Enteral nutritional therapy for induction of remission in Crohn's disease

Cochrane Database of Systematic Reviews

Volumn 2018, Issue 4, 2018, Pages

  Narula, Neeraj ^a   Dhillon, Amit ^b   Zhang, Dongni ^c   Sherlock, Mary E ^d   Tondeur, Melody ^e   Zachos, Mary ^d  

^a MCMASTER UNIVERSITY   (Canada)

^b NORTHERN ONTARIO SCHOOL OF MEDICINE   (Canada)

^c WESTERN UNIVERSITY   (Canada)

^d MCMASTER CHILDREN S HOSPITAL   (Canada)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; TRIACYLGLYCEROL; PARENTERAL SOLUTION;

BLOATING; CROHN DISEASE; CROHN DISEASE ACTIVITY INDEX; DIARRHEA; ENTERIC FEEDING; FAT CONTENT; FLATULENCE; HEARTBURN; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INTENTION TO TREAT ANALYSIS; LIPID COMPOSITION; MUSCLE WEAKNESS; NAUSEA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REMISSION; REVIEW; RISK ASSESSMENT; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW; TREATMENT OUTCOME; VOMITING; ANALYSIS; ELEMENTAL DIET; META ANALYSIS; PROCEDURES;

ADRENAL CORTEX HORMONES; CROHN DISEASE; ENTERAL NUTRITION; FOOD, FORMULATED; HUMANS; INTENTION TO TREAT ANALYSIS; PARENTERAL NUTRITION SOLUTIONS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REMISSION INDUCTION;

EID: 85034961657     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD000542.pub3     Document Type: Review

References (105)

1. Akobeng AK, Miller V, Stanton J, Elbadri AM, Thomas AG. Double-blind randomized controlled trial of glutamine-enriched polymeric diet in the treatment of active Crohn's disease. Journal of Pediatriatric Gastroenterology and Nutrition 2000;30(1):78-84. 7779337
2. Bamba T, Shimoyama T, Sasaki M, Tsujikawa T, Fukuda Y, Koganei K, et al. Dietary fat attenuates the benefits of an elemental diet in active Crohn's disease: a randomized, controlled trial. European Journal of Gastroenterology & Hepatology 2003;15(2):151-7. 7779339
3. Borrelli O, Cordischi L, Cirulli M, Paganelli M, Labalestra V, Uccini S, et al. Polymeric diet alone versus corticosteroids in the treatment of active pediatric Crohn's disease: a randomized controlled open-label trial. Clinical Gastroenterology and Hepatology 2006;4(6):744-53. 7779341
4. Gassull A, Fernandez-Banares F, Cabre E, Papo M, Giaffer MH, Sanchez-Lombrana JL, et al. Fat composition is the differential factor to explain the primary therapeutic effect of enteral nutrition in Crohn's disease. Results of a double-blind, randomized, multicenter European trial. Gastroenterology 2000;118:A117. 7779343
5. Gassull MA, Fernandez-Banares F, Cabre E, Papo M, Giaffer MH, Sanchez-Lombrana JL, et al. Fat composition may be a clue to explain the primary therapeutic effect of enteral nutrition in Crohn's disease: results of a double blind randomised multicentre European trial. Gut 2002;51(2):164-8. 7779344
6. Giaffer MH, North G, Holdsworth CD. Controlled trial of polymeric versus elemental diet in treatment of active Crohn's disease. Lancet 1990;335(8693):816-9. 7779346
7. Gonzalez-Huix F, Leon R, Acero D, Esteve M, Figa M, Abad A, et al. Total enteral nutrition with polymeric diets (TENP) as primary treatment in Crohn's disease (CD). Preliminary results of a controlled trial [abstract]. Clinical Nutrition 1991;10:47. 7779348
8. Gonzalez-Huix F, de Leon R, Fernandez-Banares F, Esteve M, Cabre E, Acero D, et al. Polymeric enteral diets as primary treatment of active Crohn's disease: a prospective steroid controlled trial. Gut 1993;34(6):778-82. 7779349
9. Griffiths AM, Pendley F, Issenman R, Cockram D, Jacobsen K, Kelley MJ, et al. Elemental versus polymeric nutrition as primary therapy of active Crohn's disease: a multi-centre pediatric randomized controlled trial. Journal of Pediatric Gastroenterology and Nutrition 2000;31(Suppl 2):S75. 7779351
