Reversibility of Covalent, Broad-Spectrum Serine β-Lactamase Inhibition by the Diazabicyclooctenone ETX2514

ACS Infectious Diseases

Volumn 3, Issue 11, 2017, Pages 833-844

  Shapiro, Adam B ^a   Gao, Ning ^b   Jahić, Haris ^b   Carter, Nicole M ^a   Chen, April ^a   Miller, Alita A ^a  

^a Entasis Therapeutics   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Acinetobacter baumannii; antibacterial; antibiotic; avibactam; lactamase; lactamase inhibitor

Indexed keywords

AVIBACTAM; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; DIAZABICYCLOOCTENONE; ETX 2514; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; AZABICYCLO DERIVATIVE; SULFONE; VCC234718;

ACYLATION; ARTICLE; BACTERIAL STRAIN; COVALENT BOND; DISSOCIATION RATE CONSTANT; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; MASS SPECTROMETRY; NONHUMAN; PARTITION RATIO; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM;

ANTI-BACTERIAL AGENTS; AZABICYCLO COMPOUNDS; BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; PSEUDOMONAS AERUGINOSA; SULFONES;

EID: 85033566555     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.7b00113     Document Type: Article

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