A Dominant EV71-Specific CD4+ T Cell Epitope Is Highly Conserved among Human Enteroviruses

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Wei, Ruicheng ^a   Yang, Chunfu ^a   Zeng, Mei ^c   Terry, Frances ^b   Zhu, Kai ^a   Yang, Chunhui ^a   Altmeyer, Ralf ^a   Martin, William ^b   De Groot, Anne S ^b,d   Leng, Qibin ^a  

^a INSTITUTE PASTEUR OF SHANGHAI   (China)

^b EpiVax Inc   (United States)

^c CHILDREN S HOSPITAL OF FUDAN UNIVERSITY   (China)

^d UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; EPITOPE; GAMMA INTERFERON; HLA DR ANTIGEN; POLIOMYELITIS VACCINE; POLYPROTEIN; PROTEIN VP1; PROTEIN VP2; PROTEIN VP3;

ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; COXSACKIE VIRUS; CROSS REACTION; CYTOKINE PRODUCTION; ECHO VIRUS; ENTEROVIRUS 71; ENZYME LINKED IMMUNOSPOT ASSAY; GENETIC CONSERVATION; HAND FOOT AND MOUTH DISEASE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; PERIPHERAL BLOOD MONONUCLEAR CELL; POLIOMYELITIS VIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CROSS REACTIONS; ENTEROVIRUS A, HUMAN; ENTEROVIRUS INFECTIONS; EPITOPES, T-LYMPHOCYTE; HAND, FOOT AND MOUTH DISEASE; HUMANS; IMMUNITY; LEUKOCYTES, MONONUCLEAR; POLIOVIRUS; POLYPROTEINS; VIRAL VACCINES;

ENTEROVIRUS; POLIOVIRUS;

EID: 84871272814     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051957     Document Type: Article

References (40)

