection in children. Pediatrics 2007, 120(3):e553-e564.