Lipid based nutrient supplements (LNS) for treatment of children (6 months to 59 months) with moderate acute malnutrition (MAM): A systematic review

PLoS ONE

Volumn 12, Issue 9, 2017, Pages

  Gera, Tarun ^a   Pena Rosas, Juan Pablo ^b   Boy Mena, Evelyn ^b   Sachdev, Harshpal S ^c  

^a SL Jain Hospital   (India)

^b WORLD HEALTH ORGANIZATION   (Switzerland)

^c SITARAM BHARTIA INSTITUTE OF SCIENCE AND RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID;

ARM CIRCUMFERENCE; ARTICLE; CALORIE; CHILD; CHILD NUTRITION; DIETARY SUPPLEMENT; FORTIFIED FOOD; HUMAN; LIPID NUTRIENT SUPPLEMENT; MALNUTRITION; META ANALYSIS; MODERATE ACUTE MALNUTRITION; NUTRITIONAL COUNSELING; SYSTEMATIC REVIEW; WEIGHT GAIN; ANIMAL; DIET THERAPY; INFANT; PRESCHOOL CHILD;

ANIMALS; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; HUMANS; INFANT; LIPIDS; MALNUTRITION;

EID: 85029671146     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0182096     Document Type: Article

References (77)

1. World Health Organization. Technical note: Supplementary foods for the management of moderate acute malnutrition in infants and children 6–59 months of age. Geneva: World Health Organization, 2012.
2. Lazzerini M, Rubert L, Pani P. Specially formulated foods for treating children with moderate acute malnutrition in low- and middle-income countries. Cochrane Database of Systematic Reviews 2013; 6:Art. No.: CD009584. https://doi.org/10.1002/14651858.CD009584.pub2 PMID: 23794237
3. UNICEF, WHO, The World Bank. Levels and Trends in Child Malnutrition: UNICEF-WHO-TheWorld Bank Joint Child Malnutrition Estimates. Washington DC: The World Bank, 2012.
4. Black RE, Allen LH, Bhutta ZA, Caulfield LE, De Onis M,Ezzati M, et al. Maternal and child undernutrition: global and regional exposures and health consequences. Lancet 2008; 371(9608):243–260. https://doi.org/10.1016/S0140-6736(07)61690-0 PMID: 18207566
5. WHO. Guideline: Updates on the management of severe acute malnutrition in infants and children. Geneva: World Health Organization, 2013.
6. Gross R, Webb P. Wasting time for wasted children:severe child undernutrition must be resolved in non-emergency settings. Lancet 2006; 367:1209–11. https://doi.org/10.1016/S0140-6736(06)68509-7 PMID: 16616563
7. Jones KD, Thitiri J, Ngari M, Berkley JA. Childhood malnutrition: Towards an understanding of infections, inflammations and antimicrobials. Food Nutr Bull 2014; 35:S64–S70. https://doi.org/10.1177/15648265140352S110 PMID: 25069296
8. Briend A, Khara T, Dolan C. Wasting and stunting—similarities and differences:Policy and programmatic implications. Food Nutrition Bulletin 2015; 36(Supplement 1):S15–S23.
9. Pelletier DL. The relationship between child anthropometry and mortality in developing countries: implications for policy, programs and future research. J Nutr 1994; 124:2047S–2081S. PMID: 7931716
10. Yip R, Scanlon K. The burden of malnutrition: a population perspective. J Nutr 1994; 124:2043S–2046S. PMID: 7931715
11. World Health Organization. Essential Nutrition Actions. Improving maternal, newborn, infant and young child health and nutrition. (http://apps.who.int/iris/bitstream/10665/84409/1/9789241505550_eng.pdf?ua=1. Geneva: WHO, 2013.
12. Navarro-Colorado C. A retrospective study of emergency supplementary feeding programmes. Save the Children/ENN Available at: http://www.ennonline.net/pool/files/research/Retrospective_Study_of_Emergency_Supplementary_Feeding_Programmes_June%202007.pdf 2007.
13. de Pee S, Bloem MW. Current and potential role of specially formulated foods and food supplements for preventing malnutrition among 6- to 23-montholdchildren and for treating moderate malnutrition among 6- to 59-month-old children. Food Nutr Bull 2009; 30:S434–63. https://doi.org/10.1177/15648265090303S305 PMID: 19998866
14. Defourny I, Seroux G, Abdelkader I, Harczi G. Managementof moderate acute malnutrition with RUTF in Niger. Field Exchange 2007; 31:2–4.
