Antibiotic treatment at delivery shapes the initial oral microbiome in neonates

Scientific Reports

Volumn 7, Issue , 2017, Pages

  Gomez Arango, Luisa F ^a,b   Barrett, Helen L ^a,b,c   McIntyre, H David ^a   Callaway, Leonie K ^a,b,c   Morrison, Mar ^a   Nitert, Marloes Dekker ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BETA LACTAMASE; RNA 16S; VIM-1 METALLO-BETA-LACTAMASE;

BACILLALES; BETA-LACTAM RESISTANCE; BIRTH; CLASSIFICATION; COHORT ANALYSIS; FEMALE; GENETICS; HUMAN; ISOLATION AND PURIFICATION; LACTOBACILLALES; MATERNAL EXPOSURE; MICROBIOLOGY; MICROFLORA; MOUTH; NEWBORN; OBESITY; PHYSIOLOGY; PLACENTA; PREGNANCY; PROTEOBACTERIA; STREPTOCOCCACEAE;

ANTI-BACTERIAL AGENTS; BACILLALES; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; COHORT STUDIES; FEMALE; HUMANS; INFANT, NEWBORN; LACTOBACILLALES; MATERNAL EXPOSURE; MICROBIOTA; MOUTH; OBESITY; PARTURITION; PLACENTA; PREGNANCY; PROTEOBACTERIA; RNA, RIBOSOMAL, 16S; STREPTOCOCCACEAE;

EID: 85034450161     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep43481     Document Type: Article

References (61)

