Supercritical CO2 extraction of mastic gum and chemical characterization of bioactive fractions using LC-HRMS/MS and GC–MS

Journal of Supercritical Fluids

Volumn 133, Issue , 2018, Pages 349-356

  Xynos, Nikos ^a   Termentzi, Aikaterini ^a,b   Fokialakis, Nikolas ^a   Skaltsounis, Leandros A ^a   Aligiannis, Nektarios ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b BENAKI PHYTOPATHOLOGICAL INSTITUTE   (Greece)

Author keywords

LC HRMS MS; Mastic gum; Masticadienonic acid; Pistacia lentiscus var. chia; Supercritical CO2 extraction

Indexed keywords

CARBON DIOXIDE; EFFLUENT TREATMENT; ESSENTIAL OILS; RESINS; SUPERCRITICAL FLUID EXTRACTION; SUPERCRITICAL FLUIDS; VALUE ENGINEERING;

CARYOPHYLLENE OXIDE; CHEMICAL CHARACTERIZATION; EXTRACTION AND ENRICHMENTS; GASTROINTESTINAL DISORDERS; LC-HRMS/MS; MASTIC GUM; PISTACIA LENTISCUS; SUPERCRITICAL CO2 EXTRACTION;

EXTRACTION;

EID: 85032920502     PISSN: 08968446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.supflu.2017.10.011     Document Type: Article

References (29)