15. Dewey KG, Arimond M. Lipid-based nutrient supplements: how can they combat child malnutrition? PLoS Med 2012; 9:e1001314. https://doi.org/10.1371/journal.pmed.1001314 PMID: 23028264
16. iLiNS Project [The International Lipid-Based Nutrient Supplements (iLiNS) Project]. http://www.ilins.org/ Accesssed September 26, 2015.
17. Ciliberto 2005 Ciliberto MA, Sandige H, Ndekha MJ, Ashorn P,Briend A, Ciliberto HM, Manary MJ. Comparison of home based therapy with ready to use therapeutic food with standard therapy in the treatment of malnourished Malawian children: a controlled clinical effectiveness trial. Am J Clin Nutr 2005; 81:864–870. PMID: 15817865
18. Diop EHI, Dossou NI, Ndour MM, Briend A,Wade S. Comparison of the efficacy of a solid ready-to-use food and a liquid, milk-based diet for the rehabilitation of severely malnourished children: a randomized trial. American J Clin Nutr 2003; 78:302–7.
19. Collins S, Henry CJK. Alternative RUTF formulations. Emergency Nutrition Network special supplement 2004; 2:35–37.
20. Community Based Managment of Severe Acute Malnutrition. A joint statement by the World Health Organization, the World Food Programme, the United Nations Systems Standing Committee on Nutrition, and the United Nations Children’s Fund 2007.
21. Dibari F, Diop El HI, Collins S, Seal A. Lowcost,ready-to-use therapeutic foods can be designed using locally available commodities with the aid of linear programming. J Nutr 2012; 142:955–961. https://doi.org/10.3945/jn.111.156943 PMID: 22457396
22. Matilsky DK, Maleta K, Castleman T, Manary MJ. Supplementary feeding with fortified spreads results in higher recovery rates than with a corn/soy blend in moderately wasted children. J Nutr 2009; 139:773–8. https://doi.org/10.3945/jn.108.104018 PMID: 19225128
23. Isanaka S, Roederer T, Djibo A, Luquero FJ, Nombela N, Guerin PJ, Grais RF. Reducing wasting in young children with preventive supplementation: a cohort study in Niger. Pediatrics 2010; 126:e442–450. https://doi.org/10.1542/peds.2009-2814 PMID: 20660552
24. Grellety E, Shepherd S, Roederer T, Manzo ML, Doyon S, Ategbo EA, Grais RF. Effect of mass supplementation with ready-to-use supplementary food during an anticipated nutritional emergency. PLoS One 2012; 7:e44549. https://doi.org/10.1371/journal.pone.0044549 PMID: 22984524
25. Moderate acute malnutrition: A decision tool for emergencies. http://www.cmamforum.org/resources#Service-ModerateAcuteMalnutritionMAMManagement. June 2014.
26. CMAM Forum. Management of Moderate Acute Malnutrition (MAM): Current Knowledge and Practice. http://www.cmamforum.org/Pool/Resources/MAM-management-CMAM-Forum-Technical-Brief-Sept2014.pdf. September 2014.
27. Phuka JC, Maleta K, Thakwalakwa C, Cheung YB, Briend A, Manary MJ, Ashorn P. Complementary feeding with fortified spread and incidence of severe stunting in 6- to 18-month-old rural Malawians. Arch Pediatr Adolesc Med 2008; 162:619–626. https://doi.org/10.1001/archpedi.162.7.619 PMID: 18606932
28. Park SE, Kim S, Ouma C, Loha M, Wierzba TF, Beck NS. Community management of acute malnutrition in the developing world. Pediatr Gastroenterol Hepatol Nutr 2012; 15:210–9. https://doi.org/10.5223/pghn.2012.15.4.210 PMID: 24010090
29. Ashworth A, Ferguson E. Dietary counseling in the management of moderate malnourishment in children. Food Nutr Bull 2009; 30:S406–33.
30. Karakochuk C, Van Den Briel T, Stephens D, Zlotkin S. Treatment of moderate acute malnutrition with ready-to use supplementary food results in higher overall recovery rates compared to corn-soya blend in children in southern Ethiopia: an operations research trial. Am J Clin Nutr 2012; 96:911–6. https://doi.org/10.3945/ajcn.111.029744 PMID: 22952175
31. Lin CA, Manary MJ, Maleta K, Briend A, Ashorn P. Anenergy-dense complementary food is associated with a modest increase in weight gain when compared with a fortified porridge in Malawian children aged 8–18 months. J Nutr 2008; 138:593–598. PMID: 18287372
