Associations of Helicobacter pylori infection and chronic atrophic gastritis with accelerated epigenetic ageing in older adults

British Journal of Cancer

Volumn 117, Issue 8, 2017, Pages 1211-1214

  Gao, Xu ^a   Zhang, Yan ^a   Brenner, Hermann ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM ANTIBODY; BIOLOGICAL MARKER; CAGA PROTEIN; IMMUNOGLOBULIN G ANTIBODY; PEPSINOGEN I; PEPSINOGEN II; PEPSINOGEN;

ADULT; AGING; ARTICLE; ATROPHIC GASTRITIS; BACTERIAL STRAIN; CANCER RISK; CELL AGING; CHRONIC GASTRITIS; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA METHYLATION; ELISA KIT; EPIGENETICS; FEMALE; HELICOBACTER INFECTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEROLOGY; STOMACH CANCER; AGED; CHRONIC DISEASE; COMPLICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC EPIGENESIS; GENETICS; HELICOBACTER PYLORI; IMMUNOLOGY; METABOLISM; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL;

AGED; AGING; ANTIBODIES, BACTERIAL; CELL AGING; CHRONIC DISEASE; DNA METHYLATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIGENESIS, GENETIC; FEMALE; GASTRITIS, ATROPHIC; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; PEPSINOGEN A; PEPSINOGEN C; SEVERITY OF ILLNESS INDEX;

EID: 85031026420     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2017.314     Document Type: Article

References (19)

1. Chen XZ, Schöttker B, Castro FA, Chen H, Zhang Y, Holleczek B, Brenner H (2016) Association of helicobacter pylori infection and chronic atrophic gastritis with risk of colonic, pancreatic and gastric cancer: a ten-year follow-up of the ESTHER cohort study. Oncotarget 7(13): 17182-17193.
2. Farinati F, Cardin R, Cassaro M, Bortolami M, Nitti D, Tieppo C, Zaninotto G, Rugge M (2008) Helicobacter pylori, inflammation, oxidative damage and gastric cancer: a morphological, biological and molecular pathway. Eur J Cancer Prev 17(3): 195-200.
3. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136(5): E359-E386.
4. Franceschi F, Niccoli G, Ferrante G, Gasbarrini A, Baldi A, Candelli M, Feroce F, Saulnier N, Conte M, Roccarina D, Lanza GA, Gasbarrini G, Gentiloni SN, Crea F (2009) CagA antigen of Helicobacter pylori and coronary instability: insight from a clinico-pathological study and a metaanalysis of 4241 cases. Atherosclerosis 202(2): 535-542.
5. Gao X, Gao X, Zhang Y, Breitling LP, Schottker B, Brenner H (2017) Associations of self-reported smoking, cotinine levels and epigenetic smoking indicators with oxidative stress among older adults: a populationbased study. Eur J Epidemiol 32(5): 443-456.
6. Gao X, Mons U, Zhang Y, Breitling LP, Brenner H (2016a) DNA methylation changes in response to active smoking exposure are associated with leucocyte telomere length among older adults. Eur J Epidemiol 31(12): 1231-1241.
7. Gao X, Zhang Y, Breitling LP, Brenner H (2016b) Relationship of tobacco smoking and smoking-related DNA methylation with epigenetic age acceleration. Oncotarget 7(30): 46878-46889.
8. Graham DY (2015) Helicobacter pylori update: gastric cancer, reliable therapy, and possible benefits. Gastroenterology 148(4): 719-31.e3.
9. Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S, Klotzle B, Bibikova M, Fan JB, Gao Y, Deconde R, Chen M, Rajapakse I, Friend S, Ideker T, Zhang K (2013) Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell 49(2): 359-367.
10. Hekimi S, Lapointe J, Wen Y (2011) Taking a 'good' look at free radicals in the aging process. Trends Cell Biol 21(10): 569-576.
11. Horvath S (2013) DNA methylation age of human tissues and cell types. Genome Biol 14(10): R115.
12. Lewerin C, Jacobsson S, Lindstedt G, Nilsson-Ehle H (2008) Serum biomarkers for atrophic gastritis and antibodies against Helicobacter pylori in the elderly: implications for vitamin B12, folic acid and iron status and response to oral vitamin therapy. Scand J Gastroenterol 43(9): 1050-1056.
13. Maekita T, Nakazawa K, Mihara M, Nakajima T, Yanaoka K, Iguchi M, Arii K, Kaneda A, Tsukamoto T, Tatematsu M, Tamura G, Saito D, Sugimura T, Ichinose M, Ushijima T (2006) High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res 12(3 Pt 1): 989-995.
14. Naito Y, Yoshikawa T (2002) Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress. Free Radic Biol Med 33(3): 323-336.
15. Pandey KB, Rizvi SI (2010) Markers of oxidative stress in erythrocytes and plasma during aging in humans. Oxid Med Cell Longev 3(1): 2-12.
16. Simpkin AJ, Hemani G, Suderman M, Gaunt TR, Lyttleton O, McArdle WL, Ring SM, Sharp GC, Tilling K, Horvath S, Kunze S, Peters A, Waldenberger M, Ward-Caviness C, Nohr EA, Sorensen TI, Relton CL, Smith GD (2016) Prenatal and early life influences on epigenetic age in children: a study of mother-offspring pairs from two cohort studies. Hum Mol Genet 25(1): 191-201.
17. Weck MN, Brenner H (2008) Association of Helicobacter pylori infection with chronic atrophic gastritis: Meta-analyses according to type of disease definition. Int J Cancer 123(4): 874-881.
18. Zhang Y, Hoffmeister M, Weck MN, Chang-Claude J, Brenner H (2012) Helicobacter pylori infection and colorectal cancer risk: evidence from a large population-based case-control study in Germany. Am J Epidemiol 175(5): 441-450.
19. Zhang Y, Zhang XR, Park JL, Kim JH, Zhang L, Ma JL, Liu WD, Deng DJ, You WC, Kim YS, Pan KF (2016) Genome-wide DNA methylation profiles altered by Helicobacter pylori in gastric mucosa and blood leucocyte DNA. Oncotarget 7(24): 37132-37144.