The role of inflammation in late-life post-traumatic stress disorder

Military Medicine

Volumn 182, Issue 11, 2017, Pages e1815-e1818

  Miller, Kenneth ^a   Driscoll, David ^b   Smith, Lynette M ^c   Ramaswamy, Sriram ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN;

AGED; BLOOD; DEVICES; HUMAN; IMMUNOLOGY; INFLAMMATION; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; PILOT STUDY; POSTTRAUMATIC STRESS DISORDER; PROCEDURES; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; PSYCHOMETRY; VERY ELDERLY; VETERAN;

AGED; AGED, 80 AND OVER; BIOMARKERS; C-REACTIVE PROTEIN; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; PILOT PROJECTS; PSYCHIATRIC STATUS RATING SCALES; PSYCHOMETRICS; STRESS DISORDERS, POST-TRAUMATIC; VETERANS;

EID: 85032720361     PISSN: 00264075     EISSN: 1930613X     Source Type: Journal    
DOI: 10.7205/MILMED-D-17-00073     Document Type: Article

References (20)

1. Andrews B, Brewin CR, Philpott R, Stewart L: Delayed-onset posttraumatic stress disorder: a systematic review of the evidence. Am J Psychiatry 2007; 164(9): 1319–26.
2. Mota N, Tsai J, Kirwin PD, et al: Late-life exacerbation of PTSD symptoms in US veterans: results from the National Health and Resilience in Veterans Study. J Clin Psychiatry 2016; 77(3): 348–54.
3. Pace TW, Heim CM: A short review on the psychoneuroimmunology of posttraumatic stress disorder: from risk factors to medical comorbidities. Brain Behav Immun 2011; 25(1): 6–13.
4. Miller AH, Maletic V, Raison CL: Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 2009; 65(9): 732–41.
5. Michopoulos V, Rothbaum AO, Jovanovic T, et al: Association of CRP genetic variation and CRP level with elevated PTSD symptoms and physiological responses in a civilian population with high levels of trauma. Am J Psychiatry 2015; 172(4): 353–62.
6. Rosen RL, Levy-Carrick N, Reibman J, et al: Elevated C-reactive protein and posttraumatic stress pathology among survivors of the 9/11 World Trade Center attacks. J Psychiatr Res 2017; 89: 14–21.
7. Lindqvist D, Wolkowitz OM, Mellon S, et al: Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress. Brain Behav Immun 2014; 42: 81–8.
8. Groer MW, Kane B, Williams SN, Duffy A: Relationship of PTSD symptoms with combat exposure, stress, and inflammation in American soldiers. Biol Res Nurs 2015; 17(3): 303–10.
9. Eraly SA, Nievergelt CM, Maihofer AX, et al: Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk. JAMA Psychiatry 2014; 71(4): 423–31.
10. Passos IC, Vasconcelos-Moreno MP, Costa LG, et al: Inflammatory markers in post-traumatic stress disorder: a systematic review, metaanalysis, and meta-regression. Lancet Psychiatry 2015; 2(11): 1002–12.
11. Michopoulos V, Norrholm SD, Jovanovic T: Diagnostic biomarkers for posttraumatic stress disorder: promising horizons from translational neuroscience research. Biol Psychiatry 2015; 78(5): 344–53.
12. Weathers FW, Blake DD, Schnurr PP, Kaloupek DG, Marx BP, Keane TM: The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5). National Center for PTSD, 2013. Available at http://www.ptsd.va.gov/PTSD/professional/assessment/adult-int/caps.asp; accessed February 23, 2015.
13. Weathers FW, Keane TM, Davidson JR: Clinician-administered PTSD scale: a review of the first ten years of research. Depress Anxiety 2001; 13(3): 132–56.
14. Hamilton M: A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 139: 297–305.
15. Cusin C, Yang H, Yeung A, Fava M: Rating scales for depression. In: Handbook of Clinical Rating Scales and Assessment in Psychiatry and Mental Health. Edited by Baer L, Blais MA. New York, NY, Humana Press, 2009.
16. Zimmerman M, Martinez JH, Young D, Chelminski I, Dalrymple K: Severity classification on the Hamilton Depression Rating Scale. J Affect Disord 2013; 150(2): 384–88.
17. van Zuiden M, Geuze E, Willemen HL, et al: Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: a prospective study. Biol Psychiatry 2012; 71(4): 309–16.
18. Beristianos MH, Yaffe K, Cohen B, Byers AL: PTSD and risk of incident cardiovascular disease in aging veterans. Am J Geriatr Psychiatry 2016; 24(3):192–200.
19. Edmondson E, Kronish IM, Shaffer JA, Falzon L, Burg MM: Posttraumatic stress disorder and risk for coronary heart disease: a meta-analytic review. Am Heart J 2013; 166(5): 806–14.
20. Uher R, Tansey KE, Dew T, et al: An inflammatory biomarker as a differential predictor of outcome of depression treatment with escitalopram and nortriptyline. Am J Psychiatry 2014; 171(12): 1278–86.