1. Romano-Keeler, J. & Weitkamp, J. H. Maternal influences on fetal microbial colonization and immune development. Pediatric research 77, 189-195, doi: 10.1038/pr.2014.163 (2015).
2. Jimenez, E. et al. Is meconium from healthy newborns actually sterile? Research in microbiology 159, 187-193, doi: 10.1016/j. resmic.2007.12.007 (2008).
3. Moles, L. et al. Bacterial diversity in meconium of preterm neonates and evolution of their fecal microbiota during the first month of life. PLoS One 8, e66986, doi: 10.1371/journal.pone.0066986 (2013).
4. Gosalbes, M. J. et al. Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology 43, 198-211, doi: 10.1111/cea.12063 (2013).
5. Oh, K. J. et al. Detection of ureaplasmas by the polymerase chain reaction in the amniotic fluid of patients with cervical insufficiency. Journal of perinatal medicine 38, 261-268, doi: 10.1515/jpm.2010.040 (2010).
6. Aagaard, K. et al. The placenta harbors a unique microbiome. Science translational medicine 6, 237ra265, doi: 10.1126/scitranslmed.3008599 (2014).
7. Antony, K. M. et al. The preterm placental microbiome varies in association with excess maternal gestational weight gain. American journal of obstetrics and gynecology 212, 653.e651-616, doi: 10.1016/j.ajog.2014.12.041 (2015).
8. Amarasekara, R., Jayasekara, R. W., Senanayake, H. & Dissanayake, V. H. Microbiome of the placenta in pre-eclampsia supports the role of bacteria in the multifactorial cause of pre-eclampsia. The journal of obstetrics and gynaecology research 41, 662-669, doi: 10.1111/jog.12619 (2015).
9. Steel, J. H. et al. Bacteria and inflammatory cells in fetal membranes do not always cause preterm labor. Pediatric research 57, 404-411, doi: 10.1203/01.pdr.0000153869.96337.90 (2005).
10. Gomez de Aguero, M. et al. The maternal microbiota drives early postnatal innate immune development. Science (New York, N.Y.) 351, 1296-1302, doi: 10.1126/science.aad2571 (2016).
11. Chu, D. M. et al. The early infant gut microbiome varies in association with a maternal high-fat diet. Genome medicine 8, 77, doi: 10.1186/s13073-016-0330-z (2016).
12. Ajslev, T. A., Andersen, C. S., Gamborg, M., Sorensen, T. I. & Jess, T. Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics. International journal of obesity (2005) 35, 522-529, doi: 10.1038/ijo.2011.27 (2011).
13. Mueller, N. T. et al. Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity. Int J Obes (Lond) 39, 665-670, doi: 10.1038/ijo.2014.180 (2015).
14. Algert, C. S., McElduff, A., Morris, J. M. & Roberts, C. L. Perinatal risk factors for early onset of Type 1 diabetes in a 2000-2005 birth cohort. Diabetic medicine: a journal of the British Diabetic Association 26, 1193-1197, doi: 10.1111/j.1464-5491.2009.02878.x (2009).
15. Alexandra, E. Livanos, T. U. G., Pajau Vangay, Wimal Pathmasiri, Delisha Stewart, Susan McRitchie, Huilin Li, Jennifer Chung, Jiho Sohn, Sara Kim, Zhan Gao, Cecily Barber, Joanne Kim, Sandy Ng, Arlin B. Rogers, Susan Sumner, Xue-Song Zhang, Ken Cadwell, Dan Knights, Alexander Alekseyenko, Fredrik Bäckhed & Martin J. Blaser. Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Nature microbiology (2016).
16. Kero, J. et al. Mode of delivery and asthma-is there a connection? Pediatric research 52, 6-11, doi: 10.1203/00006450-200207000-00004 (2002).
17. Roduit, C. et al. Asthma at 8 years of age in children born by caesarean section. Thorax 64, 107-113, doi: 10.1136/thx.2008.100875 (2009).
18. Borre, Y. E. et al. Microbiota and neurodevelopmental windows: implications for brain disorders. Trends in molecular medicine 20, 509-518, doi: 10.1016/j.molmed.2014.05.002 (2014).
19. Dominguez-Bello, M. G. et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proceedings of the National Academy of Sciences of the United States of America 107, 11971-11975, doi: 10.1073/pnas.1002601107 (2010).
20. Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A. & Brown, P. O. Development of the human infant intestinal microbiota. PLoS biology 5, e177, doi: 10.1371/journal.pbio.0050177 (2007).
21. Sampaio-Maia, B. & Monteiro-Silva, F. Acquisition and maturation of oral microbiome throughout childhood: An update. Dental research journal 11, 291-301 (2014).
22. Zou, J., Zhou, X. D. & Li, S. M. [Analysis of oral microflora early colonized in infants]. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 22, 126-128 (2004).
23. Pearce, C. et al. Identification of pioneer viridans streptococci in the oral cavity of human neonates. Journal of medical microbiology 42, 67-72, doi: 10.1099/00222615-42-1-67 (1995).
24. Smith, D. J., Anderson, J. M., King, W. F., van Houte, J. & Taubman, M. A. Oral streptococcal colonization of infants. Oral microbiology and immunology 8, 1-4 (1993).
25. Bagg, J. M. T., Poxton, L. & Smith, A. Essentials of Microbiology for Dental Students. Oxford University Press, 273 (2006).
26. Madan, J. C., Farzan, S. F., Hibberd, P. L. & Karagas, M. R. Normal neonatal microbiome variation in relation to environmental factors, infection and allergy. Current opinion in pediatrics 24, 753-759, doi: 10.1097/MOP.0b013e32835a1ac8 (2012).
27. Mueller, N. T. et al. Birth mode-dependent association between pre-pregnancy maternal weight status and the neonatal intestinal microbiome. Scientific reports 6, 23133, doi: 10.1038/srep23133 (2016).
28. Gasparrini, A. J. et al. Antibiotic perturbation of the preterm infant gut microbiome and resistome. Gut microbes, 0, doi: 10.1080/19490976.2016.1218584 (2016).
29. Al-Shehri, S. S. et al. Breastmilk-Saliva Interactions Boost Innate Immunity by Regulating the Oral Microbiome in Early Infancy. PLoS One 10, e0135047, doi: 10.1371/journal.pone.0135047 (2015).
30. Nitert, M. D. et al. SPRING: an RCT study of probiotics in the prevention of gestational diabetes mellitus in overweight and obese women. BMC pregnancy and childbirth 13, 50, doi: 10.1186/1471-2393-13-50 (2013).
31. Guidelines, K. M. R. a. A. L. Y. I. o. M. U. a. N. R. C. U. C. t. R. I. P. W. Weight Gain During Pregnancy. National Academies Press (US) (2009).
