Segmented Filamentous Bacteria Provoke Lung Autoimmunity by Inducing Gut-Lung Axis Th17 Cells Expressing Dual TCRs

Cell Host and Microbe

Volumn 22, Issue 5, 2017, Pages 697-704.e4

  Bradley, C Pierce ^a   Teng, Fei ^a   Felix, Krysta M ^a   Sano, Teruyuki ^b   Naskar, Debdut ^a   Block, Katharine E ^c   Huang, Haochu ^c   Knox, Kenneth S ^d   Littman, Dan R ^b   Wu, Hsin Jung Joyce ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

autoimmune; dual TCR; gut microbiota; gut lung axis; rheumatoid arthritis; Th17 cells

Indexed keywords

EPITOPE; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; T LYMPHOCYTE RECEPTOR; AUTOANTIBODY; CCL20 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; BACTERIUM; CONTROLLED STUDY; IMMUNE RESPONSE; INTESTINE FLORA; LUNG COMPLICATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SEGMENTED FILAMENTOUS BACTERIA; SIGNAL TRANSDUCTION; SPLEEN; TH17 CELL; ANIMAL; APOPTOSIS; AUTOIMMUNE DISEASE; C57BL MOUSE; CELL DIFFERENTIATION; CELL PROLIFERATION; DISEASE MODEL; FECES; IMMUNOLOGY; LUNG; METABOLISM; MICROBIOLOGY; MOUSE; NONOBESE DIABETIC MOUSE; PATHOGENICITY; PATHOLOGY; SYMBIOSIS; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOIMMUNE DISEASES; AUTOIMMUNITY; BACTERIA; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMOKINE CCL20; DISEASE MODELS, ANIMAL; FECES; GASTROINTESTINAL MICROBIOME; LUNG; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, TRANSGENIC; SPLEEN; SYMBIOSIS; TH17 CELLS;

EID: 85032742580     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2017.10.007     Document Type: Article

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