Early Exclusion of Major Adverse Cardiac Events in Emergency Department Chest Pain Patients: A Prospective Observational Study

Journal of Emergency Medicine

Volumn 53, Issue 3, 2017, Pages 287-294

  Leung, Yuk ki ^a   Cheng, Nga man ^a   Chan, Cangel Pui yee ^a   Lee, Anna ^b   Wong, Jeffrey Ka tak ^b   Yan, Bryan Ping yen ^b   Ahuja, Anil Tejbhan ^b   Graham, Colin Alexander ^a   Rainer, Timothy Hudson ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

acute coronary syndrome; chest pain; diagnosis; major adverse cardiac event

Indexed keywords

FATTY ACID BINDING PROTEIN; TROPONIN; TROPONIN T; FABP3 PROTEIN, HUMAN; FATTY ACID BINDING PROTEIN 3;

ACUTE CORONARY SYNDROME; ADULT; ARTICLE; CARDIOVASCULAR DISEASE ASSESSMENT; CLINICAL EVALUATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY CALCIUM SCORE; DIAGNOSTIC ACCURACY; EMERGENCY WARD; FEMALE; HISTORY ELECTROCARDIOGRAM AGE RISK FACTOR TROPONIN SCORE; HUMAN; INTERMETHOD COMPARISON; LOW RISK PATIENT; MAJOR ADVERSE CARDIAC EVENT; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; THORAX PAIN; THROMBOLYSIS IN MYOCARDIAL INFARCTION SCORE; AGED; BLOOD; EARLY DIAGNOSIS; HEART INFARCTION; HOSPITAL EMERGENCY SERVICE; MIDDLE AGED; PREDICTIVE VALUE; PROCEDURES; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; VALIDATION STUDY;

ACUTE CORONARY SYNDROME; ADULT; AGED; CHEST PAIN; EARLY DIAGNOSIS; EMERGENCY SERVICE, HOSPITAL; FATTY ACID BINDING PROTEIN 3; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; TROPONIN T;

EID: 85030660884     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2017.05.006     Document Type: Article

References (29)

