High-dose interleukin-2 (IL-2) for the treatment of melanoma: safety considerations and future directions

Expert Opinion on Drug Safety

Volumn 16, Issue 12, 2017, Pages 1347-1357

  Marabondo, Stephen ^a   Kaufman, Howard L ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Immunotherapy; interleukin 2; melanoma; safety

Indexed keywords

ALDESLEUKIN; CREATININE; INTERLEUKIN 2; LIVER ENZYME; ANTINEOPLASTIC AGENT;

ABDOMINAL PAIN; ANEMIA; ANOREXIA; CANCER IMMUNOTHERAPY; CANCER PATIENT; CAPILLARY LEAK SYNDROME; CHILL; CONFUSION; DESQUAMATION; DIARRHEA; DISORIENTATION; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; DYSPNEA; FEVER; GRAM POSITIVE INFECTION; HALLUCINATION; HEART ARRHYTHMIA; HEPATITIS; HUMAN; HYPERBILIRUBINEMIA; HYPOCALCEMIA; HYPOKALEMIA; HYPOMAGNESEMIA; HYPONATREMIA; HYPOPHOSPHATEMIA; HYPOTENSION; HYPOTHYROIDISM; HYPOXIA; INFECTION; INSOMNIA; LUNG EDEMA; LUNG TOXICITY; MELANOMA; METABOLIC ACIDOSIS; MUCOSA INFLAMMATION; MYOCARDITIS; NAUSEA; NEUROTOXICITY; NEUTROPENIA; OLIGURIA; PERIPHERAL EDEMA; PERIPHERAL NEUROPATHY; PHASE 2 CLINICAL TRIAL (TOPIC); PRURITUS; RASH; RESTLESSNESS; REVIEW; RIGOR; SIDE EFFECT; SINUS TACHYCARDIA; TACHYPNEA; THERAPEUTIC INDEX; THROMBOCYTOPENIA; TREATMENT RESPONSE; VIVID DREAM; VOMITING; DOSE RESPONSE; IMMUNOTHERAPY; METASTASIS; PATHOLOGY; PROCEDURES; SKIN TUMOR;

ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMMUNOTHERAPY; INTERLEUKIN-2; MELANOMA; NEOPLASM METASTASIS; SKIN NEOPLASMS;

EID: 85033370344     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1080/14740338.2017.1382472     Document Type: Review

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