32. Lazzerini M, Rubert L, Pani P. Specially formulated foods for treating children with moderate acute malnutrition in low- and middle-income countries. Cochrane Database of Systematic Reviews 2013; 6:Art. No.: CD009584.
33. Greiner T. The advantages, disadvantages and risks of ready-to-use foods. Breastfeeding Briefs 2014; 56/57:1–22.
34. Higgins JPT, Deeks JJ. Cochrane Handbook for Systematic Review of Interventions Version 5.1.0. The Cochrane Collaboration, 2011.
35. Ackatia-Armah RS, McDonald C, Doumbia S, Brown KH. Effect of selected dietary regimens on recovery from moderate acute malnutrition in young Malian children. FASEB 2012; 26:1031.10.
36. Ackatia-Armah RS, McDonald CM, Doumbia S, Earhardt J, Peerson J, Brown KJ. Effect of selected dietary supplements on micronutrient status during recovery from moderate acute malnutrition in young Malian children. Annals of Nutrition and Metabolism 2015; 63:842.
37. Ackatia-Armah RS, McDonald CM, Doumbia, Erhardt J. G., Hamer D. H. and Brown K. H. Malian children with moderate acute malnutrition who are treated with lipid-based dietary supplements have greater weight gains and recovery rates than those treated with locally produced cereal-legume products: A community-based, cluster-randomized trial. Am J Clin Nutr 2015; 101:632–645. https://doi.org/10.3945/ajcn.113.069807 PMID: 25733649
38. McDonald C, Ackatia-Armah R, Doumbia S, Brown K. The effect of dietary supplementation on the change in body composition of young Malian children with moderate acute malnutrition. FASEB 2014; 28.
39. Chang CY, Trehan I, Wang RJ, Thakwalakwa C, Maleta K, Deitchler M, Manary MJ. Children successfully treated for moderate acute malnutrition remain at risk for malnutrition and death in the subsequent year after recovery. J Nutr 2013; 143:215–220. https://doi.org/10.3945/jn.112.168047 PMID: 23256140
40. LaGrone LG, Trehan I, Meuli GJ, Wang RJ, Thakwalakwa C, Maleta K, Manary MJ. A novel fortified blended flour, corn-soy blend “plus-plus,” is not inferior to lipid-based ready-to-use supplementary foods for the treatment of moderate acute malnutrition in Malawian children. Am J Clin Nutr 2012; 95:212–9. https://doi.org/10.3945/ajcn.111.022525 PMID: 22170366
41. Nikiema L, Huybregts L, Kolsteren P, Lanou H, Tiendrebeogo S, et al. Treating moderate acute malnutrition in first-line health services: an effectiveness cluster-randomized trial in Burkina Faso. Am J Clin Nutr 2014; 100:241–9. https://doi.org/10.3945/ajcn.113.072538 PMID: 24808482
42. Sterne JAC, Egger M, Smith GD. Investigating and dealing with publication and other biases. In: Egger M, Smith GD, Altman DG, editor(s). Systematic Reviews in Heath Care: Meta-analysis in context. London: BMJ Books, 2001:189–208.
43. Steichen TJ, Egger M, Sterne JAC. sbe19.1: Tests for publication bias in meta-analysis. Stata Technical Bulletin 1998; 44:3–4.
44. Sterne JAC, Bradburn MJ, Egger M. Meta-analysis inSTATA TM. In: Egger M, Smith GD, Altman DG, editor(s). Systematic reviews in health care: Meta-analysis in context. London: BMJ Books, 2001:347–369.
45. Vanelli M, Contini S, Virdis R, Corradi M, Cremonini G, Fantoni S, et al. A hand-made supplementary food for malnourished children (*). Acta Biomedica 2014; 85:236–42. PMID: 25567460
46. Delchevalerie P, Herp MV, Degroot N, Monárrez-Espino J. Ready-to-use supplementary food versus corn soya blend with oil premix to treat moderate acute child malnutrition: a community-based cluster randomized trial. Unpublished.
47. Karakochuk C, van den Briel T, Stephens D, Zlotkin S. Treatment of moderate acute malnutrition with ready-to-use supplementary food results in higher overall recovery rates compared with a corn-soya blend in children in southern Ethiopia: an operations research trial. Am J Clin Nutr 2012; 96:911–916. https://doi.org/10.3945/ajcn.111.029744 PMID: 22952175
