The immune mechanism of intestinal tract Toll-like receptor in mediating EV71 virus type severe handfoot-and-mouth disease and the MAPK pathway

Experimental and Therapeutic Medicine

Volumn 13, Issue 5, 2017, Pages 2263-2266

  Zhu, Lei ^a   Li, Weihua ^a   Qi, Gongjian ^a   Liu, Na ^a   Sheng, Liping ^a   Shang, Lei ^a   Qi, Boxiang ^a  

^a XUZHOU CHILDREN S HOSPITAL   (China)

Author keywords

Cytokine; Enterovirus 71 type; MAPK signaling pathway; Severe hand foot and mouth disease; Toll like receptor

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 14; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

ARTICLE; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE RESPONSE; ENTEROVIRUS A71; FEMALE; GASTROINTESTINAL TRACT; HAND FOOT AND MOUTH DISEASE; HUMAN; IMMUNE SYSTEM; IMMUNOPATHOLOGY; MAJOR CLINICAL STUDY; MALE; MAPK SIGNALING; PATHOLOGICAL ANATOMY; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; RNA EXTRACTION; SCHOOL CHILD; SIGNAL TRANSDUCTION; THROAT CULTURE;

EID: 85032825117     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2017.4245     Document Type: Article

References (17)

1. Long DL, Zhu SY, Li CZ, Chen CY, Du WT and Wang X: Late-onset nail changes associated with hand, foot, and mouth disease: A clinical analysis of 56 cases. Pediatr Dermatol 33: 424-428, 2016.
2. Kim C, Kang H, Kim DE, Song JH, Choi M, Kang M, Lee K, Kim HS, Shin JS, Jeong H, et al: Antiviral activity of micafungin against enterovirus 71. Virol J 13: 99, 2016.
3. Li S, Cai C, Feng J, Li X, Wang Y, Yang J and Chen Z: Peripheral T lymphocyte subset imbalances in children with enterovirus 71-induced hand, foot and mouth disease. Virus Res 180: 84-91, 2014.
4. Yang J, Yang C, Guo N, Zhu K, Luo K, Zhang N, Zhao H, Cui Y, Chen L, Wang H, et al: Type I interferons triggered through the Toll-like receptor 3-TRIF pathway control coxsackievirus A16 infection in young mice. J Virol 89: 10860-10867, 2015.
5. Hsiao HB, Chou AH, Lin SI, Chen IH, Lien SP, Liu CC, Chong P and Liu SJ: Toll-like receptor 9-mediated protection of enterovirus 71 infection in mice is due to the release of danger-associated molecular patterns. J Virol 88: 11658-11670, 2014.
6. Chi J, He Y, Yu G and Lei L: Role of Toll-like receptor 7 in the production of inflammatory cytokines in EV-A71-infected human Jurkat T cells. Zhonghua Yu Fang Yi Xue Za Zhi 50: 266-269, 2016 (In Chinese).
7. Dang S, Gao N, Li Y, Li M, Wang X, Jia X, Zhai S, Zhang X, Liu J, Deng H, et al: Dominant CD4-dependent RNA-dependent RNA polymerase-specific T-cell responses in children acutely infected with human enterovirus 71 and healthy adult controls. Immunology 142: 89-100, 2014.
8. Wei R, Xu L, Zhang N, Zhu K, Yang J, Yang C, Deng C, Zhu Z, De Groot AS, Altmeyer R, et al: Elevated antigen-specific Th2 type response is associated with the poor prognosis of hand, foot and mouth disease. Virus Res 177: 62-65, 2013.
9. + T cell responses against enterovirus 71 and cross-reactivity against coxsackievirus A16 and polioviruses in a healthy population. J Immunol 191: 1637-1647, 2013.
10. Liu L, Zhang Y, Wang J, Zhao H, Jiang L, Che Y, Shi H, Li R, Mo Z, Huang T, et al: Study of the integrated immune response induced by an inactivated EV71 vaccine. PLoS One 8: e54451, 2013.
11. + T cell epitope is highly conserved among human enteroviruses. PLoS One 7: e51957, 2012.
12. Liang Y, Zhou X, Yang E, Pu J, Che Y, Wang J, Ma N, Liu L, Ding D, Tang D, et al: Analysis of the Th1/Th2 reaction in the immune response induced by EV71 inactivated vaccine in neonatal rhesus monkeys. J Clin Immunol 32: 1048-1058, 2012.
13. Dong C, Liu L, Zhao H, Wang J, Liao Y, Zhang X, Na R, Liang Y, Wang L and Li Q: Immunoprotection elicited by an enterovirus type 71 experimental inactivated vaccine in mice and rhesus monkeys. Vaccine 29: 6269-6275, 2011.
14. Lei X, Sun Z, Liu X, Jin Q, He B and Wang J: Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3. J Virol 85: 8811-8818, 2011.
15. Zhang J, Wang J, Pang L, Xie G, Welte T, Saxena V, Wicker J, Mann B, Soong L, Barrett A, et al: The co-stimulatory effects of MyD88-dependent Toll-like receptor signaling on activation of murine γδ T cells. PLoS One 9: e108156, 2014.
16. κB signaling pathways in the regulation of phagocytosis and proinflammatory cytokine expression in response to E. faecalis infection. PLoS One 10: e0136947, 2015.
17. Choi HG, Kim WS, Back YW, Kim H, Kwon KW, Kim JS, Shin SJ and Kim HJ: Mycobacterium tuberculosis RpfE promotes simultaneous Th1- and Th17-type T-cell immunity via TLR4-dependent maturation of dendritic cells. Eur J Immunol 45: 1957-1971, 2015.