10. Grogan JL, Casson DH, Terry A, Burdge GC, El-Matary W, Dalzell AM. Enteral feeding therapy for newly diagnosed pediatric Crohn's disease: A double-blind randomized controlled trial with two years follow-up. Inflammatory Bowel Diseases 2012;18(2):246-53. 7779353
11. Kobayashi K, Katsumata T, Yokoyama K, Takahashi H, Igarashi M, Saigenji K. A randomized controlled study of total parenteral nutrition and enteral nutrition by elemental and polymeric diet as primary therapy in active phase of Crohn's disease. Nippon Shokakibyo Gakkai Zasshi 1998;95(11):1212-21. 7779355
12. Leiper K, Woolner J, Mullan MM, Parker T, van der Vliet M, Fear S, et al. A randomised controlled trial of high versus low long chain triglyceride whole protein feed in active Crohn's disease. Gut 2001;49(6):790-4. 7779357
13. Lindor KD, Fleming CR, Burnes JU, Nelson JK, Ilstrup DM. A randomized prospective trial comparing a defined formula diet, corticosteroids, and a defined formula diet plus corticosteroids in active Crohn's disease. Mayo Clinic Proceedings 1992;67(4):328-33. 7779359
14. Lochs H, Steinhardt HJ, Klaus-Wentz B, Zeitz M, Vogelsang H, Sommer H, et al. Comparison of enteral nutrition and drug treatment in active Crohn's disease. Results of the European Cooperative Crohn's Disease Study. IV. Gastroenterology 1991;101(4):881-8. 7779361
15. Malchow H, Steinhardt HJ, Lorenz-Meyer H, Strohm WD, Rasmussen S, Sommer H, et al. Feasibility and effectiveness of a defined-formula diet regimen in treating active Crohn's disease. European Cooperative Crohn's Disease Study III. Scandinavian Journal of Gastroenterology 1990;25(3):235-44. 7779363
16. Mansfield JC, Giaffer MH, Holdsworth CD. Controlled trial of oligopeptide versus amino acid diet in treatment of active Crohn's disease. Gut 1995;36(1):60-6. 7779365
17. Mantzaris GJ, Archavlis E, Amberiadis P, Kourtessas D, Triantafullou G. A Prospective Randomized Trial in Active Crohn's Disease Comparing prednisolone, a Polymeric Diet and a Polymeric Diet Plus Prednisolon [abstract]. Gut 1996;39 Suppl 3:A166. 7779367
18. Mantzaris GJ, Archavlis E, Amperiadis P, Kourtessas D, Triantafyllou G. A randomized prospective trial in active Crohn's disease comparing a polymeric diet, prednisolone and a polymeric diet plus prednisolone. Gastroenterology 1996;110(4):A955. 7779368
19. Middleton SJ, Rucker JT, Kirby GA, Riordan AM, Hunter JO. Long-chain triglycerides reduce the efficacy of enteral feeds in patients with active Crohn's disease. Clinical Nutrition 1995;14(4):229-36. 7779370
20. Park RH, Galloway A, Danesh B, Russell RI. Double blind trial comparing elemental and polymeric diet as primary therapy for active Crohn's disease [abstract]. Clinical Nutrition 1989;8:79. 7779372
21. Park RH, Galloway A, Danesh B, Russell RI. Double blind trial comparing elemental and polymeric diet as primary treatment for active Crohns's disease [abstract]. Gut 1989;30 Suppl 10:A1453. 7779373
22. Park RH, Galloway A, Danesh BJ, Russell RI. Double-blind controlled trial of elemental and polymeric diets as primary therapy in active Crohn's disease. European Journal of Gastroenterology and Hepatology 1991;3(6):483-9. 7779374
23. Pigneur B, Garnier-Lengline H, Lepage P, Schmitz J, Goulet O, Dore J. Effect of exclusive enteral nutrition on the course of CD and intestinal microbiota. Journal of Crohn's and Colitis 2014;8:S433. 7779376
24. Raouf AH, Hildrey V, Daniel J, Walker RJ, Krasner N, Elias E, et al. Enteral feeding as sole treatment for Crohn's disease: controlled trial of whole protein versus amino acid based feed and a case study of dietary challenge. Gut 1991;32(6):702-7. 7779378
