Leukocyte Count and Intracerebral Hemorrhage Expansion

Stroke

Volumn 47, Issue 6, 2016, Pages 1473-1478

  Morotti, Andrea ^a,b   Phuah, Chia Ling ^b   Anderson, Christopher D ^b   Jessel, Michael J ^b   Schwab, Kristin ^b   Ayres, Alison M ^b   Pezzini, Alessandro ^a   Padovani, Alessandro ^a   Gurol, M Edip ^b   Viswanathan, Anand ^b   Greenberg, Steven M ^b   Goldstein, Joshua N ^b   Rosand, Jonathan ^b  

^a UNIVERSITY OF BRESCIA   (Italy)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

hematoma expansion; inflammation; intracerebral hemorrhage; leukocytes; monocytes; neutrophils

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN HEMATOMA; BRAIN HEMORRHAGE; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; IMAGING SOFTWARE; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MONOCYTE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NEUTROPHIL COUNT; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; AGE; BLOOD; DIAGNOSTIC IMAGING; DISEASE COURSE; HEMATOMA; LEUKOCYTOSIS; MIDDLE AGED; NEUTROPHIL; PREDICTIVE VALUE; SEX DIFFERENCE; VERY ELDERLY; X-RAY COMPUTED TOMOGRAPHY;

AGE FACTORS; AGED; AGED, 80 AND OVER; DISEASE PROGRESSION; FEMALE; HEMATOMA; HUMANS; INTRACRANIAL HEMORRHAGES; LEUKOCYTE COUNT; LEUKOCYTOSIS; MALE; MIDDLE AGED; MONOCYTES; NEUTROPHILS; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; SEX FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84964277269     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.116.013176     Document Type: Article

References (42)