48. Medoua GN, Ntsama PM, Ndzana ACA, Essa’a VJ, Tsafack JJT, Dimodi HT. Recovery rate of children with moderate acute malnutrition treated with ready-to-use supplementary food (RUSF) or improved corn–soya blend (CSB+): a randomized controlled trial. Public Health Nutrition 2016; 19(2):363–70. https://doi.org/10.1017/S1368980015001238 PMID: 25939394
49. Nackers F, Broillet F, Oumarou D, Djibo A, Gaboulaud V, Guerin PJ, Rusch B, Grais RF, Captier V. Effectiveness of ready-to-use therapeutic food compared to a corn/soy-blend-based pre-mix for the treatment of childhood moderate acute malnutrition in Niger. J Trop Pediatrics 2010; 56:407–413.
50. Dube B, Rongsen T, Mazumder S, Taneja S, Rafiqui F, Bhandari N, Bhan MK. Comparison of Ready-to-Use Therapeutic Food with Cereal Legume-based Khichri Among Malnourished Children. Indian Pediatrics 2009; 46:383–8. PMID: 19179743
51. Fabiansen C, Phelan KPQ, Cichon B, Ritz C, Briend A, Michaelsen KF, Friis H, Shepherd S. Short children with a low midupper arm circumference respond to food supplementation: An observational study from Burkina Faso. Am J Clin Nutr 2016; 103:415–421. https://doi.org/10.3945/ajcn.115.124644 PMID: 26739038
52. Iuel-Brockdorf AS, Draebel TA, Ritz C, Fabiansen C, Cichon B, Christensen VB, Yameogo C, Oummani R, Briend A, Michaelson KF, Ashorn P, Filteau S, Friis H. Evaluation of the acceptability of improved supplementary foods for the treatment of moderate acute malnutrition in Burkina Faso using a mixed method approach. Appetite 2016; 99:34–45. https://doi.org/10.1016/j.appet.2015.12.030 PMID: 26752599
53. Kuusipalo H, Maleta K, Briend A, Manary M, Ashorn P. Growth and Change in Blood Haemoglobin Concentration Among Underweight Malawian Infants Receiving Fortified Spreads for 12 Weeks: A Preliminary Trial. J Pedaitric Gastroenterol Nutr 2006; 43:525–532.
54. Lagrone L, Cole S, Schondelmeyer A, Maleta K, Manary MJ. Locally produced ready-to-use supplementary food is an effective treatment of moderate acute malnutrition in an operational setting. Annals of Tropical Paediatrics 2010; 30(2):103–108. https://doi.org/10.1179/146532810X12703901870651 PMID: 20522296
55. Lin CA, Manary MJ, Maleta K, Briend A, Ashorn P. An Energy-Dense Complementary Food Is Associated with a Modest Increase in Weight Gain When Compared with a Fortified Porridge in Malawian Children Aged 6–18 Months. J Nutr 2008; 138:593–8. PMID: 18287372
56. Maleta K, Kuittinen J, Duggan MB, Briend A, Manary M, Wales J, Kulmala T, Ashorn P. Supplementary Feeding of Underweight, Stunted MalawianChildren With a Ready-To-Use Food. Journal of Pediatric Gastroenterology and Nutrition 2004; 38:152–158. PMID: 14734876
57. Patel MP, Sandige HL, Ndekha MJ, Briend A, Ashorn P, Manary MJ. Supplemental Feeding with Ready-to-Use Therapeutic Food in Malawian Children at Risk of Malnutrition. J Health Popul Nutr 2005; 23:351–7. PMID: 16599106
58. Flax VL, Phuka J, Cheung YB, Ashorn u, Maleta K, Ashorn P. Feeding patterns and behaviors during home supplementation of underweight Malawian children with lipid-based nutrient supplements or corn-soy blend. Appetite 2010; 54:504–11. https://doi.org/10.1016/j.appet.2010.02.003 PMID: 20153389
59. Phuka J, Thakwalakwa C, Maleta K, Cheung YB, Briend A, Manary M, Ashorn P. Supplementary feeding with fortified spread among moderately underweight 6–18-month-old rural Malawian children. Maternal Child Nutrition 2009; 5:159–170. https://doi.org/10.1111/j.1740-8709.2008.00162.x PMID: 19292750
60. Purwestri RC, Scherbaum V, Inayati DA, Viravan NN, Suryantan J, Bloem MA et al. Supplementary feeding with locally-produced Ready-to-Use Food (RUF) for mildly wasted children on NiasIsland, Indonesia: comparison of daily and weekly program outcomes. Asia Pac J Clin Nutr 2012; 21(3):374–379. PMID: 22705426
61. Roy SK, Fuchs GH, Mahmud Z, Ara G, Islam S, Shafique S, Akter SS, Chakraborty B. Intensive Nutrition Education with or without Supplementary Feeding Improves the Nutritional Status of Moderately-malnourished Children in Bangladesh. J Health Popul Nutr 2005; 23:320–330. PMID: 16599102
