Crying Time and RORγ/FOXP3 Expression in Lactobacillus reuteri DSM17938-Treated Infants with Colic: A Randomized Trial

Journal of Pediatrics

Volumn 192, Issue , 2018, Pages 171-177.e1

  Savino, Francesco ^a   Garro, Maria ^a   Montanari, Paola ^b   Galliano, Ilaria ^b   Bergallo, Massimiliano ^b  

^a CITTÀ DELLA SALUTE E DELLA SCIENZA HOSPITAL   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

fecal calprotectin; FOXP3; gut microbiota; infantile colic; probiotic; ROR ; Th17 Treg balance

Indexed keywords

CALGRANULIN; MESSENGER RNA; PROBIOTIC AGENT; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TRANSCRIPTION FACTOR FOXP3; BIOLOGICAL MARKER; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

ARTICLE; BIFIDOBACTERIUM; CONTROLLED STUDY; CRYING; DOUBLE BLIND PROCEDURE; ESCHERICHIA COLI; FECES; FEMALE; HUMAN; INFANT; INFANTILE COLIC; INTESTINE FLORA; LACTOBACILLUS; LACTOBACILLUS REUTERI; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BLOOD; CASE CONTROL STUDY; CHEMISTRY; COLIC; FOLLOW UP; METABOLISM; MICROBIOLOGY; PSYCHOLOGY; TREATMENT OUTCOME;

BIOMARKERS; CASE-CONTROL STUDIES; COLIC; CRYING; DOUBLE-BLIND METHOD; FECES; FEMALE; FOLLOW-UP STUDIES; FORKHEAD TRANSCRIPTION FACTORS; GASTROINTESTINAL MICROBIOME; HUMANS; INFANT; LACTOBACILLUS REUTERI; LEUKOCYTE L1 ANTIGEN COMPLEX; MALE; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PROBIOTICS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TREATMENT OUTCOME;

EID: 85030464899     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2017.08.062     Document Type: Article

References (39)