25. Rigaud D, Cosnes J, Le Quintrec Y, Rene E, Gendre JP, Mignon M. Controlled trial comparing two types of enteral nutrition in treatment of active Crohn's disease: elemental versus polymeric diet. Gut 1991;32(12):1492-7. 7779380
26. Royall D, Jeejeebhoy KN, Baker JP, Allard JP, Habal FM, Cunnane SC, et al. Comparison of amino acid versus peptide based enteral diets in active Crohn's disease: clinical and nutritional outcome. Gut 1994;35(6):783-7. 7779382
27. Sakurai T, Matsui T, Yao T, Takagi Y, Hirai F, Aoyagi K, et al. Short-term efficacy of enteral nutrition in the treatment of active Crohn's disease: a randomized, controlled trial comparing nutrient formulas. JPEN Journal of Parenteral and Enteral Nutrition 2002;26(2):98-103. 7779384
28. Saverymuttu S, Hodgson HJ, Chadwick VS. Controlled trial comparing prednisolone with an elemental diet plus non-absorbable antibiotics in active Crohn's disease. Gut 1985;26(10):994-8. 7779386
29. Seidman EG, Lohoues MJ, Turgeon J, Bouthillier L, Morin CL. Elemental diet versus prednisone as initial therapy in Crohn's disease: early and long-term results. Gastroenterology 1991;100:150A. 7779388
30. Seidman EG, Bouthillier L, Thibault L, Lepage G, Chartre M, Deslandres C, et al. Clinical & nutritional parameters in Crohn's disease patients treated with either an n-3 PUFA-enriched semi-elemental or a polymeric diet. Results of a randomized controlled trial. Journal of Pediatric Gastroenterology and Nutrition 2003;37(3):393. 7779390
31. Terrin G, Canani RB, Ambrosini A, Viola F, De Mesquita MB, Di Nardo G, et al. A semielemental diet (Pregomin) as primary therapy for inducing remission in children with active Crohn's disease. Italian Journal of Pediatrics 2002;28(5):401-5. 7779392
32. Verma S, Brown S, Giaffer MH. Elemental versus polymeric diet in treatment of active Crohn's disease: A double-blind randomised trial. Gut 1997;41(Suppl 3):A226. 7779394
33. Verma S, Brown S, Giaffer MH. Randomised double-blind trial of polymeric versus elemental diet in treatment of active Crohn's disease. Gut 1997;40(Suppl 1):A19. 7779395
34. Verma S, Brown S, Kirkwood B, Giaffer MH. Polymeric versus elemental diet as primary treatment in active Crohn's disease: a randomized, double-blind trial. American Journal of Gastroenterology 2000;95(3):735-9. 7779396
35. Afzal NA, Davies S, Paintin M, Arnaud-Battandier F, Walker-Smith JA, Murch S, et al. Colonic Crohn's disease in children does not respond well to treatment with enteral nutrition if the ileum is not involved. Digestive Diseases and Sciences 2005;50(8):1471-5. 7779398
36. Akobeng AI, Clayton PE, Miller V, Hall CM, Thomas AG. Low serum concentrations of insulin-like growth factor-I in children with active Crohn disease: effect of enteral nutritional support and glutamine supplementation. Scandinavian Journal of Gastroenterology 2002;37:1422-7. 7779400
37. Berni Canani R, Terrin G, Borrelli O, Romano MT, Manguso F, Coruzzo A, et al. Short- and long-term therapeutic efficacy of nutritional therapy and corticosteroids in paediatric Crohn's disease. Digestive and Liver Disease 2006;38(6):381-7. 7779402
38. Buchanan E, Gaunt WW, Cardigan T, Garrick V, McGrogan P, Russell RK. The use of exclusive enteral nutrition for induction of remission in children with Crohn's disease demonstrates that disease phenotype does not influence clinical remission. Alimentary Pharmacology & Therapeutics 2009;30(5):501-7. 7779404
39. Chiang NYZ, Haslinger T, Richman E, Rhodes JM, Leiper K. Efficacy of enteral feeding with modulen in adults with Crohn's disease: A retrospective study. Gut 2009;58:A97. 7779406
