Independent and synergistic associations of biomarkers of Vitamin D status with risk of coronary heart disease

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 37, Issue 11, 2017, Pages 2204-2212

  Qi, Lu ^a,b,c,d   Ma, Wenjie ^b   Heianza, Yoriko ^a   Zheng, Yan ^c   Wang, Tiange ^a   Sun, Dianjianyi ^a   Rimm, Eric B ^b,c,d   Hu, Frank B ^b,c,d   Giovannucci, Edward ^b,c,d   Albert, Christine M ^e   Rexrode, Kathryn M ^e   Manson, JoAnn E ^b,d,e  

^a TULANE UNIVERSITY   (United States)

^b Department of Epidemiology ^*  (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d CHANNING LABORATORY   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Biomarkers; Myocardial infarction; Parathyroid hormone; Risk; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; ALBUMIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CREATININE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PARATHYROID HORMONE; TRIACYLGLYCEROL; VITAMIN D BINDING PROTEIN; 25-HYDROXYVITAMIN D; PTH PROTEIN, HUMAN; VITAMIN D;

ADULT; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CLINICAL EVALUATION; CONTROLLED STUDY; DIET; DIETARY INTAKE; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; HEART INFARCTION; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; ANALOGS AND DERIVATIVES; BLOOD; CASE CONTROL STUDY; INCIDENCE; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; NURSE; ODDS RATIO; PROTECTION; RISK ASSESSMENT; RISK FACTOR; STATISTICAL MODEL; TIME FACTOR; UNITED STATES; VITAMIN D DEFICIENCY;

ADULT; BIOMARKERS; CASE-CONTROL STUDIES; FEMALE; HUMANS; INCIDENCE; LINEAR MODELS; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; NURSES; ODDS RATIO; PARATHYROID HORMONE; PROSPECTIVE STUDIES; PROTECTIVE FACTORS; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; UNITED STATES; VITAMIN D; VITAMIN D DEFICIENCY; VITAMIN D-BINDING PROTEIN;

EID: 85032921367     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.117.309548     Document Type: Article

References (34)

