The use of neutrophil to lymphocyte ratio as a predictor for clinical outcomes in spontaneous intracerebral hemorrhage

Oncotarget

Volumn 8, Issue 52, 2017, Pages 90380-90389

  Ye, Zengpanpan ^a   Ai, Xiaolin ^a   Fang, Fang ^a   Hu, Xin ^a   Faramand, Andrew ^b   You, Chao ^a  

^a SICHUAN UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Intracerebral hemorrhage; Meta analysis; Neutrophil to lymphocyte ratio

Indexed keywords

ARTICLE; BRAIN HEMATOMA; BRAIN HEMORRHAGE; CARDIOVASCULAR MORTALITY; CLINICAL OUTCOME; CORRELATIONAL STUDY; DISEASE ASSOCIATION; HIGH RISK POPULATION; HOSPITAL MORTALITY; HOSPITAL PATIENT; HUMAN; NEUTROPHIL LYMPHOCYTE RATIO; PREDICTION; PROGNOSIS;

EID: 85032273098     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.20120     Document Type: Article

References (45)

1. Hemphill JC 3rd, Greenberg SM, Anderson CS, Becker K, Bendok BR, Cushman M, Fung GL, Goldstein JN, Macdonald RL, Mitchell PH, Scott PA, Selim MH, et al. Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/ American Stroke Association. Stroke. 2015; 46:2032-60. https://doi.org/10.1161/STR.0000000000000069
2. van Asch CJ, Luitse MJ, Rinkel GJ, van der Tweel I, Algra A, Klijn CJ. Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis. Lancet Neurol. 2010; 9:167-76. https://doi. org/10.1016/S1474-4422(09)70340-0
3. Mayer SA, Rincon F. Treatment of intracerebral haemorrhage. Lancet Neurol. 2005; 4:662-72. https://doi. org/10.1016/S1474-4422(05)70195-2
4. Aronowski J, Zhao X. Molecular pathophysiology of cerebral hemorrhage: secondary brain injury. Stroke. 2011; 42:1781-6. https://doi.org/10.1161/STROKEAHA.110.596718
5. Wang J. Preclinical and clinical research on inflammation after intracerebral hemorrhage. Prog Neurobiol. 2010; 92:463-77. https://doi.org/10.1016/j.pneurobio.2010.08.001
6. Xi G, Keep RF, Hoff JT. Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol. 2006; 5:53-63. https://doi.org/10.1016/S1474-4422(05)70283-0
7. Wang J, Dore S. Inflammation after intracerebral hemorrhage. J Cereb Blood Flow Metab. 2007; 27:894-908. https://doi.org/10.1038/sj.jcbfm.9600403
8. Leira R, Davalos A, Silva Y, Gil-Peralta A, Tejada J, Garcia M, Castillo J, Stroke Project CDGotSNS. Early neurologic deterioration in intracerebral hemorrhage: predictors and associated factors. Neurology. 2004; 63:461-7
9. Walsh KB, Sekar P, Langefeld CD, Moomaw CJ, Elkind MS, Boehme AK, James ML, Osborne J, Sheth KN, Woo D, Adeoye O. Monocyte Count and 30-Day Case Fatality in Intracerebral Hemorrhage. Stroke. 2015; 46:2302-4. https:// doi.org/10.1161/STROKEAHA.115.009880
10. Bestue-Cardiel M, Martin-Martinez J, Iturriaga-Heras C, Ara-Callizo JR, Oliveros-Juste A. Leukocytes and primary intracerebral hemorrhage. [Article in Spanish]. Rev Neurol. 1999; 29:968-71
11. Yin Y, Wang J, Wang X, Gu L, Pei H, Kuai S, Zhang Y, Shang Z. Prognostic value of the neutrophil to lymphocyte ratio in lung cancer: A meta-analysis. Clinics (Sao Paulo). 2015; 70:524-30. https://doi.org/10.6061/clinics/2015(07)10
12. Li MX, Liu XM, Zhang XF, Zhang JF, Wang WL, Zhu Y, Dong J, Cheng JW, Liu ZW, Ma L, Lv Y. Prognostic role of neutrophil-to-lymphocyte ratio in colorectal cancer: a systematic review and meta-analysis. Int J Cancer. 2014; 134:2403-13. https://doi.org/10.1002/ijc.28536
13. Tao C, Hu X, Wang J, Ma J, Li H, You C. Admission neutrophil count and neutrophil to lymphocyte ratio predict 90-day outcome in intracerebral hemorrhage. Biomark Med. 2017; 11:33-42. https://doi.org/10.2217/bmm-2016-0187
14. Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G, Meghani M, Akhtar M, Costantino T. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther. 2013; 11:55-9. https://doi. org/10.1586/erc.12.159
15. Tokgoz S, Keskin S, Kayrak M, Seyithanoglu A, Ogmegul A. Is neutrophil/lymphocyte ratio predict to shortterm mortality in acute cerebral infarct independently from infarct volume? J Stroke Cerebrovasc Dis. 2014; 23:2163-8. https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.04.007
16. Brooks SD, Spears C, Cummings C, VanGilder RL, Stinehart KR, Gutmann L, Domico J, Culp S, Carpenter J, Rai A, Barr TL. Admission neutrophil-lymphocyte ratio predicts 90 day outcome after endovascular stroke therapy. J Neurointerv Surg. 2014; 6:578-83. https://doi.org/10.1136/ neurintsurg-2013-010780
17. Idzko M, Ferrari D, Eltzschig HK. Nucleotide signalling during inflammation. Nature. 2014; 509:310-7. https://doi. org/10.1038/nature13085
18. Moses K, Brandau S. Human neutrophils: Their role in cancer and relation to myeloid-derived suppressor cells. Semin Immunol. 2016; 28:187-96. https://doi.org/10.1016/j. smim.2016.03.018
19. Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol. 2008; 102:653-7. https://doi.org/10.1016/j.amjcard.2008.05.006
20. Xue J, Huang W, Chen X, Li Q, Cai Z, Yu T, Shao B. Neutrophilto-Lymphocyte Ratio Is a Prognostic Marker in Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2017; 26:650-7. https://doi. org/10.1016/j.jstrokecerebrovasdis.2016.11.010
21. Zhou Y, Wang Y, Wang J, Anne Stetler R, Yang QW. Inflammation in intracerebral hemorrhage: from mechanisms to clinical translation. Prog Neurobiol. 2014; 115:25-44. https://doi.org/10.1016/j.pneurobio.2013.11.003
22. Wang F, Hu S, Ding Y, Ju X, Wang L, Lu Q, Wu X. Neutrophil-to-Lymphocyte Ratio and 30-Day Mortality in Patients with Acute Intracerebral Hemorrhage. J Stroke Cerebrovasc Dis. 2016; 25:182-7. https://doi.org/10.1016/j. jstrokecerebrovasdis.2015.09.013
23. Sun Y, You S, Zhong C, Huang Z, Hu L, Zhang X, Shi J, Cao Y, Liu CF. Neutrophil to lymphocyte ratio and the hematoma volume and stroke severity in acute intracerebral hemorrhage patients. Am J Emerg Med. 2017; 35:429-33. https://doi.org/10.1016/j.ajem.2016.11.037
24. Giede-Jeppe A, Bobinger T, Gerner ST, Sembill JA, Sprugel MI, Beuscher VD, Lucking H, Hoelter P, Kuramatsu JB, Huttner HB. Neutrophil-to-Lymphocyte Ratio Is an Independent Predictor for In-Hospital Mortality in Spontaneous Intracerebral Hemorrhage. Cerebrovasc Dis. 2017; 44:26-34. https://doi.org/10.1159/000468996
25. Lattanzi S, Cagnetti C, Provinciali L, Silvestrini M. Neutrophil-to-Lymphocyte Ratio Predicts the Outcome of Acute Intracerebral Hemorrhage. Stroke. 2016; 47:1654-7. https://doi.org/10.1161/strokeaha.116.013627
26. Lattanzi S, Cagnetti C, Provinciali L, Silvestrini M. Neutrophil-to-lymphocyte ratio and neurological deterioration following acute cerebral hemorrhage. Oncotarget. 2017; 8:57489-57494. https://doi.org/10.18632/oncotarget.15423
27. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. European Journal of Epidemiology. 2010; 25:603-5. https://doi.org/10.1007/s10654-010-9491-z
28. Patsopoulos NA, Evangelou E, Ioannidis JP. Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation. Int J Epidemiol. 2008; 37:1148-57. https://doi.org/10.1093/ije/dyn065