40. Day AS, Whitten KE, Lemberg DA, Clarkson C, Vitug-Sales M, Jackson R, et al. Exclusive enteral feeding as primary therapy for Crohn's disease in Australian children and adolescents: A feasible and effective approach. Journal of Gastroenterology and Hepatology 2006;21(10):1609-14. 7779408
41. Engelman JL, Black L, Murphy GM, Sladen GE. Comparison of a semi-elemental diet (peptamen) with prednisolone in the primary treatment of active ileal Crohn's disease. Gastroenterology 1993;104:697A. 7779410
42. Gassull A, Fernandez-Banares F, Cabre E, Papo M, Giaffer MH, Sanchez-Lombrana JL, et al. Fat composition is the differential factor to explain the primary therapeutic effect of enteral nutrition in Crohn's disease. Results of a double-blind, randomized, multicenter European trial. Gastroenterology 2000;118:A117. 7779412
43. Giffin N, Grant A, Mahdi G, Rashid M, Otley AR. Exclusive enteral nutrition optimizes growth outcomes versus corticosteroid therapy for pediatric Crohn's disease. Gastroenterology 2014;5(Suppl 1):S-217. 7779414
44. Goncalves JP, Quaresma L, Rego H, Ratola A, Tavares M, Trindade E, et al. Steroids may reduce the benefit of exclusive enteral feeding in paediatric Crohn's disease. Journal of Crohn's and Colitis 2014;8:S207. 7779416
45. Gorard DA, Hunt JB, Payne-James JJ, Palmer KR, Rees RG, Clark ML, et al. Initial response and subsequent course of Crohn's disease treated with elemental diet or prednisolone. Gut 1993;34(9):1198-202. 7779418
46. Hunt JB, Payne-James JJ. A randomised controlled trial of elemental diet versus prednisolone in treatment of new and recurrent Crohn's disease [abstract]. Clinical Science 1989;77 Suppl 2:26p. 7779420
47. Hunt JB, Payne-James JJ, Palmer KR, Kumar PK, Clark M L, Farthing MJ. A randomised controlled trial of elemental diet versus prednisolone in the treatment of new & recurrent Crohns disease [abstract]. Clinical Nutrition 1989;8:80. 7779419
48. Grover Z, Muir R, Lewindon P. A prospective study of new cases of paediatric Crohn's disease treated with exclusive enteral nutrition: Early clinical, biochemical, mucosal and transmural outcomes. Gastroenterology 2012;142(5 Suppl. 1):S76-7. 7779422
49. Gunasekera AV, Rajendran N, Mendall MA, Kumar D. An igg4 specific food exclusion diet improves both clinical disease activity and quality of life in Crohn's disease; a randomised sham diet controlled study. Gastroenterology 2012;1:S567. 7779424
50. Hirakawa H, Fukuda Y, Tanida N, Hosomi M, Shimoyama T. Home elemental enteral hyperalimentation (HEEH) for the maintenance of remission in patients with Crohn's disease. Gastroenterologia Japonica 1993;28(3):379-84. 7779426
51. Johnson T, Macdonald S, Hill SM, Thomas A, Murphy MS. Treatment of active Crohn's disease in children using partial enteral nutrition with liquid formula: a randomised controlled trial. Gut 2006;55(3):356-61. 7779428
52. Jones VA. Comparison of total parenteral nutrition and elemental diet in induction of remission of Crohn's disease. Long-term maintenance of remission by personalized food exclusion diets. Digestive Diseases and Sciences 1987;32(12 Supplement):100S-7S. 7779430
53. Klerkus J, Szymanska S, Szczepanski M, Wiernicka A, Szymanska E, Matuszczyk M, et al. The efficacy of total enteral nutrition in inducing remission and improving nutritional status in children with moderate to severe Crohn's disease. Przeglad Gastroenterologiczny 2013;8(1):57-61. 7779432
54. Levine A, Turner D, Gik TP, Dias JA, Veres G, Shaoul R, et al. Comparison of outcomes parameters for induction of remission in new onset pediatric Crohn's disease: Evaluation of the Porto IBD group "Growth relapse and outcomes with therapy" (GROWTH-CD) study. Inflammatory Bowel Diseases 2014;20:278-85. 7779434