1. Ebeling PR. Vitamin D and bone health: Epidemiologic studies. Bonekey Rep. 2014;3:511. doi: 10.1038/bonekey.2014.6.
2. Schnatz PF, Manson JE. Vitamin D and cardiovascular disease: An appraisal of the evidence. Clin Chem. 2014;60:600-609. doi: 10.1373/clinchem.2013.211037.
3. Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin EJ, Dagostino RB, Wolf M, Vasan RS. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008;117:503-511. doi: 10.1161/CIRCULATIONAHA.107.706127.
4. Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men: A prospective study. Arch Intern Med. 2008;168:1174-1180. doi: 10.1001/archinte.168.11.1174.
5. Marniemi J, Alanen E, Impivaara O, Seppänen R, Hakala P, Rajala T, Rönnemaa T. Dietary and serum vitamins and minerals as predictors of myocardial infarction and stroke in elderly subjects. Nutr Metab Cardiovasc Dis. 2005;15:188-197. doi: 10.1016/j.numecd.2005.01.001.
6. Melamed ML, Michos ED, Post W, Astor B. 25-hydroxyvitamin d levels and the risk of mortality in the general population. Arch Intern Med. 2008;168:1629-1637.
7. Cawthon PM, Parimi N, Barrett-Connor E, Laughlin GA, Ensrud KE, Hoffman AR, Shikany JM, Cauley JA, Lane NE, Bauer DC, Orwoll ES, Cummings SR; Osteoporotic Fractures in Men (MrOS) Research Group. Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men. J Clin Endocrinol Metab. 2010;95:4625-4634. doi: 10.1210/jc.2010-0638.
8. Leong A, Rehman W, Dastani Z, Greenwood C, Timpson N, Langsetmo L, Berger C, Fu L, Wong BY, Malik S, Malik R, Hanley DA, Cole DE, Goltzman D, Richards JB; METASTROKE. The causal effect of vitamin D binding protein (DBP) levels on calcemic and cardiometabolic diseases: A Mendelian randomization study. PLoS Med. 2014;11:e1001751. doi: 10.1371/journal.pmed.1001751.
9. Adams JS, Chen H, Chun R, Ren S, Wu S, Gacad M, Nguyen L, Ride J, Liu P, Modlin R, Hewison M. Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: The human innate immune response. J Bone Miner Res. 2007;22(suppl 2):V20-V24. doi: 10.1359/jbmr.07s214.
10. Chun RF. New perspectives on the vitamin D binding protein. Cell Biochem Funct. 2012;30:445-456. doi: 10.1002/cbf.2835.
11. Gomme PT, Bertolini J. Therapeutic potential of vitamin D-binding protein. Trends Biotechnol. 2004;22:340-345. doi: 10.1016/j.tibtech.2004.05.001.
12. Rocchiccioli S, Andreassi MG, Cecchettini A, Carpeggiani C, L'Abbate A, Citti L. Correlation between vitamin D binding protein expression and angiographic-proven coronary artery disease. Coron Artery Dis. 2012;23:426-431. doi: 10.1097/MCA.0b013e328358781c.
13. Gasparri C, Curcio A, Torella D, Gaspari M, Celi V, Salituri F, Boncompagni D, Torella M, Gulletta E, Cuda G, Indolfi C. Proteomics reveals high levels of vitamin D binding protein in myocardial infarction. Front Biosci. 2010;2:796-804.
14. Mendel CM. The free hormone hypothesis: A physiologically based mathematical model. Endocr Rev. 1989;10:232-274. doi: 10.1210/edrv-10-3-232.
15. Powe CE, Ricciardi C, Berg AH, Erdenesanaa D, Collerone G, Ankers E, Wenger J, Karumanchi SA, Thadhani R, Bhan I. Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res. 2011;26:1609-1616. doi: 10.1002/jbmr.387.
16. Andersson P, Rydberg E, Willenheimer R. Primary hyperparathyroidism and heart disease-a review. Eur Heart J. 2004;25:1776-1787. doi: 10.1016/j.ehj.2004.07.010.
17. Kestenbaum B, Katz R, de Boer I, Hoofnagle A, Sarnak MJ, Shlipak MG, Jenny NS, Siscovick DS. Vitamin D, parathyroid hormone, and cardiovascular events among older adults. J Am Coll Cardiol. 2011;58:1433-1441. doi: 10.1016/j.jacc.2011.03.069.
18. Saliba W, Barnett O, Rennert HS, Lavi I, Rennert G. The relationship between serum 25(OH)D and parathyroid hormone levels. Am J Med. 2011;124:1165-1170. doi: 10.1016/j.amjmed.2011.07.009.
19. Wang L, Song Y, Manson JE, Pilz S, März W, Michaëlsson K, Lundqvist A, Jassal SK, Barrett-Connor E, Zhang C, Eaton CB, May HT, Anderson JL, Sesso HD. Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: A meta-analysis of prospective studies. Circ Cardiovasc Qual Outcomes. 2012;5:819-829. doi: 10.1161/CIRCOUTCOMES.112.967604.
20. van Ballegooijen AJ, Visser M, Kestenbaum B, Siscovick DS, de Boer IH, Gottdiener JS, deFilippi CR, Brouwer IA. Relation of vitamin D and parathyroid hormone to cardiac biomarkers and to left ventricular mass (from the Cardiovascular Health Study). Am J Cardiol. 2013;111:418-424. doi: 10.1016/j.amjcard.2012.10.021.
21. Manousaki D, Mokry LE, Ross S, Goltzman D, Richards JB. Mendelian randomization studies do not support a role for vitamin D in coronary artery disease. Circ Cardiovasc Genet. 2016;9:349-356. doi: 10.1161/CIRCGENETICS.116.001396.
22. Afzal S, Brøndum-Jacobsen P, Bojesen SE, Nordestgaard BG. Genetically low vitamin D concentrations and increased mortality: Mendelian randomisation analysis in three large cohorts. BMJ. 2014;349:g6330.
23. Bhan I, Powe CE, Berg AH, Ankers E, Wenger JB, Karumanchi SA, Thadhani RI. Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients. Kidney Int. 2012;82:84-89. doi: 10.1038/ki.2012.19.
24. Bikle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab. 1986;63:954-959. doi: 10.1210/jcem-63-4-954.
25. Arnaud J, Constans J. Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP). Hum Genet. 1993;92:183-188.
26. Melander O, Modrego J, Zamorano-León JJ, Santos-Sancho JM, Lahera V, López-Farré AJ. New circulating biomarkers for predicting cardiovascular death in healthy population. J Cell Mol Med. 2015;19:2489-2499. doi: 10.1111/jcmm.12652.
27. Rostand SG, Druëke TB. Parathyroid hormone, vitamin D, and cardiovascular disease in chronic renal failure. Kidney Int. 1999;56:383-392. doi: 10.1046/j.1523-1755.1999.00575.x.
28. van Ballegooijen AJ, Reinders I, Visser M, Brouwer IA. Parathyroid hormone and cardiovascular disease events: A systematic review and metaanalysis of prospective studies. Am Heart J. 2013;165:655-664, 664.e1-5. doi: 10.1016/j.ahj.2013.02.014.
29. Folsom AR, Alonso A, Misialek JR, Michos ED, Selvin E, Eckfeldt JH, Coresh J, Pankow JS, Lutsey PL. Parathyroid hormone concentration and risk of cardiovascular diseases: The atherosclerosis risk in communities (ARIC) study. Am Heart J. 2014;168:296-302.
30. Powe CE, Evans MK, Wenger J, Zonderman AB, Berg AH, Nalls M, Tamez H, Zhang D, Bhan I, Karumanchi SA, Powe NR, Thadhani R. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med. 2013;369:1991-2000. doi: 10.1056/NEJMoa1306357.
31. Hoofnagle AN, Eckfeldt JH, Lutsey PL. Vitamin D-binding protein concentrations quantified by mass spectrometry. N Engl J Med. 2015;373:1480-1482. doi: 10.1056/NEJMc1502602.
32. Denburg MR, Hoofnagle AN, Sayed S, Gupta J, de Boer IH, Appel LJ, Durazo-Arvizu R, Whitehead K, Feldman HI, Leonard MB; Chronic Renal Insufficiency Cohort Study Investigators. Comparison of two ELISA methods and mass spectrometry for measurement of vitamin D-binding protein: Implications for the assessment of bioavailable vitamin D concentrations across genotypes. J Bone Miner Res. 2016;31:1128-1136. doi: 10.1002/jbmr.2829.
33. Harris SS, Dawson-Hughes B. Seasonal changes in plasma 25-hydroxyvitamin D concentrations of young American black and white women. Am J Clin Nutr. 1998;67:1232-1236.
34. Robinson-Cohen C, Hoofnagle AN, Ix JH, Sachs MC, Tracy RP, Siscovick DS, Kestenbaum BR, de Boer IH. Racial differences in the association of serum 25-hydroxyvitamin D concentration with coronary heart disease events. JAMA. 2013;310:179-188. doi: 10.1001/jama.2013.7228.