Lactitol and the maintenance of normal defecation: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

EFSA Journal

Volumn 13, Issue 10, 2015, Pages

[No Author Info available]

Author keywords

bowel function; defecation; health claim; lactitol

Indexed keywords

EID: 85031818917     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2015.4252     Document Type: Article

References (27)

1. Ballonque J, Schumann C and Quignon P, 1997. Effects of lactulose and lactitol on colonic microflora and enzymatic activity. Scandinavian Journal of Gastroenterolenterology, Suppl., 222, 41–44.
2. Clausen MR, Jørgensen J and Mortensen PB, 1998. Comparison of diarrhea induced by ingestion of fructooligosaccharide Idolax and disaccharide lactulose: role of osmolarity versus fermentation of malabsorbed carbohydrate. Digestive Diseases and Sciences, 43, 2696–2707.
3. Delas N, Gislon J, Glikmanas M, Henri-Biabaud E, Lemerez M, Licht H, Slama JL and Gillaume PN, 1991. [Lactitol in the treatment of constipation in the adult. Open, non-comparative study of its efficacy and its clinical and biological tolerance]. Annales de Gastroenterologie et d'Hepatologie (Paris), 27, 231–233.
4. Doffoel M, Berthel M and Bockel R, 1990. Etude comparative du Lactitol et du lactulose dans le traitment de la constipation fonctionelle du sujet age. Médecine Chirurgie Digestives, 19, 257–259.
5. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2011a. General guidance for stakeholders on the evaluation of Article 13.1, 13.5 and 14 health claims. EFSA Journal 2011;9 (4): 2135, 24 pp. doi:10.2903/j.efsa.2011.2135.
6. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2011b. Scientific and technical guidance for the preparation and presentation of an application for authorisation of a health claim (revision 1). EFSA Journal 2011;9 (5): 2170, 36 pp. doi:10.2903/j.efsa.2011.2170.
7. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2011c. Guidance on the scientific requirements for health claims related to gut and immune function. EFSA Journal 2011;9 (4): 1984. [12 pp.] doi:10.2903/j.efsa.2011.1984.
8. Goevaerts L and Ravelli GP, 1993. Lactitol monohydrate for the treatment of chronic constipation; a multicentre study on the efficacy and tolerability of an individually adjusted daily dose. Acta Therapeutica, 19, 61–71.
9. Grimble GK, Patil DH and Silk DB, 1988. Assimilation of lactitol, an ‘unabsorbed’ disaccharide in the normal human colon. Gut, 29, 1666–1671.
10. Hammer B and Ravelli GP, 1992. Chronische funktionelle obstipation, eine multizentrische Vergleichsstudie zwischen Lactitol und Lactulose. Therapiewoche Schweiz, 8, 328–335.
11. Heitland W and Mauersberger H. 1988. Study of the laxative effect of Lactitol as opposed to lactulose in an open, randomized comparative study. Schweizerische Rundschau fur Medizin Praxis, 77, 493–495.
12. Mäkivuokko H, Forssten S, Saarinen M, Ouwehand A and Rautonen N, 2010. Synbiotic effects of lactitol and Lactobacillus acidophilus NCFMTM in a semi-continuous colon fermentation model. Beneficial Microbes, 1, 131–137.
13. Martino AM, Pesce F and Rosati U. 1992. The effects of lactitol in the treatment of intestinal stasis in childhood. Minerva Pediatrica, 44, 319–323.
14. Miller LE, Tennilä J and Ouwehand AC, 2014. Efficacy and tolerance of lactitol supplementation for adult constipation: a systematic review and meta-analysis. Clinical and Experimental Gastroenterology, 12, 241–248.
15. Minella R, Alagna M, Franco MT, Emiliano M, Lervol C, Scoppa A and Cucchiara S, 1993. Treatment of functional chronic constipation with lactitol. Rivista Italiana di Pediatria (IJP), 19, 77–81.
16. Oku T and Nakamura S, 2007. Threshold for transitory diarrhea induced by ingestion of xylitol and lactitol in young male and female adults. Journal of Nutritional Science and Vitaminology (Tokyo), 53, 13–20.
17. Oku T, Nakamura S and Ichinose M, 2005. Maximum permissive dosage of lactose and lactitol for transitory diarrhea, and utilizable capacity for lactose in Japanese female adults. Journal of Nutritional Science and Vitaminology (Tokyo), 51, 51–57.
18. Patil DH, Grimble GK and Silk DB, 1987a. Lactitol, a new hydrogenated lactose derivative: intestinal absorption and laxative threshold in normal human subjects. British Journal of Nutrition, 57, 195–199.
19. Patil DH, Westaby D, Mahida YR, Palmer KR, Rees R, Clark ML, Dawson AM and Silk DB, 1987b. Comparative modes of action of lactitol and lactulose in the treatment of hepatic encephalopathy. Gut, 28, 255–259.
20. Pitzalis G, Deganello F, Mariani P, Chiarini-Testa MB, Virgilii F, Gasparri R, Calvani L and Bonamico M, 1995. [Lactitol in chronic idiopathic constipation in children]. La Pediatria Medica e Chirurgica, 17, 223–226.
21. Pontes FA, Silva AT and Cruz AC, 1995. Colonic transit times and the effect of Lactulose or Lactitol in hospitalized patients. European Journal of Gastroenterology and Hepatology, 7, 441–446.
22. Ravelli GP, Whyte A and Spencer R, 1995. The effect of Lactitol intake upon stool parameters and the faecal bacterial flora in chronically constipated women. Acta Therapeutica, 21, 243–255.
23. Vanderdonckt J and Ravelli GP, 1993. Lactitol as an alternative to harsh laxatives, an explanatory, open pilot study in chronic functional constipation. Acta Therapeutica, 19, 295–308.
24. Vanderdonckt J, Coulon J, Denys W and Ravelli GP, 1990. Study of the laxative effect of lactitol (Importal) in an elderly institutionalized but not bedridden, population suffering from constipation. Journal of Clinical Experimental Gerontolology, 21, 171–189.
25. Van Es AJ, De Groot L and Vogt JE, 1986. Energy balances of eight volunteers fed on diets supplemented with either lactitol or saccharose. British Journal of Nutrition, 56, 545–554.
26. Walder M, Buclin T, Biollaz J, Kitler ME and Schelling JL, 1988. [Dose-response curve and preliminary clinical study of a laxative, lactitol]. Schweizerische Medizinische Wochenschrift, 118, 1925–1927.
27. Xu Z, Dai J, Shi R, Sun S, Chen L, Yang L and Lu L, 2012. A multicenter, randomized, single-blinded, parallel-controlled trial on lactitol in treatment of constipation. Chinese Journal of Gastroenterology, 17, 168–172.