29. Stovold E, Beecher D, Foxlee R, Noel-Storr A. Study flow diagrams in Cochrane systematic review updates: an adapted PRISMA flow diagram. Syst Rev. 2014; 3:54. https://doi.org/10.1186/2046-4053-3-54
30. Gong C, Hoff JT, Keep RF. Acute inflammatory reaction following experimental intracerebral hemorrhage in rat. Brain Res. 2000; 871:57-65
31. Xue MZ, Del Bigio MR. Intracortical hemorrhage injury in rats-Relationship between blood fractions and brain cell death. Stroke. 2000; 31:1721-7
32. Xue M, Del Bigio MR. Comparison of brain cell death and inflammatory reaction in three models of intracerebral hemorrhage in adult rats. J Stroke Cerebrovasc Dis. 2003; 12:152-9. https://doi.org/10.1016/S1052-3057(03)00036-3
33. Kalita J, Bastia J, Bhoi SK, Misra UK. Systemic Inflammatory Response Syndrome Predicts Severity of Stroke and Outcome. J Stroke Cerebrovasc Dis. 2015; 24:1640-8. https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.03.057
34. Dirnagl U, Klehmet J, Braun JS, Harms H, Meisel C, Ziemssen T, Prass K, Meisel A. Stroke-induced immunodepression: experimental evidence and clinical relevance. Stroke. 2007; 38:770-3. https://doi.org/10.1161/01. STR.0000251441.89665.bc
35. Morotti A, Phuah CL, Anderson CD, Jessel MJ, Schwab K, Ayres AM, Pezzini A, Padovani A, Gurol ME, Viswanathan A, Greenberg SM, Goldstein JN, Rosand J. Leukocyte Count and Intracerebral Hemorrhage Expansion. Stroke. 2016; 47:1473-8. https://doi.org/10.1161/STROKEAHA.116.013176
36. Suzuki S, Kelley RE, Dandapani BK, Reyes-Iglesias Y, Dietrich WD, Duncan RC. Acute leukocyte and temperature response in hypertensive intracerebral hemorrhage. Stroke. 1995; 26:1020-3
37. Meisel C, Schwab JM, Prass K, Meisel A, Dirnagl U. Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci. 2005; 6:775-86. https://doi. org/10.1038/nrn1765
38. Lattanzi S, Cagnetti C, Provinciali L, Silvestrini M. Blood Pressure Variability and Clinical Outcome in Patients with Acute Intracerebral Hemorrhage. J Stroke Cerebrovasc Dis. 2015; 24:1493-9. https://doi.org/10.1016/j. jstrokecerebrovasdis.2015.03.014
39. Lattanzi S, Silvestrini M. Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2. Neurology. 2015; 85:557-8. https://doi.org/10.1212/01. wnl.0000470918.40985.d0
40. Fogelholm R, Murros K, Rissanen A, Avikainen S. Admission blood glucose and short term survival in primary intracerebral haemorrhage: a population based study. J Neurol Neurosurg Psychiatry. 2005; 76:349-53. https://doi. org/10.1136/jnnp.2003.034819
41. Takagi K. Body temperature in acute stroke. Stroke. 2002; 33:2154-5; author reply-5
42. Radberg JA, Olsson JE, Radberg CT. Prognostic parameters in spontaneous intracerebral hematomas with special reference to anticoagulant treatment. Stroke. 1991; 22:571-6
43. Lattanzi S, Bartolini M, Provinciali L, Silvestrini M. Glycosylated Hemoglobin and Functional Outcome after Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2016; 25:1786-91. https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.03.018
44. Lattanzi S, Silvestrini M, Provinciali L. Elevated blood pressure in the acute phase of stroke and the role of Angiotensin receptor blockers. Int J Hypertens. 2013; 2013:941783. https://doi.org/10.1155/2013/941783
45. Zangari R, Zanier ER, Torgano G, Bersano A, Beretta S, Beghi E, Casolla B, Checcarelli N, Lanfranconi S, Maino A, Mandelli C, Micieli G, Orzi F, et al. Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke. J Neuroinflammation. 2016; 13:16. https:// doi.org/10.1186/s12974-016-0481-2