55. Ludvigsson JF, Krantz M, Bodin L, Stenhammar L, Lindquist B. Elemental versus polymeric enteral nutrition in paediatric Crohn's disease: a multicentre randomized controlled trial. Acta Paediatrica 2004;93(3):327-35. 7779436
56. Middleton SJ, Riordan AM, Hunter JO. Comparison of elemental and peptide-based diets in the treatment of acute Crohn's disease. Italian Journal of Gastroenterology 1991;23:609. 7779438
57. Munkholm Larsen P, Rasmussen D, Ronn B, Munck O, Elmgreen J, Binder V. Elemental diet: a therapeutic approach in chronic inflammatory bowel disease. Journal of Internal Medicine 1989;225(5):325-31. 7779440
58. Navas Lopez VM, Blasco Alonso J, Sierra Salinas C, Barco Galvez A, Vicioso Recio MI. Efficacy of exclusive enteral feeding as primary therapy for paediatric Crohn's disease. Anales de Pediatria 2008;69(6):506-14. 7779442
59. O'Morain C, Segal AW, Levi AJ. Elemental diet as primary treatment of acute Crohn's disease: a controlled trial. British Medical Journal 1984;288(6434):1859-62. 7779444
60. Otley AR, Grant A, Giffin N, Rashid M, Mahdi G, Van Limbergen J. Steroids No More! exclusive enteral nutrition therapy in pediatric patients with Crohn's disease results in long-term avoidance of corticosteroid therapy. Gastroenterology 2015;1:S72. 7779446
61. Papadopoulou A, Rawashdeh MO, Brown GA, McNeish AS, Booth IW. Remission following an elemental diet or prednisolone in Crohn's disease. Acta Paediatrica 1995;84(1):79-83. 7779448
62. Rabast U, Heskamp R. Adjuvant therapy with elemental diet in chronic inflammatory intestinal diseases. Comparative study. Deutsche Medizinische Wochenschrift 1986;111(8):293-7. 7779450
63. Riordan AM, Hunter JO, Cowan RE, Crampton J R, Davidson AR, Dickinson RJ. Treatment of active Crohn's disease by exclusion diet: East Anglian multicentre controlled trial. Lancet 1993;342:1131-4. 7779452
64. Ruuska T, Savilahti E, Maki M, Ormala T, Visakorpi JK. Exclusive whole protein enteral diet versus prednisolone in the treatment of acute Crohn's disease in children. Journal of Pediatric Gastroenterology and Nutrition 1994;19(2):175-80. 7779454
65. Sanderson IR, Udeen S, Davies PS, Savage MO, Walker-Smith JA. Remission induced by an elemental diet in small bowel Crohn's disease. Archives of Disease in Childhood 1987;62(2):123-27. 7779456
66. Seidman EG, Grifftiths AM, Jones A, Issenman R. Semi-elemental diet versus prednisone in pediatric Crohn's disease. Gastroenterology 1993;104:A778. 7779458
67. Sigall-Boheh R, Pfeffer-Gik T, Segal I, Zangen T, Boaz M, Levine A. Partial enteral nutrition with a Crohn's disease exclusion diet is effective for induction of remission in children and young adults with Crohn's disease. Inflammatory Bowel Diseases 2014;20:1353-60. 7779460
68. Sökülmez P, Demirba AE, Arslan P, Diibeyaz S. Effects of enteral nutritional support on malnourished patients with inflammatory bowel disease by subjective global assessment. Turkish Journal of Gastroenterology 2014;25(5):493-507. 7779462
69. Soo J, Malik BA, Turner JM, Persad R, Wine E, Siminoski K, et al. Use of exclusive enteral nutrition is just as effective as corticosteroids in newly diagnosed pediatric Crohn's disease. Digestive Diseases and Sciences 2013;58:3584-91. 7779464
70. Thomas AG, Taylor F, Miller V. Dietary intake and nutritional treatment in childhood Crohn's disease. Journal of Pediatric Gastroenterology and Nutrition 1993;17(1):75-81. 7779466