1. Goodacre, S., Cross, E., Arnold, J., et al. The health care burden of acute chest pain. Heart 91 (2005), 229–230.
2. Amsterdam, E.A., Kirk, J.D., Bluemke, D.A., et al. American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee of the Council on Clinical Cardiology, Council on Cardiovascular Nursing, and Interdisciplinary Council on Quality of Care and Outcomes Research. Testing of low-risk patients presenting to the emergency department with chest pain: a scientific statement from the American Heart Association. Circulation 122 (2010), 1756–1776.
3. CDARS Hospital Authority, Clinical Data Analysis and Reporting System. 2013, CDARS Hospital Authority, Hong Kong.
4. Than, M., Cullen, L., Reid, C.M., et al. A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): a prospective observational validation study. Lancet 377:9771 (2011), 1077–1084.
5. Ko, H.F., Lee, H.Y., Ho, H.F., A 2-hour accelerated chest pain protocol to assess patients with chest pain symptoms in an accident and emergency department in Hong Kong. HKJEM, 2013, 261–269.
6. McCord, J., Nowak, R.M., McCullough, P.A., et al. Ninety-minute exclusion of acute myocardial infarction by use of quantitative point-of-care testing of myoglobin and troponin I. Circulation 104 (2001), 1483–1488.
7. Ng, S.M., Krishnaswamy, P., Morissey, R., et al. Ninety-minute accelerated critical pathway for chest pain evaluation. Am J Cardiol 88 (2001), 611–617.
8. Cullen, L., Mueller, C., Parsonage, W.A., et al. Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome. J Am Coll Cardiol 62 (2013), 1242–1249.
9. Kelly, A.M., Klim, S., Prospective external validation of an accelerated (2-h) acute coronary syndrome rule-out process using a contemporary troponin assay. Int J Emerg Med, 7, 2014, 42.
10. Rubini Gimenez, M., Twerenbold, R., Reichlin, T., et al. Direct comparison of high-sensitivity-cardiac troponin I vs. T for the early diagnosis of acute myocardial infarction. Eur Heart J 35 (2014), 2303–2311.
11. Cullen, L., Aldous, S., Than, M., et al. Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain. Clin Biochem 47 (2014), 321–326.
12. Haaf, P., Reichlin, T., Twerenbold, R., et al. Risk stratification in patients with acute chest pain using three high-sensitivity cardiac troponin assays. Eur Heart J 35 (2014), 365–375.
13. Chan, C.P.Y., Sanderson, J.E., Glatz, J.F., et al. A superior early myocardial infarction marker. Human heart-type fatty acid-binding protein. Z Kardiol 93 (2004), 388–397.
14. Backus, B.E., Six, A.J., Kelder, J.C., et al. Chest pain in the emergency room: a multicenter validation of the HEART Score. Crit Pathw Cardiol 9 (2010), 164–169.
15. Backus, B.E., Six, A.J., Kelder, J.C., et al. A prospective validation of the HEART score for chest pain patients at the emergency department. Int J Cardiol 168 (2013), 2153–2158.
16. Marcoon, S., Chang, A.M., Lee, B., et al. HEART score to further risk stratify patients with low TIMI scores. Crit Pathw Cardiol 12 (2013), 1–5.
17. Body, R., Acute MI: triple-markers resurrected or Bayesian dice?. Lancet 377:9771 (2011), 1049–1050.
18. Nakata, T., Hashimoto, A., Hase, M., et al. Human heart-type fatty acid-binding protein as an early diagnostic and prognostic marker in acute coronary syndrome. Cardiology 99 (2003), 96–104.
19. Williams, J.R., Revising the Declaration of Helsinki. World Med J 54 (2008), 120–122.
20. ICH Expert Working Group. ICH Topic E6 Guideline for Good Clinical Practice, ICH Harmonised Tripartite guideline (CPMP/ICH 135/95), EMEA status as of July 2002. Available at: www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500002874.pdf. Accessed May 12, 2016.
21. Thygesen, K., Alpert, J.S., Jaffe, A.S., et al. Third universal definition of myocardial infarction. J Am Coll Cardiol 60 (2012), 1581–1598.
22. Kip, K.E., Hollabaugh, K., Marroquin, O.C., et al. The problem with composite end points in cardiovascular studies: the story of major adverse cardiac events and percutaneous coronary intervention. J Am Coll Cardiol 51 (2008), 701–707.
23. Giannitsis, E., Katus, H.A., Current recommendations for interpretation of the highly sensitive troponin T assay for diagnostic, therapeutic and prognostic purposes in patients with a non-ST-segment-elevation acute coronary syndrome. Eur Cardiol Rev 5:2 (2009), 44–47.
24. Thygesen, K., Mair, J., Giannitsis, E., et al. Study Group on Biomarkers in Cardiology of ESC Working Group on Acute Cardiac Care. How to use high-sensitivity cardiac troponins in acute cardiac care. Eur Heart J 33 (2012), 2252–2257.
25. Abramson, J.H., WINPEPI updated: computer programs for epidemiologists, and their teaching potential. Epidemiol Perspect Innov, 8, 2011, 1.
26. Rainer, T.H., Leung, Y.K., Lee, A., et al. Add-on tests for improving risk-stratification in emergency department patients with chest pain who are at low to moderate risk of 30-day major adverse cardiac events. Int J Cardiol 220 (2016), 299–306.
27. Carlton, E.W., Cullen, L., Than, M., et al. A novel diagnostic protocol to identify patients suitable for discharge after a single high-sensitivity troponin. Heart 101 (2015), 1041–1046.
28. Carlton, E.W., Khattab, A., Greaves, K., Identifying patients suitable for discharge after a single-presentation high-sensitivity troponin result: a comparison of five established risk scores and two high-sensitivity assays. Ann Emerg Med 66 (2015), 635–645.
29. Santi, L., Farina, G., Gramenzi, A., et al. The HEART score with high-sensitive troponin T at presentation: ruling out patients with chest pain in the emergency room. Intern Emerg Med 12 (2017), 357–364.