Overcoming chemotherapy resistance by targeting hyaluronan/CD44-mediated stem cell marker (Nanog) signaling and microRNA-21 in breast, ovarian, and head and neck cancer

Stem Cells and Cancer Stem Cells: Therapeutic Applications in Disease and Injury

Volumn 9, Issue , 2013, Pages 291-298

  Bourguignon, Lilly Y W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85031410446     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-94-007-5645-8_28     Document Type: Chapter

References (29)

1. Al-Hajj M, Wicha MS, Benito-Hemandez A, Morrison SJ, Clarke MF (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 100:3983-3988
2. Asangani I A, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, Allgayer H (2008) MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasa-tion and metastasis in colorectal cancer. Oncogene 27:2128-2136
3. Baker EK, El-Osta A (2004) MDR1, chemotherapy and chromatin remodeling. Cancer Biol Ther 3:819-824
4. Bhalla KN (2003) Microtubule-targeted anticancer agents and apoptosis. Oncogene 22:9075-9086
5. Bourguignon LY (2008) Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression. Semin Cancer Biol 18:251-259
6. Bourguignon LY, Peyrollier K, Xia W, Gilad E (2008) Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells. J Biol Chem 283:17635-17651
7. Bourguignon LY, Spevak CC, Wong G, Xia W, Gilad E (2009a) Hyaluronan-CD44 interaction with PKCe promotes oncogenic signaling by the stem cell marker, Nanog and the production of microRNA-21 leading to downregulation of the tumor suppressor protein, PDCD4, anti-apoptosis and chemotherapy resistance in breast tumor cells. J Biol Chem 284:26533-26546
8. Bourguignon LY, Xia W, Wong G (2009b) Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells. J Biol Chem 284:2657-2671
9. Bourguignon LY, Earle C, Wong G, Spevak CC, Krueger K (2012) Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresis-tance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells. Oncogene 31:149-160
10. Cai X, Hagedorn CH, Cullen BR (2004) Human microR-NAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 10:1957-1966
11. Chang SS, Jiang WW, Smith I, Poeta LM, Begum S, Glazer C, Shan S, Westra W, Sidransky D, Califano JA (2008) MicroRNA alterations in head and neck squamous cell carcinoma. Int J Cancer 123:2791-2797
12. Cowland JB, Hother C, Gronbaek K (2007) MicroRNAs and cancer. APMIS 115:1090-1106
13. Darnell JE Jr (1997) STATs and gene regulation. Science 277:1630-1635
14. Davis BN, Hilyard AC, Lagna G, Hata A (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454:56-61
15. de la Cruz J, Kressler D, Linder P (1999) Unwinding RNA in Saccharomyces cerevisiae:DEAD-box proteins and related families. Trends Biochem Sci 24:192-198
16. Gewirtz DA (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunoru-bicin. Biochem Pharmacol 57:727-741
17. Giraldez AJ, Cinalli RM, Glasner ME, Enright AJ, Thomson JM, Baskerville S, Hammond SM, Bartel DP, Schier AF (2005) MicroRNAs regulate brain morphogenesis in zebrafish. Science 308:833-838
18. Harnett PR, Kirsten F, Tattersall MH (1986) Drug resistance in clinical practice: patterns of treatment failure in advanced breast and ovarian cancer. J Clin Oncol 4:952-957
19. Higgins CF (1992) ABC transporters: from microorganisms to man. Annu Rev Cell Biol 8:67-113
20. Hunter AM (2007) The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis 12:1543-1568
21. Lee JY, Spicer AP (2000) Hyaluronan: a multifunctional, megadalton, stealth molecule. Curr Opin Cell Biol 12:581-586
22. Lee Y, Kim M, Han J, Yeom KH, Lee S, Baek SH, Kim VN (2004) MicroRNA genes are transcribed by RNA polymerase II. EMBO J 23:4051-4060
23. Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, Maruyama M, Maeda M, Yamanaka S (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113:631-642
24. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics 2002. CA Cancer J Clin 55:74-108
25. Salzman DW, Shubert-Coleman J, Furneaux H (2007) P68 RNA helicase unwinds the human let-7 microRNA precursor duplex and is required for let-7-directed silencing of gene expression. J Biol Chem 282:32773-32779
26. Screaton GR, Bell MV, Jackson DG, Cornelis FB, Gerth U, Bell JI (1992) Genomic structure of DNA coding the lymphocyte homing receptor CD44 reveals 12 alternatively spliced exons. Proc Natl Acad Sci USA 89:12160-12164
27. Toole BP, Wight T, Tammi M (2002) Hyaluronan-cell interactions in cancer and vascular disease. J Biol Chem 277:4593-4596
28. Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R (2006) Control of translation and mRNA degradation by miR-NAs and siRNAs. Genes Dev 20:515-524
29. Wang S, Bourguignon LY (2011) Role of hyaluronan-mediated CD44 signaling in head and neck squamous cell carcinoma progression and chemoresistance. Am J Pathol 178:956-963