1. Qureshi AI, Mendelow AD, Hanley DF. Intracerebral haemorrhage. Lancet. 2009;373:1632-1644. doi: 10.1016/S0140-6736(09)60371-8.
2. Ikram MA, Wieberdink RG, Koudstaal PJ. International epidemiology of intracerebral hemorrhage. Curr Atheroscler Rep. 2012;14:300-306. doi: 10.1007/s11883-012-0252-1.
3. Dowlatshahi D, Demchuk AM, Flaherty ML, Ali M, Lyden PL, Smith EE; VISTA Collaboration. Defining hematoma expansion in intracerebral hemorrhage: relationship with patient outcomes. Neurology. 2011;76:1238-1244. doi: 10.1212/WNL.0b013e3182143317.
4. Brouwers HB, Greenberg SM. Hematoma expansion following acute intracerebral hemorrhage. Cerebrovasc Dis. 2013;35:195-201. doi: 10.1159/000346599.
5. Suzuki S, Kelley RE, Dandapani BK, Reyes-Iglesias Y, Dietrich WD, Duncan RC. Acute leukocyte and temperature response in hypertensive intracerebral hemorrhage. Stroke. 1995;26:1020-1023.
6. Behrouz R, Hafeez S, Miller CM. Admission leukocytosis in intracerebral hemorrhage: associated factors and prognostic implications. Neurocrit Care. 2015;23:370-373. doi: 10.1007/s12028-015-0128-7.
7. Sun W, Peacock A, Becker J, Phillips-Bute B, Laskowitz DT, James ML. Correlation of leukocytosis with early neurological deterioration following supratentorial intracerebral hemorrhage. J Clin Neurosci. 2012;19:1096-1100. doi: 10.1016/j.jocn.2011.11.020.
8. Leira R, Dávalos A, Silva Y, Gil-Peralta A, Tejada J, Garcia M, et al; Stroke Project, Cerebrovascular Diseases Group of the Spanish Neurological Society. Early neurologic deterioration in intracerebral hemorrhage: predictors and associated factors. Neurology. 2004;63:461-467.
9. Agnihotri S, Czap A, Staff I, Fortunato G, McCullough LD. Peripheral leukocyte counts and outcomes after intracerebral hemorrhage. J Neuroinflammation. 2011;8:160. doi: 10.1186/1742-2094-8-160.
10. Di Napoli M, Godoy DA, Campi V, del Valle M, Piñero G, Mirofsky M, et al. C-reactive protein level measurement improves mortality prediction when added to the spontaneous intracerebral hemorrhage score. Stroke. 2011;42:1230-1236. doi: 10.1161/STROKEAHA.110.604983.
11. McEver RP. Adhesive interactions of leukocytes, platelets, and the vessel wall during hemostasis and inflammation. Thromb Haemost. 2001;86:746-756.
12. Esmon CT. The interactions between inflammation and coagulation. Br J Haematol. 2005;131:417-430. doi: 10.1111/j.1365-2141.2005.05753.x.
13. Bouchard BA, Tracy PB. Platelets, leukocytes, and coagulation. Curr Opin Hematol. 2001;8:263-269.
14. Biffi A, Cortellini L, Nearnberg CM, Ayres AM, Schwab K, Gilson AJ, et al. Body mass index and etiology of intracerebral hemorrhage. Stroke. 2011;42:2526-2530. doi: 10.1161/STROKEAHA.111.617225.
15. Brouwers HB, Falcone GJ, McNamara KA, Ayres AM, Oleinik A, Schwab K, et al. CTA spot sign predicts hematoma expansion in patients with delayed presentation after intracerebral hemorrhage. Neurocrit Care. 2012;17:421-428. doi: 10.1007/s12028-012-9765-2.
16. Wada R, Aviv RI, Fox AJ, Sahlas DJ, Gladstone DJ, Tomlinson G, et al. CT angiography "spot sign" predicts hematoma expansion in acute intracerebral hemorrhage. Stroke. 2007;38:1257-1262. doi: 10.1161/01. STR.0000259633.59404.f3.
17. Brouwers HB, Chang Y, Falcone GJ, Cai X, Ayres AM, Battey TW, et al. Predicting hematoma expansion after primary intracerebral hemorrhage. JAMA Neurol. 2014;71:158-164. doi: 10.1001/jamaneurol.2013.5433.
18. Furie B, Furie BC. Mechanisms of thrombus formation. N Engl J Med. 2008;359:938-949. doi: 10.1056/NEJMra0801082.
19. Afshar-Kharghan V, Thiagarajan P. Leukocyte adhesion and thrombosis. Curr Opin Hematol. 2006;13:34-39.
20. Keep RF, Hua Y, Xi G. Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol. 2012;11:720-731. doi: 10.1016/S1474-4422(12)70104-7.
21. Gillis S, Furie BC, Furie B. Interactions of neutrophils and coagulation proteins. Semin Hematol. 1997;34:336-342.
22. Ruf W, Ruggeri ZM. Neutrophils release brakes of coagulation. Nat Med. 2010;16:851-852. doi: 10.1038/nm0810-851.