71. Ueki M, Matsui T, Yamada M, Sakurai T, Yao T, Okada M, et al. Randomized controlled trial of amino acid based diet versus oligopeptide based diet in enteral nutritional therapy of active Crohn's disease. Nippon Shokakibyo Gakkai Zasshi 1994;91(9):1415-25. 7779468
72. Watanabe O, Ando T, Ishiguro K, Takahashi H, Ishikawa D, Miyake N, et al. Enteral nutrition decreases hospitalization rate in patients with Crohn's disease. Journal of Gastroenterology and Hepatology 2010;25(Suppl 1):S134-7. 7779470
73. Zoli G, Care M, Falco F, Parazza M, Spano C, Gasbarrini G. Effect of oral elemental diet on nutritional status, intestinal permeability and disease activity in Crohn's patients. Gastroenterology 1996;110(4):A1054. 7779472
74. Zoli G, Care M, Parazza M, Spano C, Biagi PL, Bernardi M, et al. A randomized controlled study comparing elemental diet and steroid treatment in Crohn's disease. Alimentary Pharmacology and Therapeutics 1997;11(4):735-40. 7779474
75. NCT00265772. Phase IV Study Comparing a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis. clinicaltrials.gov/show/NCT00265772 (accessed 3 August 2017). 7779476
76. NCT01728870. Comparison of Partial Enteral Nutririon (Modulen) With a Unique Diet to Exclusive Enteral Nutrition (Modulen) for the Treatment of Pediatric Crohn's Disease. A Prospective Randomized Controlled Trial. clinicaltrials.gov/show/NCT01728870 (accessed 3 August 2017). 7779478
77. NCT02056418. A Randomized, Controlled, Single-blind Study of Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult. clinicaltrials.gov/show/NCT02056418 (accessed 23 July 2017). 7779480
78. NCT02231814. Pilot Study of Partial Enteral Nutrition With a Unique Diet for the Treatment of Adult Patients With Crohn's Disease. clinicaltrials.gov/show/NCT02231814 (accessed 3 August 2017). 7779482
79. NCT02843100. Diet for Induction and Maintenance of Remission and Re-biosis in Crohn's Disease. clinicaltrials.gov/show/NCT02843100 (accessed 3 August 2017). 7779484
80. NCT03176875. Comparison of Partial and Exclusive Enteral Nutrition in the Treatment of Active Childhood-onset Crohn's Disease. clinicaltrials.gov/show/NCT03176875 accessed 3 bAugust 2017. 7779486
81. Afzal NA, Van Der Zaag-Loonen HJ, Arnaud-Battandier F, Davies S, Murch S, Derkx B, et al. Improvement in quality of life of children with acute Crohn's disease does not parallel mucosal healing after treatment with exclusive enteral nutrition. Alimententary Pharmacology & Therapeutics 2004;20(2):167-72.
82. Afzal NA, Fagbemi A, Arnaud-Battandier F, Paintin M, Thomson M, Walker-Smith JA, et al. Enteral nutrition treats children with chronic Crohn's disease more effectively if the ileum is also involved. Archives of Disease in Childhood 2005;86(Suppl 1):A22.
83. Fell JM, Paintin M, Arnaud-Battandier F, Beattie RM, Hollis A, Kitching P, et al. Mucosal healing and a fall in mucosal pro-inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn's disease. Alimentary & Pharmacologic Therapeutics 2000;14(3):281-9.
84. Fernandez-Banares F, Cabre E, Esteve-Comas M, Gassull MA. How effective is enteral nutrition in inducing clinical remission in active Crohn's disease? A meta-analysis of the randomized clinical trials. JPEN Journal of Parenteral and Enteral Nutrition 1995;19(5):356-64.
85. Griffiths AM, Ohlsson A, Sherman PM, Sutherland LR. Meta-analysis of enteral nutrition as a primary treatment of active Crohn's disease. Gastroenterology 1995;108(4):1056-67.
86. Guyatt GH, Oxman, AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2003;327(7414):557-60.
87. Heuschkel RB, Menache CC, Megerian JT, Baird AE. Enteral nutrition and corticosteroids in the treatment of acute Crohn's disease in children. Journal of Pediatric Gastroenterology and Nutrition 2000;31(1):8-15.