1. Benninga, M.A., Faure, C., Hyman, P.E., St James Roberts, I., Schechter, N.L., Nurko, S., Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology 150 (2016), 1443–1455.
2. Savino, F., Castagno, E., Bretto, R., Brondello, C., Palumeri, E., Oggero, R., A prospective 10-year study on children who had severe infantile colic. Acta Paediatr Suppl 94 (2005), 129–132.
3. Savino, F., Focus on infantile colic. Acta Paediatr 96 (2007), 1259–1264.
4. Savino, F., Grassino, E.C., Guidi, C., Oggero, R., Silvestro, L., Miniero, R., Ghrelin and motilin concentration in colicky infants. Acta Paediatr 95 (2006), 738–741.
5. Camilleri, M., Park, S.Y., Scarpato, E., Staiano, A., Exploring hypotheses and rationale for causes of infantile colic. Neurogastroenterol Motil, 29, 2017, 10.1111/nmo.12943.
6. Gensollen, T., Iyer, S.S., Kasper, D.L., Blumberg, R.S., How colonization by microbiota in early life shapes the immune system. Science 352 (2016), 539–544.
7. Lu, C.Y., Ni, Y.H., Gut microbiota and the development of pediatric diseases. J Gastroenterol 50 (2015), 720–726.
8. Savino, F., Cordisco, L., Tarasco, V., Calabrese, R., Palumeri, E., Matteuzzi, D., Molecular identification of coliform bacteria from colicky breastfed infants. Acta Paediatr 98 (2009), 1582–1588.
9. Rhoads, J.M., Fatheree, N.Y., Norori, J., Liu, Y., Lucke, J.F., Tyson, J.E., et al. Altered fecal microflora and increased fecal calprotectin in infants with colic. J Pediatr 155 (2009), 823–828 e1.
10. Savino, F., Cresi, F., Pautasso, S., Palumeri, E., Tullio, V., Roana, J., et al. Intestinal microflora in breastfed colicky and non-colicky infants. Acta Paediatr 93 (2004), 825–829.
11. de Weerth, C., Fuentes, S., Puylaert, P., de Vos, W.M., Intestinal microbiota of infants with colic: development and specific signatures. Pediatrics 131 (2013), e550–e558.
12. + regulatory T cells. Science 6251 (2015), 993–997.
13. Nagao-Kitamoto, H., Shreiner, A.B., Gillilland, M.G. 3rd, Kitamoto, S., Ishii, C., Hirayama, A., et al. Functional characterization of inflammatory bowel disease-associated gut dysbiosis in gnotobiotic mice. Gastroenterol Hepatol 2 (2016), 468–481.
14. Pärtty, A., Kalliomäki, M., Salminen, S., Isolauri, E., Infantile colic is associated with low-grade systemic inflammation. J Pediatr Gastroenterol Nutr 64 (2017), 691–695.
15. Diller, M.L., Kudchadkar, R.R., Delman, K.A., Lawson, D.H., Ford, M.L., Balancing inflammation: the link between Th17 and regulatory T cells. Mediators Inflamm, 2016, 2016, 6309219.
16. Degraeuwe, P.L., Beld, M.P., Ashorn, M., Canani, R.B., Day, A.S., Diamanti, A., et al. Faecal calprotectin in suspected paediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr 60 (2015), 339–346.
17. Wu, R.Y., Pasyk, M., Wang, B., Forsythe, P., Bienenstock, J., Mao, Y.K., et al. Spatiotemporal maps reveal regional differences in the effects on gut motility for Lactobacillus reuteri and rhamnosus strains. Neurogastroenterol Motil 25 (2013), e205–e214.
18. Perez-Burgos, A., Wang, L., McVey Neufeld, K.A., Mao, Y.K., Ahmadzai, M., Janssen, L.J., et al. The TRPV1 channel in rodents is a major target for antinociceptive effect of the probiotic Lactobacillus reuteri DSM 17938. J Physiol 593 (2015), 3943–3957.
19. Kunze, W.A., Mao, Y.K., Wang, B., Huizinga, J.D., Ma, X., Forsythe, P., et al. Lactobacillus reuteri enhances excitability of colonic AH neurons by inhibiting calcium-dependent potassium channel opening. J Cell Mol Med 13 (2009), 2261–2270.
20. Haileselassie, Y., Navis, M., Vu, N., Qazi, K.R., Rethi, B., Sverremark-Ekström, E., Lactobacillus reuteri and Staphylococcus aureus differentially influence the generation of monocyte-derived dendritic cells and subsequent autologous T cell responses. Immun Inflamm Dis 4 (2016), 315–326.
21. Liu, Y., Fatheree, N.Y., Mangalat, N., Rhoads, J.M., Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-κB signaling in the intestine. Am J Physiol Gastrointest Liver Physiol 302 (2012), G608–G617.
22. Thomas, C.M., Hong, T., van Pijkeren, J.P., Hemarajata, P., Trinh, D.V., Hu, W., et al. Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling. PLoS ONE, 7, 2012, e31951.
23. Savino, F., Cordisco, L., Tarasco, V., Palumeri, E., Calabrese, R., Oggero, R., et al. Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial. Pediatrics 126 (2010), e526–e533.
24. Roos, S., Dicksved, J., Tarasco, V., Locatelli, E., Ricceri, F., Grandin, U., et al. 454 Pyrosequencing analysis on faecal samples from a randomized DBPC trial of colicky infants treated with Lactobacillus reuteri DSM 17938. PLoS ONE, 8, 2013, e56710.
25. Biagioli, E., Tarasco, V., Lingua, C., Moja, L., Savino, F., Pain-relieving agents for infantile colic. Cochrane Database Syst Rev(9), 2016 CD009999.
26. Barr, R.G., Kramer, M.S., Boisjoly, C., McVey-White, L., Pless, I.B., Parental diary of infant cry and fuss behaviour. Arch Dis Child 63 (1988), 380–387.
27. Hawthorne, G., Richardson, J., Day, N.A., A comparison of the Assessment of Quality of Life (AQoL) with four other generic utility instruments. Ann Med 33 (2001), 358–370.
28. Mi, G.L., Zhao, L., Qiao, D.D., Kang, W.Q., Tang, M.Q., Xu, J.K., Effectiveness of Lactobacillus reuteri in infantile colic and colicky induced maternal depression: a prospective single blind randomized trial. Antonie Van Leeuwenhoek 107 (2015), 1547–1553.
29. Bergallo, M., Galliano, I., Montanari, P., Brusin, M.R., Finotti, S., Paderi, G., et al. Development of a quantitative real-time PCR assay for sapovirus in children under 5-years-old in Regina Margherita Hospital of Turin, Italy. Can J Microbiol 63 (2017), 296–302.
30. Mareschi, K., Castiglia, S., Sanavio, F., Rustichelli, D., Muraro, M., Defedele, D., et al. Immunoregulatory effects on T lymphocytes by human mesenchymal stromal cells isolated from bone marrow, amniotic fluid, and placenta. Exp Hematol 44 (2016), 138–150 e1.
31. Penders, J., Vink, C., Driessen, C., London, N., Thijs, C., Stobberingh, E.E., Quantification of Bifidobacterium spp., Escherichia coli and Clostridium difficile in faecal samples of breast-fed and formula-fed infants by real-time PCR. FEMS Microbiol Lett 243 (2005), 141–147.
32. Schreck Bird, A., Gregory, P.J., Jalloh, M.A., Risoldi Cochrane, Z., Hein, D.J., Probiotics for the treatment of infantile colic: a systematic review. J Pharm Pract 30 (2017), 366–374.
33. Harb, T., Matsuyama, M., David, M., Hill, R.J., Infant colic-what works: a systematic review of interventions for breast-fed infants. J Pediatr Gastroenterol Nutr 62 (2016), 668–686.
34. Pärtty, A., Kalliomäki, M., Endo, A., Salminen, S., Isolauri, E., Compositional development of Bifidobacterium and Lactobacillus microbiota is linked with crying and fussing in early infancy. PLoS ONE, 7, 2012, e32495.
35. Walsham, A.D., MacKenzie, D.A., Cook, V., Wemyss-Holden, S., Hews, C.L., Juge, N., et al. Lactobacillus reuteri inhibition of enteropathogenic Escherichia coli adherence to human intestinal epithelium. Front Microbiol, 7, 2016, 244.
36. Kimura, A., Kishimoto, T., IL-6: regulator of Treg/Th17 balance. Eur J Immunol 40 (2010), 1830–1835.
37. Walter, J., Britton, R.A., Roos, S., Host-microbial symbiosis in the vertebrate gastrointestinal tract and the Lactobacillus reuteri paradigm. Proc Natl Acad Sci USA 108:Suppl 1 (2011), 4645–4652.
38. Spinler, J.K., Sontakke, A., Hollister, E.B., Venable, S.F., Oh, P.L., Balderas, M.A., et al. From prediction to function using evolutionary genomics: human-specific ecotypes of Lactobacillus reuteri have diverse probiotic functions. Genome Biol Evol 6 (2014), 1772–1789.
39. He, B., Hoang, T.K., Wang, T., Ferris, M., Taylor, C.M., Tian, X., et al. Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors. J Exp Med 214 (2017), 107–123.