23. Steppich BA, Seitz I, Busch G, Stein A, Ott I. Modulation of tissue factor and tissue factor pathway inhibitor-1 by neutrophil proteases. Thromb Haemost. 2008;100:1068-1075.
24. Maugeri N, Brambilla M, Camera M, Carbone A, Tremoli E, Donati MB, et al. Human polymorphonuclear leukocytes produce and express functional tissue factor upon stimulation. J Thromb Haemost. 2006;4:1323-1330. doi: 10.1111/j.1538-7836.2006.01968.x.
25. Mócsai A. Diverse novel functions of neutrophils in immunity, inflammation, and beyond. J Exp Med. 2013;210:1283-1299. doi: 10.1084/jem.20122220.
26. Massberg S, Grahl L, von Bruehl ML, Manukyan D, Pfeiler S, Goosmann C, et al. Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med. 2010;16:887-896. doi: 10.1038/nm.2184.
27. Gould TJ, Vu TT, Swystun LL, Dwivedi DJ, Mai SH, Weitz JI, et al. Neutrophil extracellular traps promote thrombin generation through platelet-dependent and platelet-independent mechanisms. Arterioscler Thromb Vasc Biol. 2014;34:1977-1984. doi: 10.1161/ATVBAHA.114.304114.
28. Hwang SM, Kim JE, Han KS, Kim HK. Thrombomodulin phenotype of a distinct monocyte subtype is an independent prognostic marker for disseminated intravascular coagulation. Crit Care. 2011;15:R113. doi: 10.1186/cc10139.
29. McCachren SS, Diggs J, Weinberg JB, Dittman WA. Thrombomodulin expression by human blood monocytes and by human synovial tissue lining macrophages. Blood. 1991;78:3128-3132.
30. Pou J, Rebollo A, Piera L, Merlos M, Roglans N, Laguna JC, et al. Tissue factor pathway inhibitor 2 is induced by thrombin in human macrophages. Biochim Biophys Acta. 2011;1813:1254-1260. doi: 10.1016/j. bbamcr.2011.03.020.
31. Mracsko E, Veltkamp R. Neuroinflammation after intracerebral hemorrhage. Front Cell Neurosci. 2014;8:388. doi: 10.3389/fncel.2014.00388.
32. Walsh KB, Sekar P, Langefeld CD, Moomaw CJ, Elkind MS, Boehme AK, et al. Monocyte count and 30-day case fatality in intracerebral hemorrhage. Stroke. 2015;46:2302-2304. doi: 10.1161/STROKEAHA.115.009880.
33. Adeoye O, Walsh K, Woo JG, Haverbusch M, Moomaw CJ, Broderick JP, et al. Peripheral monocyte count is associated with case fatality after intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2014;23:e107-e111. doi: 10.1016/j.jstrokecerebrovasdis.2013.09.006.
34. Yao Y, Tsirka SE. The CCL2-CCR2 system affects the progression and clearance of intracerebral hemorrhage. Glia. 2012;60:908-918. doi: 10.1002/glia.22323.
35. Wang J, Doré S. Inflammation after intracerebral hemorrhage. J Cereb Blood Flow Metab. 2007;27:894-908. doi: 10.1038/sj.jcbfm.9600403.
36. Kellner CP, Connolly ES Jr. Neuroprotective strategies for intracerebral hemorrhage: trials and translation. Stroke. 2010;41(10 suppl):S99-102. doi: 10.1161/STROKEAHA.110.597476.
37. Hwang BY, Appelboom G, Ayer A, Kellner CP, Kotchetkov IS, Gigante PR, et al. Advances in neuroprotective strategies: potential therapies for intracerebral hemorrhage. Cerebrovasc Dis. 2011;31:211-222. doi: 10.1159/000321870.
38. Zhou Y, Wang Y, Wang J, Anne Stetler R, Yang QW. Inflammation in intracerebral hemorrhage: from mechanisms to clinical translation. Prog Neurobiol. 2014;115:25-44. doi: 10.1016/j.pneurobio.2013.11.003.
39. Jacobs AH, Tavitian B; INMiND consortium. Noninvasive molecular imaging of neuroinflammation. J Cereb Blood Flow Metab. 2012;32:1393-1415. doi: 10.1038/jcbfm.2012.53.
40. Steiner T, Bösel J. Options to restrict hematoma expansion after spontaneous intracerebral hemorrhage. Stroke. 2010;41:402-409. doi: 10.1161/STROKEAHA.109.552919.
41. Yao X, Xu Y, Siwila-Sackman E, Wu B, Selim M. The HEP score: a nomogram-derived hematoma expansion prediction scale. Neurocrit Care. 2015;23:179-187. doi: 10.1007/s12028-015-0147-4.
42. Huynh TJ, Aviv RI, Dowlatshahi D, Gladstone DJ, Laupacis A, Kiss A, et al.; PREDICT/Sunnybrook CTA Investigators. Validation of the 9-point and 24-point hematoma expansion prediction scores and derivation of the PREDICT A/B scores. Stroke. 2015;46:3105-3110. doi: 10.1161/STROKEAHA.115.009893.