1. The European Medicines Agency, Committee on Herbal Medicinal Products (HMPC), Assessment Report on Pistacia Lentiscus L., Resin (mastix)., 2015.
2. Paraschos, S., Mitakou, S., Skaltsounis, A.L., Chios gum mastic: a review of its biological activities. Curr. Med. Chem. 19 (2012), 2292–2302.
3. Van den Berg, K.J., Van der Horst, J., Boon, J.J., Sudmeijer, O., cis-1, 4-Poly-β- myrcene: the structure of the polymeric fraction of mastic resin (Pistacia lentiscus L.) elucidated. Tetrahedron Lett. 39 (1998), 2645–2648.
4. Papageorgiou, V.P., Mellidis, A.S., Argyriadou, N., The chemical composition of the essential oil of mastic gum. J. Esent. Oil Res. 3 (1991), 107–110.
5. Papageorgiou, V.P., Bakola-Christianopoulou, M.N., Apazidou, K.K., Psarros, E.E., Gas chromatographic-mass spectroscopic analysis of the acidic triterpenic fraction of mastic gum. J. Chromatogr. A 769 (1997), 263–273.
6. Magiatis, P., Melliou, E., Skaltsounis, A.L., Chinou, I.B., Mitaku, S., Chemical composition and antimicrobial activity of the essential oils of Pistacia lentiscus var. Chia. Planta Med. 65 (1999), 749–752.
7. Daferera, D., Pappas, C., Tarantilis, P.A., Polissiou, M., Quantitative analysis of α-pinene and β-myrcene in mastic gum oil using FT-Raman spectroscopy. Food Chem. 77 (2002), 511–515.
8. Paraschos, S., Magiatis, P., Mitakou, S., Petraki, K., Kalliaropoulos, A., Maragkoudakis, P., Mentis, A., Sgouras, D., Skaltsounis, A.L., In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori. Antimicrob. Agents Chemother. 51 (2007), 551–559.
9. Barton, D.H.R., Seoane, E., Triterpenoids. Part XXII. The constitution and stereochemistry of masticadienonic acid. J. Chem. Soc. 189 (1956), 4150–4157.
10. Vuorinen, A., Seibert, J., Papageorgiou, V.P., Rollinger, J.M., Odermatt, A., Schuster, D., Assimopoulou, A.N., Pistacia lentiscus oleoresin: virtual screening and identification of masticadienonic and isomasticadienonic acids as inhibitors of 11 β-hydroxysteroid dehydrogenase 1. Planta Med. 81 (2015), 525–532.
11. Assimopoulou, A.N., Papageorgiou, V.P., GC–MS analysis of penta- and tetracyclic triterpenes from resins of Pistacia species. Part I. Pistacia lentiscus var. chia. Biomed. Chrom. 19 (2005), 285–311.
12. Assimopoulou, A.N., Papageorgiou, V.P., GC–MS analysis of penta- and tetra-cyclic triterpenes from resins of Pistacia species. Part II. Pistacia terebinthus var. Chia. Biomed. Chrom. 19 (2005), 586–605.
13. Warren, J.R., Marshall, B., Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 321 (1983), 1273–1275.
14. Peek, R.M., Crabtree, J.E., Helicobacter infection and gastric neoplasia. J. Pathol. 208 (2006), 233–248.
15. Tassou, C.C., Nychas, G.J.E., Antimicrobial activity of the essential oil of mastic gum (Pistacia lentiscus var chia) on gram positive and gram negative bacteria in broth and model food system. Int. Biodeterior. Biodegrad. 36 (1995), 411–420.
16. Huwez, F.U., Thirlwell, D., Cockayne, A., Ala'Aldeen, D.A., Mastic gum kills Helicobacter pylori. N. Engl. J. Med., 339, 1998, 1946.
17. Bona, S., Bono, L., Daghetta, L., Marone, P., Bactericidal activity of Pistacia lentiscus gum mastic against Helicobacter pylori. Am. J. Gastroenterol., 96, 2001, S49.
18. Marone, P., Bono, L., Leone, E., Bona, S., Carretto, E., Perversi, L., Bactericidal activity of Pistacia lentiscus mastic gum against Helicobacter pylori. J. Antimicrob. Chemother. 13 (2001), 611–614.
19. Al-Habbal, M.J., Al-Habbal, Z., Huwez, F.U., A double-blind controlled clinical trial of mastic and placebo in the treatment of duodenal ulcer. Clin. Exp. Pharmacol. Physiol. 11 (1984), 541–544.
20. Al-Said, M.S., Ageel, A.M., Parmar, N.S., Tariq, M., Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal ulcer activity. J. Ethnopharmacol. 15 (1986), 271–278.
21. Koutsoudaki, C., Krsek, M., Rodger, A., Chemical composition and antibacterial activity of the essential oil and the gum of Pistacia lentiscus var. Chia. J. Agric. Food Chem. 53 (2005), 7681–7685 Nat Prod Bioprospect.
22. Miyamoto, T., Okimoto, T., Kuwano, M., Chemical composition of the essential oil of mastic gum and their antibacterial activity against drug-resistant Helicobacter pylori. Nat. Prod. Bioprospect. 4 (2014), 227–231.
23. Mukhopadhyay, M., Natural Extracts Using Supercritical Carbon Dioxide. 2000, CRC Press.
24. Martinez, J.L., Supercritical Fluid Extraction of Nutraceuticals and Bioactive Compounds. 2007, CRC Press, Taylor and Francis group, New York.
25. Sung, T.V., Peter-Katalinic, J., Adam, G., A bidesmosidic triterpenoid saponin from Schefflera octophylla. Phytochemistry 30 (1991), 3717–3720.
26. Ito, J., Chang, F.R., Wang, H.K., Park, Y.K., Ikegaki, M., Kilgore, N., Lee, K.-H., Anti-AIDS agents. 48. Anti-HIV activity of moronic acid derivatives and the new melliferone-related trierpenoid isolated from Brazilian propolis. J. Nat. Prod. 64 (2001), 1278–1281.
27. Mulholland, D.A., Nair, J.J., Triterpenoids from Disoxylum pettigrewianum. Phytochemistry 37 (1994), 1409–1411.
28. Pozzo-Balbi, Τ., Nobile, L., Scapini, G., Cini, M., The triterpenoid acids of Schinus molle. Phytochemistry 17 (1978), 2107–2110.
29. Van der Doelen, G.A., van der Berg, K.J., Boon, J.J., Shibayama, N., de la Rie, E.R., Genuit, W.J.L., Analysis of fresh triterpeneoid resins and aged triterpenoid varnishes by high −performance liquid chromatography-atmospheric pressure chemical ionisation (tandem) mass spectrometry. J. Chrom. A 809 (1998), 21–37.