Clinical impact of the 2010–2012 low-end shift of high-sensitivity cardiac troponin T

European Heart Journal: Acute Cardiovascular Care

Volumn 5, Issue 6, 2016, Pages 399-408

  Wildi, Karin ^a   Twerenbold, Raphael ^a   Jaeger, Cedric ^a   Rubini Giménez, Maria ^a,b,c   Reichlin, Tobias ^a   Stoll, Melanie ^a   Hillinger, Petra ^a   Puelacher, Christian ^a   Boeddinghaus, Jasper ^a   Nestelberger, Thomas ^a   Grimm, Karin ^a   Grob, Maja ^a   Rentsch, Katharina ^a   Arnold, Christiane ^d   Mueller, Christian ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b Pneumology Department   (Spain)

^c Parc de Salut Mar   (Spain)

^d KANTONSSPITAL   (Switzerland)

Author keywords

Clinical implication; Diagnosis of acute myocardial infarction; High sensitivity cardiac troponin T (hs cTnT); Low end shift of hs cTnT; Recalculation of hs cTnT

Indexed keywords

TROPONIN T; BIOLOGICAL MARKER;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; CALIBRATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ANGIOGRAPHY; DIAGNOSTIC ERROR; DIAGNOSTIC TEST ACCURACY STUDY; ECHOCARDIOGRAPHY; FEMALE; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; HUMAN; LIMIT OF DETECTION; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PULSE OXIMETRY; ST SEGMENT ELEVATION; T WAVE INVERSION; THORAX RADIOGRAPHY; ALGORITHM; BLOOD; CLINICAL TRIAL; ELECTROCARDIOGRAPHY; MIDDLE AGED; MYOCARDIAL INFARCTION; OBSERVER VARIATION; SENSITIVITY AND SPECIFICITY;

AGED; ALGORITHMS; BIOMARKERS; DIAGNOSTIC ERRORS; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; OBSERVER VARIATION; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; TROPONIN T;

EID: 85016032177     PISSN: 20488726     EISSN: 20488734     Source Type: Journal    
DOI: 10.1177/2048872616642952     Document Type: Article

References (36)

