Identification of the optimal dose and calpain system regulation of tetramethylpyrazine on the prevention of skeletal muscle atrophy in hindlimb unloading rats

Biomedicine and Pharmacotherapy

Volumn 96, Issue , 2017, Pages 513-523

  Zhang, Jie ^a   Li, Yang ^a   Li, Guangyue ^a,b   Ma, Xiufeng ^a   Wang, Huiping ^a   Goswami, Nandu ^c   Hinghofer Szalkay, Helmut ^c   Chang, Hui ^a   Gao, Yunfang ^a  

^a NORTHWEST UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Calpains; Disuse atrophy; Muscle functional properties; Tetramethylpyrazine

Indexed keywords

CALPAIN 1; CALPAIN 2; CALPASTATIN; MUSCLE RING FINGER 1 PROTEIN; TETRAMETHYLPYRAZINE; CALPAIN; PYRAZINE DERIVATIVE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRY WEIGHT; EXTENSOR DIGITORUM LONGUS MUSCLE; FAST MUSCLE; FEMALE; HINDLIMB; IMMUNOHISTOCHEMISTRY; MUSCLE ATROPHY; MUSCLE CONTRACTION; MUSCLE FUNCTION; MUSCLE WET WEIGHT; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; OPTIMAL DRUG DOSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; ANIMAL; DOSE RESPONSE; DRUG EFFECT; IMMOBILIZATION; PHYSIOLOGY; PROCEDURES; SKELETAL MUSCLE; SPRAGUE DAWLEY RAT;

ANIMALS; CALPAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HINDLIMB SUSPENSION; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MUSCULAR ATROPHY; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; VASODILATOR AGENTS;

EID: 85031103924     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2017.10.012     Document Type: Article

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