Direct Comparison of Cardiac Myosin-Binding Protein C with Cardiac Troponins for the Early Diagnosis of Acute Myocardial Infarction

Circulation

Volumn 136, Issue 16, 2017, Pages 1495-1508

  Kaier, Thomas E ^a   Twerenbold, Raphael ^b,c   Puelacher, Christian ^b   Marjot, Jack ^a   Imambaccus, Nazia ^a   Boeddinghaus, Jasper ^b   Nestelberger, Thomas ^b   Badertscher, Patrick ^b   Sabti, Zaid ^b   Giménez, Maria Rubini ^b,c   Wildi, Karin ^b,d   Hillinger, Petra ^b   Grimm, Karin ^b   Loeffel, Sarah ^b   Shrestha, Samyut ^b   Widmer, Dayana Flores ^b   Cupa, Janosch ^b   Kozhuharov, Nikola ^b   Miró, Òscar ^e,f   Martín Sánchez, F Javier ^e,g   Morawiec, Beata ^f,h   Rentsch, Katharina ^b   Lohrmann, Jens ^b   Kloos, Wanda ^b   Osswald, Stefan ^b   Reichlin, Tobias ^b   Weber, Ekkehard ⁱ   Marber, Michael ^a   Mueller, Christian ^b,f   more..

^a ST THOMAS HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c UNIVERSITY HEART CENTER HAMBURG   (Germany)

^d INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^e HOSPITAL CLÍNIC   (Spain)

^f Global Research in Acute Conditions Network   (United States)

^g HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^h UNIVERSITY OF SILESIA   (Poland)

ⁱ MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

cardiac myosin binding protein C; cMyC; myocardial infarction, APACE; troponin I; troponin T

Indexed keywords

BIOLOGICAL MARKER; MYOSIN BINDING PROTEIN C; TROPONIN; CARRIER PROTEIN; MYOSIN-BINDING PROTEIN C; TROPONIN I; TROPONIN T;

ACUTE HEART INFARCTION; ADULT; ARTICLE; BLOOD ANALYSIS; CARDIOVASCULAR MORTALITY; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; EARLY DIAGNOSIS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORTALITY RATE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SECRETION; RISK FACTOR; SENSITIVITY ANALYSIS; THORAX PAIN; AGED; AREA UNDER THE CURVE; BLOOD; CLINICAL TRIAL; EMERGENCY HEALTH SERVICE; EUROPE; HOSPITAL EMERGENCY SERVICE; MORTALITY; MULTICENTER STUDY; MYOCARDIAL INFARCTION; RECEIVER OPERATING CHARACTERISTIC; REPRODUCIBILITY; TIME FACTOR; UPREGULATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AREA UNDER CURVE; BIOMARKERS; CARRIER PROTEINS; EARLY DIAGNOSIS; EMERGENCY SERVICE, HOSPITAL; EUROPE; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PREDICTIVE VALUE OF TESTS; PROGNOSIS; REPRODUCIBILITY OF RESULTS; ROC CURVE; TIME FACTORS; TRIAGE; TROPONIN I; TROPONIN T; UP-REGULATION;

EID: 85030232359     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.117.028084     Document Type: Article

References (40)

1. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics. National Hospital Ambulatory Medical Care Survey: 2012 Emergency Department Summary Tables [published online ahead of print May 3, 2017]. CDC.gov. http:// www.cdc.gov/nchs/data/ahcd/nhamcs-emergency/2012-ed-web-tables. pdf
2. McManus DD, Gore J, Yarzebski J, Spencer F, Lessard D, Goldberg RJ. Recent trends in the incidence, treatment, and outcomes of patients with STEMI and NSTEMI. Am J Med. 2011;124:40-47. doi: 10.1016/j. amjmed.2010.07.023.
3. Katus HA, Remppis A, Neumann FJ, Scheffold T, Diederich KW, Vinar G, Noe A, Matern G, Kuebler W. Diagnostic efficiency of troponin T measurements in acute myocardial infarction. Circulation. 1991;83:902-912.
4. Reichlin T, Hochholzer W, Bassetti S, Steuer S, Stelzig C, Hartwiger S, Biedert S, Schaub N, Buerge C, Potocki M, Noveanu M, Breidthardt T, Twerenbold R, Winkler K, Bingisser R, Mueller C. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med. 2009;361:858-867. doi: 10.1056/NEJMoa0900428.
5. Amsterdam EA, Wenger NK, Brindis RG, Casey DE Jr, Ganiats TG, Holmes DR Jr, Jaffe AS, Jneid H, Kelly RF, Kontos MC, Levine GN, Liebson PR, Mukherjee D, Peterson ED, Sabatine MS, Smalling RW, Zieman SJ. 2014 ACC/AHA guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;130:e344-e426. doi: 10.1161/ CIR.0000000000000134.
6. Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, Bax JJ, Borger MA, Brotons C, Chew DP, Gencer B, Hasenfuss G, Kjeld sen K, Lancellotti P, Landmesser U, Mehilli J, Mukherjee D, Storey RF, Windecker S, Baumgartner H, Gaemperli O, Achenbach S, Agewall S, Badimon L, Baigent C, Bueno H, Bugiardini R, Carerj S, Casselman F, Cuisset T, Erol Ç, Fitzsimons D, Halle M, Hamm C, Hildick-Smith D, Huber K, Iliodromitis E, James S, Lewis BS, Lip GY, Piepoli MF, Richter D, Rosemann T, Sechtem U, Steg PG, Vrints C, Luis Zamorano J; Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology. 2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: task force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016;37:267-315. doi: 10.1093/ eurheartj/ehv320.
7. Reichlin T, Twerenbold R, Maushart C, Reiter M, Moehring B, Schaub N, Balmelli C, Rubini Gimenez M, Hoeller R, Sakarikos K, Drexler B, Haaf P, Osswald S, Mueller C. Risk stratification in patients with unstable angina using absolute serial changes of 3 high-sensitive troponin assays. Am Heart J. 2013;165:371.e3-378.e3. doi: 10.1016/j. ahj.2012.11.010.
8. Boeddinghaus J, Reichlin T, Cullen L, Greenslade JH, Parsonage WA, Hammett C, Pickering JW, Hawkins T, Aldous S, Twerenbold R, Wildi K, Nestelberger T, Grimm K, Rubini-Gimenez M, Puelacher C, Kern V, Rentsch K, Than M, Mueller C. Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction by use of high-sensitivity cardiac troponin I. Clin Chem. 2016;62:494-504. doi: 10.1373/ clinchem.2015.249508.
9. Offer G, Moos C, Starr R. A new protein of the thick filaments of vertebrate skeletal myofibrils: extractions, purification and characterization. J Mol Biol. 1973;74:653-676.
10. Fougerousse F, Delezoide AL, Fiszman MY, Schwartz K, Beckmann JS, Carrier L. Cardiac myosin binding protein C gene is specifically expressed in heart during murine and human development. Circ Res. 1998;82:130-133.
11. The Human Protein Atlas. MYBPC3 [published online ahead of print May 3, 2017]. proteinatlas.org. http://www.proteinatlas.org/ENSG00000134571- MYBPC3/tissue. doi: 10.3791/50786.
12. Kuster DWD, Barefield D, Govindan S, Sadayappan S. A sensitive and specific quantitation method for determination of serum cardiac myosin binding protein-C by electrochemiluminescence immunoassay. J Vis Exp. 2013. doi: 10.3791/50786.
13. Kuster DW, Cardenas-Ospina A, Miller L, Liebetrau C, Troidl C, Nef HM, Möllmann H, Hamm CW, Pieper KS, Mahaffey KW, Kleiman NS, Stuyvers BD, Marian AJ, Sadayappan S. Release kinetics of circulating cardiac myosin binding protein-C following cardiac injury. Am J Physiol Heart Circ Physiol. 2014;306:H547-H556. doi: 10.1152/ajpheart.00846.2013.
