In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels

PLoS ONE

Volumn 12, Issue 9, 2017, Pages

  Cherry, Jonathan J ^a,e   Didonato, Christine J ^b,c   Androphy, Elliot J ^d   Calo, Alessandro ^a   Potter, Kyle ^b,c   Custer, Sara K ^d   Du, Sarah ^a   Foley, Timothy L ^a   Gopalsamy, Ariamala ^a   Reedich, Emily J ^b,c   Gordo, Susana M ^a,e   Gordon, William ^a   Hosea, Natalie ^a,f   Jones, Lyn H ^a   Krizay, Daniel K ^a   Larosa, Gregory ^a   Li, Hongxia ^d   Mathur, Sachin ^a   Menard, Carol A ^a   Patel, Paraj ^a   Ramos Zayas, Rebeca ^a   Rietz, Anne ^d   Rong, Haojing ^a   Zhang, Baohong ^a   Tones, Michael A ^a   more..

^a PFIZER INC   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c CHILDREN'S MEMORIAL HOSPITAL   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Translate Bio Inc   (United States)

^f Takeda San Diego Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINOQUINAZOLINE DERIVATIVE; C 5 SUBSTITUTED 2,4 DIAMINOQUINAZOLINE INHIBITOR; COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DOLICHYL PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3; ENZYME INHIBITOR; FAS ANTIGEN; MESSENGER RNA; PF 06738066; PF 06802336; PF 06832344; PF-06687859; PF-06738066; PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS W; POLOXAMER; POVIDONE; PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 8; PROTEASOME 26S SUBUNIT NON ATPASE 14; PROTEIN NOXA; PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2; RG3039; SMALL NUCLEAR RNA; SURVIVAL MOTOR NEURON PROTEIN; SURVIVAL MOTOR NEURON PROTEIN 2; UNCLASSIFIED DRUG; 2,4-DIAMINOQUINAZOLINE; 5-((1-(2,6-DICHLOROBENZYL)PIPERIDIN-4-YL)METHOXY)QUINAZOLINE-2,4-DIAMINE; DCPS PROTEIN, HUMAN; QUINAZOLINE DERIVATIVE; RIBONUCLEASE; SMN2 PROTEIN, HUMAN; SMN2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DNA SYNTHESIS; DOWN REGULATION; DPM3 GENE; ENZYME INHIBITION; EXON; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; PAQR8 GENE; PHENOTYPE; PIGW GENE; POLYMERASE CHAIN REACTION; PPP4R2 GENE; PROMOTER REGION; PROTEIN EXPRESSION; PSMD14 GENE; RNA ISOLATION; RNA SEQUENCE; SEQUENCE ANALYSIS; SMN2 GENE; SPINAL CORD; SPINAL MUSCULAR ATROPHY; TRANSCRIPTION INITIATION; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; DEFICIENCY; DISEASE MODEL; ENZYMOLOGY; FEMALE; GENE SILENCING; GENETICS; HEK293 CELL LINE; KNOCKOUT MOUSE; MALE; METABOLISM; MUSCULAR ATROPHY, SPINAL;

ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; ENDORIBONUCLEASES; ENZYME INHIBITORS; FEMALE; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; MALE; MICE; MICE, KNOCKOUT; MUSCULAR ATROPHY, SPINAL; PROMOTER REGIONS, GENETIC; QUINAZOLINES; RNA, MESSENGER; SURVIVAL OF MOTOR NEURON 2 PROTEIN;

EID: 85029750377     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0185079     Document Type: Article

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