1. Hamm CW, Bassand J-P, Agewall S, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. The Task Force for the Management of Acute Coronary Syndromes (ACS) in Patients Presenting Without Persistent ST-elevation. Eur Heart J 2011; 32: 2999-3054.
2. Thygesen K, Alpert JS, White HD, et al. Universal definition of myocardial infarction. Circulation 2007; 116: 2634-2653.
3. Thygesen K, Mair J, Katus H, et al. Recommendations for the use of cardiac troponin measurement in acute cardiac care. Eur Heart J 2010; 31: 2197-2204.
4. Twerenbold R, Jaffe A, Reichlin T, et al. High-sensitive troponin T measurements: what do we gain and what are the challenges? Eur Heart J 2012; 33: 579-586.
5. Giannitsis E, Kurz K, Hallermayer K, et al. Analytical validation of a high-sensitivity cardiac troponin T assay. Clin Chem 2010; 56: 254-261.
6. Kavsak PA, MacRae AR, Yerna MJ, et al. Analytic and clinical utility of a next-generation, highly sensitive cardiac troponin I assay for early detection of myocardial injury. Clin Chem 2009; 55: 573-577.
7. Keller T, Zeller T and Ojeda F. Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction. JAMA 2011; 306: 2684-2693.
8. Reichlin T, Hochholzer W, Bassetti S, et al. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med 2009; 361: 858-867.
9. Reichlin T, Irfan A, Twerenbold R, et al. Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction. Circulation 2011; 124: 136-145.
10. Apple FS and Jaffe AS. Clinical implications of a recent adjustment to the high-sensitivity cardiac troponin T assay: user beware. Clin Chem 2012; 58: 1599-1600.
11. Hallermayer K, Jarausch J, Menassanch-Volker S, et al. Implications of adjustment of high-sensitivity cardiac troponin T assay. Clin Chem 2013; 59: 572-574.
12. Kavsak P, Hill S, McQueen MJ, et al. Implications of adjustment of high-sensitivity cardiac troponin T assay. Clin Chem 2013; 59: 574-576.
13. Kuster N, Dupuy A-M, Monnier K, et al. Letters to the Editor: Implications of adjustment of high-sensitivity cardiac troponin assay. Clin Chem 2012; 59: 570-571.
14. Reiter M, Twerenbold R, Reichlin T, et al. Early diagnosis of acute myocardial infarction in patients with pre-existing coronary artery disease using more sensitive cardiac troponin assays. Eur Heart J 2011; 33: 988-997.
15. Haaf P, Drexler B, Reichlin T, et al. High-sensitivity cardiac troponin in the distinction of acute myocardial infarction from acute cardiac noncoronary artery disease. Circulation 2012; 126: 31-40.
16. Thygesen K, Alpert JS, Jaffe AS, et al. Third universal definition of myocardial infarction. Eur Heart J 2012; 33: 2551-2567.
17. Thygesen K, Mair J, Giannitsis E, et al. How to use highsensitivity cardiac troponins in acute cardiac care. Eur Heart J 2012; 33: 2252-2257.
18. Mueller M, Biener M, Vafaie M, et al. Absolute and relative kinetic changes of high-sensitivity cardiac troponin T in acute coronary syndrome and in patients with increased troponin in the absence of acute coronary syndrome. Clin Chem 2012; 58: 209-218.
19. Vasile VC, Saenger AK, Kroning JM, et al. Biological and analytical variability of a novel high-sensitivity cardiac troponin T assay. Clin Chem 2010; 56: 1086-1090.
20. Wu A, Lu QA, Todd J, et al. Short-and long-term biological variation in cardiac troponin I measured with a high-sensitivity assay: implications for clinical practice. Clin Chem 2009; 55: 52-58.
21. Keller T, Zeller T, Peetz D, et al. Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 2009; 361: 868-877.
22. Reichlin T, Schindler C, Drexler B, et al. One-hour ruleout and rule-in of acute myocardial infarction using highsensitivity cardiac troponin T. Arch Intern Med 2012; 172: 1211.
23. Hoeller R, Rubini Gimenez M, Reichlin T, et al. Normal presenting levels of high-sensitivity troponin and myocardial infarction. Heart 2013; 99(21): 1567-1572.
24. Rubini Gimenez M, Hoeller R, Reichlin T, et al. Rapid rule out of acute myocardial infarction using undetectable levels of high-sensitivity cardiac troponin. Int J Cardiol 2013; 168: 3896-3901.
25. Body R, Carley S, McDowell G, et al. Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay. J Am Coll Cardiol 2011; 58: 1332-1339.
26. Bandstein N, Ljung R, Johansson M, et al. Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction. J Am Coll Cardiol 2014; 63: 2569-2578.
27. Zhelev Z, Hyde C, Youngman E, et al. Diagnostic accuracy of single baseline measurement of Elecsys Troponin T highsensitive assay for diagnosis of acute myocardial infarction in emergency department: systematic review and meta-analysis. BMJ 2015; 350: h15.
28. Roffi M, Patrono C, Collet J-P, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J 2015; ehv320.
29. Rubini Gimenez M, Twerenbold R, Jaeger C, et al. Onehour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. hs-Cardiac troponin T for 1-hour diagnosis of AMI. Am J Med 2015; 128(8): 861-870.
30. Jaeger C, Wildi K, Twerenbold R, et al. One-hour rule-in and rule-out of acute myocardial infarction using highsensitivity cardiac troponin I. Am Heart J 2016; 171: 92-102.e5.
31. de Lemos JA, Drazner MH, Omland T, et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA 2010; 304: 2503-2512.
32. Reichlin T, Irfan A, Twerenbold R, et al. Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction. Circulation 2011; 124: 136-145.
33. Haaf P, Drexler B, Reichlin T, et al. High-sensitivity cardiac troponin in the distinction of acute myocardial infarction from acute cardiac noncoronary artery disease. Circulation 2012; 126: 31-40.
34. Artunc F, Mueller C, Breidthardt T, et al. Sensitive troponins-which suits better for hemodialysis patients? Associated factors and prediction of mortality. PLoS One 2012; 7: e47610.
35. McMurray JJ, Adamopoulos S, Anker SD, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 2012; 33: 1787-1847.
36. Konstantinides S, Torbicki A, Agnelli G, et al. 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism: The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Endorsed by the European Respiratory Society (ERS). Eur Heart J 2014; 35: 3033-3069.