14. Lynch TL, Sadayappan S. Surviving the infarct: A profile of cardiac myosin binding protein-C pathogenicity, diagnostic utility, and proteomics in the ischemic myocardium. Proteomics Clin Appl. 2014;8:569-577. doi: 10.1002/prca.201400011.
15. Govindan S, Kuster DW, Lin B, Kahn DJ, Jeske WP, Walenga JM, Leya F, Hoppensteadt D, Fareed J, Sadayappan S. Increase in cardiac myosin binding protein-C plasma levels is a sensitive and cardiac-specific biomarker of myocardial infarction. Am J Cardiovasc Dis. 2013;3:60-70.
16. Baker JO, Tyther R, Liebetrau C, Clark J, Howarth R, Patterson T, Möllmann H, Nef H, Sicard P, Kailey B, Devaraj R, Redwood SR, Kunst G, Weber E, Marber MS. Cardiac myosin-binding protein C: a potential early biomarker of myocardial injury. Basic Res Cardiol. 2015;110:23. doi: 10.1007/ s00395-015-0478-5.
17. Jacquet S, Yin X, Sicard P, Clark J, Kanaganayagam GS, Mayr M, Marber MS. Identification of cardiac myosin-binding protein C as a candidate biomarker of myocardial infarction by proteomics analysis. Mol Cell Proteomics. 2009;8:2687-2699. doi: 10.1074/mcp.M900176-MCP200.
18. Marjot J, Kaier TE, Martin ED, Reji SS, Copeland O, Iqbal M, Goodson B, Hamren S, Harding SE, Marber MS. Quantifying the release of biomarkers of myocardial necrosis from cardiac myocytes and intact myocardium. Clin Chem. 2017;63:990-996.
19. Marjot J, Liebetrau C, Goodson RJ, Kaier T, Weber E, Heseltine P, Marber MS. The development and application of a high-sensitivity immunoassay for cardiac myosin-binding protein C. Transl Res. 2016;170:17.e5-25.e5. doi: 10.1016/j.trsl.2015.11.008.
20. Kaier TE, Anand A, Shah AS, Mills NL, Marber M. Temporal relationship between cardiac myosin-binding protein C and cardiac troponin I in type 1 myocardial infarction. Clin Chem. 2016;62:1153-1155. doi: 10.1373/ clinchem.2016.257188.
21. Rubini Gimenez M, Twerenbold R, Reichlin T, Wildi K, Haaf P, Schaefer M, Zellweger C, Moehring B, Stallone F, Sou SM, Mueller M, Denhaerynck K, Mosimann T, Reiter M, Meller B, Freese M, Stelzig C, Klimmeck I, Voegele J, Hartmann B, Rentsch K, Osswald S, Mueller C. Direct comparison of high-sensitivity-cardiac troponin I vs. T for the early diagnosis of acute myocardial infarction. Eur Heart J. 2014;35:2303-2311. doi: 10.1093/ eurheartj/ehu188.
22. Reichlin T, Hochholzer W, Stelzig C, Laule K, Freidank H, Morgenthaler NG, Bergmann A, Potocki M, Noveanu M, Breidthardt T, Christ A, Boldanova T, Merki R, Schaub N, Bingisser R, Christ M, Mueller C. Incremental value of copeptin for rapid rule out of acute myocardial infarction. J Am Coll Cardiol. 2009;54:60-68. doi: 10.1016/j.jacc.2009.01.076.
23. Haaf P, Reichlin T, Twerenbold R, Hoeller R, Rubini Gimenez M, Zellweger C, Moehring B, Fischer C, Meller B, Wildi K, Freese M, Stelzig C, Mosimann T, Reiter M, Mueller M, Hochgruber T, Sou SM, Murray K, Minners J, Freidank H, Osswald S, Mueller C. Risk stratification in patients with acute chest pain using three high-sensitivity cardiac troponin assays. Eur Heart J. 2014;35:365-375. doi: 10.1093/eurheartj/eht218.
24. Thygesen K, Alpert JS, White HD; Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. Circulation. 2007;116:2634-2653. doi: 10.1161/CIRCULATIONAHA. 107.187397.
25. Thygesen K, Mair J, Giannitsis E, Mueller C, Lindahl B, Blankenberg S, Huber K, Plebani M, Biasucci LM, Tubaro M, Collinson P, Venge P, Hasin Y, Galvani M, Koenig W, Hamm C, Alpert JS, Katus H, Jaffe AS; Study Group on Biomarkers in Cardiology of ESC Working Group on Acute Cardiac Care. How to use high-sensitivity cardiac troponins in acute cardiac care. Eur Heart J. 2012;33:2252-2257. doi: 10.1093/eurheartj/ ehs154.
26. Apple FS, Wu AH, Jaffe AS. European Society of Cardiology and American College of Cardiology guidelines for redefinition of myocardial infarction: how to use existing assays clinically and for clinical trials. Am Heart J. 2002;144:981-986. doi: 10.1067/mhj.2002.124048.