88. Higgins JPT, Altman DG, Sterne JAC (editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
89. Kansal S, Wagner J, Kirkwood CD, Catto-Smith AG. Enteral nutrition in Crohn's disease: an underused therapy. Gastroenterology Research and Practice 2013;2013:482108.
90. Knight C, El-Matary W, Spray C, Sandhu BK. Long-term outcome of nutritional therapy in paediatric Crohn's disease. Clinical Nutrition 2005;24(5):775-9.
91. Landi B, Ahn TN, Cortot A, Soule JC, Rene E, Gendre JP, et al. Endoscopic monitoring of Crohn's disease treatment: a prospective, randomized clinical trial. Gastroenterology 1992;102(5):1647-53.
92. Levine A, Milo T, Buller H, Markowitz J. Consensus and controversy in the management of pediatric Crohn disease: an international survey. Journal of Pediatric Gastroenterology and Nutrition 2003;36(4):464-9.
93. Messori A, Trallori G, D'Albrasio G, Milla M, Vannozzi G, Pacini F. Defined-formula diets versus steroids in the treatment of active Crohn's disease: a meta-analysis. Scandinavian Journal of Gastroenterology 1996;31(3):267-72.
94. Modigliani R, Mary JY, Simon JF, Cortot A, Soule JC, Gendre JP, et al. Clinical, biological and endoscopic picture of attacks of Crohn's disease. Evolution on prednisolone. Gastroenterology 1990;98(4):811-8.
95. Rubio A, Pigneur B, Garnier-Lengline H, Talbotec C, Schmitz J, Canioni D, et al. The efficacy of exclusive nutritional therapy in paediatric Crohn's disease, comparing fractionated oral vs. continuous enteral feeding. Alimentary Pharmacology & Therapeutics 2011;33(12):1332-9.
96. Ruemmele FM, Veres G, Kolho KL, Griffiths A, Levine A, Escher JC, et al. Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease. Journal of Crohn's & Colitis 2014;8(10):1179-207.
97. Sandborn WJ, Feagan BG, Hanauer SB, Lochs H, Lofberg R, Modigliani R, et al. A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease. Gastroenterology 2002;122(2):512-30.
98. Sanderson IR, Croft NM. The anti-inflammatory effects of enteral nutrition. JPEN Journal of Parenteral and Enteral Nutrition 2005;29(4 Suppl):S134-8.
99. Schunemann HJ, Oxman AD, Vist GE, Higgins JPT, Deeks JJ, Glasziou P, et al. Chapter 12: Interpreting results and drawing conclusions. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
100. Takagi S, Utsunomiya K, Kuriyama S, Yokoyama H, Takahashi S, Iwabuchi M, et al. Effectiveness of an 'half elemental diet' as maintenance therapy for Crohn's disease: A randomized-controlled trial. Alimentary & Pharmacology Therapeutics 2006;24(9):1333-40.
101. Voitk AJ, Echave V, Feller JH, Brown RA, Gurd FN. Experience with elemental diet in the treatment of inflammatory bowel disease. Is this a primary therapy?. Archives of Surgery 1973;107(2):329-33.
102. Wilschanski M, Sherman P, Pencharz P, Davis L, Corey M, Griffiths A. Supplementary enteral nutrition maintains remission in paediatric Crohn's disease. Gut 1996;38(4):543-8.
103. Yamamoto T, Nakahigashi M, Saniabadi AR, Iwata T, Maruyama Y, Umegae S, et al. Impacts of long-term enteral nutrition on clinical and endoscopic disease activities and mucosal cytokines during remission in patients with Crohn's disease: A prospective study. Inflammatory Bowel Disease 2007;13(12):1493-1501.
104. Zachos M, Tondeur M, Griffiths AM. Enteral nutritional therapy for inducing remission of Crohn's disease. Cochrane Database of Systematic Reviews 2001, Issue 3. [DOI: 10.1002/14651858.CD000542]
105. Zachos M, Tondeur M, Griffiths AM. Enteral nutritional therapy for induction of remission in Crohn's disease. Cochrane Database of Systematic Reviews 2007, Issue 1. [DOI: 10.1002/14651858.CD000542.pub2]