62. Scherbaum V, Purwestri RC, Stuetz W, Inayati DA, Suryantan J, Bloem MA, Biesalski HK. Locally produced cereal/nut/legume-based biscuits versus peanut/milk-based spread for treatment of moderately to mildly wasted children in daily programmes on Nias Island, Indonesia: an issue of acceptance and compliance? Asia Pacific J Clin Nutr 2015; 24:152–161.
63. Singh AS, Kang G, Ramachandran A, Sarkar R, Peter P, Bose A. Locally Made Ready-to-Use Therapeutic Food for Treatment of Malnutrition: A Randomized Controlled Trial. Indian Pediatrics 2010; 47:679–686. PMID: 20972285
64. Thakwalakwa C, Ashorn P, Phuka J, Cheung YB, Briend A, Puumalainen T, Maleta K. A Lipid-Based Nutrient Supplement but Not Corn-Soy Blend Modestly Increases Weight Gainamong 6- to 18-Month-Old Moderately Underweight Children in Rural Malawi. J Nutr 2010; 140:2008–13. https://doi.org/10.3945/jn.110.122499 PMID: 20861218
65. Thakwalakwa CM, Ashorn P, Phuka JC, Cheung YB, Briend A, Maleta KM. Impact of lipid-based nutrient supplements and corn–soy blend on energy and nutrient intake underweight 8–18-month-old children participating in a clinical trial. Maternal Child Nutrition 2014.
66. Thakwalakwa CM, Ashorn P, Jawati M, Phuka JC, Cheung YB, Maleta KM. An effectiveness trial showed lipid-based nutrient supplementation but not corn–soya blend offered a modest benefit in weight gain among 6- to 18-month-old underweight children in rural Malawi. Public Health Nutrition 2012; 15(9):1755–1762. https://doi.org/10.1017/S1368980012003023 PMID: 22691922
67. Tomedi A, Rohan-Minjares F, McCalmont K, Ashton R, Opiyo R, Mwanthi M. Feasibility and effectiveness of supplementation with locally available foods in prevention of child malnutrition in Kenya. Public Health Nutrition 2012; 15(4):749–756. https://doi.org/10.1017/S1368980011002217 PMID: 21896234
68. Traore T, Mouquet-Rivier C, Kabore C, Bruyeron O. Efficacy of different fortified gruels on the recovery from moderate acute malnutrition in Burkinabe 6–23 month old children. Annals of Nutrition and Metabolism 2013; 63:1024–5.
69. Friis H. Effectiveness of improved diets for children with moderate acute malnutrition: a randomized controlled trial in Province du Passoré, Burkina Faso. ISRCTN 2013;ISRCTN42569496.
70. Manary MJ, Rogers B. Comparison of Four Different Supplementary Foods in the Treatment of Moderate Acute Malnutrition (MAM) in Children in Sierra Leone: a Cluster-randomised, Controlled Clinical Effectiveness Trial. clinicaltrial.gov 2014;NCT02077907.
71. Marron B, Green J, Jayson L, Suri D, Marcus S, Boiteau M, Manary M, Webb P, Rogers B. Comparison of Four Different Supplementary Foods in the Treatment of Moderate Acute Malnutrition (MAM) in Children Under Five in Sierra Leone. Faseb 2015; 29.
72. van der Kam S, Salse-Ubach N, Roll S,Swarthout T, Gayton-Toyoshima S, Jiya NM, et al. Effect of Short-Term Supplementation withReady-to-Use Therapeutic Food or Micronutrients forChildren after Illness for Prevention of Malnutrition: ARandomised Controlled Trial in Nigeria. PLoS Med 2016; 13(2): e1001952. https://doi.org/10.1371/journal.pmed.1001952 PMID: 26859559
73. World Health Organisation. World Health Statistics. Geneva: World Health Organization, 2013.
74. Ramalingaswami V, Jonsson U, Rohde J. The Asian enigma: Commentary. In: The Progress of Nations. UNICEF, 1996.
75. Guyatt GH, Oxman AD, Schünemann HJ, Tugwell P,Knotterus A. GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. Journal of Clinical Epidemiology 2010; 64(4):380–2. https://doi.org/10.1016/j.jclinepi.2010.09.011 PMID: 21185693
76. Suri D, Moorthi D, Rosenberg I. Systematic Review and Meta-Analysis of Food-Based Interventions on Recovery from Moderate Acute Malnutrition in Young Children. FASEB J 2013; 27:lb332.
77. Lenters LM, Wazny K, Webb P, Ahmed T, Bhutta ZA. Treatment of severe and moderate acute malnutrition in low- and middle-income settings:a systematic review, meta-analysis and Delphiprocess. BMC Public Health 2013; 13(Suppl 3):S23.