32. Smaill, F. M. & Grivell, R. M. Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section. Cochrane Database of Systematic Reviews, doi: 10.1002/14651858.CD007482.pub3 (2014).
33. Ledger, W. J. & Blaser, M. J. Are we using too many antibiotics during pregnancy? BJOG: an international journal of obstetrics and gynaecology 120, 1450-1452, doi: 10.1111/1471-0528.12371 (2013).
34. Kuperman, A. A. & Koren, O. Antibiotic use during pregnancy: how bad is it? BMC medicine 14, 91, doi: 10.1186/s12916-016-0636-0 (2016).
35. Arboleya, S. et al. Intestinal microbiota development in preterm neonates and effect of perinatal antibiotics. The Journal of pediatrics 166, 538-544, doi: 10.1016/j.jpeds.2014.09.041 (2015).
36. Stokholm, J. et al. Antibiotic use during pregnancy alters the commensal vaginal microbiota. Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20, 629-635, doi: 10.1111/1469-0691.12411 (2014).
37. Lif Holgerson, P., Harnevik, L., Hernell, O., Tanner, A. C. & Johansson, I. Mode of birth delivery affects oral microbiota in infants. Journal of dental research 90, 1183-1188, doi: 10.1177/0022034511418973 (2011).
38. Care, A. C. o. S. a. Q. i. H. Antimicrobial prescribing practice in Australian hospitals: results of the 2014 National Antimicrobial Prescribing Survey. ACSQHC, Sydney (2015).
39. Shin, N. R., Whon, T. W. & Bae, J. W. Proteobacteria: microbial signature of dysbiosis in gut microbiota. Trends in biotechnology 33, 496-503, doi: 10.1016/j.tibtech.2015.06.011 (2015).
40. Narciso-da-Rocha, C., Vaz-Moreira, I. & Manaia, C. M. Genotypic diversity and antibiotic resistance in Sphingomonadaceae isolated from hospital tap water. The Science of the total environment 466-467, 127-135, doi: 10.1016/j.scitotenv.2013.06.109 (2014).
41. Voronina, O. L. et al. The Variability of the Order Burkholderiales Representatives in the Healthcare Units. BioMed research international 2015, 680210, doi: 10.1155/2015/680210 (2015).
42. Eugene Rosenberg, E. F. D., Stephen, Lory, Erko, Stackebrandt & Fabiano, Thompson. The Prokaryotes, Chapter: The Family Oxalobacteraceae. 919-974, doi: 10.1007/978-3-642-30197-1-291 (2014).
43. Kreth, J., Merritt, J. & Qi, F. Bacterial and host interactions of oral streptococci. DNA and cell biology 28, 397-403, doi: 10.1089/dna.2009.0868 (2009).
44. Jenkinson, H. F. & Lamont, R. J. Streptococcal adhesion and colonization. Critical reviews in oral biology and medicine: an official publication of the American Association of Oral Biologists 8, 175-200 (1997).
45. Bode, L. Human milk oligosaccharides: every baby needs a sugar mama. Glycobiology 22, 1147-1162, doi: 10.1093/glycob/cws074 (2012).
46. Keski-Nisula, L. et al. Maternal intrapartum antibiotics and decreased vertical transmission of Lactobacillus to neonates during birth. Acta paediatrica (Oslo, Norway: 1992) 102, 480-485, doi: 10.1111/apa.12186 (2013).
47. Sjogren, Y. M., Jenmalm, M. C., Bottcher, M. F., Bjorksten, B. & Sverremark-Ekstrom, E. Altered early infant gut microbiota in children developing allergy up to 5 years of age. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology 39, 518-526, doi: 10.1111/j.1365-2222.2008.03156.x (2009).
48. Aas, J. A., Paster, B. J., Stokes, L. N., Olsen, I. & Dewhirst, F. E. Defining the normal bacterial flora of the oral cavity. Journal of clinical microbiology 43, 5721-5732, doi: 10.1128/jcm.43.11.5721-5732.2005 (2005).
49. Gosalbes, M. J. et al. High frequencies of antibiotic resistance genes in infants' meconium and early fecal samples. Journal of developmental origins of health and disease 7, 35-44, doi: 10.1017/s2040174415001506 (2016).
50. Herruzo, R., R. G., Burgos, C., Perez-Blanco, V., Gallego, S., Mora, E. & Omeñaca, F. If you are looking for, you can find endemic bla-VIM gene microorganisms, in Children's Hospitals. Global Advanced Research Journal of Microbiology 5, 042-049 (2016).
51. Sardelic, S., Pallecchi, L., Punda-Polic, V. & Rossolini, G. M. Carbapenem-resistant Pseudomonas aeruginosa-carrying VIM-2 metallo-beta-lactamase determinants, Croatia. Emerging infectious diseases 9, 1022-1023, doi: 10.3201/eid0908.020373 (2003).
52. Shah, P., Nathan, E., Doherty, D. & Patole, S. Prolonged exposure to antibiotics and its associations in extremely preterm neonates - the Western Australian experience. The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet 26, 1710-1714, doi: 10.3109/14767058.2013.791274 (2013).
53. Langdon, A., Crook, N. & Dantas, G. The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome medicine 8, 39, doi: 10.1186/s13073-016-0294-z (2016).
54. Chapman, S. J. & Owen, J. Randomized trial of single-dose versus multiple-dose cefotetan for the postpartum treatment of intrapartum chorioamnionitis. American journal of obstetrics and gynecology 177, 831-834 (1997).
55. Edwards, R. K. & Duff, P. Single additional dose postpartum therapy for women with chorioamnionitis. Obstetrics and gynecology 102, 957-961 (2003).
56. Yu, Z. & Morrison, M. Improved extraction of PCR-quality community DNA from digesta and fecal samples. BioTechniques 36, 808-812 (2004).
57. Caporaso, J. G. et al. QIIME allows analysis of high-throughput community sequencing data. Nature methods 7, 335-336, doi: 10.1038/nmeth.f.303 (2010).
58. DeSantis, T. Z. et al. Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB. Applied and environmental microbiology 72, 5069-5072, doi: 10.1128/aem.03006-05 (2006).
59. Paulson, J. N., Stine, O. C., Bravo, H. C. & Pop, M. Differential abundance analysis for microbial marker-gene surveys. Nature methods 10, 1200-1202, doi: 10.1038/nmeth.2658 (2013).
60. Knights, D. et al. Bayesian community-wide culture-independent microbial source tracking. Nature methods 8, 761-763, doi: 10.1038/nmeth.1650 (2011).
61. Segata, N. et al. Metagenomic biomarker discovery and explanation. Genome biology 12, R60, doi: 10.1186/gb-2011-12-6-r60 (2011).