1. Tan X, Huang X, Zhu S, Chen H, Yu Q, et al. (2011) The persistent circulation of enterovirus 71 in People's Republic of China: causing emerging nationwide epidemics since 2008. PLoS One 6: e25662.
2. Yang C, Deng C, Wan J, Zhu L, Leng Q, (2011) Neutralizing antibody response in the patients with hand, foot and mouth disease to enterovirus 71 and its clinical implications. Virol J 8: 306.
3. Xu W, Liu CF, Yan L, Li JJ, Wang LJ, et al. (2012) Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications. Virol J 9: 8.
4. Zhu Z, Zhu S, Guo X, Wang J, Wang D, et al. (2010) Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008. Virol J 7: 300.
5. Rabenau HF, Richter M, Doerr HW, (2010) Hand, foot and mouth disease: seroprevalence of Coxsackie A16 and Enterovirus 71 in Germany. Med Microbiol Immunol 199: 45-51.
6. Fujimoto T, Chikahira M, Yoshida S, Ebira H, Hasegawa A, et al. (2002) Outbreak of central nervous system disease associated with hand, foot, and mouth disease in Japan during the summer of 2000: detection and molecular epidemiology of enterovirus 71. Microbiol Immunol 46: 621-627.
7. Notes from the field: severe hand, foot, and mouth disease associated with coxsackievirus a6- alabama, connecticut, california, and nevada, november 2011-february 2012. MMWR Morb Mortal Wkly Rep 61: 213-214.
8. Bracho MA, Gonzalez-Candelas F, Valero A, Cordoba J, Salazar A, (2011) Enterovirus co-infections and onychomadesis after hand, foot, and mouth disease, Spain, 2008. Emerg Infect Dis 17: 2223-2231.
9. Mirand A, Henquell C, Archimbaud C, Ughetto S, Antona D, et al. (2012) Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study. Clin Microbiol Infect 18: E110-118.
10. Hu X, Zhang Y, Zhou X, Xu B, Yang M, et al. (2012) Simultaneously typing nine serotypes of enteroviruses associated with hand, foot, and mouth disease by a GeXP analyzer-based multiplex reverse transcription-PCR assay. J Clin Microbiol 50: 288-293.
11. Park SH, Choi SS, Oh SA, Kim CK, Cho SJ, et al. (2011) Detection and characterization of enterovirus associated with herpangina and hand, foot, and mouth disease in Seoul, Korea. Clin Lab 57: 959-967.
12. Chong CY, Chan KP, Shah VA, Ng WY, Lau G, et al. (2003) Hand, foot and mouth disease in Singapore: a comparison of fatal and non-fatal cases. Acta Paediatr 92: 1163-1169.
13. Huang CC, Liu CC, Chang YC, Chen CY, Wang ST, et al. (1999) Neurologic complications in children with enterovirus 71 infection. N Engl J Med 341: 936-942.
14. Chang LY, Hsiung CA, Lu CY, Lin TY, Huang FY, et al. (2006) Status of cellular rather than humoral immunity is correlated with clinical outcome of enterovirus 71. Pediatr Res 60: 466-471.
15. Chang LY, Chang IS, Chen WJ, Huang YC, Chen GW, et al. (2008) HLA-A33 is associated with susceptibility to enterovirus 71 infection. Pediatrics 122: 1271-1276.
16. Lin YW, Chang KC, Kao CM, Chang SP, Tung YY, et al. (2009) Lymphocyte and antibody responses reduce enterovirus 71 lethality in mice by decreasing tissue viral loads. J Virol 83: 6477-6483.
17. McKinstry KK, Strutt TM, Swain SL, (2010) The potential of CD4 T-cell memory. Immunology 130: 1-9.
18. Pepper M, Jenkins MK, (2011) Origins of CD4(+) effector and central memory T cells. Nat Immunol 12: 467-471.
19. Foo DG, Macary PA, Alonso S, Poh CL, (2008) Identification of human CD4 T-cell epitopes on the VP1 capsid protein of enterovirus 71. Viral Immunol 21: 215-224.
20. Cello J, Strannegard O, Svennerholm B, (1996) A study of the cellular immune response to enteroviruses in humans: identification of cross-reactive T cell epitopes on the structural proteins of enteroviruses. J Gen Virol 77 (Pt 9): 2097-2108.
21. Meister GE, Roberts CG, Berzofsky JA, De Groot AS, (1995) Two novel T cell epitope prediction algorithms based on MHC-binding motifs; comparison of predicted and published epitopes from Mycobacterium tuberculosis and HIV protein sequences. Vaccine 13: 581-591.
22. Bond KB, Sriwanthana B, Hodge TW, De Groot AS, Mastro TD, et al. (2001) An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res Hum Retroviruses 17: 703-717.
23. Dong Y, Demaria S, Sun X, Santori FR, Jesdale BM, et al. (2004) HLA-A2-restricted CD8+-cytotoxic-T-cell responses to novel epitopes in Mycobacterium tuberculosis superoxide dismutase, alanine dehydrogenase, and glutamine synthetase. Infect Immun 72: 2412-2415.
24. McMurry JA, Gregory SH, Moise L, Rivera D, Buus S, et al. (2007) Diversity of Francisella tularensis Schu4 antigens recognized by T lymphocytes after natural infections in humans: identification of candidate epitopes for inclusion in a rationally designed tularemia vaccine. Vaccine 25: 3179-3191.
25. Otero M, Calarota SA, Dai A, De Groot AS, Boyer JD, et al. (2006) Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy. Vaccine 24: 4461-4470.
26. De Groot AS, Ardito M, Moise L, Gustafson EA, Spero D, et al. (2011) Immunogenic consensus sequence T helper epitopes for a pan-Burkholderia biodefense vaccine. Immunome Res 7: 7.
27. Moss SF, Moise L, Lee DS, Kim W, Zhang S, et al. (2011) HelicoVax: epitope-based therapeutic Helicobacter pylori vaccination in a mouse model. Vaccine 29: 2085-2091.
28. De Groot AS, Martin W, (2009) Reducing risk, improving outcomes: bioengineering less immunogenic protein therapeutics. Clin Immunol 131: 189-201.
29. Lalvani A, Brookes R, Hambleton S, Britton WJ, Hill AV, et al. (1997) Rapid effector function in CD8+ memory T cells. J Exp Med 186: 859-865.
30. De Groot A, Ardito M, Moise L, Gustafson EA, Spero D, et al. (2011) Immunogenic Consensus Sequence T helper Epitopes for a Pan-Burkholderia Biodefense Vaccine. Immunome Res 7: 3.
31. Zhang Y, Tan XJ, Wang HY, Yan DM, Zhu SL, et al. (2009) An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China. J Clin Virol 44: 262-267.
32. McMinn P, Lindsay K, Perera D, Chan HM, Chan KP, et al. (2001) Phylogenetic analysis of enterovirus 71 strains isolated during linked epidemics in Malaysia, Singapore, and Western Australia. J Virol 75: 7732-7738.
33. Brown BA, Oberste MS, Alexander JP Jr, Kennett ML, Pallansch MA, (1999) Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998. J Virol 73: 9969-9975.
34. Wu Y, Yeo A, Phoon MC, Tan EL, Poh CL, et al. (2010) The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. Int J Infect Dis 14: e1076-1081.
35. Leclerc C, Deriaud E, Mimic V, van der Werf S, (1991) Identification of a T-cell epitope adjacent to neutralization antigenic site 1 of poliovirus type 1. J Virol 65: 711-718.
36. Kutubuddin M, Simons J, Chow M, (1992) Identification of T-helper epitopes in the VP1 capsid protein of poliovirus. J Virol 66: 3042-3047.
37. Mahon BP, Katrak K, Nomoto A, Macadam AJ, Minor PD, et al. (1995) Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor. J Exp Med 181: 1285-1292.
38. Wilkinson TM, Li CK, Chui CS, Huang AK, Perkins M, et al. (2012) Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans. Nat Med 18: 274-280.
39. Schanen BC, De Groot AS, Moise L, Ardito M, McClaine E, et al. (2011) Coupling sensitive in vitro and in silico techniques to assess cross-reactive CD4(+) T cells against the swine-origin H1N1 influenza virus. Vaccine 29: 3299-3309.
40. Deng C, Yang C, Wan J, Zhu L, Leng Q, (2011) Irregular poliovirus vaccination correlates to pulmonary edema of hand, foot, and mouth disease. Clin Vaccine Immunol 18: 1589-1590.