27. Apple FS, Jesse RL, Newby LK, Wu AH, Christenson RH, Cannon CP, Francis G, Morrow DA, Ravkilde J, Storrow AB, Tang W, Jaffe AS, Mair J, Ordonez-Llanos J, Pagani F, Panteghini M, Tate J; IFCC Comittee on Standardization of Markers of Cardiac Damege; National Academy of Clinical Biochemistry. National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: analytical issues for biochemical markers of acute coronary syndromes. Clin Chem. 2007;53:547-551. doi: 10.1373/ clinchem.2006.084715.
28. Pickering JW, Endre ZH. New metrics for assessing diagnostic potential of candidate biomarkers. Clin J Am Soc Nephrol. 2012;7:1355-1364. doi: 10.2215/CJN.09590911.
29. Harrell FE Jr, Califf RM, Pryor DB, Lee KL, Rosati RA. Evaluating the yield of medical tests. JAMA. 1982;247:2543-2546.
30. Pencina MJ, D'Agostino RB Sr, D'Agostino RB Jr, Vasan RS. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med. 2008;27:157-172. doi: 10.1002/sim.2929.
31. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD; the Writing Group on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction. Third universal definition of myocardial infarction. Circulation. 2012;126:2020-2035. doi: 10.1161/ CIR.0b013e31826e1058.
32. Nestelberger T, Wildi K, Boeddinghaus J, Twerenbold R, Reichlin T, Giménez MR, Puelacher C, Jaeger C, Grimm K, Sabti Z, Hillinger P, Kozhuharov N, du Fay de Lavallaz J, Pinck F, Lopez B, Salgado E, Miró Ò, Bingisser R, Lohrmann J, Osswald S, Mueller C. Characterization of the observe zone of the ESC 2015 high-sensitivity cardiac troponin 0h/1h-algorithm for the early diagnosis of acute myocardial infarction. Int J Cardiol. 2016;207:238-245. doi: 10.1016/j.ijcard.2016.01.112.
33. Hallermayer K, Jarausch J, Menassanch-Volker S, Zaugg C, Ziegler A. Implications of adjustment of high-sensitivity cardiac troponin T assay. Clin Chem. 2013;59:572-574. doi: 10.1373/clinchem.2012.197103.
34. Kavsak PA, Hill SA, McQueen MJ, Devereaux PJ. Implications of adjustment of high-sensitivity cardiac troponin T assay. Clin Chem. 2013;59:574-576. doi: 10.1373/clinchem.2012.197434.
35. Wildi K, Twerenbold R, Jaeger C, Rubini Giménez M, Reichlin T, Stoll M, Hillinger P, Puelacher C, Boeddinghaus J, Nestelberger T, Grimm K, Grob M, Rentsch K, Arnold C, Mueller C. Clinical impact of the 2010-2012 low-end shift of high-sensitivity cardiac troponin T. Eur Heart J Acute Cardiovasc Care. 2016;5:399-408. doi: 10.1177/2048872616642952.
36. Apple FS, Hollander J, Wu AH, Jaffe AS. Improving the 510(k) FDA process for cardiac troponin assays: in search of common ground. Clin Chem. 2014;60:1273-1275. doi: 10.1373/clinchem.2014. 229286.
37. U.S. Food and Drug Administration. 510(k) Premarket Notification [published online ahead of print April 3, 2017]. FDA.gov. https://www.accessdata. fda.gov/scripts/cdrh/cfdocs/cfPMN/pmn.cfm?ID=K162895. Accessed September 27, 2017.
38. Haaf P, Drexler B, Reichlin T, Twerenbold R, Reiter M, Meissner J, Schaub N, Stelzig C, Freese M, Heinzelmann A, Meune C, Balmelli C, Freidank H, Winkler K, Denhaerynck K, Hochholzer W, Osswald S, Mueller C. Highsensitivity cardiac troponin in the distinction of acute myocardial infarction from acute cardiac noncoronary artery disease. Circulation. 2012;126:31-40. doi: 10.1161/CIRCULATIONAHA.112.100867.
39. Hoeller R, Rubini Giménez M, Reichlin T, Twerenbold R, Zellweger C, Moehring B, Wildi K, Freese M, Stelzig C, Hartmann B, Stoll M, Mosimann T, Reiter M, Haaf P, Mueller M, Meller B, Hochgruber T, Balmelli C, Sou SM, Murray K, Freidank H, Steuer S, Minners J, Osswald S, Mueller C. Normal presenting levels of high-sensitivity troponin and myocardial infarction. Heart. 2013;99:1567-1572. doi: 10.1136/heartjnl-2013-303643.
40. Keller T, Zeller T, Ojeda F, Tzikas S, Lillpopp L, Sinning C, Wild P, Genth-Zotz S, Warnholtz A, Giannitsis E, Möckel M, Bickel C, Peetz D, Lackner K, Baldus S, Münzel T, Blankenberg S. Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction. JAMA. 2011;306:2684-2693. doi: 10.1001/jama.2011.1896.